Inhibitors Cholinesterase: ukusetyenziswa imithi

Yinto eyaziwayo ukuba luvo iye leesynapse ezininzi. Kuba iyimfuneko ekudluliseni neemvakalelo. Le nkqubo ibandakanya iintlobo ezininzi mediators. Phakathi kwazo, - .., Acetylcholine, norepinephrine, Gaba, serotonin, njl mediators (zidlulisele) ziyafuneka ukuze ukutshintshwa lwemiqondiso phakathi luvo. Ngaphezu koko, ngenxa kubo ithwalwa excitation okanye inhibition musculature. Xa ezimbi ezahlukeneyo umsebenzi inkqubo neurotransmitters luvo ukuba anyhashwe. Oku kwenzeka ngenxa yeenkqubo atrophic kwaye sisiba mandundu apha ebuchotsheni. Kule meko, sebenzisa iziyobisi ezifunekayo ukuze mculo ngokwandisa okanye attenuating uphawu transmission. Xa iqela efanayo amayeza abo cholinesterase inhibitors. Bona kusetyenziswa myasthenia, neuritis, lateral sclerosis, isifo i-Alzheimer, ezimbi zengqondo.

Isiphumo cholinesterase inhibitors

inhibitors Cholinesterase - iyeza ukuba sisetyenziswa ngokubanzi yeenkqubo zengqondo kunye zengqondo. Zahlula-hlulwe ngamaqela eziliqela, iyileyo kusebenza kwityala elithile. Isenzo kula machiza benza ngokubhloka cholinesterase. Le enzyme ifumaneka zombini kubantu abasempilweni nabo bathwaxwa zizifo ezahlukahlukeneyo. Kuyimfuneko ukuba Yodilizwa neurotransmitter - acetylcholine. Ngenxa samaza yayo inyathelo kuthotywa ukuya choline kunye acetic acid. Xa ezimbi ezahlukahlukeneyo yoma uthinte ebuchotsheni kwenzeka ngokuthe ngcembe. Ngenxa yoko, ezinye izakhiwo lungasebenzi, kubandakanywa nenkqubo cholinergic. Ngaphandle yoma ingqondo, oku kukhokelela iinkqubo sisiba mandundu of samathambo, ezasulelayo, uhlobo wentsholongwane egazini. Ngenxa ekutshatyalalisweni eziba yangaphambili kukho ukunqongophala ngokukhawuleza of neurotransmitter - acetylcholine. Ixesha elide kangangoko kunokwenzeka kwakungekho nokunqongophala iziyobisi, kuyimfuneko ukwenza enzyme bayitshabalalise. Ukulungiselela le njongo, le cholinesterase inhibitors zisetyenziswa. Enkosi kubo, umsebenzi neurotransmitter usenokungaguquki iminyaka eliqela.

inhibitors Cholinesterase: iziyobisi yokuhlela

Kukho iintlobo ezininzi zamachiza anticholinesterase. Bona zahlelwa ngokungqinelana neziphumo amayeza kwi enzyme. Ezinye zazo uvimba cholinesterase vuhlayiseki, abanye - okwethutyana. Bekela bucala 3 amaqela imithi. Phakathi kwabo:

1. blocker umva. Ezi cholinesterase inhibitors enze uphawu postsynaptic. Enkosi kubo, i-enzayim uphazamiseka okwexeshana. Eli qela libandakanya acridines kunye piperidine.
2. Psevdoneobratimye blocker cholinesterase. indlela yabo amanyathelo ngokudibene inxalenye onionovoy kwemolekyuli enzyme. Ukongeza, ukuba unako ukumbopha ukuya receptor acetylcholine. Le mihlaba liqela carbamates.
3. inhibitors lakho cholinesterase. Eli qela lamachiza eyaziwa ngokuba organo-phosphate iindlela. Ummeli medicament "Metrifonate".

Iqela acridines ziquka "ifildi yodibaniso 'iziyobisi' Velnakrin". Abameli carbamates - amayeza "rivastigmine", "Epistatigmin".

Izinto ezibonisa ukuba ukusetyenziswa kwe cholinesterase inhibitors

Cholinesterase inhibitors zisetyenziselwa ukunyanga izifo kwezihlunu imvelaphi engundoqo, yoma kunye nezigulo ebuchotsheni sisiba mandundu. Ukongeza, eminye imithi ziyafumaneka ngohlobo kuncipha. Zisetyenziswa ngamandla ephakamileyo intraocular - glaucoma. Iziyobisi anqanda cholinesterase ingathityazwa, lubonise ukuba unyango sengqondo esiyingozi, isifo Pick kunye sokulibala. Kukhethwa kukunika iqela piperidine, ekubeni uyakhetha kwaye zineziphumo ebezingalindelekanga ezimbalwa. Kwiminyaka yakutshanje, kubonakala ukuba ukusetyenziswa kweziyobisi landa. Oku kungenxa yokuba i Ufundo ngakumbi iimpawu zazo. Kuba izifo apho amachiza anticholinesterase emiselweyo ziquka myasthenia gravis, atony isisu, muscular dystrophy, lateral sclerosis, ukukhubazeka kwamalungu imvelaphi sisiba mandundu. Ayibuyiseki umva inhibitors asetyenziswa kwimeko yityhefu.

Izimo ukuba ukusetyenziswa kweziyobisi cholinesterase

Amayeza kweli qela alisetyenziswa ukuphazamiseka convulsive, hyperkinesis nawuphi na umyalezo. Kananjalo contraindicated kwizigulane kunye ukusilela ngentliziyo kakhulu, isifuba, thyrotoxicosis. It ayinqweneleki ukuthatha anticholinesterases kunye isilonda kwamanani esiswini, enteritis. Amayeza ayiboniswanga abafazi abakhulelweyo kunye phindeke.

inhibitors Cholinesterase: ukhetho amachiza ukuba isifo i-Alzheimer

isifo i-Alzheimer - yinto atrophic CNS, apho kukho kunesifo, ubuntu sifo sengqondo esixhalabisayo. Izazinzulu ehlabathini lonke uzama ukufumana unyango ngenxa yesi sifo. Xa aqine olulamileyo eziphakathi malunga sifo ichiza yokhetho "donepezil". Libhekisela cholinesterase inhibitor ingathityazwa, kuba nomphumela uyakhetha. Iyeza esetyenziselwa iinjongo unyango pathogenetic. Yena angabi nako ukumphilisa ngokupheleleyo isigulane, kodwa ukucola uphuhliso iimpawu zesifo sika-Alzheimer.