Hydrochloride Loperamide. hydrochloride Loperamide - yemiyalezo

Yintoni na ichiza "hydrochloride Loperamide '? Impendulo comprehensive lo mbuzo inokufunyanwa kwi zinto zokufunda kubonelelwe yi-nqaku. Ukongeza, siza kukuxelela nzulu malunga ukuba ayinonophele njani amayeza, nini kwaye yintoni umthamo.

ulwazi jikelele

Le medicament "hydrochloride Loperamide" sisiyobisi ibonisa elithanda esetyenziswa ukunyanga ukurhuda oyingozi futhi ezigulo ezondeleyo. Eli chiza ithengiswe ngaphandle amayeza babethengisa phantse yonke imithi ngexabiso elifikelelekayo.

imiphumela kwemithi

Ukulungiselela "hydrochloride Loperamide" imfundiso leyo ifakwe kwi ibhokisi, kunciphisa motility kunye nethoni zihlunu kakuhle emathunjini kunye abangaphangeliyo peristalsis umzimba, ukwandisa kakhulu ixesha sokuhambisa ngezinto ezilapho kuyo. Ngoko ke, lo medicament thaca abonakalisa ukusebenza antidiarrhoeal. Kufuneka kuqatshelwe ukuba ichiza "hydrochloride Loperamide" iqalisa ukwenza ngokukhawuleza kakhulu. Phezu yokwamkela eli chiza ngaphakathi isiphumo enyangayo ithatha malunga 4-6 iiyure.

Pharmacokinetics

Loo medicament ifunxwe ethunjini yi kwengalunganga (40%). Ngenxa yokufana eliphezulu receptors beendonga isisu, kwakunye iqondo eliphezulu biotransformation ngecala elingaphesheya lokuqala kumanqanaba zesibindi plasma kwicandelo unmodified emva kokufumana kuthetha 2 mg (1 philisi) ungaphantsi kwama-2 ng / ml. Le xi iphezulu into esebenzayo emva sisombululo ukusetyenziswa kuphunyelelwa emva malunga 2.5 kweeyure, kwaye emva kokuba njengezingxobo - emva kweeyure ezi-5. Ukubambana kwiiproteni plasma kwenzeka ngo-97%. Eli chiza umzimba esibindini kwaye ephuma inxenye umchamo, njengoko conjugates kunye inyongo, kwakunye ne endleni.

uhlobo Ukukhutshwa amayeza nokubunjwa kwayo

Ukulungiselela "hydrochloride Loperamide," ukusetyenziswa ichazwa apha, le ithunyelwa ngohlobo:

• Ukusetyenziswa olungumgubo isisombululo.
• 2 amacwecwe mg, zibekwe kwi ibhokisi 50, 30, 20 okanye 10 ziingceba.
• 2 njengezingxobo mg ibekwa iphakheji 30, 20 okanye 10 ziingceba.
• njengezingxobo Gelatin nzima yellow, nto leyo ibe ngumgubo emhlophe kunye icandelo esebenzayo - hydrochloride loperamide. Isingxobo ngasinye iqulethe 2 mg into esebenzayo. Ngaphandle medicament emelwe iqulethe kumafa yayo izithako abangabancedani: talc, starch ingqolowa, lactose, nemagnesium stearate kunye dust colloidal. njengezingxobo Gelatin zifumaneka ukuthengiswa ibhokisi iziqwenga-20 okanye 10.

Apho enye iqulathe i hydrochloride esebenzayo nto loperamide? Ukusetyenziswa kwale into Pharmacology kwaye ivumela iziyobisi ezifana 'Imodium "yaye" Diara ". Nangona kunjalo, ipesenti yayo kwezi nemixube mncinci kakhulu kwi medicament ngasentla.

Drug "hydrochloride Loperamide": yintoni ukuthini?

Ngokutsho imiyalelo, kufuneka ichiza ukuba kwezi meko zilandelayo:

• Bunjani esitulweni at ileostomy.
• Xa Ukuphazamiseka pathways kunye nokufunxwa isisu, ezo zibangelwa utshintsho ngesiquphe yaye olukhulu kwisidlo okanye ukwakhiwa eqhelekileyo zokutya (umzekelo, xa kukho ukutya, uhambo).
• Njengoko ichiza abangabancedani ngo sorhudo esosulelayo.
• Njengoko unyango siyefana for oyingozi okanye engapheliyo sorhudo (kukwalisa, imitha, iziyobisi okanye imvelaphi emotional).

Izimo ukusetyenziswa iyeza

Kwezinye iimeko, awukwazi ukusebenzisa iziyobisi "loperamide" (tablets)? Imiyalelo anikwe amayeza ithi ayikhuthazwa tu into yokuba:

• emathunjini;
• sorhudo, nto leyo iye yakhula ngenxa segazi, enterocolitis etsolo pseudomembranous okanye ezinye izifo ze wokugaya;
• diverticulosis;
• wenze olunamandla;
• hypersensitivity.

Kufuneka kuqatshelwe ukuba ezi machiza antidiarrheal abantwana kufuneka imiselwe kuphela kunyaka-4. Ukongeza, ngokwemiyalelo, lithetha "loperamide" into contraindicated kwithuba leenyanga ezintathu zokuqala zokukhulelwa kunye ngexesha zisanyisa. Ngononophelo olukhulu ichiza ezimiselweyo sisibindi.

Le medicament "hydrochloride Loperamide": imiyalelo yokusebenzisa

Macwecwe kunye njengezingxobo beziyobisi ekufuneka athathwe ngomlomo ngaphandle ehlafuna. Le umthamo ichiza kuxhomekeke kubudala yomguli kunye nesifo ubukhulu.

Xa sorhudo etsolo abadala njengoko kwedosi yokuqala ilawulwa 4 mg beziyobisi uze - 2 mg emva defecation ngamnye (ukuba ngusihlalo kusenjalo wamanzi).

Xa komthamo ezingapheliyo utyatyazo lokuqala 2 mg. unyango noncedo abantu abadala kufuneka yenziwe ukuze isitulo frequency yomguli 1 okanye 2 ngosuku amaxesha. Le idosi iphezulu yemihla ngemihla - 16 mg.

Isiphumo therapeutic ukuthatha isiyobisi enjalo kukhulisa kwisithuba seeyure ezingama-48. Ukuba, ke, iintsuku 2-4, usebenzisa ukuya ku-16 mg beziyobisi yonke imihla, awukwazi ukufikelela oko akufunayo, kufuneka usoloko udibane nogqirha, wawahlangula ukuba iyiqwalasele le isifo. Ukusetyenziswa ichiza kungaba liphindwe, kodwa ke kuphela unyango xa ezithile okanye babophe akuthethi bunjani esitulweni.

Njengoko ngenxa yoonyana, ichiza kufuneka kusetyenziswa kwiminyaka-4 kuphela ubudala. Iidosi kwakhona kuxhomekeke kubudala yomguli kunye nobungozi besi sifo.

Iintsana ukususela kwiminyaka-4 ukuya kowe-7, ichiza kufuneka anikwe amaxesha 3-4 ngemini 1 mg. Ubude unyango na iintsuku ezi-3. Abantwana abaneminyaka 7 ukuya ku-12 zilawulwa kane ngemini 1 tablet iintsuku ezi-5. Kwiintsana oyidlayo yokuqala utyatyazo etsolo kufuneka 1 capsule. Le idosi iphezulu imihla yabantwana - 8 mg.

Ukuba umntwana sele urhudo waphawula emva kokuba isenzo ngasinye defecation ngexesha elide, ngalo lonke ixesha kufuneka anikwe 1 Isingxobo, kodwa hayi ngaphezulu kwe-6 mg nganye-20 kg ubunzima bomzimba ngosuku. Ukuba umntwana akafuni ukuya kwindlu yangasese iiyure ezingaphezu kwama-12, yaye emva kuqheleke reception isitulo thaca yi ichiza bayacetyiswa ukuba ayeke.

libanda, iziyobisi

Kwimeko libanda, nalo eli chiza xa isigulane alandelayo lungakho singabonakala:

• yokuphazamiseka lulungelelaniso kweentshukumo;
• constriction abafundi;
• wobuthongo;
• ukozela;
• ukwanda kwezihlunu skeletal;
• wamathumbu kokuphazamiseka;
• ukuxinezeleka sokuphefumla.

Ukuze yokuphatha ithi zophendlo lwezifo ezifana oogqirha iziyobisi "Naloxone" lisetyenziswa kunye nonyango ngaxeshanye nomqondiso.

imiphumela emibi

Kufuneka kuqatshelwe ukuba emva kokuba isicelo yokulungiselela "hydrochloride Loperamide" izigulane zinokuba neziphumo ebezingalindelekanga ezahlukeneyo. rhoqo ukuba kwenzeka ngokusebenzisa elide ichiza. Ngaloo medicament zimelwe kunokubangela iziphumo ebezingalindelekanga kulandelayo:

• flatulence;
• ukukhubazeka electrolyte;
• ukuphalaza;
• amahlaba isisu;
• nesiyezi;
• gastralgia;
• isicaphucaphu;
• hypovolemia;
• ukozela;
• umlomo owomileyo.

Xa abantwana abaselula, ichiza kubangela kabi esiswini, kwakunye irhashalala. Kakhulu kunqabile medicament "hydrochloride Loperamide 'inokuba negalelo ukugcinwa wokuchama okanye emathunjini.

Ukuba emva kweentsuku 2 la musa zinyamalale, kwaye isigulane akafuni uzive ngcono, kufuneka usoloko udibane nogqirha, ngubani na oya kumisela ezinye imveliso (efanayo). Ukuba ichiza swi nga pfuna, kuhle ukukhangela lwezifo ezibangela urhudo.

imithi

Ngokutsho imiyalelo, lo gama isicelo ngamalungiselelo "Loperamide hydrochloride" yaye "Cholestyramine" ukusebenza yokuqala kunganciphisa. Ukuba ufuna ukusebenzisa ichiza kunye neendlela "Co-trimoxazole" okanye "Ritonavir", ngoko ufanele wazi ukuba bioavailability yayo inyuswe kakhulu.

oyi

Drug "hydrochloride Loperamide" kufuneka zithathwe ngononophelo kakhulu kwi lomonakalo hepatic. Kwakhona akukho Kucetyiswa ukuba basebenzise ngayo kwezi meko clinical apho inhibition of peristalsis emathunjini. Xa engekho isiphumo eyaneleyo zonyango emva kweentsuku-2 emva kokuba ulawulo ichiza kuyanqweneleka ukulungisa lokufunyaniswa ugqirha kunye nokuphelisa esosulelayo genesis urhudo.