"Formetin": imiyalelo, real

Okwangoku safumana abantu abaninzi abanesifo seswekile kunye iingxaki uhlobo ukutyeba. Amachiza amaninzi olukhoyo unyango ezi zifo. Enye yazo unyango "Formetin". iimpawu zayo eqalise ziya kucaciswa kweli nqaku.

isigaba yezemithi

"Formetin" imiyalelo ukusetyenziswa oboniswe kweli nqaku, eli qela biguanide iziyobisi hypoglycemic.

Inkcazelo ubume kunye ukukhululwa ifomu

Kwenye tablet yayo;

iziyobisi Ezikhoyo "Formetin" kwi namadyungudyungu 100, 60 okanye tablets-30.
Umbala White amacwecwe kunye idosi ifomu kuxhomekeke izinto kwisiseko. Kwi 500 mg ploskotsilindricheskoy zibe imilo setyhula kunye ephawulweyo chamfered. Kwakhona ke umthamo 1000 mg okanye 850 mg uye "Formetin". Amacwecwe kulo mzekelo, khaxa kunye elimbhoxo. Yokuba ingozi elinye macala.

pharmacodynamics

Metformin ( "Formetin") ukucola gluconeogenesis aqukuqela kwesibindi, yaye ngaloo ndlela kukho ukuhla kwiivenkile glycogen kuyo. Esi sixhobo kunegalelo nobunzima kukufakwa ukusuka iswekile isisu, ukuphucula ukushenxiswa amaqondo eswekile yegazi le nkqubo. Oku kwandisa impendulo izicwili insulin ngaphandle kokuchaphazela imveliso ezidalwe nesabelo salo zepancreas B-iiseli, ngokudlulisela indlela hypoglycemic, kuba akukho iyasebenza imveliso kweziyobisi yathi.

"Formetin" ncomo lweziyobisi bethetha impumelelo yayo, ukucutha ubuninzi igazi kwi-cholesterol "nezingalunganga" kunye triglycerides. Umxholo we lipoproteins ache oku kwandisa ukuya 20-30%. Kunye kwawo of "Formetin" imiyalelo ukutya iziyobisi ukwenzela ukusetyenziswa ichazwa kweli nqaku kunceda ukunciphisa kunye / okanye uzinzo ubunzima yesigulane. Oku kwenzeka ngenxa yokuba igcwala glucose ngu ioksijini-free kunye nokunciphisa ukutya. Kwakhona buthelezi zomzimba inkqubo lokuvula plasminogen ngokwenza inhibitor yayo, apho isiphumo hemostatic ibonakala.

Pharmacokinetics

Nokwenziwa metformin iqala kwisiqwenga zesisu. Inani lobuninzi kweziyobisi igazi malunga 2.5 iiyure emva kokuba isicelo kwi isantya unit idosi yokufunxa - 50-60%. Sokufunxa umgangatho kweziyobisi emzimbeni echaphazela uqhagamshelwano phakathi kweziyobisi esebenzayo kunye neprothini kwi plasma. Emacwecweni "Formetina" akukho xhulumaniso kwiiproteni plasma. Oku uthetha malunga ukusebenza kwayo. Ekubeni ezincane into yokubopha, iyeza ako ngcono. Yokulahlwa kwe lo kwizintso, isibindi, xa izihlunu kwezihlunu, kwi kwamadlala amathe. Emzimbeni, metformin kuhlala ingatshintshanga. Yena kamva kwazona yi nezintso. Ngoko ke, xa zokugxojwa umsebenzi wabo uyabonakala abekwe. Eziphilayo isiqingatha-ubomi iiyure 1.5-4.5.

nomgomo

Medicine "Formetin" isetyenziselwa unyango kwiindidi ezithile izifo. Oko kukuthi, phambi uhlobo II seswekile, kunye namatyala ukutyeba ne enzima xa umxhesho swi nga pfuna ukugcina amaqondo eswekile yegazi eziqhelekileyo, nkqu ezidityaniswe sulfonylurea. Kwakhona olusebenzayo i "Formetin" ukunciphisa umzimba.

Indlela ukuthatha?

Ithamo logqirha kuthetha ngokukhetha, ezisekelwe kubungakanani glucose egazini. Ulawulo yomlomo kuyimfuneko ukusebenzisa emva kwesidlo, ukusela kunye yonge ulwelo yaye ebhenca machining tablet. Njengoko sele kukhankanyiwe ngentla apha, idosi imiselwe kuxhomekeke umxholo glucose egazini. Kuthathela ngesixa esincinci - 0.5 g okanye 0.85 g ngosuku. kwiintsuku ezimbini emva kokuqala unyango nalo eli chiza bekusoloko isiqulatho uthotho metformin egazini. Ukukhetha, kancane kancane idosi de ixabiso elikhulu. Oku kuyafana 3 grams.

Ekubeni abantu abakhulileyo waphawula uphuhliso lactic acidosis, kubo inqanaba idosi iphezulu yemihla ngemihla ka-1 g imali ichiza zanciphisa nokunyhashwa ukutya, ukuze kuthintelwe uxabane nawo, esizibonakalisa ngohlobo irhashalala, kunye nezinye iziganeko ezingalunganga kunokwenzeka, nto leyo eza zicaciswe ngezantsi.

Izimo

Kulo mba, kukho bokuqonda ezininzi. imiyalelo "Formetin" kweziyobisi ukwenzela ukusetyenziswa oboniswe kwesi sicatshulwa, ithe contraindicated phambi:

• ketoacidosis seswekile, precoma, ukufa isiqaqa.
• kakuhle ukusebenza sezintso Severe.
• ukusilela ezesifuba zokuphefumla.
• Phase of iposi engabalulekanga.
• Emzimbeni.
• etywaleni Chronic kunye nezinye iimeko ezinokuba negalelo ngokubonakala yokuphuhlisa lactic acidosis.
• stroke olunamandla.
• Ukukhulelwa kunye nokuncancisa.
• Hypersensitivity kule srudstvu.
• utyando olukhulu okanye ukonzakala, xa insulin umiswa.
• Izifo ezosulelayo Severe.
• nokuphazamiseka olusebenzayo esibindini.
• Ityhefu utywala olunamandla.
• lactic acidosis (kuquka imbali).
• Ukudla Hypocaloric (ngaphantsi kwama-1000 kcal. Per ngosuku).
• Adioizotopnyh okanye izifundo radiographic, ulawulo uhlobo kweziyobisi iodide.

Kwakhona akukho Kucetyiswa ukuba basebenzise iziyobisi "Formetin" abantu abangaphezu kweminyaka engamashumi amathandathu, nokwenza umsebenzi odinga. Ukususela kulo mzekelo, sengozini enkulu yokuba lactic acidosis.

effect side

Kukuvela iimpawu ezingemnandi ezifana kukungcamla "eqaqambileyo bubuhle 'emlonyeni, ukugabha, isicaphucaphu, urhudo, flatulence, ukungabi namdla kufuna ukupheliswa ukusetyenziswa konyango kunye nokudluliselwa ekhawulezileyo yincutshe. ukusetyenziswa Long-term beziyobisi kubangela ukuphazamiseka okanye kumiwe ngokupheleleyo kwe vitamin _B-12, nto leyo ekhokelela ukuba sokuzuza kumzimba yokugqibela, ebangela iziphene vitamin. Kwiimeko ezinqabe kakhulu, ukuphuhlisa uphendule - megaloblastic _{I-12 ezinqabileyo} anemia. Ukuba asilungiselelwanga ilawulwa ithamo hypoglycemia kunokwenzeka. Usenokuba kwakhona ukusabela komzimba ezifana irhashalala. Ngoko ke, ichiza "Formetin" ngamazwe kwi ngokufaneleka kwayo ekusetyenzisweni kwe ezahlukeneyo, kufuneka kuqeshwa kuphela ngugqirha khona.

oyi

Into ebalulekileyo echazwe imiqathango yokugcina ezisisiseko kweziyobisi "Formetina" emzimbeni kunye ngenxa yalo.

Ukuthintela ukuqokelela lactic acidosis kunye nokuthintela metformin, kuyimfuneko ukuba esweni izalathi si zokunikwa umsebenzi wezintso kwaye iimvavanyo ukujonga umxholo lactic acid emzimbeni amaxesha ubuncinane 2 ngonyaka ngamnye. Kwakhona, ukuba ngaba une uqaqanjelwa izihlunu kufuneka retested.

Isiphumo kweziyobisi wathi ukukwazi ukuqhuba iinkqubo ze aqhube isithuthi

Kulo mzekelo, njengoko kukho bokuqonda ethile. Impact "Formetina 'ukukwazi ukuba basebenza ngoomatshini kunye nezothutho lwenzeka kuphela xa ukusetyenziswa kudibaniso nge iziyobisi ezichaphazela iinkqubo zomsebenzi ezifuna isantya iimpendulo kunye nokwanda ingqalelo. Kubalulekile ukwazi.

Ukusetyenziswa ukukhulelwa kunye nokuncancisa

Ukulungiselela "Formetin", imiyalelo yokusetyenziswa ichazwa apha, lineziphumo ekukhuleni kosana olungekazalwa kudidi «B» yi FDA. Ngexesha lokukhulelwa uyakwazi ukufumana le mali. Nangona kunjalo, ukusetyenziswa kwayo kunokuba kuphela kwiimeko ezithile. Ezizezi - xa iziphumo ezilindelekileyo kwesi unyango luya kugqithisela nokufumaneka ingozi olungekazalwa. izifundo ezithile kunye ityala ngokusetyenziswa isixhobo efana iziyobisi "Formetin" kwaqhutywa ngethuba lokukhulelwa. Ngexesha unyango kufuneka uyeke ukuluncancisa. Enoba kunjalo, kufuneka ubuze ugqirha.

imithi

Metformin kwandisa inqanaba iswekile yegazi. Oku kubonakala ngakumbi omoya ngaxeshanye a non-steroidal amachiza anti-ukudumba, avela sulfonylurea kunye clofibrate, monoamine oxidase inhibitors, acarbose, insulin, oxytetracycline, cyclophosphamide, inhibitors of angiotensin ukuguqula blocker enzyme kunye nohlobo.

Xa isicelo kunye namachiza yonyango (zokucwangcisa ngomlomo, corticosteroids, sympathomimetics epinephrine, hormone nobubovu, glucagon, thiazide kunye "ngokwenzekayo" womchamo, avela phenothiazine, avela acid nicotinic) ukuze metformin inkqubo unyathela hypoglycemic.

Ngokudibanisa isixhobo efana iziyobisi "Formetin" ne "Tsimidinom" "nifedipine" umngcipheko nokukhula lactic acidosis, metformin ziyibuyisela umva le zinomgutyulo emzimbeni. Ezo iqatshelwe nokuqeshwa imveliso utywala, xa Vol. H. In nokwakheka amayeza.

arhente Cationic (quinidine, amiloride, digoxin, procainamide, morphine, umkhwinini, vancomycin, ranitidine, triamterene) eqalisiweyo tubules, kuzo ifuna unyango lwexesha elide inkqubo yezothutho kwaye kungandisa umgangatho ukuzikisa ngamachiza kwi-60%.

libanda

Libanda, "Formetinom" yathi xa uthatha 0.85 grams ngemini kwaye bandiqumbise lactic acidosis. Kwakhona, enesiqulatho eliphezulu metformin ngenxa ukusilela kwezintso.

Iimpawu Yokuqala lactic acidosis na ubuthathaka umzimba uphela, ukuqumba, ubushushu bomzimba ephantsi, iintlungu esiswini kunye nezihlunu, uxinzelelo lwegazi ephantsi, bradyarrhythmia reflex. Kwezinye iimeko, kukho ibonwa rhoqo ukuphazamiseka nokuphefumla, isiyezi, kwaye, ngenxa yoko, kukho uphuhliso isiqaqa.

Xa nakancinane iimpawu libanda, kufuneka uyeke ukusebenzisa ichiza aze adibane nogqirha ukuqinisekisa lokufunyaniswa lactic acidosis. Kuba ukususwa osisiqu esebenzayo ye-arhente kunye lactic acid evela ephilayo iya nehemodialysis ngaxeshanye kunye nonyango nomqondiso.

"Formetin": nabalingani

Kukho iweb eninzi kwemithombo kolu hlobo. Analogue "Formetina" ezivelileyo nemixube eziqulathe kumafa bazo njengelungu eziphambili metformin hydrochloride. Omnye umzekelo ichiza kwabavelisi Russian, "Vero Metformin," "Gliformin", "metformin", "Metformin-iRichter", naphesheya - "Glucophage", "Glucophage" yaye "Glyukofazh Long" (France), "Lanzherin "(Slovakia)" Metfogamma "ezishiyanayo iidosi ngeempahla ebonakalayo 0,100, 0,500 no 0,850 g (Germany).

Iimeko namagama

Kulo mba, kukho iimeko ezithile. Ukulungiselela "Formetin" esinamandla, ngoko ekhululwe kuphela ngokumiselwa kwaye ufuna ukugcina kubushushu igumbi, ingafumaneki abantwana kunye nendawo yelanga. Impilo ngayo - kwiminyaka emi-2.

iindleko

Ixabiso eliqhelekileyo ichiza "Formetin" umiselwe ngokuxhomekeke esithathwa ukusuka 59 engange. 0.5 g le blister, 133 engange. ka 0.85 g ne-232 engange. ngaphezu konyaka 1

isiphelo

Zonke angasentla luquka ulwazi oluninzi luncedo. Emva kokufunda eli nqaku, wonke umntu uya kuba nako ukufumana impendulo yombuzo ukuba ayinonophele njani 'Formetin "noko kuye iipropati.