Avidity - kuthetha ntoni? Avidity IgG antibodies Cytomegalovirus: iimpawu kunye decrypting

Ngoku ngaphezulu kunakuqala, kubalulekile ukubhaqwa kunye nokukhuselwa kwezifo ezosulelayo. Oku kufuna ezikumgangatho ophezulu kunye neendlela okukhawulezayo. Ngokwemveli iklinikhi usebenzisa iindlela serological yokuqingqa ubuzaza kwenkqubo kunye nento bafudukela izifo wentsholongwane egazini, bacteria fungal. Kodwa ezi mvavanyo ukuba sensitive ngokwaneleyo ukwahlula phakathi kosulelo lokuqala, kwakhona kunye likakade. Ngoko ke, oosonzululwazi mihla ecetywayo indlela yokuqingqa avidity ka IgG-antibodies.

Avidity: kuthetha ntoni?

Ukwahlula iingqiqo ngokokuzalana kunye avidity. NoFaro - isici thermodynamic nangokobungakanani echaza amandla impefumlelwano le lomzimba kunye iantigens zazo. Ngenxa yoko, le avidity imisela amandla ubuhlobo phakathi iantigens lomzimba. La magama ezinxulumene ngqo omnye komnye. Imvuthuluka ngaphezulu iantigens rhoqo, ngokuqina udibaniso. Ukwahlula avidity ephantsi phezulu.

Leyo ethetha avidity ophezulu? Makhe uphando. Xa awakwazi ngenisa emzimbeni okokuqala, zisenza iiseli B ezibangela immunoglobulins. Okokuqala nje IgM, kodwa ke athathelwa indawo IgG. Emva umfowunelwa wokuqala oludla, kwaye kungoko avidity, phantsi, njengokuba kuphela neendlela umzimba wayezithethelela ukuqhelana lwegciwane entsha. Emva kweeveki ezisixhenxe, IgG «oqolileyo», ngaba kakhulu ezithile, ngoko, le avidity eliphezulu. Kwaye ngoku, kwimeko kwakhona losuleleko-, amajoni omzimba ziya kuba zikulungele ukusabela ngokukhawuleza izisongelo.

index avidity

Inqanaba avidity bomzimba ixhomekeke idosi iantigens kunye nohlobo kunye nenqanaba yemfuza kwiiseli zabantu. I ezincinane ithamo okokuqala, kungona oludla, kunye vice versa.

Emva koko pathophysiology kunye zizifo senze le ngxaki yokusetyenziswa wokuhla omzimba kunye nobudala. Sasicinga yaye kwakuthe ratio esithile, ekuthiwa index avidity. Kuthetha ukuthini index avidity? Lo mfanekiso ubonisa umsebenzi wayesisalamane immunoglobulin ukubophelela iantigens. Isalathisi kwi kuluhlu phakathi kwe-15 ne-50 ekhulwini ezibonisa usulelo ephambili, ukuba ixabiso kune-50 pesenti, isigulane ke ngoko sele ubunzima sesi sifo.

rubella

Le ntsholongwane rubella kunefuthe elibi kakhulu ekukhuleni kosana olungekazalwa, ngoko ke kubalulekile ukuqinisekisa ukuba ngaba umama okhulelweyo wayegula sifo, okanye ngaphambi ukukhulelwa kufuneka agonywe. Ngokuba ukusetyenziswa diagnostic kuvavanyo lenzululwazi yegazi omzimba sendiselane ukuya awakwazi. Ukuba immunoglobulins phantse ngokupheleleyo ngenxa amasuntswana wentsholongwane egazini, ngoko izilwa avidity eliphezulu. Oku kubonisa nokuba kukho usuleleko yangaphambili, kunye nezifo elungileyo emva kogonyo.

Maxa wambi, ngenxa nokukhuthaza clones lymphocyte zentsholongwane rubella ibanjiwe indlela lobuxoki esebenzise immunoglobulin M. Ukongeza, japan enjalo kunokubonwa kwezo izigulane kwaphakanyiswa apho igazi factor samathambo. Kuphela kukho phambi omzimba abe avidity eliphantsi. Kuthetha ukuthini? Oku kungathathwa nje ubungqina usuleleko zaseprayimari virus rubella. Xa nokubeleka kubonisa ngqo ukuba isisu.

toxoplasmosis

Ngokuqhelekileyo, le usuleleko yi ezifihlakeleyo, ngokubonakala iimpawu zonyango kunye kwezimilo lufundiwe (umzekelo, ezifana ezalathelwe nkovu mbile) unalo ixabiso diagnostic ephantsi, xa ufuna ukufumana phandle umntu egula ixesha elide kangakanani. Ukumiselwa omzimba avidity IgG yi kakhulu ethile indlela ethe ngenxa lokufunyaniswa toxoplasmosis zaseprayimari ludlule, nto leyo ibaluleke kakhulu xa ehlola abasetyhini abakhulelweyo ekupheliseni ingozi enokubakho toxoplasmosis naso ebantwaneni.

Kude kube kamva nje, lo kulingwa ekhoyo serologic kuphela ukufumanisa ubuzaza inkqubo ukubona udidi immunoglobulin M kwandisa titer of IgG. Ukuba ingaphelanga iveki imali immunoglobulin G banda izihlandlo ezine okanye ngaphezulu, oko bubungqina engangqalanga phambili kwesifo.

Nakuba iimvavanyo ze-serological ugqirha kunzima ukumisela ngqo xa umntu osulelwe, njengoko immunoglobulin M kunye G ungase uqhubeke ixesha elide egazini. Ngoko ke, le ndlela kuphela kukuqinisekisa avidity. Kuthetha ukuthini? Oludla ophantsi yaye ngaloo ndlela avidity Toxoplasma i ngaphambili eyangena emzimbeni. Ngaphezu koko, kutshanje wavula indlela wokwahlula oludla kunye ngobuhlobo eliphezulu antibodies ephantsi lula ukubala kunye nokumisela uhlobo losulelo.

Herpes virus simplex

Abantu abaninzi ehlabathini usulelwe yintsholongwane herpes simplex. isifo othile kwenzeka ngendlela afihlakeleyo, kodwa iimpawu ezininzi kuyagcinwa, nokuba ezincinane. Ukongeza, kukho ezinye ubunzima kunye ukujonga indlela avidity of herpes. Oko kuthetha ngokubonakalayo? Le ntsholongwane luphawulwa omzimba Nedlac, kusenokuba emzimbeni ubomi, enika iziphumo lobuxoki-HIV kwaye lobuxoki-negative. negatives False sizimisele xa immunoglobulins hayi akhiwa okanye xa serum ngezixa umkhondo. iziphumo False-HIV kwenzeka ngenxa yokuba ixesha elide ajikelezayo izilwa-kungakhathaliseki ukuba unosulelo.

Ukongeza, iye nezakhi cross-izidubuli zaqina indlela awakwazi histocompatibility izicwili omzimba eqhelekileyo, kunye nezinye iintlobo zentsholongwane herpes. Enye basabele okungamanga zigqitywa usuleleko zamabanga-human immunodeficiency virus.

usuleleko cytomegalovirus

Le ntsholongwane ngumtyholwa oluqhelekilyo isisu ekukhulelweni ekuqaleni. Ingozi yosulelo kuxhomekeke kwizinga antibodies kwi unina ngexesha ukukhulelwa. Ukuba inqanaba lesi sifo okokuqala yenzeka ezintathu yokuqala, amathuba osulelo yi-50 ekhulwini.

Kuthetha ukuthini avidity for CMV? Njengoko kuzo zonke ezinye iimeko, ukuqingqwa oludla ka IgG kunye IgM indlela omhle ukuqinisekisa ngokuchanekileyo okanye ukuphika ubukho usulelo primary CMV. Ukongeza, it ikuvumela ukuba uphephe iinkqubo buhlungu kwaye iyabiza ukuba umama okhulelwe.

Hepatitis C virus

Uxilongo sohlobo isekelwe ekugqibeni abamakishi ezithile ezibonisa uphuhliso inkqubo losuleleko. Kulo mzekelo, IgM unako kwenzeka kamva kunalowo IgG, okanye ngaxeshanye kunye nabo. Kunzima ukumisela ekuqaleni kwesi sifo kunye nexesha yosulelo ephambili.

Uhlalutyo serological uthembekile kuphela serokoversiya kunye avidity IgG on. Kuthetha ukuthini? Ukuba isalathisi avidity iphantsi, oku isiqinisekiso ngqo zokosuleleka zaseprayimari. Kwimeko yovandlakanyo avidity eliphezulu izilwa iklasi IgG ngengqiniseko kohlobo okanye bafudukele.