"Kordinik": imiyalelo ukusetyenziswa, analogs kunye nohlolo

iziyobisi Antianginal ebizwa iziyobisi ukwandisa flow igazi entliziyweni, kwakunye nokunciphisa imfuno yayo oksijini. La mayeza rhoqo zisetyenziselwa isiqabu okanye nokuthintelwa yokuhlaselwa angina.

Angina - sisifo luphawulwa iintlungu okanye ukungaphatheki emva breastbone. Ngokuqhelekileyo, intlungu sifo enjalo kubonakaliswa ngequbuliso phantsi koxinzelelo ngokweemvakalelo okanye ukusebenzisa uxinezeleko, yaye emva ukusetyenziswa isidlo. Ngokuqhelekileyo inikeza entanyeni, nengalo ngasekhohlo, phakathi iibhleyidi zamagxa, umhlathi ephantsi novulelweyo mmandla subscapular. mizwa ezinjalo ekhathazayo shwaka phezu ¼ ngeyure. Kwakhona, iintlungu liyalahleka emva kumiwe lokuzilolonga okanye emva kokuthatha iziyobisi anti-anginal. Njengoko yokugqibela isoloko kakhulu kusetyenziswa amayeza "Kordinik". Imiyalelo zokusetyenziswa, inkcazo ukulungiswa kunye iimpahla zazo thaca ngezantsi.

Inkcazelo ngemveliso amayeza, yayo ifomu, ukwakhiwa kunye nokupaka

Yintoni uhlobo ezendeleyo medicament "Kordinik" na? Imiyalelo isicelo ibonisa ukuba ichiza ifumaneka azipilisi. Bathi ifomu ploskotsilindricheskoy, yiba omhlophe okanye umbala ungatyhafi nombala-elityheli.

Ukubunjwa ichiza ethathelwa ingqalelo ziquka nicorandil. Njengoko components abancedisayo kusetyenziswa neetapile starch calcium stearate kunye microcrystalline kwincindi.

Ukuthengiswa kweziyobisi imiyalelo "Kordinik" ukusetyenziswa ezitransparenti imfumba yekhadibhodi engena iiseli nentaba.

Pharmacology medicament

Yintoni na iziyobisi ephawulekayo "Kordinik" (tablets)? Imiyalelo yokusebenzisa ibonisa ukuba nicorandil lineziphumo antianginal. Oku kusekelwe ngokudibanisa nitratopodobnyh iipropati, kwakunye nokukwazi ukuvula amajelo potassium. Ngenxa impahla yokugqibela ichiza kubangela hyperpolarization yeseli ndizayo.

ukusebenza Nitratopodobny yale iyeza kukwandisa okuqulethwe guanilmonofosfata elibujikele intracellularly. iziphumo ezifana amayeza ukukhuthaza kuthanjiswa zihlunu anencasa nokukhusela myocardium ngexesha ischemia.

Ngokumalunga neziphumo hemodynamic, ke zibonakaliswa ukwehla elungeleleneyo post-kunye ukulayisha. Ngenxa vasodilation (uyakhetha) imithambo yenhliziyo lomthwalo myocardium kobuchopho kuncitshiswe.

Nicorandil alunasiphumo kwi contractility engabalulekanga. Ukongeza, le nto ayitshintshi kulo izinga entliziyweni. Nangona kunjalo, oku kunciphisa uxinzelelo lwegazi systemic, kwaye kananjalo kwamnceda ebuchotsheni flow igazi abantu ngesibetho kobuchopho.

Ziziphi ezinye iipropati ezendeleyo iziyobisi "Kordinik"? Imiyalelo yokusebenzisa (iziyobisi analogue ezidweliswe ngezantsi) ithi nicorandil alunasiphumo kwi nethe glucose kunye lipid ukutya. Ancede angina, yaye kunciphisa intlungu imizuzu ezisixhenxe emva kokuba ulawulo phantsi kolwimi. Zalisa ukupheliswa kabi waphawula kamva ¼ iiyure.

Kinetics izimali

Indawo wendele iziyobisi "Kordinik"? Imiyalelo yokusebenzisa ibonisa ukuba kukufakwa ichiza ethathelwa ingqalelo kuvela lokugaya. Oku kufikelela incopho eyavela kwi plasma emva kwemizuzu 35-60.

Nicorandil ibotshelelwe kancinane kuphela iiproteni plasma. iqhekeza lwayo free kwigazi 75%.

Le ichiza lakufumana yokucolwa olunzulu esibindini. Yena salawo yi izintso kwisithuba semizuzu engama-50.

Ezibonisa yokwamkelwa

Ndingayisebenzisa Xa iipilisi 'Kordinik "? Manual ukuba oku kuthetha elungileyo esizibonakalisa nge:

• ukuthintelwa imivimbo (izinzile) xa zidityaniswe namanye amachiza antianginal;
• ukukhululeka angina;
• monotherapy xa kwimeko zobandlululo BCCI beta-blocker.

Izimo ukuba kokufumana

Xa tablets kufuneka abasayi kwenziwa "Kordinik"? Imiyalelo yokusebenzisa (izithethantonye imveliso echazwe zidweliswe ngezantsi) ikuthethayo Izimo, ezifana:

• ukuwa, ukothuka cardiogenic;
• AV-block leyesithathu kunye isidanga sesibini;
• Okubuhlungu iposi engabalulekanga, yaye iintsuku ezingama-90 emva koko;
• angina eziguquguqukayo ;
• ukusilela Chronic intliziyo (kwiklasi yesithathu okanye eyesine NYHA yokuhlela functional);
• hypotension wegazi;
• ngexesha lokukhulelwa;
• bradycardia;
• zisanyisa;
• ekhohlo ventricular insufficiency yancitshiswa ukugcwaliswa uxinzelelo;
• yobudala minor;
• ukusetyenziswa ngaxeshanye phosphodiesterase-5 inhibitors (umz: "Sildenafil", "Vardenafil" okanye "tadalafil");
• hypersensitivity ukuba ichiza.

Amanyathelo anjalo iipilisi ezimiselweyo kweepesente intliziyo isingqisho, Prinzmetal angina, AV-kuvalwe iindlela kumlinganiselo yokuqala, hypotension, umsebenzi isibindi nkene kidney hypovolemia, nokudumba yemiphunga, hyperkalemia, engile-ukuvalwa neglaucoma kunye nezinye.

Drug "Kordinik": Izikali kunye nolawulo

Tablets "Kordinik" kufuneka kuthathwe ngomlomo, kungakhathaliseki ukuba ukutya.

Le umthamo ichiza ukhethe ngamnye. Ngokubanzi, kuxhomekeke ixesha kunye nobungozi besi sifo.

Kuba ukukhululeka imithi angina kufuneka asetyenzisiweyo ngumqondiso wokuqala yokugula. Kule meko ke inokusetyenziswa ngendlela of mg-20. Tablet obekwe phantsi kolwimi ubambe kangangoko nje iyachithakala.

Kuba ukuthintela ukuhlaselwa angina zizinze (kuquka unyango ixesha elide) ichiza idla inokusetyenziswa ngendlela ka 10-20 mg kathathu ngemini.

Idosi iphezulu ichiza ngosuku 80 mg. Yintloko ithamo zokuqala lincitshiswe.

imiphumela emibi

Into ekufuneka uyazi phambi kokuthatha iipilisi 'Kordinik "? Imiyalelo yokusebenzisa uthi ukuba le arhente ukuze baxabane ezingalunganga ezifana:

• ubuthathaka, iyangongoza, intloko ebuhlungu, sinciphise uxinzelelo lwegazi, isiyezi;
• tachycardia, ukuduma, "amaza" wegazi eluswini, efuna;
• negazi lakho, nokudumba peripheral, isicaphucaphu;
• imvakalelo nenzaliseko esiswini, ukugabha, umsebenzi eyandileyo "kwesibindi" transaminases, ukungakhululeki esiswini, stomatitis.

An libanda, iipilisi

Xa ufumana inani elikhulu iipilisi isigulane uneempawu ezifana tachycardia kunye nokwehla ekucebiseni uxinzelelo lwegazi. Kulo mzekelo, ixhoba wahlanjwa esiswini kwaye zinika iyasebenza namalahle. Kwakhona ukuxhasa umsebenzi kwenkqubo sentliziyo.

Intsebenziswano kunye namanye amachiza

iziyobisi Antianginal phantsi ingqalelo ngakumbi ngeli lakhula, vasodilators, phosphodiesterase-5 inhibitors, antihypertensives, kunye nemithi yokunciphisa tricyclic. Kunjalo ke nanga- womchamo, Mao inhibitors, beta-blocker kunye ethanol.

izincomo ezithile

Lokusula ichiza kufuneka ibe kancinci. Ngexesha unyango kuyimfuneko iliso ECG kunye noxinzelelo lwegazi esimbaxa, kwakunye umxholo sodium kunye potassium ion egazini. Kwakhona, ukuthathwa oku kungenzeka ukwandisa arrhythmias inhliziyo.

Analogs kunye ntonye ze ichiza, ixabiso layo

Ngoku uyazi indlela i amayeza "Kordinik". Imiyalelo ukusetyenziswa, iifoto kunye neempawu ichiza ziye uchazwe apha ngasentla.

Zingaphi iindleko iziyobisi ingqalelo? Njengoko umthetho, ixabiso amacwecwe isixhobo 60 (10 mg) yi-450 engange. Ngoxa kwezinye kwimimandla kwilizwe lethu, oku nani linokuba kwandiswa okanye, phezu koko, zehla.

Abadinga etsolo ukuba amayeza ukuba kufakwe analogs ezifana "Dilasidom", "Korvamin", "Carbochromen", "Korvaton", "Sydnopharm", "Oxycardin", "Reasanz" kunye nabanye.

Njengoko kuba ntonye, ichiza kuphela "Coronel" yabhalwa nguye.

Reviews imithi

About "Kordinik" chiza ezininzi reviews ezintle. Abasebenzisi athi loo arhente antianginal ukumelana ngokupheleleyo kulo msebenzi. Ukwamkela tablet ngasentla iyasebenza ekunciphiseni angina, kwakunye ishenxisa intlungu kuhlolwe emva breastbone.

Ukongeza eziluncedo kweli chiza ziquka nokufumaneka kwayo kunye nesakhono ukuze endaweni oothixo, bobubi - ixabiso eliphezulu kwaye inani elikhulu ngayo ezibi.