IGH-study - yintoni na?

Izifo ze-oncological yiyona nto iyingozi kakhulu kubantu abaninzi. Kodwa ukuze uqaphele ingxaki ebalulekileyo ngexesha kwaye uqale ukuwukhupha ngokufanelekileyo, kuyimfuneko ukuqhuba uphando oluthile. исследование. Enye yazo i-IHC isifundo.

Iimvelaphi, izilwanyana kunye nezinto zokukhula

Izizathu ezibangela ukuba iiseli zihlanganyele ngokuzibandakanya, ukwenza ama-neoplasms, ngokuqhelekileyo ukuba ne-orientational orientation, aziyazi into yesayensi. Kodwa nantsi indlela ukukhula kweeseli sele kufundwe ngokwaneleyo. Iiselithi zeetuncu zinezakhiwo eziyinkimbinkimbi. -рецепторы. Kwi-cell surface kukhona okubizwa ngokuba yi-HE R-2 receptors. Bakhonza njengobunjani be-antenna, bephulaphula imiyalelo yomzimba. берет начало от английского словосочетания human epidermal growth factor receptor 2 , что в дословном переводе значит "рецептор человеческого эпидермального фактора роста". Ngendlela, isicatshulwa se-HE R-2 sivela kwi-English word inhlanganisela "i- epidermal growth factor receptor 2" , eguqulelwe ngokoqobo ithetha "i-epidermal growth factor receptor". Lezi kunye nezifunyenwe zenza iseli ukwahlula, sikhule okanye sizilungiselele.

Umsebenzi we-receptor esebenzayo kunye ne-tumor

Ngelishwa, akusoloko umzimba womzimba usebenza njengoko kufanelekile, ngaphandle kokusilela kunye nezifo. -рецепторы начинают активно получать команды "делиться и размножаться". Nangona inzululwazi engazi kakuhle ukuba kutheni, kodwa kwenzeka ukuba i-HE R-2 receptors ziqala ukufumana ngokuthe ngqo "imiyalelo yezabelo nokuphindaphinda". Kwaye ekubeni ezi zixhobo zamaselula ziphezulu, ziphoqelela iiseli ukuba zihlukane ngokwahlukileyo, zenze i-tumor. Iimviwo zonyango kuphela, kubandakanywa ne-IHH- uphando, avumela ukucacisa isimo se-neoplasm, kwakunye nokuchazwa kwonyango nobomi bogulane.

Isimo se-Gene sesisu

Ukuqulunqwa kweeyolojikiyo zonyango zanamhlanje zichongiwe yimeko ye-hormonal therapy. Le meko ingaba yinto engalunganga (engeyiyo) kwaye ifanelekile (enhle). Ihcho- isifundo sinceda ukucacisa uhlobo lwe-neoplasm . Yintoni i-immunohistochemistry ebonisa? Olu pho nonongo lunceda ukumisela ukuxhomekeka kwe-hormonal ye-neoplasm-status herceptal, kwaye ngoko ke, ukukhetha indlela yokunyanga eyiyo yokufumana umphumo ophumelelayo.

Ukungalungi kunye nokuhle

Inyaniso yokuba i-hormonal herceptor-tumor status inegama elithi "positive" okanye "negative", liya kuxela kakhulu ugqirha onobungcali. Kodwa ngaphakathi kwaye ngokwayo ezi ngcaciso azibhekiseli kwiimvakalelo, njenge-philistine elula owakuqala ukuva malunga novavanyo lwe-ICG unokucinga. I-hecept positive status status ibonisa ukuba lolu hlobo lomhlaza luyingozi, lukhula ngokukhawuleza, lusasazeka ngomzimba ngokusebenzisa i-metastasis. Kodwa ngelo xesha, isifo esinjalo esibi esinokuphakanyiswa kwamanqanaba athile amayeza. Isimo esilungileyo se-herceptus-neoplasm siya kuthetha ukuba i-tumor ikhula ngokukhawuleza, kodwa ayikho imithi eyaneleyo okwamanje.

Immunohistochemistry - yintoni na?

Esinye sezifo ezixhaphakileyo kwi-incological phakathi kwabasetyhini ngumhlaza webele. I-IHH-study inceda ekufumaneni uhlobo lwe-neoplasm kwaye ukhethe unyango ngokuhambelana nemeko ekhoyo. I-Immunohistochemistry yiphando lokuhlola i - biopsy specimen (i-biomaterial efakwe kwinkqubo ye-biopsy) ngoncedo lwezinto ezikhethekileyo zembala. -рецепторы, и чем больше рецепторов, влияющих на появление и развитие "ненормальной" клетки, тем ярче будет окраска исследуемого биоматериала. Le nkunkuma igqithisa i- R-2 receptors, kunye nezinye iimpembelelo ezichaphazela ukubonakala nokuphuhliswa kweseli "engavamile", kukhanya umbala we-biomaterial iya kuba.

Umoya we-neoplasm uzimisele njani?

I-colored biomaterial ibona ukuhlolwa kweemviwo ngexesha lovavanyo lwebhubhoratri yokumisela imeko ye-hercept. Ngenxa yale njongo, isalathisi esikhethekileyo sisetyenzisiweyo, esinombala we-gradient ukusuka ku-0 ukuya ku-3+. Le ndlela ivumela ukuba sikwazi ukuhlukanisa izibonda ezi-4 eziphambili, kuxhomekeke kulokho ekufuneka ziholele isiguli. Kubonakala-yintoni elula? Dya iifom zolu vavanyo kunye nenkunkuma ekhethekileyo, indawo phantsi kwe-microscope, uhlolisise ngenyameko, ukuthelekisa okubonwayo kunye neesampuli zokulawula umbala, kwaye umise i-herceptor-tumor status. Kodwa nendima enkulu idlala ngumntu, izinto zokukhanyisa njalo njalo.

Kuqhutyelwa njani isifundo se-IHC

Ukuba ukukhankanywa komhlaza kufunyaniswa, isifuba siyahlolwa. Ukuchazwa kweemviwo ze-immunohistochemical iqulethe ezine kuphela. Kodwa ingxaki kukuba imilinganiselo emibini emibini, kwaye oku kuya kuba ngu-1 + no-2 + kwinqanaba, sibonise isiphumo esingacacile esifuna uphando olongezelelweyo ngenye indlela. Oko kukuthi, i-IHH- isifundo yindlela ekhethileyo yokutyhila isimo sengqondo sokumelana ne-neoplasm. Ukongeza, iimeko zomntu kunye neemeko zangaphandle zichaphazela kakhulu umphumo wophando, njengoko sele zikhankanywe. Into eyona nto ichanekileyo ngokuchanekileyo iziphumo ezibini ezibi kakhulu - ezingalunganga 0 (i-neoplasm ine-negative status status) kunye ne-3+ (imeko ye-hormonal ye-tumor is positive).

Amahomoni wesifazana kunye nezihlamba

Njengoko unyango lwanamhlanje luthi, ezininzi iinambuku zesondo zentlobano yesini zixhomekeke kumgangatho we-hormone wendalo. Uphuhliso lwazo lukhokelela kakhulu kwi-hormone yesinikazi yesini - i-progesterone ne-estrogen. Ama-receptors kula ma hormone agqiba ukubunjwa nokuphuhliswa komhlaza. Ukuxhomekeka kwe-hormonal eqinisekisiwe kuvumela ukuchaza isicwangciso sokonyango ngokubaluleka okulandelayo ngokucacileyo. Ukongezelela, aba balamkeli badlala indima kungekhona nje ngomhlaza wesifuba, kodwa nakwiingxaki ezinzulu ezifana nokungabikho komfazi, i-endometriosis nomhlaza wesifo somzimba - isisu, amaqanda, umlomo wesibeleko. Uhlobo lwe-herceptor-ye-tumor, eyenziwa ngexesha loviwo lwe- IHC -i-endometrium, umzekelo, liya kwenza ukuba kunokwenzeka ukuba kunikezelwe unyango ngokuchanekileyo kwezo zonyango eziya kunceda ukufezekisa isiphumo esaneleyo ngaphandle kokuvavanywa okungadingekanga nokukhethwa kwamachiza kwimeko ethile.

Ukuba ukungazinzi

Ukungenanto kungxaki enkulu kwiintsapho ezininzi zanamhlanje. Izifundo ezenziwa ngamaziko ezonyango zenzululwazi zibonise ukuba kwinani elikhulu lamatyala ukungabikho kwengqondo ngenxa yokungabi nakwimvelaphi ye-endometrial ye-hormonal - i-epithelial layer encining in the stine cavity. Yimeko ye-hecept evumela umntu ukuba abone i-IHC- isifundo sokwamkelwa kwe-endometrium. Ama-hormone esini esetyhini asebenzayo kwinkqubo yokwenziwa kweqanda, ukuchumisa, ukufakelwa kwesibindi kumbindi we-uterine, kunye nesisu sokukhulelwa nokuzala. Ukuhlolwa kwe-endometrial ischemic endometrial, njengoko sitshilo, kwenza ukuba kube lula ukufumanisa isimo senkohliso yeeseli ze-endometrial ukuya kwi-estrogen kunye neprogesterone kwaye, ngokuhambelana nemiphumo efunyenweyo, ukhethe unyango olufanelekileyo kumfazi.

Ukuxilongwa kwe-lymphoma

Izifo ze-ecological is the calamity of mankind. Nangona i-pharmacology yanamhlanje kunye nophuhliso lobuchwepheshe lunokuphilisa ezi zifo. Kodwa ukuxilonga kubaluleke kakhulu apha, ingakumbi kwizigaba zokuqala zesifo. I-lymph oncology yinkinga eqhelekileyo. Ukuhlolwa kwe-IGH kunye ne-lymphoma enye yeendlela zokwenza uvavanyo oluchanekileyo, ngoko ke ukunika unyango olwaneleyo. Olu pho nonongo luqhutyelwa kwisampula se-biopsy ye-lymphatic fluid okanye izicubu ze-hematopoiesis. Izinto eziphathekayo, ezithathwa ukuze zihlolwe iimviwo, zithatha izibonda kunye nezinto ezizodwa ezikunceda ukufumana abaqhubi. Ngelishwa, olu hlobo lophando alufezekanga kwaye kwiimeko ezininzi zixhaswa ezinye iindlela zokuxilonga. Ukongezelela, ngokuqhelekileyo i-lymphatic system ngokwayo ayibangeli ingxaki. Yilokho eyenza sikwazi ukubona i-IHX-i-lymph.

Uhlalutyo lwe-IHC - ulwazi olufike ngexesha

Iingxaki zempilo mazifumaneke kwaye zichongwe ngexesha. Ukwenza oku, sifuna zonke iintlobo zeendlela zokuhlola iimviwo, ukuhlalutya. исследование - один из наиболее распространенных методов диагностики новообразований или других проблем с тканями различных органов. I-IGH- uphando ngenye yeendlela eziqhelekileyo zokuxilonga i-neoplasms okanye ezinye iingxaki kunye nezicubu zeenxalenye ezahlukeneyo. Ucwaningo lwe-IHC lwenziwe kwizinto eziphathisiwe ukucacisa ingxaki-oko kuthiwa yi-biopsy. Izinto eziphathekayo zinezixhobo ezizodwa kwiinjongo ezithile, kwaye ngoncedo lokufaniswa okubonakalayo oluqhutyelwa ngugqirha-ngqapheli wezilwanyana, abafakeli beefowuni bafakwe ukubonisa enye okanye enye ingxaki. Ukungafezeki kokuphandwa kwe-immunohistochemical kukuba izinto ezingenakwanela, izinto eziza kubamba indima, okanye izizathu zangaphandle aziyi kuvumela ukuseka umfanekiso ochanekileyo wengxaki. исследование. Kwimeko nayiphi na imeko, ukuba isifo esaneleyo sesi sifo, ngokukodwa kwi-oncological, kubalulekile ukuqhuba uphando olunzulu, apho enye yamanyathelo iya kuba yi-IHC . какого-ибо органа, ткани? Yintoni na ngomhlaza wesinye isitho, izicubu? I-biopsy ihlolwe ngamanqaku e-tumor, avumele ukuvavanya ukuba khona kwabo kwisampuli. Njengoko uncedo ekufumaneni i-IHH-study isingenakwenzeka, lusetyenziswa ngokukhawuleza ekusekeni izizathu zokungabikho komntwana.

Amachiza, kuquka ukuxilongwa, uhlala ehla. Mhlawumbi kwixesha elizayo uphando lwe-immunohistochemical luya kufezekiswa kwaye luya kwenza abantu abaninzi ukuba babe nokuxilongwa okwaneleyo kunye nenkcitho encinane yexesha kunye nomzamo.