"Gabapentin" kunye notywala: ncomo. "Gabapentin": imiyalelo ukusetyenziswa, angqina nomonde kunye noogqirha

Ukususela kumaxesha ngamaxesha, amahlaba kwezihlunu iyakukhathaza abantu abaninzi. Noko ke, bambalwa abantu abacinga ngayo kutheni kuvela ngokubanzi ezinjalo States.

Ngokutsho ubugcisa, ukuxhuzula zinokuba nomahluko: nolahlo ngokubanzi (indihlaziya, clonic, indihlaziya-clonic kunye myoclonic) kunye noluphakathi (ezilula kunye nezintsonkothileyo). ichiza asetyenziselwa ukunyanga uhlaselwe yokugqibela "Gabapentin". Imiyalelo ukusetyenziswa, ncomo kunye Izimo beziyobisi kuya kwenziwa kancinane emva koko.

Kufuneka ngoko nangoko kuqatshelwe ukuba, ngokuba uxhuzula inxenye esibonakala ngokungabikho zokulahleka sezingqondweni. imeko enqabileyo enjalo. Babonakala clonic ukuxhuzula indalo esichaphazela izandla kwezihlunu, iinyawo nobuso.

Ubume, inkcazelo, imveliso nokupakishwa nokubunjwa kwayo

wathengisa medicament "Gabapentin" Ngayiphi indlela? Baqinisekiswa ingxelo yokuba eli yeza zingathengwa ekhemesti ngokohlobo njengezingxobo gelatin nzima ezimhlophe. Umxholo yabo sisiyobisi lomgubo omhlophe okanye elityheli.

Le esisebenza yale arhente yi gabapentin. Kwakhona, kuquka enye into owongezelelweyo ngendlela sodium carboxymethyl wesitatshi, calcium stearate kunye microcrystalline kwincindi. Njengoko ngokuba njengezingxobo, bona ziqulathe gelatin kunye titanium dioxide.

Xa iphakheji wathengisa ichiza "Gabapentin"? ncomo Consumer bathi ezishelfini abantu ezikhemisti ichiza inokufumaneka Imiqulu zekhadibhodi, neziwela mhlawumbi polymeric njengezingxobo iitoti okanye imiqolo yayo kwiseli.

Umgaqo Isenzo isiyobisi

Njani ichiza "Gabapentin"? Imiyalelo (reviews of iyeza zinikwa ekupheleni nqaku) libika ukuba ichiza kubume bayo ufana kakhulu ukuya neurotransmitter gamma-aminobutyric acid (Gaba for short). Nakuba kunjalo, kufanele kuqatshelwe ukuba umgaqo wesenzo yahluke kuyaphi namanye amachiza ezisebenzisana kunye Gaba-receptors (umz, valproate, barbiturates, benzodiazepines, Gaba transaminase inhibitors, Gaba reuptake inhibitors, Gaba agonists kunye prodrugs ka Gaba).

iziyobisi kujongwa akanayo iipropati Gaba-ing kwaye alichaphazeli bamba yokucolwa ka Gaba. Iingcali zophando zibonise ukuba isithako esebenzayo yomenzeli ngokuzibophelela kwi α2-δ-enganeno lamajelo calcium ombane-abaxhomekeke, ukunciphisa kakhulu ithombo ion calcium, abadlala indima ebalulekileyo ekuqaleni intlungu neuropathic.

Features iziyobisi anticonvulsant

Ziziphi ezinye iipropati ziye ubephethwe ichiza "Gabapentin"? Izimvo oogqirha bathi ukuba ziyasebenza intlungu neuropathic. Eli chiza kunciphisa glutamate-oxhomekeke ukufa neuronal, ukwandisa Gaba kuyondelelaniswe, kwakunye inkqubo kwezithandani amaqela ukukhululwa kunye monoamine neurotransmitter.

Asikwazi ukuba xa zoqhaphelo ngokwezonyango efanelekileyo iziyobisi "Gabapentin" akathanga ukubophelela receptors kwamanye amachiza (okanye neurotransmitters), kubandakanywa receptors neGibheha kunye GABAB, kunye glutamate, receptors benzodiazepine, glycine, kunye N-methyl-D- aspartate.

Ngokungafaniyo "Carbamazepine" yaye "phenytoin", sancokola medicament angavumelaniyo ngemizila sodium. Ukulungiselela "gabapentin" ngokuyinxenye attenuates iimpembelelo glutamate receptor agonist ezifana N-imethyl-D-aspartate. Ngaphezu koko, kunciphisa kakhulu ukukhululwa neurotransmitters monoamine.

Iimpawu kwikinetiki ye ichiza

Zeziphi sibubona kwikinetiki parameters njengezingxobo "Gabapentin"? Baqinisekiswa akayi kuba nako ukuphendula lo mbuzo. Ukuze ufumane oko, kuya kufuneka ukuba babuyele iingcali ezinamava okanye imiyalelo apha.

Ngokutsho yokugqibela, lo bioavailability yathi iziyobisi ayikho ngokomlinganiselo idosi eyamkelweyo. Xa isixa beziyobisi lifinyele.

Emva kokufumana le medicament ibe ingqondo yakhe eliphezulu plasma waphawula emva 3 h. Le bioavailability ngokupheleleyo beziyobisi njengezingxobo nama-60%. Ukutya, kubandakanywa etyebe kakhulu, alunasiphumo kwi the kinetics beziyobisi.

Ukurhoxiswa "Gabapentin 'igazi yomguli ikhutshwa phandle umfuziselo yomgama. nesiqingatha sexesha-ubomi ezimeleyo ithamo kwaye nama-5-7 iiyure.

Iimpawu kwikinetiki beziyobisi ayitshintshi xa lisetyenziswa ngokuphindelela ngisho. Uyondelelwano lwee- kweziyobisi egazini linakho ukuqikelelwa ngokusekelwe kwiziphumo umthamo yayo enye.

Le medicament "Gabapentin" kakhulu akazibopheleli kwiiproteni plasma (ngaphantsi kwe-3%). Oku kubonakaliswa luhlobo ingaguqukanga yi nezintso.

Ukugaya iyeza ayengaseleki. Ngaphezu koko, akukho nto ukuhenda enzayim oxidative hepatic, aqukiweyo nethe nezinye iziyobisi.

Ukususwa yomenzeli egazini izinciphiso abantu abadala kunye izigulane umsebenzi kidney kakuhle.

Ukulungiselela "gabapentin" liyasuswa umzimba olugqitha esikhumbeni.

Ubungqina obubonakalayo buxela ukuba bafumane amayeza

Ziziphi izifo thina sicinga nto iziyobisi esiphumelelayo? Yintoni abantu bathi ngale impendulo?

"Gabapentin" eziboniswa elungileyo ngokwalo ku:

• ubuhlungu neuropathic kwizigulane abadala (iminyaka eli-18 nangaphezulu);
• monotherapy okanye isiyobisi igcwalisa kunyango ukuxhuzula buso, ekhatshwa gabalala zamabanga abadala kunye abafikisayo ukususela kwiminyaka eli-12 ubudala.

Izimo ekufumaneni amayeza

Yintoni na ichiza Izimo uye "Gabapentin"? Izimvo isicelo ingxelo ukuba ibe nefuthe elibi emzimbeni, ukuba iyeza sele amkelwe:

• hypersensitivity kuyo nayiphi na into;
• ukuxhuzula ubuso abangaphantsi kweminyaka engama-12.

inkathalelo eyodwa yindlela esimiselweyo ukusilela kwezintso.

Kufuneke njani amayeza "Gabapentin"?

Uphengululo (neuralgia eli yeza kunceda elungileyo kakhulu) karhulumente ukuba ichiza kufuneka kuphela ligqwetha ngugqirha onamava, emva kokuba uxilongo echanekileyo.

njengezingxobo Gelatin esithathwe ngomlomo ngokuthi yokuginya liphela, ngendlela yabo. Ichiza ziphele kungakhathaliseki isidlo, ahlambe phantsi ulwelo luninzi. Ukuba ufuna ukunciphisa umthamo iyeza ukucima okanye ukutshintsha analogu layo, ngoko oku kufuneka kwenziwe ngokuthe ngcembe ngeveki.

Unyango ubuhlungu neuropathic kubantu abadala

Njengoko kulo izenzo zikarhulumente amayeza ingqalelo? Yintoni abantu bathi malunga ncomo zonyango? "Gabapentin" esizibonakalisa ngempumelelo kakhulu ngokwayo intlungu neuropathic. Ekunyangeni imeko okokuqala idosi ngemihla kufuneka 900 mg. imali uthe yahlulwe ibe ziinxalenye ezintathu. Ukuba kuyimfuneko, ithamo ebegqwese izazekile iphezulu (ngamanye amazwi, ukuya ku 3600 mg ngosuku).

zesifo akakhethi

Kufuneke njani amayeza "gabapentin" kule sifo? Ukuphonononga baxele ukuba kwiminyaka elivisayo 12 isixhobo linokukwenziwa nje kuphela abantu abadala, kodwa.

Ithamo olusebenzayo uxhuzula inxenye ingqalelo 900-2400 mg ngosuku. Unyango lwesi sifo nga uqale 300 mg beziyobisi kathathu ngemini. Kamva idosi yemihla ngemihla kufuneka kwandiswe ukuze 900 mg, kwaye ngaphezulu ukuya ku-2400 mg ngosuku (yahlulwe amathamo kathathu ngokulinganayo).

Ixesha lokuphumla phakathi lidle amachiza yokwamkela yayo triple kufuneka ibe iiyure ngaphezulu kwama-12 (ukuthintela kut- sokuwa).

imiphumela emibi

Ziziphi reactions elibi kungenzeka izigulane zifumana anticonvulsant? Yintoni abantu bathi ngale ncomo kubathengi? "Gabapentin" kwi unyango intlungu neuropathic kungabangela:

• asthenia, ukwenzakala ngengozi, intlungu eyendawo ezahlukeneyo, iqolo, usuleleko, umkhuhlane syndrome, intloko ebuhlungu, ukutyeba, nokudumba neuropathy;
• iqinelwa ukuphazamiseka, Ataxia, kunesifo, hypoesthesia, ukudideka, isiyezi, ukucinga kakuhle, ukozela, lafa;
• kwesisu, flatulence, urhudo, ukugabha, umlomo owomileyo, ukuqunjelwa, isicaphucaphu, iintlungu esiswini;
• ufunga kwesikhumba;
• ukuphelelwa umoya, umqala obuhlungu;
• amblyopia.

Xa unyango ukuxhuzula buso, ichiza negalelo ekuveleni:

• iqolo, ukudinwa, ifiva, intloko ebuhlungu, usuleleko wentsholongwane egazini, nokudumba peripheral, ukutyeba, ukudinwa, umkhuhlane, nokudumba yobuso;
• kwesisu, isifo wamazinyo, urhudo, ukungacoleki kokutya, kwanda, umlomo owomileyo okanye emqaleni, isicaphucaphu okanye ukugabha, iintlungu esiswini, ukuqumba, ukudla, gingivitis;
• uphawu vasodilation okanye wegazi;
• leukopenia, purpura;
• iintanda, myalgia kunye arthralgia;
• kunesifo, Ataxia, ukudideka, incoordination, ukudakumba, dysarthria, lability ngokweemvakalelo, sokulibala, uvalo, nystagmus, ukozela, ukucinga okungaqhelekanga, lafa, twitching kwezihlunu, isiyezi, hyperkinesia; inzuzo, kuncipha okanye ukungabikho ikhaliphe, ixhala, paresthesia, ubutshaba;
• abrasions, amaqhakuva, isikhumba ukurhawuzelela, irhashalala;
• ukukhohlela, pharyngitis, nokuthimliswa, inyumoniya;
• amblyopia, diplopia, ukungaboni;
• izifo womchamo, induku.

amacala libanda

Zeziphi iimpawu libanda kunokubangela uthe medicament? Kuthekani oku bathi nokubuyekezwa? "Gabapentin" libanda, ebangela kabini umbono, isiyezi, ukozela, intetho kakuhle, silale kunye norhudo.

Ukuze ukususa ithi unyango kwangumqondiso, kwakunye ixhoba wahlamba nesisu kwaye umnike wamalahle yasebenza.

Izigulane insufficiency kakhulu kwezintso, ihaemodialysis iyaboniswa.

Drug "Gabapentin" kunye notywala

iingcali Ukuphonononga ingxelo ukuba ukusebenza iziyobisi ingqalelo liphezulu kakhulu. Kodwa ke kuphela xa kuthe ixesha isicelo sayo isigulana ishiyelwa ngokupheleleyo ukusetyenziswa iziselo ezinxilisayo.

Ukuba ichiza kudityaniswe utywala, isiguli sibe sibi kakhulu basabela egwenxa evela kwinkqubo luvo (badengeka, Ataxia, njalo njalo).

imithi

Drug "gabapentin" kwi neuroscience, ukubuyekeza apho ezingaphezu kwe-HIV, zinokudityaniswa kungekhona onke amayeza.

Ngokutsho imiyalelo, asidi ukunciphisa bioavailability beziyobisi.

iziyobisi Myelotoxicity ukwandisa njengezingxobo haematotoxicity "Gabapentin".

Xa kudityaniswe icaffeine pharmacokinetics walo ayikatshintshi. Noko ke, xa indibaniselwano onjalo kufuneka esweni ngenyameko indlela mhlawumbi egwenxa-luvo.

medicament kujongwa angathatyathwa ngaxeshanye kunye namachiza antiepileptic (umz, "pentobarbital", "Carbamazepine", "Phenytoin" kunye valproic acid) kunye zokucwangcisa ngomlomo. Kulo mzekelo, ayithethi utshintshe kinetics.

izincomo ezithile

Ngaphandle kwento yokuba syndrome yokurhoxa lubandakanywe nezenzo uxhuzula kwi unyango "gabapentin" akazange iphawulwe yi kumiwe esikhawulezileyo zonyango kunye namachiza antiepileptic kubantu abane uxhuzula anga kodwa ukubacaphukisa yombono olomeleleyo.

iyeza kujongwa ayikho indlela ephumelelayo ukuyiphelisa ukungabikho sokuwa.

Abantu abafuna unyango ezintsonkothileyo ne morphine, kusenokufuneka ukuba idosi eyandileyo "gabapentin". Kulo mzekelo, ukuqinisekisa esweni rhoqo sesigulane kuphuhliso ukozela. Xa amayeza ayo ukuchonga ithamo kufuneka incitshiswe ngokwaneleyo.

Xa zidibene "gabapentin" kunye namanye amachiza anticonvulsant ziye ingxelo iziphumo okungamanga ekumisweni iiprothini umchamo usebenzisa iziqwengana uvavanyo ucimeke N-Multistix SG. Kule nkalo, kuba izifundo ezinjalo bacebisa ukusetyenziswa indlela kwezulu ezithile sulfosalicylic acid.

iingcali Izimvo kunye nabathengi

reviews Inkoliso oogqirha kunye nezigulane malunga ukulungiselela "Gabapentin" esihle. Ezi ngxelo zibonisa ukuba ichiza ngempumelelo ukumelana nomsebenzi. Noko ke, xa kudityaniswe utywala bavame iintshukumo eziqatha egwenxa kwi luvo.

Akunakwenzeka ukuba uqaphele into yokuba ukurhoxiswa ngokukhawuleza beziyobisi kungabangela ezingqondweni izigulane buthelezi, silale kunye ungatyhilekanga.

Abantu ezininzi ziye zaphawula ukuba ukuthathwa oku kuthetha ukuba kufuneka yaphambana kunye neengcinga zokuzibulala. Kwakhona, iyeza kubangela uphuhliso pancreatitis ahlekise.

Iingcali Siyaleza unyango ngamachiza "Gabapentin" kuphela phantsi kweliso likagqirha oya kuba nako ngokukhawuleza ukulungisa irejimeni nezinyangayo njengoko kuyimfuneko.