Leukemia Acute myeloid

leukemia Acute - isifo kwenkqubo hematopoietic, ngokusekelwe kwi - ukwanda mda weeseli ithumba, ezo zeendawana yayo morphological. leukemia Acute myeloid kwi zokuhlela FAB yahlulwe iinketho ezisixhenxe. Isiseko yokuhlelwa - inqanaba umahluko iiseli emele leukemia zeendawana. Clone Myeloblasts Ithumba livela iiseli esiqwini, leyo bayakwazi ukuvelisa amathanga inani elandayo myeloid iiseli, megakaryocytes, erythrocytes, macrophage.

Eyona njalo wabona wobeko M0-M3. Isiseko zokuqala ezimbini - iiseli ngaphandle umahluko. differentsirovanokletochny - M2 ukhetho. M3 ngobuwena promyelocytic luphawulwa iiseli ezingaqhelekanga ukuya iinkozo ingxilimbela. M4 and M5 - leukemia myeloblastic kunye monoblastny. M6 - erythromyelosis, nokonyuka kunyebeleziso iiseli erythroid. M7 - leukemia megacaryoblastic. Kuzo zonke iinketho, leyo zinikwa leukemia etsolo myeloblastic, ALS lifanelekileyo xa M0-M2.

etiopathogenesis leukemia

Yintoni leukemia yondele myelogenous. Isifo - ukukwazi lemigangatho iiseli ukuba izakhi ngenxa isenzo yeemeko yangaphandle (radiation, iintsholongwane, imichiza) kunye ukuthambekela ukungazinzi yemfuza zofuzo. Oku kuphumela kwiiseli ithumba ekwaziyo sisahlula mda. Bakha clone nto leyo, ukuguquka waphinda bangela subclones.

iiseli Ithumba rhoqo yenziwa ngumongo wethambo, kwaye kwanyanzeleka eyonakalisayo eqhelekileyo lwegciwane hematopoiesis. Ngokuthe ngcembe, baya igazi neuropathy iyakhula zivamvo, iSayensi neThekhinoloji nakujoliso olutsha eyongezelelweyo hematopoiesis engaqhelekanga. Ukuphuhlisa leukemia myeloid kumfanekiso clinical iimpawu kuye.

Clinic etsolo leukemia myelogenous

Ngenxa uphazamiseko hematopoiesis eqhelekileyo izigulane igazi, inani neutrophils abaqolileyo neeplatelets kunciphisa kabukhali. nesiyezi ekhathazekile. ubuthathaka. Kukho iimpawu ukopha: hemorrhages eluswini kwakunye nomkhwinya imifinya, ukwanda ukopha esexesheni, nokopha. Ubuhlungu emathanjeni, iindawo nkovu zidumbileyo kumaqela ahlukeneyo. spleen Ukwanda zesibindi. Ngenxa izifo umsebenzi leukocytes, ukunciphisa umzimba usulelo eqale kwemali leukemia myeloblastic bukhali. udla ubonisa angina kakhulu.

Kumanqanaba kamva ukuze iqhotyoshelwe iimpawu ukusilela kwezintso kunye neempawu luvo.

Xa flow yayo leukemia etsolo myeloblastic kunabela inyathelo obubonakala eziku, uxolelo, likakade. Kwimeko unyango angasebenzi igcina i-terminal yeqonga. Inqanaba le sifo luphawulwa iimpawu zonyango ezithile kunye nomfanekiso igazi umongo wethambo.

ukuxilongwa wegazi

leukemia Acute myeloid yenziwa izifundo cytochemical iiseli emele zeendawana kunye immunophenotyping yayo - ekumiseleni abamakishi myeloid. iindlela Morphological ekufunyanisweni kweeseli kuqhuma ekugqibeni uhlobo wegazi unikezwa ixabiso olubonakalisiweyo, nangona iqhubeka oyithandayo.

Maxa wambi kusetyenziswa iindlela genotypic esekelwe kwi-Polymerase Chain Reaction. Oku kusetyenziswa ukuze kwenziwe izigqibo ezibonisa intsalela zesi sifo izigulane esweni.

Acute myelogenous leukemia ALS kakuhle ngaphantsi kwe-ALS wegazi ahlekise emithanjeni. Ukuya kwi 75% ye izigulane unyango eyaneleyo baphumelela kuxolelwa. Kukho ubungqina yokuphilisa ka-20% uxolelo kwafezwa okuqhubekayo unyango olunzulu. Iziphumo ekhuthazayo ezifunyenwe lomongo wethambo abohlukeneyo.