Ichiza "Topamax": Iimpendulo ezigulane kunye amagqirha

Isebenza ukuba onjalo ichiza, njengoko "Topamax"? Izimvo koogqirha kunye nezigulane ziza kuboniswa ngezantsi. Kwakhona, uya kufunda koko yabelwa eli chiza kufuneka ingasetyenziswa yaye zeziphi iimpawu zonyango Lubonakala.

Ukubunjwa, imilo

Ziziphi fomu athengisa iziyobisi "Topamax"? Baqinisekiswa ingxelo ukuba esi sixhobo zingathengwa ngohlobo njengezingxobo gelatin, emhlophe esiqinileyo.

Eyona nto elikhutheleyo ichiza topiramate. Kwakhona kumafa yayo ibandakanya ezi zinto zilandelayo abangabancedani: umgrayo iswekile, povidone, neselulosi acetate.

Ukuthengisa iziyobisi "Topamax" (reviews oogqirha ngayo ukuba umlinganiswa ingacaci kakhulu) ingena ngeebhotile zeplastiki kunye iipakethe ikhadibhodi ngokulandelelana.

Iimpawu kabi

Yintoni njengezingxobo "Topamax"? Ukuphonononga baxele ukuba eli chiza antiepileptic, nto leyo ichaza ukuba fructose. yokusebenza yayo element nako ukuze kuthintelwe amajelo isodiyam kodwa isantya ukuqhubela kokuphindaphinda nekhono amanyathelo xa depolarization elide iindonga neuron.

Reception ingxelo iindlela kwandisa umsebenzi γ-aminobutyric acid ngokubhekiselele kwiintlobo ezithile Gaba-receptor. Ngaphezu koko, iziyobisi esebenzayo ekwaziyo olubiyele ukusebenza kainate ukuba glutamate receptors, nokulawula umsebenzi Gaba-receptor. iziphumo ezifana imithi yedosi-mthetho olunxulumene neziyobisi kunye waphawula ukuba intsingiselo yalo egazini 1-205 micromolar.

Ziziphi ezinye iimpawu uphawu iziyobisi "Topamax 'na? Ukuphonononga uxele ukuba zithako yayo ephambili uyakwazi zinqanda umsebenzi inani anhydrase గుర్తులు ibhaloni of isomers. Kufuneka kuqatshelwe ukuba ubungqongqo iimpawu amayeza le echiza kakhulu ngaphantsi inhibitors anhydrase గుర్తులు ibhaloni, ie acetazolamide. umsebenzi okunjalo ichiza ayikho enye yezinto ezibalulekileyo wesenzo antiepileptic.

iimpawu entshukumo yokulungiselela

Nokuba iyeza ako "Topamax"? Ukuphonononga bathi emva kokuthatha le into esebenzayo nto ithetha ako ngokukhawuleza kakhulu ukusuka emathunjini. Ngaloo ndlela bioavailability of topiramate ifikelela 81%. Ukutya ukutya ayinasiphumo kwesi salathisi.

Ukubambana kwecandelo isiyobisi esebenzayo kwiiproteni plasma ifikelela 13-16%.

Ukuphumeza lizama xa abantu kumsebenzi kidney yesiqhelo kufuneka malunga 4-8 iintsuku. Inguqu ivavanywa malunga ne-20% ye-mali zedosi ifunyenwe. Oku kwenza metabolites ezintandathu (engasebenziyo).

Topiramate, ngokunjalo zonke avela yayo, isuselwe izintso. Koko isiqingatha-ubomi babo iiyure-22.

Iimpawu ngokufumana njengezingxobo amayeza

Kwezinye iimeko, izigulane emiselweyo iyeza "Topamax"? Izimvo migraine ezincomekayo kuphela. ukulungiselela kujongwa lisetyenziswa hayi kuphela unyango lwe uthe isifo luvo, kodwa ukuvimbela yayo.

Kufuneka kuqatshelwe kanjalo ukuba esi sixhobo kubonakaliswa kakuhle ngokwayo xa ukuxhuzula. Isetyenziswa monotherapy abantwana ukususela kwiminyaka emibini ubudala kunye nabantu abadala. Ukongezelela, "Topamax" lidla kucetyiswa ukuba abantu abanale abasandula sifo.

Njengenxalenye yale unyango entsonkothileyo kweli chiza iboniswe abantwana kwizigulane kwiminyaka emibini ubudala yaye abadala kunye nokuxutha buso okanye i-tonic-clonic ngokubanzi, kwakunye ngenxa yonyango Lennox-Gastaut syndrome.

Izimo ukufumana njengezingxobo amayeza

Kwezinye iimeko, awukwazi ukuthatha njengezingxobo 'Topamax "? Uphengululo (abantwana abangaphantsi kweminyaka emibini kule ichiza contraindicated) lithi wabheka ichiza isetyenziswe kwizigulane hypersensitive amacandelo yayo.

Ngononophelo kakhulu kufuneka kusetyenziswe iyeza kunye isibindi, nefrourolitiaze, ukusilela kwezintso kunye hypercalciuria.

umthamo

Yamkela iziyobisi "Topamax" kufuneka ufakwe ngomlomo. Le njengezingxobo nga kuginywa liphela, yaye kusenokwenzeka ukuba ukuxuba imixholo kunye imali encinane yokutya ethambileyo.

Kuba control of sokuwa unyango ekucetyiswa ukuba akuqali amathamo medicament ukwamkelwa ephantsi, uze emva koko titrated ukuya kakuhle zabo.

Xa wokuqinisa-clonic ukuxhuzula kunye syndrome Lennox-Gastaut ubuncinane idosi olusebenzayo ichiza 200 mg ngamnye ngosuku. Kwezinye iimeko, izigulane abafumana idosi iphezulu yemihla ngemihla kungaboniswa ilingana no-1600 mg.

Xa abantwana kweminyaka emibini idosi ekucetyiswa ngemihla 5-9 mg kg ubunzima bomzimba ngalinye.

Indlela yokuphatha ichiza kufuneka mazithathwe sokuwa? abadala Monotherapy emiselweyo 25 mg kanye ngemini ngeveki enye. Ngaphezu koko, eli nani linyuke 25-50 mg zonke 1-2 iiveki.

Esithathwa Kucetyiswa ukuba monotherapy yexhuzula kubantwana abaselula ziyahluka kuluhlu 100-400 mg ngosuku.

Kuthintelo migraine eli chiza kufuneka uthathe 50 mg kabini ngemini. Ukuba kuyimfuneko, ithamo angandiswa (ukuya nokuqalisa legalelo clinical).

icala elingenzi nto-ngesimilo

iziyobisi kujongwa kunokubangela ezahlukahlukeneyo ngayo icala. Amaninzi wabonakalaliswa zimi ngolu hlobo lulandelayo:

• ukozela, ubuthathaka, isiyezi, iingcangcazela, ukungakhathali, apraxia, ukucinga okungaqhelekanga, kunesifo, ulungelelwaniso kakuhle, DYSTONIA;
• ukudideka, edanduluka esithi, ukucinga kade, ukuba nemibono, ukudakumba, sinciphise yobuntu, imo euphoric, ukusabela silwe;
• ukudla, pancreatitis, gastritis, flatulence, iimpawu dyspeptic;
• aqaqambayo, amahlaba, ukudumba namalungu;
• blindness unilateral, presbyopia, nokudumba conjunctival, kunye nabanye.

Medicament "Topamax": ncomo

Sokuwa - isifo zaseprayimari apho ichiza zinikwa ingqalelo. Ngokutsho iingxelo oogqirha kunye uxilongo olu nyango akusoloko ukubonisa ngempumelelo ngokwaneleyo nezinyangayo. Ukongeza, ziphakamisa ezininzi reactions kwicala yolwamkelo, kuquka inxalenye yenkqubo Wayesoyika psyche.

Ke ukuba izigulane, kuba baphawula ukuba tolerability abaziintsizana ichiza. Yiloo nto abantu abaninzi kubo ukhetha ukusebenzisa i ngakumbi yokufumana imali ukuba ugqirha incoma.

Asinako ukuba ichiza kuthethwa ngokubanzi ezisetyenziswa izigulane ezininzi njengendlela ukuncipha. Noko ke, iingcali ingxelo ukuba xa uthatha njengezingxobo "Topamax" ukulungiselela ezi njongo kufuneka ithathelwe ingqalelo letyhefu yalo phezulu.