Isiza "I-Ivabradin": imiyalelo yokusetyenziswa, iifanekiso kunye nokuhlaziywa

Iingxaki kunye nenkqubo ye-cardiovascular kwiindawo ezininzi ziphezulu uluhlu lwezifo eziqhelekileyo. Nangona kunjalo, akumangalisi. Ukuxinwa kweengxaki zanamhlanje, isigqirha esincinci sokuphila, iindlela zokutya ezimbi, ukungabikho komsebenzi kunye nemeko emibi yezinto eziphilayo kungathintela imeko yezinto zangaphakathi zomntu. Inhliziyo iyilungu elingenakuthobeka. Nangona kunjalo, kufuna uncedo oluthile. Ukuba akukho okwaneleyo i-calcium ne-vitamin C ekudleni okudliwayo, intliziyo inokuthi iphumelele kwangaphambili. Gwema ezi ntlobo zeengxaki okanye ukusombulula ezikhoyo ziza kunceda imishanguzo esemgangathweni enqunyiwe kwimisebenzi enjalo. Unokuzikhethela nge-PCP yakho owaziyo ukugula kwakho. Isiza "Ivabradin" sithandwa kakhulu kwiingcali kunye nezigulane. Nangona kunjalo, ukuqala ukuthabatha iziyobisi, kufuneka ufunde ngako ngokunokwenzeka. Kubalulekile ukufumana ulwazi olunzulu malunga nesibonelelo se "Ivabradin". Ixabiso, ukuphononongwa, iifanekiso-malunga nalo lonke eli nqaku. Ngenxa yendlela efanelwe ukuhanjiswa okunjalo? Ziziphi iimpawu zalo mziza? Ngubani ongafanelanga ukumisela izilwanyana kumbuzo? Ngamaphi amayeza kunye nezixhobo akufanele zidibaniswe ekulungiseleleni irejimeni yonyango? Izimpendulo ezicacileyo kule mibuzo kunye neminye ingayifumana kamva kweli nqaku.

Ukwakhiwa

Kwimimandla ebalulekileyo yechiza elithi "Ivabradin" umyalelo ubhekisela kwi-ivabradine njengento ebonakalayo esebenzayo. Njengezakhelo ezongezelelweyo, isitatshi sommbila, i-glycerin, i-red oxide, i-macrogol, i-yellow oxide, i-lactose, i-maltodextrin, i-titanium dioxide, i-magnesium stearate, i-hypromellose kunye ne-colloidal anhydr silicon dioxide isetyenziswa.

Ifom yokukhutshwa

Isilwayo "i-Ivabradin" sikhululwe ngendlela yamacwecwe, ehlanganiswe nefom membrane.

Iimpawu zokusetyenziswa

Kukho imimiselo yeemeko apho umbuzo onombuzo uphumelele. U-Ivabradin uncoma ukusebenzisa iyeza kumatyala alandelayo:

• Ischemic heart disease;
• Ingcinezelo engapheliyo;
• Ukunciphisa usongelo lweziganeko zomoya;
• Ukukhubazeka kwentliziyo.

Kuzo zonke iimeko ezikhankanywe apha ngasentla, ukusetyenziswa kwesilwanyana esikulo mbuzo kuya kusebenza.

Ukungqinelana

Isilwayo "I-Ivabradin" imiyalelo yokusetyenziswa evimbela ukusetyenziswa phambi kwezi nkcazo ezilandelayo:

• Bradycardia;
• I-Myocardial infarction;
• Uxinzelelo lwengqondo
• Angina engaqinisekanga ;
• Ukutshatyalaliswa kwe-Cardiogenic;
• I-Syndrome "yobuthakathaka be-sinus node";
• I-blockinoxy block;
• Ukungafezeki kwe-Hepatic;
• Ukunganyamezelani komntu ngamnye kwipilisi.

Akuvunyelwe ukudibanisa ne-anti-antial agents, i-macrolide antibiotics, i-nefazodone kunye ne-antifungal agents.

Indlela yesicelo

Iibhilethi "I-Ivabradin" zenzelwe ukulawulwa komlomo ngabantu abadala. Bamele bathathwe kabini ngosuku ngokutya.

Ukuba usebenzisa iipilisi zezigidi ezihlanu, ziyakwazi ukwahlula. Nangona kunjalo, iipilisi zee-miligram eziyisixhenxe kunye nesiqingatha akufanele zihlulwe.

Kwimeko apho isilwanyana sisetyenziselwa ukulwa nesifo senhliziyo, kubalulekile ukuba uthathe ngokulandela izikhokelo ezilandelayo. I dose enye iyimiligram emihlanu. Kufuneka kuthathwe kabini ngosuku. Ngokuxhomekeka kwindlela umzimba uphendule ngayo lolu hlobo lonyango, i-dose eyodwa yokusebenza kufuneka ikhuphuke ibe ngama-milligram. Ukuba iimpendulo kwiyeza zihambelana nemiphumo emibi, ngoko i-dosage kufuneka iyancitshiswe okanye ikhutshwe unyango. Nangona kunjalo, ugqirha kuphela oya kulungelelanisa i-regimen yonyango.

Isicwangciso sonyango esifanayo sisetyenzisiweyo, kwaye ukuba iipilisi zisetyenziselwa ukulwa nokungaphumeleli kwintliziyo.

Izigulane eziguga kufuneka zithathe ii-milligram ze "Ivabradine" kabini ngosuku. Ukuba impendulo yomzimba ifanelekile, ngoko umthamo unganyuka kancane.

Izigulane ezinobunzima obuthathaka obuthathaka zingathabatha inkunkuma kulo mbuzo kumanani afanayo. Ukuba isiganga sesi sifo sinomlinganiselo, isigulane sidinga ukulandelwa rhoqo ngugqirha. Izigulane ezinobungozi obunzima begazi kufuneka zithathe izidakamizwa.

Izimpembelelo ezimbi

Isiphumo esisecaleni esisetyenziswayo xa usebenzisa le nkunkuma yinto eyenzekayo ye-photopsy (ukukhanya okukhethekileyo kubonakalisa okwethutyana phambi kwamehlo, okungabonisa ukunyuka okukhawulezayo ekukhanyeni kombono kwimeko ethile kwimiba yombono). Njengomthetho, bavela kuloo mizuzu xa ukukhanya kokukhanya kuguquka ngokukhawuleza. Esi siphumo sempembelo siqhelekileyo kwiinyanga ezimbini zokuqala zonyango. Nangona kunjalo, kwezinye iimeko, ziyakwenzeka emva koko.

Kwiqela elincinci lezigulane, i-bradycardia yabonwa kwiinyanga ezimbini zokuqala ukuya kwiinyanga ezintathu emva kokuqaliswa kweyeza.

Ukugqithisa

Iipilisi "I-Ivabradine" imigaqo icetyiswa kakhulu ukuba ithathe amanyathelo okucetyiswa kuphela. Ukugqithiselela kwabo kunokukhokelela kwimiphumo engathandekiyo. Ezi ziquka ibradycardia enamandla. Kufuneka uphathwe ngokuphawulekayo kumaziko ezonyango kunye nokuthatha inxaxheba kwabasebenzi bezonyango abanekhono. Ngamanye amaxesha kunye nesicelo sexeshana se-pacemaker siyadingeka.

Izixhobo zoMsebenzi

"I-Ivabradine" ayihloselwe ukukhusela okanye ukulawula u-arrhythmia.

Ngethuba lokunyanga kunye neziyobisi, kubalulekile ukuba iliso rhoqo kwimeko yesigulane ngasinye. Oku kuya kunceda ukuphepha yonke imiphumo emibi.

Ezi zi gulane ezine-stroke akufanele zonyulwe.

Kubonakala ukuba ukulungiswa kumbuzo kunempembelelo enkulu ekusebenzeni kwe-retina. Nangona oku kubonakala kungabi yingozi, igalelo layo lisoloko kunzima ukuqikelela. Ngoko ke, ukuba unayo nayiphi na imiphumo engathandekiyo kwamehlo akho, kufuneka ususe ngokukhawuleza ukusebenzisa le mayeza kwaye ufuna uncedo kudokotela wakho.

Ungayisebenzisi izilwanyana ezisemthethweni ngexesha elifanayo kunye ne-block calcium. Oku kunciphisa ukuphumelela kweyeza.

Izigulane ezinobungozi begazi kufuneka ziphantsi kolawulo lwegqirha elifanelekileyo kulo lonke ixesha lokunyanga.

Esi sidakamizwa asifanelekanga kwizigulane ezithwaxwa yi-lactose yokuzala.

Awukwazi ukusebenzisa ijusi yamagilebhisi ngexesha lonyango kunye nokuthatha inxaxheba kwe "Ivabradin". Ekubeni eli phuza kakhulu landisa ingxube yeziyobisi kwi-plasma yegazi, echaphazela ngokuphawulekayo ukusebenza kwayo.

Impembelelo kwisilinganiso sokuphendula

Ichaphazela njani ukukwazi ukuqhuba imoto kunye neendlela eziyinkimbinkimbi zeIwabradin? Umyalelo uchaza ukuba lo lungiso alunamthelelo ombi kwisigulana somntu kunye nesantya sokwenza kwakhe. Nangona kunjalo, xa usebenzisa isicatshulwa esikulo mbuzo, ukuphazamiseka kwexesha elifutshane lomgangatho wombono kunokwenzeka. Bamele ukubonakala ngokukhawuleza kokukhanya okukhanyayo okanye umbono obonakalayo. Ngokuqhelekileyo, ezi zimpawu zidibene nokutshintsha ngokukhawuleza ekunyaneni okulula kwaye zidlulise ngokwabo emva kwexesha. Oku kubalulekile ukuqwalasela abo baceba ukuqhuba imoto okanye basebenze nayiphi na indlela.

Ukusebenzisana namanye amayeza

Isidakamizwa sase-Ivabradine asivumeli ukusetyenziswa kwezidakamizwa ze-cardiovascular (umzekelo, i-bepiridil, i-quinidine, ibutilide, i-sotalol, i-dizopramide kunye ne-amiodarone) kunye nezinto ezingenayo i-cardiovascular (njenge-cisapride, i-ziprasidone, i-mefloquine, i-pimozide, i-erythromycin intravenous, i-pentamidine , Sertindole, halofantrine).

Ukuba le nhlanganisela isacingekile, kufuneka uqaphele rhoqo izinga lentliziyo yesigulane kwiziko elizodwa lonyango.

Isicelo ngexesha lokukhulelwa

Sebenzisa ngexesha lokuthwala umntwana okanye ngexesha lokuncelisa i-"Iwabradine". Isilwayo singena kumngcipheko we-placental kunye nobisi lwebele kwaye, ngenxa yoko, inefuthe elibi kakhulu ekuphuhlisweni komntwana.

Kwakhona, akukhuthazwa ukusebenzisa le myeza ukuphatha abantwana abangaphantsi kweminyaka elishumi elinesibhozo, kuba akukho datha kwokhuseleko kunye nokusebenza kwezilwanyana kweli gama lezigulane.

Analogues

Ezi zi gulane, ngenxa yezizathu ezithile, azikwazi ukuthatha izilwanyana ezibhekiselele kumbuzo, zingatshintsha iingqalelo kwiimpawu ze-drug Ivabradin. Iingqungquthela eziqukethe into efanayo ebonakalayo. Izona ziyaziwayo kakhulu yiKoraksan. Ezinye iindlela eziqhelekileyo zichazwe yiengcali "i-Bravadin", "iVivaroxan" kunye ne "Ryan". Zonke ezi ziziyobisi zineminqweno efanayo yokusetyenziswa kwaye, ngokubhekiselele kwizibuyekezo, zinokusebenza okufanayo.

Uphononongo

Izigulane zicebisa "i-Ivabradin" njengesisombululo esisebenzayo, esilungele ukusetyenziswa. Uninzi lwabantu abayisebenzisayo, abaziveki naluphi na ukuphendula. Kwaye isiphumo sesenzo, ngokuchaseneyo, siyabonakala emva kokusela kokuqala kweyeza "Ivabradin". Ukuphononongwa kuqinisekisa ukusebenza kwayo. Nangona kunjalo, zonke izigulane zigxininisa imfuno yokubambisana rhoqo kunye nodokotela oya kuzo ukuze agweme nayiphi na imiphumo engathandekiyo isigulane.

Umhla wokuphela

Isiza esicatshungulwayo sigcina iimpahla zayo eziyimfuneko iminyaka emithathu ukususela ngexesha lokuveliswa kwayo. Emva kokuphela kwesi sihlandlo, ukusetyenziswa kwesi sidakamizwa kungenanto okanye kuyingozi kumguli, ngoko ke, emva komhla wokuphelelwa yisikhathi, eli liyeza livumelekile.

Ukugcina nokuhambisa kwiifommesi

Iyeza "I-Ivabradin" lihluke ekubeni alilahlekelwa izinto ezifanelekileyo phantsi kweemeko ezahlukahlukeneyo zokukhanyisa kunye neemeko zokushisa, ngoko akukho imfuneko ukudala iimeko ezizodwa zokugcina. Nangona kunjalo, kubalulekile ukugcina isilwanyana kumbuzo kwindawo apho abantwana abakwazi ukufikelela kuyo. Iyeza linikezwa kwii-pharmacy kuphela kwimigqaliselo ekhutshwe ngudokotela. Ixabiso eliqhelekileyo leziyobisi (iipilisi kwii-milligrams ezintlanu) li malunga newaka elinamakhulu ama-ruble.

I-Ivabradin ingasetyenzwa ngaphandle kokwesaba, kuphela emva kokufunda ngokucophelela eli nqaku kunye nokubonisana nengcali enekhono. Ulawulo loogqirha oya kungena isiqinisekiso sokuphumelela kwonyango kunye neziyobisi. Izigulane ezininzi zaziyokwazi ukugcina ubomi babo kuphela ngenxa yokuba zihambelane ngokuthe ngqo kwezi zi ngcebiso kwaye azizange zityeshele ukunxibelelana kunye noogqirha babo. Ukuzama ukulondoloza ngeli xesha kungabangela ukulahlekelwa kokugqibela kwempilo. Ngaba kukho into ekufanelekile ukuba nayo ingozi?

Ngoko ke, qiniseka ukuba uhlolisise yonke inkcazelo ephathelele ukusetyenziswa kweziyobisi "I-Ivabradin": imiyalelo yokusetyenziswa, iifaneli, ukuchasene kunye nemiphumo emibi. Indlela efanelekileyo yokukhetha indlela yokonyango iboniswa ziziphumo zayo eziphumeleleyo.

Inyaniso yokuba inhlalakahle yomntu incike kakhulu kwiimeko zempilo yakhe yinto engenakuphikiswa. Izifo zingabangela ukukhawuleka kwamandla ethu kwaye anganikeli ithuba lokuqonda iingcamango zabo, iiminqweno kunye nokuqala. Lumkela impilo yakho kwaye ungavumeli naziphi na izifo zithathe ubomi bakho phantsi kolawulo!