Antibodies TPO kunye nefuthe lazo kwinkqubo hormone

Omzimba ukuba tereoperoksidaze ube nefuthe kwinkqubo yabantu hormone kuchaphazela impilo yakhe kunye nokusebenza obuqhelekileyo. Iseti umgangatho wezifundo igazi hormone ukutshekisha nokusebenza lengqula kubandakanya nokumisela kwinqanaba TSH, T3, T4, CT3, FT4 kunye AT ku TPO. Ngaphambili, alwa TPO kuncwadi zonyango ekuthiwa imizimba antimikrosomalnymi.

Ngexesha lokusebenza okuqhelekileyo antibodies ndlala le TPO igazi abekho okanye ngoku ngeedosi ezincinane kakhulu. Inani labo landa ngendlela emangalisayo izifo sokuhlasela. Amazinga aphezulu zarekhodwa kwi thyroiditis Hashimoto kaThixo. Esi sifo ngokuqhelekileyo kwenzeka kwabasetyhini abadala. Chances litshitshiswe amalungu thyroiditis Hashimoto ngayo intsapho, ngokungathi sifo akukho ukuthambekela ilifa usasazwa ugqithiselwa kwinqanaba yemfuza. Abantu ukuguquka chromosomal kuba nengozi ephezulu yokufumana esi sifo.

Antibodies TPO nazo zifumaneka izigulane ukubandezeleka ngenxa yezifo Graves '. In kwentamo goiter hyperfunctioning lengqula nobubovu ukunyuka ngobukhulu, isigulana ikhalazela of tachycardia, arrhythmia, lafa kwamalungu omzimba, iingxaki kunye iinkophe namehlo. A excess encinane amaxabiso avumelekile antibodies TPO egazini kunokubonisa hypothyroidism. Xa hypothyroidism ehla nethe, kwandisa amathuba ukutyeba, ngokunjalo nomthamo umsebenzi, umntu usoloko uziva ukudinwa, silale, iingxaki nawenkumbulo. Ukuba antibodies TPO zifumaneka kumzimba umfazi omithiyo kungenzeka ukuphuhlisa hyperthyroidism emva kokuzalwa komntwana wakhe. Ukuphuhlisa esizalweni, usana kusenokwenzeka ukuba adluliswe ukuthambekela ukuphazamiseka hormone.

Ukujonga nobubovu lengqula, ngokwaneleyo ukuze uphumelele uvavanyo. Antibodies TPO uphando serum igazi, igazi emthanjeni kuyimfuneko Kwathi kusasa ungatyanga. Phambi zokuqokelela izinto eziphilayo isifundo, kungakuhle ukuba kwimo yokuphumla; karhulumente yimincili inokuyichaphazela secretion hormone. Ngenye imini phambi kokuba unikezelo zohlalutyo ukwahlula amandla enzima emzimbeni, utywala, kunye midiza.

Ziziphi ezi ndlela zokuphila esebenzayo, nto leyo ukubonisa uhlalutyo kwi antibodies TPO? Ummiselo omzimba isusela ukusuka kwi-0 ukuya kwi-30 iiyunithi ngamazwe milliliter nganye. Kodwa ukuba iziphumo izifundo ezibhalwe iziphumo kancinane ngentla eqhelekileyo, musa ukothuka. Ngenxa secretion nokunyuka thyroxine kunye triiodothyronine omzimba TPO ukukhusela ngokuchasene uphuhliso hyperthyroidism kunye thyrotoxicosis. Nangona kunjalo, i asezantsi amanqaku, kuyanqaba ukufumana isifo samathambo ebudaleni. Emva kweminyaka engama-30, inani antibodies lengqula peroxidase kwi serum iba ephakamileyo kancinci.

Antibodies TPO baqale kwenziwa xa inqanaba hormone lengqula-zivuse egazini uba ngaphezulu. Omzimba ngaphezulu eziqulathwe emzimbeni, ukuba kube nzima ukunyanga esi secretion ka T3 kunye T4, nethe kancinci. Kwakhona, isizathu ukuvela omzimba zingasebenza ukwandisa cytokine anti-ukudumba. Kulo mzekelo, kukho xi eyandileyo antibodies thyroglobulin.

Iziphumo zohlalutyo kwi hormone zilungiselelwa ukusuka kwiintsuku enye ukuya kwezintathu. Iindleko uhlahlelo yahluka ukusuka engange-100 ukuya kuma-400 kuxhomekeka kummandla. Izalathi si zokunikwa antibodies TPO ayikwazi azivavanywa ngaphandle data malunga uphuhliso hormone lengqula-ekuvuseleleni, inqanaba triiodothyronine kunye thyroxine, malunga igazi lwee- hormone a khulula, uhlobo non-protini. Kuphela uhlalutyo olubanzi Izifundo hormone endocrinologist kuya kunceda ufumane unyango elifanelekileyo kwimeko nganye.