"Budesonide": imiyalelo ukusetyenziswa kunye analogue. "Budesonide" inhalation: ncomo, ixabiso

Isifo Sombefu ubekwa kwindawo yokuqala ehlabathini phakathi izifo ezinxulumene ukungahlaliseki kwamajoni omzimba. Ukuluphatha idala isixa esikhulu iziyobisi. Enye ezinjalo isixhobo i "budesonide". Analogs kweli chiza kwakhona rhoqo isetyenziselwa ukunyanga broncho-obstructive syndrome. Ngoko ke yintoni na eli yeza?

Yintoni "Budesonide"?

Eli chiza bobabo kwiqela glucocorticoids ukurhogele. Esi sixhobo ke analog eyenziweyo kuhlelwe emzimbeni wethu (kwi neuron adrenal) iihomoni. Enjani ngefuthe "Budesonide"?

Imiyalelo zokusetyenziswa ichiza ibonisa ukuba arhente kwandisa isixa receptors esebenzayo beta-adrenergic kwi yomoya.

Ngaphezu koko, iibhloko ichiza isenzo prostaglandins ukudumba kunye leukotrienes, nto leyo esithintelayo uphuhliso ukudumba kwindawo isifo inyumoniya.

It ababi imiphumela yayo emva ulawulo ngemihla iintsuku eziliqela (idla malunga 5-7 iintsuku).

Le yenye amachiza eziphambili ekunyangeni sisifo inyumoniya kwaye ezingapheliyo obstructive isifo miphungeni. Xa sikwinqanaba lokuqala lophuhliso ezi zifo alisebenzi.

Njani, ke, "Budesonide" onesiphumo kwiiseli target?

pharmacodynamics

Ichiza ngokusebenzisa isicelo inhalation, ukufunxile kakuhle ukusuka kumphezulu kwemiphunga (ukusuka phezu isifo ngeempumlo phantse afikelela kwegazi).

Ubuninzi plasma abasuka ichiza wayiphawula phakathi kwemizuzu engama-45 emva kokuba inhalation. 85 ekhulwini zonke iziyobisi engenayo enebana igazi albumin inxalenye eseleyo salawo ingatshintshwanga.

Oku kusingathwa sisibindi. Kwazona ivela emzimbeni iphecana zesisu (kwi enyongweni) kunye nomchamo.

Izigulane nala maqumrhu ngezifo waphawula obude ekulibaziseni ichiza egazini, oko kwabangela uphuhliso uninzi ingxaki kunye libanda hormone glucocorticoid.

Kuyenzeka ukuba usebenzise iziyobisi azipilisi yonyango yethishyu systemic nokuqina (kodwa pesenti 10 kuphela kwimali iyonke ichiza ongene iphecana zesisu babe nemiphumo therapeutic).

Kananjalo zingasetyenziswa ekunyangeni izifo non-yokukrala isifo ngeempumlo ngenxa Namanyathelo athathwa kwingingqi ixesha elide.

Ubungqina obubonakalayo buxela

Kwezinye iimeko, ke, unganika "Budesonide"? Imiyalelo yokusebenzisa lidwelisa izifo eziphambili apho ezinokusetyenziswa la machiza:

• somoya inyumoniya. Ichiza baba wabulela idumile isiphumo yayo anti-ukudumba kwaye zikwazi ukunqanda umsebenzi yabalamli arhabaxa.
• isifo Crohn kaThixo. Ngokuba ukunyanga isifo asebenzise ifomu tableted olufanelekileyo lwechiza. Ichiza inikwa ekuba uxolelo kwiintlobo wobulali kunye neliphakathi esi sifo.
• Unyango lwe nokuthimliswa. Ibonisa isabelo yefom intranasal le budesonide uncedo kweempawu hay fever nokuthimliswa komzimba. I-arhente elisemagqabini zokunyanga esi sifo "Budesonide Formoterol".
• Prevention of ukuphinda polyposis, isifo ngeempumlo. Ichiza isetyenziswa kwixesha lokuqala postoperative. Phantse 95 ekhulwini amatyala uthintele nokusetyenziswa kwakhona kuphuhliso polyposis.

Ezi zifo akuhlu iinkqubo eziphambili, apho amisiweyo "budesonide".

Ngamanye amaxesha, ichiza nga kwenziwa ukuthintela ukunwenwa kwesifo kwemiphunga. Kwiimeko ezinjalo ziquka izigulane izifo emsebenzini okanye umsebenzi iimeko ezinobungozi. Kodwa simele sikhumbule ukuba noba usebenzisa ichiza ukuvimbela, asifanele silibale nomthamo ngononophelo ichiza, kuba ngenye indlela umngcipheko omkhulu ukufumana iingxaki adrenal, kunye nokurhoxiswa syndrome glucocorticoids.

Kwezinye iimeko, kunjalo, ukusetyenziswa kwaso contraindicated?

Izimo

Kuphantsi kwaziphi iinkqubo kunye nezifo, musa ukusebenzisa "Budesonide"? Imiyalelo zokusetyenziswa ichiza ibonisa ezi zifo zilandelayo:

• ubuntununtunu Ukwanda ukuba ichiza okanye iinxalenye zayo. Umngcipheko wokuhlaselwa angioedema.
• Ifom esebenzayo sephepha.
• Izifo imvelaphi yokuphefumla ezinzwaneni.
• iinkqubo Acute esosulelayo kwisiqwenga zesisu.
• insufficiency Severe hepatic.
• yobudala yabantwana.

Kuzo zonke ezi zifo, ukusetyenziswa corticosteroids akuvumelekanga. Oku kungenxa yokuba ichiza okanye ikhuthaza inkqubo iyenze okanye zimbi ikhondo layo. Abantwana abakwazi ukusebenzisa eli chiza kuba enokuphazamisana imveliso komzimba zamadlala glucocorticoid ngenxa amatyala le uthinte adrenal.

Kukho ezinye imida, apho isilumkiso kakhulu kufuneka kusetyenziswe "budesonide". Imiyalelo isicelo ulumkisa ukuba ngenyameko kakhulu ukuba ukusebenzisa ichiza kubantu abane lwegazi, isifo seswekile, pheochromocytoma, isilonda kukutyeba esiswini kunye isilonda duodenal.

effect side

Okwangoku akukho iziyobisi, ukusetyenziswa zazingathandanga ukuba iphuhlise nefuthe kwicala elithile. Ngelishwa, "Budesonide" Kwakhona lichiza kunye kuluhlu enkulu kangangoko iziganeko ezibi yesenzo yayo.

Ukuba usebenzisa "budesonide" inhalation, iziphumo ebezingalindelekanga engundoqo ukusetyenziswa kwayo kuya kuba ukuphazamiseka intetho (dysphonia), hoarseness, umlomo owomileyo, ukukhohlela, uphuhliso bronchospasm ngamazwi.

Xa kuthathwa ngomlomo, ukuze kukudakumba, isiyezi, yaye akhawuleze ukucaphuka.

Nemithambo yegazi ukuze basabela njani ukuqaliswa "Budesonide" uphuhliso vasculitis, ukwanda koxinzelelo lwegazi systemic, tachycardia.

Ichiza kunokubangela kunye ukuqhubela kwezifo emathunjini - izilonda, pancreatitis. Ukongeza, kukhuthaza uphuhliso ukuphazamiseka dyspeptic.

Uchaphazela ngokungalunganga inkqubo musculoskeletal. Mhlawumbi kwamathambo, myasthenia gravis, ubuhlungu bamalunga.

Isiphumo kunawo yi Cushing engqondweni. Oku kwenzeka ngenxa yokuba ngexesha lokufumana glucocorticoids kusehla Yindibanisela emzimbeni wayo. Ukuba corticosteroids asetyenziselwa ixesha elide, i adrenal kupheliswe nje nokulungelelanisa into komzimba oko kuchaphazela impilo umguli. Yiyo loo nto kubalulekile ukuba esweni ngenyameko iihomoni ithamo ezifunyenweyo, kwakunye ilungelo ndiziyeke.

uhlengahlengiso balawule

Ziziphi amathamo kufuneka lusekelwe "Budesonide? Imiyalelo emisela inikeza irejimeni Umthamo elandelayo.

Ukusebenzisa iindlela inhalation "budesonide" isekelwe phezu nobungozi besi sifo. Ithamo elilelona ukuba omdala micrograms 200-800 ngosuku. Le idosi iphezulu yemihla ngemihla mayingagqithi 1.5 mg. Ebantwaneni, ichiza contraindicated ukusetyenziswa, kwaye analogs zalo zabelwe ngokungqinelana ubuzaza tyala.

Ifom ngomlomo beziyobisi isetyenziswa imizuzu 30-60 phambi izidlo. Ukusetyenziswa ukuya ku-3 mg 3 amaxesha ngosuku. Ikhosi ye unyango amayeza yomlomo iinyanga 2. Ukwala ichiza yenziwa ngcembe ukunqanda iimpawu ukurhoxiswa.

Intranasal yesitshixo sele inikezelwe kwi "Budesonide Iziheyler". Le yedosi kukhethiwe ngamnye ukuze umntu ngamnye, ngokuxhomekeke ebukhulwini yenkqubo. Kwi-avareji, basebenzisa 2-3 ngamathontsi ichiza ethatheni ngalinye kabini yonke imihla. Xa abantwana, olu hlobo ichiza contraindicated. Ikhosi ye unyango iiveki ezi-2.

Intsebenziswano kunye namanye amachiza

Amanye amachiza xa ukusetyenziswa kudibaniso nge "Budesonide" uyakwazi imoshe ukufunxeka kwayo. La machiza ziquka inhibitors of cytochrome P450. Umzekelo, ukuba usebenzisa zombini "budesonide" ( "Pulmicort" - njengoko analog) kunye namachiza ezifana "Ketoconazole" "Erythromycin" kungenza zinomgutyulo evela igazi glucocorticoid, nto leyo igcwele kunye nophuhliso kunxilwe hormone ukubonakala iziphumo ezibi le ichiza.

Ngaxeshanye ufumana "Budesonide" kwaye ezinye womchamo ( "Indap") igalelo kuphuhliso hypokalemia kwi umguli, nto leyo ngokungathandabuzekiyo kuchaphazela umsebenzi kwentliziyo.

Ezininzi amachiza (umz, asidi - "Almagel") xa usebenzisa i "budesonide" kunamandla kwezinye isiphumo ngasinye inzondo, ngamanye musa ukuvumela kwezinye ekuphembeleleni isiphumo yayo nezinyangayo. Ngenxa yoku, kucetyiswa ukuba usebenzise la machiza kwi lokuphumla ubuncinane iiyure ezimbini (isebenza kuphela kwifom yomlomo iziyobisi).

Ukusebenzisa ichiza ukuze inhalation

Ekubeni iyeza sele wadalelwa ngenxa yonyango izifo phecana yokuphefumla, kubalulekile ukuqonda oko indlela kufuneka lona.

uhlobo wayisezela beziyobisi wadala kakhulu lukhulu, kodwa usebenziso lwabo ngokubanzi converges ngeendlela ezininzi.

Okokuqala, le Amachiza esuke usebenzisa డొమైన్ idomeyini. Lo matshini ikuvumela ukuba ungene yomoya ithamo afane ngokungqongqo zeyeza. Ngokuqhelekileyo kulahleke enye inxalenye olungumgubo inhalation, ukuya kubamba iimpawu zobuthathaka begazi okanye COPD.

Ukulungiselela le njongo, ngokuqhelekileyo kusetyenziswa "Budesonide-lweenkobe." Le ichiza nelungelo yi bumabumela Russian. Kumafa yayo ichiza uthwala a ukumiswa (okanye lomgubo) "Budesonide". Le డొమైన్ idomeyini ilayishe cassette kunye ichiza, ngoko arhente inspiratory engena bronchi kunye nemiphunga.

amachiza amaninzi ayafumaneka ngohlobo lwe inkonxa, nayo leyo iqulathe "budesonide". Igama Trade kungaba kwahluka enye kwenye, kodwa eyona nto esebenzayo iseyeyona glucocorticoid efanayo. Ukuba ukuthatha ichiza enjalo, kufuneka kukhunjulwe ukuba idosi enye ye zetoti iqulethe 0.05 ml budesonide (kubalulekile ukwazi ukuze kubangele libanda of glucocorticoids).

Iindleko ichiza

Ngenxa ubungakanani imarike kwamayeza yangoku Akukho nzima ukukhetha up ngokwabo, "Budesonide" ukuze inhalation. ixabiso layo kunye analogue zayo ungahluka, kodwa kufuneka ukhumbule ukuba zonke ngokufanayo kubume kwabo eyona nto iphambili esebenzayo i budesonide. Ixabiso iziyobisi ziya kuxhomekeka owenza amayeza, nokuba sisiyobisi enziwe ngumenzi okanye amachiza afana nalawo.

Ichiza kuthengiswa kuphela ezikhemisti. uya kubiza malini "Budesonide"? ixabiso layo kunye analogue yayo yi-avareji ye-300 ukuya ku-2000 engange. bonke Oku kuxhomekeke ekubeni ngubani na umenzi kunye nefomu wokukhulula lweziyobisi. Umzekelo, ezifana neziyobisi "benacort" evela ngokohlobo njengezingxobo kunye olungumgubo inhalation. Kwi-avareji, loo nto ikutya imali engange-400. amachiza British ayabiza kakhulu ngakumbi. Umzekelo, "Budesonide Formoterol" lemveliso British ibekwe ngaphakathi engange 2,000, nto leyo asinguye wonke umntu akwazi ukufikelela. Ngokulula ukuthenga iimveliso Slovenian, ezo musa kwahluka phakathi komsebenzi, kwaye sitshiphu.

Xa izifundo sele kubonakele ukuba amachiza abizayo phantse akukho ndlela obuphantsi noogxa mali yazo. Ngoko ke, yintoni iziyobisi ukuba uthenge - ukhetho lomntu ngamnye, ngokuxhomekeke kwiimfuno kunye nokhuseleko yakhe.

Izimvo ngamalungiselelo

iziyobisi Glucocorticoid kudala esetyenziswa izigulane ezininzi kunye syndrome of obstructive ezinganyangekiyo okanye asthma. Phantse zonke izigulane kunye kakhulu lwe enye yezi zifo sabelwe "budesonide". analogue zayo ziyathandwa iseli ngokubanzi ngokufanelekileyo kwirejista amayeza ezi zifo, ngoko ngokufuthi ziyaviwa kuyo yonke indawo. Olu nyango ezifana, umzekelo, "Apulein" "Benakap" "Buderin", esele zikhankanywe ngasentla "Pulmicort" yaye "benacort" njl

Ngokutsho izigulane ezininzi, la machiza intle unyango lwezifo ze iphecana sokuphefumla. Lidla abantu abambalwa ongamenzanga yayisiza uhlobo inhalation le glucocorticoid okanye indibanisela yalo beta-agonists.

Kunye olufanelekileyo iyeza nomthamo wakwazi ukuphumeza ukuphucuka okubonakalayo kwezi izigulane. Okwangoku, abaninzi abakwazi kumitha ubomi kunye ubomi obuqhelekileyo ngaphandle ukusetyenziswa kwala machiza.

Noko ke, nangona ncomo ezininzi ezintle, kukho icala ezimnyama neziyobisi "Budesonide" - ixabiso.

Ukuze ixesha elide kwakukho utyekelo ukuqeshwa ivideo amayeza sombefu kwizigulane abasweleyo. Zonke izigulane eze ekhemesti, naphezu ntetho njengoxwebhu ukufumana amayeza simahla iimfuno zabo.

Okwangoku, kukho kwakhona kwenziwa, kodwa unazo, abanelungelo ukuba akhulule la machiza iingqameko kakhulu. Ngoku la machiza azihlawulelwa kuphela kubantu abakhubazekileyo 1 kunye namaqela-2, kunye nabantwana; Abanye abantu ukuba bathenge amayeza imali yabo. Sisazi ukuba amalungiselelo kuthatha kakhulu kakhulu, hayi wonke umntu unako ukuthenga impatho enjalo.