Analogu of Plavix.

Enye unyango antiplatelet kuhlanganisiwe sisiyobisi, "Plavix". Namhlanje kwakhona rhoqo kakhulu kusetyenziswa amayeza, ezifana-analogue of Plavix zilt. Ukwakheka chiza ibandakanya zombini clopidogrel kunye acetylsalicylic acid. Okwenziwayo yokulungiselela amayeza uyalwa ukuba inhibition ka ADP-receptor onoxanduva udibaniso kwiiseli (in zegazi ezithile). A uphawu yokulungiselela yi esibophelelayo lakho ADP-receptors, nto leyo ekhokelela ukuba nempembelelo bezinzile udibaniso. Ngenxa yomsebenzi receptor kwakhona kuphela xa ukufa endala kunye Yindibanisela ziiplatelets ezintsha. Leyo isakhiwo indlela yokusebenza ye-analogu of Plavix - zilta.

Clopidogrel (Plavix analogu) lisetyenziswa umthamo 75 milligrams. Ngosuku lokuqala ezithatha ichiza wabonisa eziphango ebalulekileyo yomsebenzi zegazi udibaniso. Phezu isicelo esilandelayo kwandisa ukusebenza iziyobisi. Hour yokulungiselela Cycle zamachiza i-avareji iintsuku ezintathu ukuya kwezisixhenxe. Emva ukupheliswa isiphumo ichiza ngayo liyasetyenziswa (asiyihlaziyanga ngokupheleleyo de uninzi ubume zegazi) esinye isithuba seentsuku ezintlanu ukuya esixhenxe.

Salicylic acid ebangela inhibition of zegazi udibaniso ngenxa inhibition lakho cyclooxygenase (Cox-1). Ngenxa yoko, lancitshiswa thromboxane kuyondelelaniswe kunye vasoconstriction okuncitshiswe. Njengoko kwimeko clopidogrel isiphumo eyabangelwa lugcinwa ngaphezulu kobomi le iiseli (zegazi).

Kutheni usebenzisa i kwiwotshi of Plavix kunye ichiza ngokwawo? Usebenziso oluqhelekileyo lwe indibanisela unyango antiplatelet bugwetyelwe basengozini enkulu yokuba thrombosis semithambo nawuphi na indawo phambi izilonda atherosclerotic.

Kukho esinye ngaphezulu analogu kakhulu eyahlekileyo ye Plavix - listab. Noko ke, yena, efana nabanye abaninzi (klopilet, lopirel, plargil, detromb, plogrel, Trocken, kardutol), akukho sisetyenziswa ngokubanzi yezonyango mihla.

Plavix okanye zilt?

Oogqirha abaninzi ungqiyame ngokubhekiselele ekusetyenzisweni Plavix, ekubeni impumelelo yayo abangqine izilingo kokuhlola. isiseko Ubungqina ichiza wasukuma emva ngo-2007 kwaye kule minyaka mihlanu idlulileyo, ukusetyenziswa ebonakalayo kuphela yalomeleza isihloko "imveliso best". Ke ukuba zilta, ukusebenza kwayo, njengoko kuqatshelwe yi oogqirha ngokwabo, ngaphantsi ngandlel ngaphezu wathi, ngoko kuthelekiswa woogxa balo ngokuphathelele kumgangatho unyango yena akakwazi. Ngokuyintloko, izazinzulu zikholelwa ukuba ukusebenza phantsi le yokugqibela kungenxa ukungafezeki inkqubo uzobe olwenziwe mveliso ichiza. Biophysics efanayo uqaphele ukungangqinelani kwengcaciso ethile kubume ngemolekyula phakathi Plavix kunye analogue yayo.

Njengoko ngexabiso, ithe kakhulu Plavix ziltu. Ngoko ke, ixabiso lokuqala izihlandlo ezithathu ixabiso le yesibini. Kwiimeko ezininzi, iindleko ichiza kukhokelela imfuneko yokusebenzisa betye oluf. Phezu ziqinisekiso oogqirha leekliniki mihla, ukuba awukwazi ukuthenga Plavix imali kufuneka athenge analogu enganeno kwayo - zilt. Ngokupheleleyo siyishiye ukwamkelwa ichiza ayikhuthazwa.

Njengoko neziyobisi "Ko Plavix," loo ngoko olubalaseleyo kukho umthamo eyandileyo yinxalenye amacandelo (100 no-75 mg salicylic acid, kwaye clopidogrel, ngokulandelelana).

Ngelishwa, ukuba umhla technology lemveliso "Plavix" medicament, kwakunye amacandelo alo ayabiza kakhulu, nto leyo ekhokelela ekubeni kweendleko eziphezulu amayeza. Inzuzo eya ukunceda izigulana afumileyo kuza nucleoside elungileyo kakhulu amachiza kraca-gama.