Inhibitors Impompo Proton: uluhlu iziyobisi, indlela yokusebenza, reviews

Ukususela ukuqunjelwa, heartburn kunye gastritis ubunzima ngaphezu kwama-90% abantu, kodwa bambalwa abantu bazi ukuba amachiza eyenzelwe ukunciphisa le meko, yaye kukho kudala ngokubanzi ezisetyenziswa yezonyango kwiimeko apho asidi musa ukunceda. Makhe sihlolisise oko inhibitor pump Proton, uluhlu imveliso uya ingqalelo.

Apho emzimbeni womntu bavela kwimpompo?

impompo Proton, okwabizwa ngokuba kwimpompo Proton - le protini enzyme ikhuthaza imveliso ye zehydrochloric acid esiswini. Eli linyathelo kuyimfuneko yaye kubalulekile ukuba inkqubo ukwetyisa. Nangona kunjalo, oku kudla ngokwenzeka ukuba esiti uqalisa ziveliswe ngobuninzi ezinkulu, obuquka imvakalelo krakra okanye kube buhlungu apha esiswini.

Ubungqina obubonakalayo buxela

A impompo Proton inhibitor (uluhlu neziyobisi ziza aboniswe ngezantsi) lusetyenziswa kakhulu rhoqo.

Inhibitors, blocker okanye impompo Proton - iziyobisi nge apho unyango lwezifo ye phecana zesisu kubenza iasidi:

- gastritis, kubandakanywa ilunga;

- nezilonda esiswini kunye duodenum;

- duodenitis - duodenal isifo komtshiso oko;

- GERD - isifo reflux, apho imixholo esiswini juba phezulu rhoqo emphinjeni, nto leyo esisizathu sokuba ngokuhamba kwexesha iparafini isifo le kuvuleke iminxunya, uqhoqhoqho kunye pharynx;

- ukuqunjelwa - inkqubo esiswini apho kukho imvakalelo ukuhlatywa / ukusika intlungu epigastric (indawo plexus solar) emva kokungenisa;

- ifuthe non-steroidal amachiza-ukudumba (ezifana "Diclofenac") ukubacaphukisa iphecana gastro-emathunjini;

- Zollinger-Ellison Syndrome - gastrinoma - ithumba, ibangela secretion olongeziweyo zehydrochloric acid.

Kuzo zonke ezi meko iboniswa abafumana pump Proton inhibitors.

indlela isenzo

Macwecwe okanye njengezingxobo IPP yaginywa ngomlomo, inganyityilikiswa emathunjini amancinci babathwalela igazi nge kwesibindi kungena canaliculi secretory, apho aqale yande. Ngenxa ifuthe ngqo kwi tubules, ekuthi kwezo nto kuphume zehydrochloric acid secretion inhibitors ukunciphisa ngokukwanjalo yayo kusehla ndlongondlongo yejusi esiswini.

A impompo Proton inhibitor (uluhlu isiyobisi iyafumaneka na ekhemesti) unikwe ugqirha.

Indlela zonke iziyobisi kule hlobo iyafana, kodwa asitshintshe xi wenkqu asebenzayo apho ugcina i-pH kunye isantya nempembelelo. Ukuze ukhethe ugqirha wabo kuphela emva imilinganiselo asidi, oko kwenziwa emini. Ukongeza ichiza esifanelekileyo sele uwunikiwe, yaye kubekwe esweni komsebenzi wayo. Ukuba isiqabu akayi kuza, kodwa oku kunokwenzeka kwimeko yokunganyangeki ngamachiza hlobo, kuyimfuneko kufuna indawo.

Ngokwemigaqo ye-pH zilawulwa ngurhulumente we-asidi iphecana zesisu. iiyunithi Iyonke 14, amanzi cala, uphakathi lentsalela acid-isiseko kwaye pH 7. Xa icala esezantsi amanzi bume asidi kwi eliphezulu - obrak.

Kwiintlobo ezahlukeneyo izifo ezinxulumene ne ukwandisa imveliso ye zehydrochloric acid, luphawulwa imigangatho eyahlukeneyo ixabiso pH. Umzekelo, isilonda duodenal kukuqulungana esikwaziyo kwi pH ngaphezu 3 emini, umbulale igciwane Helicobacter pylori, kuyimfuneko wavuma acid medium sikuyo pH mkhulu ku-5.

Ngokutsho pH yesiqhelo kunye uxilongo, ugqirha ubeka ichiza ethile evela kwiqela blocker pump Proton kwi esithathwa ethile kangangexesha elithile.

ubude bexesha

Ikhosi ye unyango ungatsala iinyanga eziliqela okanye iminyaka. ichaza umzekelo, iyeza, "Rabeprazole" isikhokelo kunye nobude ulwamkelo. Impompo Proton inhibitors ezikhuselekileyo umzimba, ngokuba zisebenza ekuhlaleni kwaye ayikhobokisi, kuyenzeka ukuba Musani ukumoyika ebizwa ngokuba "Nhoza syndrome" emva kwekhosi. Olu hlobo iziyobisi musa ziliminxe sifo, laphola ngokupheleleyo.

Ngoku ke kucacile ukuba loo inhibitor pump Proton. Uluhlu iziyobisi kumba kakhulu.

Group pump Proton blocker

"Omeprazole" sisiyobisi esaziwa kakuhle. Kuba sale:

- "Acre Omeprazole."

- "Omeprazole-iRichter" - uguqulelo zinamandla.

- "Sandoz Omeprazole". isixhobo Ludityanisiwe esetyenziswa ukuba ukunyenyisa ukuveliswa zehydrochloric acid, kwaye iphecana zesisu.

Kudala kwaziwa ukuba "Omeprazole" - nempompo Proton inhibitor, kodwa namhlanje, usuke waba ukuba abele ngaphantsi, ngenxa yokuba kukho isizukulwana esitsha lwamachiza ahlukile ngcono zombini ukusebenza kunye neziphumo ebezingalindelekanga.

Kuvumelekile ukuba ethule nje ngomlomo kuphela kodwa butofelwe, okwenza ukuba isiphumo ngokukhawuleza. Ukwenzeka sifo kwaqwalaselwa kwiminyaka engama-10 alandele-up kwizigulane.

"Pantoprazole"

Impahla nganye ikhona kuyo ichiza "Pantoprazole" umyalelo manual. Price of ichiza yi-avareji engange 130.

"Pantoprazole" ngenyameko enkulu, kodwa ezimiselweyo trimesters-2 no-3 zokukhulelwa ngaphandle kokuba uncedo olunokubakho Kucingelwa zibaluleke ukogqitha umngcipheko umntwana. Iimvavanyo abasetyhini abakhulelweyo khange lwenziwe, kodwa yeziphumo izilwanyana elibi ekukhuleni kosana olungekazalwa ziye ingxelo.

Ngaphambi kokuba nokusebenzisa i "omeprazole" yaye "Pantoprazole" kufuneka ufundisise uluhlu olubanzi imithi-neziyobisi udibane nogqirha xa ulwamkelo naliphi na iyeza kwi uluhlu kucwangciswe ngentsebenziswano kunye namanye amayeza. Togu - "Nolpaza".

Kutheni ukumisela eli chiza? Oku kwakhona inhibitor pump Proton. Ifike iintlobo ezimbini - iipilisi nengqayi ukuze ngenaliti. Kodwa ke eneneni ampoules - a lyophilisate apho isisombululo uzilungiselele for ngenaliti. Amaninzi ezimiselweyo isifo isilonda Peptic, kodwa iye isetyenziswe ngempumelelo kwezinye izifo phecana zesisu.

Ngenxa ichiza, incindi esiswini iveliswa kangangoko encinane, yangaphakathi kangaka ayikho axakane. Ukuba kukho izilonda kunye erosions, baza ngokuthe ngcembe zarubtsovyvayutsya. Nale umsebenzi oncomekayo "Nolpaza". Kutheni amisele ichiza, kwacaca. Analogs - "Lanzap", "Lansofed", "Loenzar-sanovel", "Epicure", "Akrilanz" njl Boundedly lisetyenziswa unyango abafazi abakhulelweyo kunye nabantwana, wokusebenzisa kunganqwenelekiyo ukuba ezinye iziyobisi ungakhetha ..

"Rabeprazole" - kwelinye ichiza evela kwiqela blocker pump Proton.

Xa iziyobisi "Rabeprazole" umyalelo ibonisa ukuba asihambisani asidi ulwelo. amanyathelo Olomeleziweyo ngaxeshanye bethabathe "warfarin", "diazepam" "theophylline" yaye "Phenytoin". Analogs - "ithatha", "Zolispan", "Noflyuks" "Pariet", "Rabelok", "Hayrabezol" et al.

"Lansoprazole" - ichiza olusebenzayo izifo iphecana zesisu. Ikhupha uvimba imveliso incindi esiswini. Oku kuqinisekisa ukuba ichiza "Lansoprazole" umyalelo. Ukongeza, ichiza uyasokola igciwane Helicobacter pylori. omzimba athile kuyo ziphuhliswa ngokuzimisela ngenxa yesenzo ichiza. Ubuninzi kuphathwe kwiintsuku zokuqala ezimbalwa amalungiselelo kunye ekuqaleni ulwamkelo. Analogs -. "Emanera", "Nexium", "Losek", "Sanpraz", njl Amanye amayeza ezithathiweyo ngaxeshanye "Lansoprazole" kungandisa eyavela plasma kunye nokukhuthaza ifuthe. Oku "Imipramine", "clomipramine" "Citalopram". "Diazepam" yaye "Phenytoin" ukwandisa isiqulatho kancinane, yaye "ketoconazole", "Itraconazole" yaye "clarithromycin" kungacutha ukusebenza amayeza. Lichaza 'Lansoprazole "umyalelo manual.

"Esomeprazole" - ichiza elungileyo izilonda esiswini kunye nezilonda duodenal. Ingasetyenziswa ngokusebenzisana antibiotics. Iziphatha zifo kwisigaba exacerbation kwaye kusetyenziswa ukukhusela. Abangaphangeliyo zixhaphakile Helicobacter pylori. Ukulungiselela "esomeprazole" (njengezingxobo nesisombululo ukuba isitofu) asetyenziselwa ngenyanga kwi umthamo we-40 mg ngosuku. Kuba ekuthintelweni pamo na sehle.

amanyathelo okhuseleko

Le blocker unyango, iimpawu umhlaza pump Proton basenokuba lubonakale nje, ngoko phambi kokuba uqale unyango kufuneka umana ukuthintela ukuvela yamathumba. Ukongeza, uphando ongxamisekileyo efunekayo kunye ukugabha rhoqo, ngakumbi isitulo igazi sifo, ukutshintsha umbala walo kunye nevumba, kwakunye umzimba elibukhali. Ngoko, isilumkiso kufuneka yamkelwe "rabeprazole sodium."

Eli qela iziyobisi, ngokutsho kwizifundo lwakutshanje, kwandisa ubu amathambo, ngokulandelelana, kunye nengozi yokuba ngokwaphulwa, kwakunye Ngokuqunjiswa urhudo ezinxulumene (oko kukuthi, zibangelwa ukuthathwa amayeza athile), hypomagnesemia, kwaye ukutyhileka komqondo abadala.

Ngenxa yesi sizathu, ugqirha kufuneka kuqala kubabela oyidlayo iphantsi kunokwenzeka okanye mhlawumbi ikhosi emfutshane ukwamkela ubukele isiphumo.

Ukusetyenziswa olwa

inhibitors impompo Proton (iziyobisi besizukulwana esitsha) zisetyenziswa ukunyanga izifo ezibangelwa igciwane Helicobacter pylori, unako leyo zombini negalelo kwiingxaki iphecana emathunjini, kwaye ukuba bamqumbise likakade ziye ezibonakala unyangiwe izifo. Kulo mzekelo, imithi ezidityaniswe unyango, ikakhulu tetracycline.

Oku iqela antibiotics sinxilisayo, ngoko kunjalo akunakwenzeka ukuba abamisele yena yedwa.

imiphumela emibi

Njengayo nayiphi na amayeza, kufuneka blocker, impompo Proton kukho iqela yeziphumo ebezingalindelekanga okunokwenzeka:

• ukwandisa ukozela - ngoko olu hlobo iziyobisi abavumelekanga sisamkela abantu abankonzo kufuna ingqalelo kunye nesantya yokusabela, ezifana abaqhubi;

• intloko, ukuya kufikelela uqaqanjelwa - mali protivomigrenoznye azivumelekanga ukufumana ngaxeshanye PPI, kodwa ngokubhungisana kagqirha enqwenelekayo;

• isiyezi okanye ubuthathaka;

• intlungu imilenze, emqolo, amalungu;

• ukuqunjelwa - isifo sorhudo okanye ukuqhina, isicaphucaphu;

• utshintsho ecocekile;

• umlomo owomileyo;

• ziyabagulisa - urticaria, ukurhawuzelela;

• kuyehla ukuyilwa iiseli - iiseli ezimhlophe zegazi;

• ukubila banda, kuthibaza.

Kule meko wenza ngokuyimfuneko kwaziwa ukuba igqirha kokuya, owathi, ngokuqhelekileyo unikela kwelinye ichiza efanelekileyo IPP.

Kufuneka kukhunjulwe ukuba iziphumo ebezingalindelekanga ezinqabileyo kwaye zikholisa bungako ngokwaneleyo kuzo zonke, ke ngoko, phantsi kweliso likagqirha yesicelo ngakumbi idla kakhulu kunokwenzeka.

Ukuba inhibitors impompo esetyenziselwa Proton (isizukulwana esitsha lwamachiza), iziphumo ebezingalindelekanga ezinqabileyo.

Izimo

Izimo Jikelele yonke impompo Proton inhibitor:

- ithuba lokwaphusa nokukhulelwa, ingakumbi 1 ezintathu, ukusetyenziswa kwezinye iziyobisi kweli iqela trimesters-2 no-3 optionally nge imvume gqirha. La machiza bioavailable kakhulu, ukuba uyakwazi ukungena kwi ancedisana, kuquka ngumkhaya yaye inokuqokelelana ngobisi lwebele. Nangona kungekho datha kuqinisekiswa ngeengozi zezi mali ukuya kwimveku, akukho ingxelo ngaphandle eksperimenti kunye nezilwanyana.

- Abantwana abangaphantsi kweminyaka engama-12, ukususela umsebenzi kwamadlala ezidalwe iphantsi kophuhliso kunye ukuyilwa, ngoko naliphi na uphazamiseko kungabangela ukungasebenzi.

- zokwalana okanye hypersensitivity ukuya ichiza.

Umzekelo, uchaza ukuba bonke ichiza "Pantoprazole" umyalelo manual.

inani

Amaxabiso blocker iziyobisi pump Proton yohluka kakhulu, kodwa zifumaneka lula. Kwi-avareji, iindleko into engange-90. ukupakisha "Omeprazole" ukuya engange 500. nokupakishwa nezinye iimveliso isizukulwana esitsha.

Ixabiso ixhomekeke kwinani njengezingxobo / amacwecwe kwiphakheji kunye kwilizwe lemvelaphi. Umzekelo, generics Russian zingathengwa ngenxa 20-100 engange, kodwa kufuneka kuqondwe ukuba amachiza afana nalawo -. Asinto kwendlela yokuqala. Bavame kakuhle kangako yaye ngaphantsi ukunyamezelana, kusenokwenzeka ukuba wehlelwa ziziphumo ebezingalindelekanga.

reviews

Amalungiselelo eli qela kubangwa ingxelo entle. Bayaphumelela ngokwenene izifo phecana zesisu. Iindleko kwamkelekile kakhulu.

Kukho, Kakade ke, ezinye iziphumo ebezingalindelekanga, ezifana norhudo. Kodwa kwenzeka kwiimeko ezinqabileyo, kodwa ukuba ukhethe i balawule, kuba baya konke konke.

isiphelo

Impompo Proton inhibitors zisoloko ukuba ngcono. Oku kwakuquka zesayensi ezisuka kumazwe ezahlukeneyo zehlabathi. iziyobisi "Dekslansoprazol" yakhululwa malunga-6 kwiminyaka eyadlulayo. It is engekavunyelwa ukuba ukusetyenziswa ngaphandle kwemiqathango, kodwa isifo reflux gastroesophageal ngoncedo baphathwa kakhulu ngempumelelo.

Okwangoku eJapan phambili "tenatoprazole," ethi ibekwe njengoko blocker isebenzayo pump Proton.

Korean "Ilaprazol" isebenza kakuhle yaye ngokukhawuleza "omeprazole", nangona kunjalo eRashiya, i-US kunye EU ukuba Akuvunyelwe ukuyisebenzisa ngenxa yezizathu ezingaziwayo.

Amalungiselelo eli qela zithathwa rhoqo amaxesha 1-2 ngemini, nto leyo eyenza ukusebenzisa kwabo lula. Kodwa ke kufuneka amisele ugqirha emva anamnesis uvavanyo, ngokuba ichiza ngalinye iimpahla zazo, kwaye ke wonke ubani iimpawu zabo sifo. Siye sahlolisisa ngokweenkcukacha pump Proton inhibitors. Indlela yokusebenza uchazwa.