Lymphoma Follicular: iimpawu, oonobangela, unyango. Ithuba kuxolelwe kunye lymphoma ukubuyela follicular

Lymphoma ebizwa sisifo esichaphazela esikule emithanjeni. Kulo mzekelo, iiseli abachaphazelekayo aqale ukukhula kwaye kuzichasa ukumqumbisa ukuphazamiseka eqhelekileyo yokusebenza amalungu angaphakathi omzimba womntu. iqela ezifana izifo: isifo Hodgkin ngayo (okanye-kuthiwa isifo Hodgkin kaThixo) kunye lymphoma non-Hodgkin kaThixo (kubandakanywa follicular non-Hodgkin lymphoma).

Le nkqubo emithanjeni. Yintoni le

Inxalenye amajoni omzimba yomzimba wethu ke nkovu, umsebenzi engundoqo iyileyo - ukhuseleko nxamnye nazo zonke iintlobo zosulelo kunye nezinye izifo. Kuyinto uthungelwano Kusungulwe apho ulwelo ihambisa isinye - nkovu. Ekuhambeni ngcanjana waphawula nodes nkovu apho nkovu kuba natyetyiswa iiseli ezikhethekileyo - lymphocyte. Kukho zenyathi eziliqela. B lymphocyte banoxanduva okukwazi ezifunyenwe kwizifo ezosulelayo. Qhagamshelana ne pathogen, abasusa imiphumela yayo uze uyigcine kwinkumbulo wam. B lymphocyte - zingabameli ezibalulekileyo lokusekwa imiphumo emihle zisigonyelwe. Uninzi (80%) nkovu ziquka lymphocyte T. Banoxanduva ngenxa yokwaphuka zonke iintlobo iintsholongwane, iintsholongwane. NK-iiseli zifumaneka nkovu kwi imali encinci (ukuya kwi-10%). Owona msebenzi wabo - ukutshatyalaliswa iiseli zayo ezonakeleyo (kubandakanywa kule sifo ezifana lymphoma follicular).

Njani na inkqubo elinobuhlungu kwinkqubo emithanjeni

inkqubo Neoplastic iqala ukuphuhlisa ukusuka iiseli inkqubo emithanjeni (B cells). Isifo unesifo ikakhulu kubantu abadala, abantwana zenzeka kwiimeko ezinqabileyo. lymphoma Follicular wafumana igama layo ngenxa yokuba kakhulu echaphazela follicle iinwele. Amaxesha amaninzi, nangezilonda kuvandlakanywa entanyeni, amakhwapha, ubudoda. Le peculiarity yale lymphoma kukuba izigulane bafuna uncedo kakhulu emva kwexesha. Iiseli ezichaphazelekayo angene kuwo onke amalungu angaphakathi, ukuphazamisa umsebenzi wabo. Nangona lymphoma follicular iiia lulutho ngokwaneleyo ngokwayo kakuhle kuthomalaliso, izigaba kamva loxilongo musa ukuvumela ukuba ngokupheleleyo balahle sifo.

ezibangela kwesi sifo

Izizathu ngqo ukuba negalelo kuphuhliso umhlaza, iingcali ayikwazi kubizwa ngokuba. Noko ke, kukho izinto ezininzi ezandisa amathuba yobubi. Omnye wabo - zofuzo, chromosome. Ukusebenza kweemeko ezingentle, wadibana enombhalo iikhemikhali eziyingozi nako yempela zikwimeko lymphoma follicular. Izinto ezibangela le sifo ngolu hlobo lulandelayo: sesichengeni radiation, immunodeficiency buthathaka umzimba, kunye nesifo samathambo. Ezinye iingcali bahlule izinto ezifana nokutshaya, ngokuthatha amayeza athile, nkqu ukutyeba.

symptomatology lymphoma

Iimpawu lymphoma Follicular yi kunokuba ababuthathaka, ingakumbi isanda. Okokuqala, kukho abathile ukwanda kwiindawo nkovu. Noko ke, ukuba elula. Akumangalisi, ukudumba kancinane ngamathuba shwaka, ngoko kuyabuya. Oku kufuneka aqaphele ngokukodwa. Yandisa kwiiyunithi kunye kwentamo. Ngaphandle kokuba kuboniswe ukukhohlela, bamba umphefumlo. Amathuba ubuso encinane run-off. Kwezinye iimeko, ukubandezeleka udakada. Iimpawu lymphoma Follicular banokuba eliqhelekileyo: ukwehla kobunzima, ukudinwa jikelele, buthathaka umzimba. Noko ke, le miqondiso - ngaphandle kunokuba umthetho, baya kuvandlakanywa umguli enye kuphela ngaphandle ezilishumi. izigaba ezibalaseleyo kakhulu zesi sifo luphawulwa umonakalo luvo, ingakumbi umongo wethambo. Kwindawo enye yokuba nesiyezi, isicaphucaphu, kunye zingqondweni kunokwenzeka.

Ukuhlelwa imihlaza kunye nezigaba lokuhamba

Kukho iintlobo ezininzi lymphoma. Okokuqala - follicular. Iziqulatho zale zoboya kulo mzekelo 75%. Ukuba kukho ku ezahlukene 25-75%, oku zenyathi follicular-kwentamo. Xa uhlobo ehlasela esidumileyo ngaphantsi kwe-25% of zoboya. lymphoma Follicular (iiia) lwenzeka ngokwamanqanaba eziliqela. Ngelo isanda, ummandla omnye kuphela banazo iindawo nkovu. Inqanaba lesibini iphawulwa yinkqubo zophendlo lwezifo ebandakanya iinxalenye ezimbini okanye ngaphezulu (kodwa kwicala elinye uvalo). Xa-degree wesithathu ochaphazelekayo ndawo kumacala omabini uvalo. Isigaba kunawo ezine. Utshintsho kwakhona kwenzeka amalungu kunye neenkqubo (ezinomongo, isibindi, njl) lwangaphakathi. Ngamanye amaxesha neenyumerali sigaba lymphoma ukongeza oonobumba A okanye B Oku kubonisa ukuba iimpawu lymphoma follicular uhlobo ulandelayo: "B" - kukho utshintsho lobushushu emzimbeni (neendyebo athile), ukwehla kobunzima, ukubila ebusuku. Lymphoma c isimaphambili "A" - iinkcukacha akukho iimpawu.

Iindlela lymphoma ukuxilonga

Okokuqala, ingcali (onco-segazi) ukuqhuba uviwo olubonakalayo malunga nesigulane eso. Kunyanzelekile iimviwo histological isampula. Ukuze wenze oku, kukho biopsy olwenziweyo. Iqhekeza elo nkovu malungu achaphazelekayo lisusiwe kwaye ancinwe ngemicroscope. Kukwabalulekile ukuqaphela uhlobo ezintathu cytological lwesifo ezifuna unyango ezahlukeneyo. Uhlobo lokuqala luphawulwa bubukho centroblasts ukuya ezintlanu entsimini yokucingela neemicroscope, okwesibini - nakwiiyunithi ze-15. Uhlobo lwesibini bothukile cytological kufuna ichemotherapy kuba lunamandla ngokwaneleyo. Follicular uhlobo lymphoma 3A cytological unalo ALS ezingaginyisi mathe. Entsimini ngenxa neemicroscope ungabona nangezilonda ngokubanzi. Ukongeza, isigulane kufuneka igazi (markers ithumba, uhlalutyo ngokubanzi), ipasise uviwo ultrasound enyama yangaphakathi, CT okanye MRI. Ukuze kuqinisekiswe ukuba ngaba wabetha inkqubo luvo, umnqonqo wayebeka ucingo olunye uphando iiseli umhlaza.

lymphoma Follicular. unyango

Kwiminyaka yakutshanje, inani lezigulane unesifo onjalo liye landa kakhulu. Ngokuqhelekileyo, le ngaphambili akazange azibone neziqu, ngcono ukulondoloza impilo kunye nobomi babo amathuba yesigulana. Lymphoma lubonakala ngokuba ngababuthuntu ngokufanelekileyo ngaphezulu, ngoko kwezinye iimeko ugqirha ukhetha umdlalo elindileyo, ebukele zonke utshintsho emzimbeni womntu. Oku kungenxa yokuba bobabini ichemotherapy kunye kotyando bebengayivavanyanga ngokupheleleyo yaye macala zabo ezimbi. Follicular lymphoma uxolelo unokuthatha iminyaka eliqela. Ukuba inkqubela somhlaza luqala, uthomalaliso kufuneka wenziwe ngokukhawuleza. Phakathi iindlela eziphambili unyango kufuneka zenziwe radiation, ichemotherapy, iziyobisi amayeza. Ngokuxhomekeka kuhlobo lymphoma, sesichengeni zommandla unako ukuthintela likakade kunokwenzeka. Inxaxheba kwinqanaba lokuqala ixesha ngesifo kuxolelwe ibhalwe izigulane ezininzi.

chemotherapy Ukufeza

chemotherapy ndlongo (neziyobisi kubhetele ezininzi) kumabakala okuqala lymphoma unga nciphisa ngokubaluleka okuba ukuphinda. Kangangexesha elide le ndlela kwakujongwa unyango lokuqala zomhlaza. Chemotherapy lujoliswe ilishwa iiseli ithumba ngexesha phinda zabo. imixube kolimo anganefuthe kwinkqubo yokuphunyezwa kwe candelo ngezigaba ezahlukeneyo, ngoko ukusetyenziswa kwazo ngempumelelo ngakumbi. Noko ke, chemotherapy lineziphumo yonakalisa kwezinye izigqeba (eluswini, iinwele, njalo njalo. N.). Unale la machiza kunye umongo wethambo. Ngexesha unyango, umntu uba basengozini kwizifo ezosulelayo zinokuvela ukugruzuka ezininzi kwegazi. amayeza onyango badla kunokubangela imveliso lokuwandisa uric acid, nto leyo ekhokelela kuseko ngamatye zezintso. Nangona kunjalo, bonke abasabela ezibi shwaka emva kweeveki ezimbalwa emva kwekhosi. Kufuneka kuqatshelwe ukuba iziyobisi ezithile ichemotherapy kunganciphisa yenzala ngabantu, ukumqumbisa iinkunzi kwabasetyhini.

Unyango ne Monoclonal Isilwa buhlungu

lymphoma Follicular iphathwa, yaye loo amachiza amatsha afana omzimba monoclonal. Bathi ngenjongo kutshabalalisa kuphela iiseli lymphoma. Le nqubo olugqibeleleyo, ngokukodwa zidityaniswe kunye ichemotherapy. omzimba Monoclonal ngandlel ekunciphiseni ubungozi wemichiza. Izigulane waphawula ubude kuxolelwe lymphoma follicular. Kwezinye iimeko, basabele nawo, ngoko ke ulawulo yokuqala izilwa ezenzeka ixesha elithile. Phambi kokuba unyango isigulane efunekayo izinga amachiza antiallergic.

ukuphinda izifo

isifo danae lubonakala ngokuba ukuqhubela okucothayo usaqala, ixesha uxolelo ingahlala iminyaka engama-20. Njalo lymphoma nezolo follicular kuvandlakanywa uhlobo 3A cytology. Kulo mzekelo, kusenokufuneka stem cell abohlukeneyo. Le mali inokuba umzalwana (udade), kunye nezalamane non-gazi. Lenquba yenzelwa e izigulane kweminyaka engama-70, nto leyo wasabela kuhle ukuba kusetyenziswe amachiza kwaye kufuneka urhulumente eyanelisayo yempilo. Emva abohlukeneyo, ukuphuculwa kuvandlakanywa malunga nesiqingatha izigulane. Survival kuxhomekeke kwizinto ezininzi. Okokuqala, ibakala esi sifo kubalulekile, utshintsho morphology (unakano follicular lymphoma kunokuba kukuhanjiswa kwi inyathelo wesine). Kufuneka kuqatshelwe ukuba bamelane ngcono nesi sifo sabantu abatsha. Kubalulekile ukuqaphela lymphoma ngexesha, ngoko musa ukunikezela iimviwo othintelo ziingcali.