Omzimba TPO izilwa-buhlungu

Ukuza kuthi ga ngoku, ingxaki ehlabathini lonke yendlala nobubovu angalahlekelwa ukufaneleka kwayo. Ukungabikho iodine emzimbeni elifana neli-40% abantu abadala kunye% abantwana-50. Oku kungenxa nje kuphela into ilifa, kodwa impembelelo engentle yokusingqongileyo. Kulo mzekelo, iodine ezingaphiliyo ukuba Yindibanisela iihomoni ezifana T3 kunye T4, leyo ixhomekeke kwinani yebhinqa lengqula ekhuthazayo hormone (TSH), lengqula ukulawula umsebenzi.

Kufuneka ke ukuba xa ndlala lengqula akayifezi ngokwaneleyo imisebenzi yayo, izifo ezithile (samathambo) ukuphuhlisa emzimbeni. Ngenxa yoko, ukufunda ubhaqo AT TPO izilwa asenokubonisa iwonga silwe omzimba ngokuphathelele umzimba. Kungenxa yoko le nto iindidi ngeendidi zezifo lengqula yabelwa isifundo kwinqanaba TSH igazi kunye nobukho antibodies AT TPO. Ukuba yokugqibela nangoku waphawula, ngoko omnye uthetha sisifo samathambo.

AT TPO imele enzayimi ababandakanyekayo Yindibanisela hormone SHCHZ ngexesha hormone iodization. Yena a iantigens ilungu tireyodnogo.

Isizathu sokuba uhlalutyo unako ukukhonza njenge ukubonwa kwezifo ezifana goiter, esihanahanisa- kunye hyperthyroidism, isifo akuMazwe, drumsticks tireoinid nokudumba. Kwakhona, uhlalutyo emiselweyo ngexesha ukhulelwe ukuba umngcipheko tireoinita emva kokuzalwa (10% abasetyhini babe nesi sifo).

Kufuneka kuqatshelwe ukuba TPO izilwa-buhlungu, izinga apho umntu omdala 5.6 U / ml, emzimbeni inika ayodini Ukwakheka esebenzayo. Izilwa kule enzyme kuthintela umsebenzi wayo, ngoko kunciphisa ukuba secretion ka emzimbeni T4 kunye T3. Kodwa hayi kuzo zonke iimeko, lengqula peroxidase ibonisa ubukho yinkqubo sokuhlasela.

Olu phando buyafuneka ukwenzela iziphumo zokuxilonga izifo ndlala. Imbonakalo kwephulwa umsebenzi wayo ngumqondiso wokuqala hypothyroidism. Xa usebenzisa iindlela ezibuthathaka kakhulu diagnostikiAT TPO, ngoko esi sifo ifumaneka 94% ezigulane kunye nesifo Graves '- 84%, lengqula neautoimunnye izifo - 15% zabantu. amanqanaba asezantsi enzyme amaninzi zifumaneka kubantu abasempilweni, ngoko kule meko mbuzo kuphuhliso zizifo ezahlukahlukeneyo ayiqondakali kahle.

Kufuneka kuqatshelwe ukuba kwimeko apho AT TPO banda, oku kubonisa inkqubo efana hypothyroidism. Olu hlobo ephula ivela njenge ngenxa yomsebenzi TPO deceleration omzimba, umyinge igcwala ayodini, yaye, ke ngoko, ukwamkelwa uhlobo yayo esebenzayo. Kulo mzekelo, i hormone abayi kuhlelwe.

Uphononongo iya kwizigaba eziliqela. Xa abantu, igazi kuthathwa, njengoko apho inqanaba lokuhlola TSH kunye T4. Kwimeko yokusebenza T4 oqhelekileyo kunye TSH ephantsi, wenziwe ukufunda T3. Kwimeko yokugqibela, kufuneka ugcwalise iphetshana uphando kwi AT TPO izilwa-buhlungu.

Ngoko ke, kubonakala ukuba isifundo unako ukukhonza njenge goiter okukrokrelwayo, hypothyroidism kunye thyroiditis Hashimoto kaThixo. Kodwa ke kufuneka kukhunjulwe ukuba ukungabikho antibodies lengqula peroxidase Ait nto ayikuthinteli ubukho emzimbeni. Ukufunyanwa kwalo enzyme igazi ayiniki nentembelo ngokupheleleyo kukho isifo samathambo, ekubeni kwiimeko ezininzi le AT TPO ekhoyo kubantu ngenye besempilweni.

Ukusuka konke oku kulandela ukuba ekufumanekeni le enzyme kuyimfuneko ukwenza uphando olubanzi ngenjongo ukuphelisa ubungozi Ait.

Ngenxa yoko, kungakhathaliseki meko, lengqula peroxidase umkhathalele ngokwaneleyo ukungaqheleki test samathambo e lengqula, kunjalo, izifundo ezo zisetyenziswa phantse zonke kwiziko lonyango.