Ukulungiselela "Kalimin": imiyalelo yokusetyenziswa, ukuphononongwa

I-Myasthenia gravis isifo esifanayo. Kubonisa ukuba i-asthenic bulbar ikhubazekile. Ubonakaliswa bubuthakathaka obuthatywayo kunye nokukhathala okukhawulezileyo kwemisipha. Kwinkqubo yesi sifo, nayiphi na inxalenye yomzimba inokuchaphazeleka, kodwa umlomo, ulwimi, pharynx kunye nentamo zisengozini. Ukugula okunjalo kudinga unyango lobugcisa. Enye yezilwanyana ezifunwayo kunye neziphambili zokunyanga i-myasthenia gravis yiyeza "Kalimin". Izikhokelo zokusetyenziswa zikwiphakheji eneepilisi.

Ulwakhiwo lweyeza

I-arhente "Kalimin" ithathwa njenge -inhibitor ye-cholinesterase. Iipilisi zimhlophe, zincinci. Unesimo esibomvu esinobunzima obuncinane. Ephakathi kwebhebhulethi ihlulwe ngumhlubo. Into ephambili ekubunjweni yi-pyridostigmine i-bromide kwisilinganiso se-60 mg. Izixhobo ezincedisayo zeziyobisi yi- microcrystalline cellulose, isitashi samabele, i-silicon dioxide, i-polyvidone, i- glutamic acid hydrochloride, amanzi ahlambulukileyo, i- magnesium stearate.

Isilwanyana senziwa kwiibhola ezimnyama, iipilisi eziyi-100 nganye. Nangona ipilisi "i-Kalimin" ihanjiswa ngaphandle kwemithi, imiyalelo yokusetyenziswa kufuneka ifundwe ngaphambi kokuqala unyango.

Isenzo se "i-tablet" zePalimin

Isilwanyana sithuthukisa ukutshatyalaliswa kweentsimbi kunye nemisipha, kwandisa i-motility yesiginci sesisu, kwandisa ithoni yebladder, bronchus, ukukhutshwa kweentlanzi ze-endocrine. Ubangela ibradycardia, i-miosis ebuthakathaka, i-spasm yokuhlala. Iziphumo zomphumo omkhulu kumzimba kufuneka zilindeleke kwiiyure ezingama-2. Ukufumaneka kwezidakamizwa ngu-20%.

Ukuthatha iyeza kunye nokutya akunciphisi ukuhlaziywa kwezinto eziphilayo, kodwa kunciphisa ixesha lokuphumeza umphumo nge-1.5 iiyure. I-arhente ayifaki ukungena kwinqanaba legazi-yengqondo. Isilwayo asixhomeke ngokukodwa kwi-plasma. Ngomlinganiselo othile, i-metabolized in the liver, ifomabolites ezingasebenziyo emva kokucoca. Iyeza elithi "Kalimin" lidityaniswa yizintso ezingatshintshiyo. Ubungqina, ubungqina, isilinganisi esilungileyo - nayo yonke into kufuneka ufunde ngaphambi kokuqala unyango.

Iinkcazo kunye nokuchasene

Isibonakaliso sokusetyenziswa kweziyobisi yi-myasthenia gravis. Musa ukumisela izilwanyana ze-bronchial asthma kunye ne-bronchitis engavimbayo. Izifo ezithintekayo kwiphepha le-biliary kunye ne-urinary liyi-contraindication. Musa ukusela amacwecwe ngexesha loxinzelelo lwamathumbu emathunjini, i-myotonia. Ukungqinelana nokusetyenziswa kweziyobisi kukhulelwa kunye nokukhwabanisa, iminyaka engama-18 ubudala. Ngobukhulu besisindo kumacandelo amacwecwe, akufanele kuthathwe.

Qaphela, kubalulekile ukusebenzisa isilungiso kubantu abaxhomekeke ekuphenduleni. Kubalulekile ukwazi ukuba phantsi kwengcinezelo encinci, iimpso kunye nokungaphumeleli kwintliziyo, isicatshulwa sinqunywe phantsi kocwangco olusondeleyo logqirha. Ngethuba lonyango, kuyimfuneko ukubeka iliso uxinzelelo lwegazi. Ukunyamekela kusetyenziswa iipilisi zesifo sikashukela, isilonda sesisu kunye ne-duodenum, kunye ne-hyperthyroidism, emva kokuhlinzwa kwisisu.

Ngaphambi kokuqala kokonyango kubalulekile ukuba ufunde ngokucokisekileyo ukuchasene nokusetyenziswa kwe "Kalimin". Imiyalelo yokusetyenziswa, impendulo - konke oku kubalulekile ngolwazi kwizigulane.

Isilinganisi seziyobisi

Ithebhulethi ithathwa ngomlomo. Kunconywa ukuba uphuze kunye neninzi yamanzi. Ukufezekisa umphumo wokukhawuleza, kuyafaneleka ukusebenzisa i-arhente kwisisu esingenalutho. Ekuqaleni kwesifo kufuneka uphuze iipilisi okanye isigidimi ngokuphindwe kabini ngosuku. Kwiimeko ezinzima ze-myasthenia gravis, umiselwe ukuba uthathe iipilisi ezintathu okanye ezine ngosuku. Inqanaba elivumelekileyo lokuthatha usuku li-tablet 12. Izinga lemihla ngemihla kunye nobude bonyango lubekwe ngugqirha ngamnye. Iimpawu ezizodwa zendalo kunye nokuqhubela phambili kwesi sifo ziqwalaselwa.

Izigulane ezijongene neentsholongwane zeentso kufuneka zithathe amachiza kwinqanaba elincinci. Kufuneka kukhunjulwe ukuba uKalimin unokubangela iziphumo ezibi. Imiyalelo yokusetyenziswa iqulethe ulwazi malunga neyonyango yokuthintela.

Ukugqithisa

Xa ukugqithisela kweziyobisi kwandisa i-salivary, i-sweat, ithawula izigulane. Isigulane sibomvu, ubuthakathaka bubonakala, umbono ubonakali. Ukucoca ngokungafunekiyo kunye nokuchaswa kungenziwa. Isigulane sikhalaza isicupunu, ukuhlanza, ukunyanzelwa kwengcinezelo, ukunyuka kwe-bronchospasm kwanda. Kwiimeko ezinzima zokugqithisa, ukubanjwa komzimba kungenzeka, okukhokelela ekufeni. Le meko idinga uncedo olukhawulezileyo. I-antipode yee-tablet ze-Kalimin "i-Atropine". Kumele ukuba ilawulwe nge-intravenously kwisilinganiso se-2 ml.

Ukongeza, kuxhomekeka kwimeko yesigulane, unokuphinda uphinde ulawulo lweziyobisi emva kweeyure ezintathu. Kucetyiswa ukuba uhlambe isisu kwaye unike umxube. Isigulane kufuneka siphathwe ngabasebenzi bezonyango ukuze iphefumle. Ngokwezibonakaliso, kubalulekile ukuqhuba amanyathelo okuvuselela. Imiphumo emibi kakhulu yokugqithisa ngokweqile ingaba neyeza elibizwa ngokuba yi "Kalimin". Uphononongo lubonisa ukuba imiphumo emibi ilindeleke kuphela ukuba imyeza isetyenziswe ngokungafanelekileyo.

Ukusebenzisana namanye amaqela eziyobisi

"I-Atropine" iyanciphisa umphumo weziyobisi "Kalimin", kodwa ayichaphazeli izihlunu zamathambo. I-Pyridostigmine i-bromide, eyinxalenye yamacwecwe, inyuse isenzo se "Morphine" kunye neerbiturates. Isiza asihambelani ngokupheleleyo ne-ethanol. Ukunciphisa isiphumo esichaziweyo se-"Quinidine", i-ganglin blockers, i-anti-depressants, i-antiepileptic kunye ne-anti-Parkinsonics.

Xa ukhulelwe kwaye ukondla akukhuthazwa ukuba unikwe izilwanyana. Kwiinyanga zokugqibela zokukhulelwa, unokudala ukuzalwa kwangaphambili. Xa ukondla, loo nto ingena ebisi, leyo ingabangela ubuthi kwiintsana ezinokuthi "Kalimin". Imigaqo yokusetyenziswa kufuneka ifundwe ukwenzela ukuphepha imiphumo emibi yonyango.

Uphononongo malunga neziyobisi

Izigulane ezithintekayo kwi-myasthenia graver, ziphendula ngokufanelekileyo malunga neziyobisi "Kalimin." Imiyalelo yokusetyenziswa iya kuqhelana nesigulane ngokuchasene kunye nezibonakaliso kwifomu efumanekayo. Iibhulethi ngexesha elifutshane linemiphumo emihle yokwelapha, izigulane ziphawula. Isilwanyana sinomlinganiselo onokuhlawuleka kunye nomgangatho omhle.

Isiyobisi asikho umlutha kwaye kudla ngokunyamezela ngokufanelekileyo. Nangona kunjalo, iziganeko zeemeko ezibi kakhulu ziyaziwa.