I-homocysteine ephakamileyo ekukhulelweni: yintoni eyoyikisayo?

I-Homocysteine yinto eyenzayo ngokuthe ngqo kumzimba ngexesha lokusetyenziswa kwe-amino acid methionine. Umntu wokugqibela uhamba kunye nokutya. Eyona nto icebile kwiicidi ze-acids ziyimveliso enjengenyama, amaqanda kunye nemveliso yobisi yobunandi. Ekubunjweni kwe-homocysteine, zonke iivithamini zeqela B, ngakumbi iivithamini B6 ne-B12, kwakunye ne-folic acid inxaxheba.

Ngenkambo yobomi, inqanaba le nkunkuma egazini likhula kancinci. Kwamadoda, esi sibonakaliso siphezulu kunabasetyhini abaneminyaka engama-50. I-homocysteine ephakamileyo ngexesha lokukhulelwa kunokukhokelela kwiinkathazo ezinzulu, kubandakanywa ukuphazamiseka kwangoko, oko kukuthi, ukukhulelwa kwesisu. Ukongezelela, kukho inokwenzeka ukuba iya kulimaza iinqanawa, zenze iindonga zikhululeke. Ngenxa yoko, kuba lula ukulungisa i-cholesterol kunye ne-calcium kwiindonga zeenqanawa zenze i- cholesterol plaque. Le meko inegalelo ekuphuhliseni i-thrombi, eyingozi kakhulu kungekhona kuphela kwimpilo, kodwa kubomi buntu. Ngokwezibalo, kubasetyhini ingozi yeengxaki ezinjalo ziphezulu kunamadoda ngama-20 ekhulwini.

Ukuphakanyiswa kwe-homocysteine ngexesha lokukhulelwa kungenziwa ngenxa yezizathu ezahlukeneyo, umzekelo, ukutshaya, ukusela utywala kunye nekhofi ngokubanzi. Kwiminyaka embalwa edlulileyo, iziganeko zokutshatyalaliswa kwesisu phakathi kwezilwanyana zihlala ziqhelekileyo, kwaye le ncwadana iyanda minyaka yonke. Kwaye ukuba kwakunokwenzeka ukugcina ukukhulelwa nokuzala umntwana ngokuqhelekileyo, ngexesha lokubeletha, ukwandisa i-homocysteine ngexesha lokukhulelwa kuya kwenza ukuba uzive, njengoko kunzima ukuxhamla kwe-thrombotic okanye microcirculatory nature.

Esinye sezifo ezinzima kakhulu ukungabikho komsebenzi, okwenzeka ngenxa yesiphene ngexesha lokumiselwa kwembungu. Kwi- yesithathu yesithathu yesithathu yokukhulelwa, ukuphulwa kwezinga le-homocysteine egazini kukhokelela ekuvelweni kwe-gestosis ekupheleni, kwaye kwiimeko ezinqabileyo zivela ku-fetal asphyxia, oko kukuthi, ukutywina komntwana ongakazalwa. Ngokuqhelekileyo, abasetyhini abanokuxilongwa bazalise iintsana ezinobunzima obuncinane kwaye babhekane "nembulunga" yezifo nakwixesha elizalwayo.

I-Homocysteine ngexesha lokukhulelwa liyakwazi ukungena ngokukhululekile kwinkqubo yokunxibelelana komntwana kunye nomzimba womama nge-placenta, kwaye sele sele ithintela kakubi ukuphuhliswa komntwana. Ngenxa yoko, ezinye iintsholongwane zenzeka kule nqanaba. Ukunciphisa i-homocysteine ngethuba lokukhulelwa liyakwazi ukuchaphazela kakubi intlalo yabesifazane. Kodwa ukwehla okuncinci kwinqanaba leli gama egazini kuthathwa njengesiqhelo kumfazi kwisimo esithakazelisayo kwaye akudingi unyango.

Kukho uluhlu oluhlukeneyo lwabasetyhini, oogqirha batusa ukuba bathathe uvavanyo kumgangatho we-homocysteine egazini. Ezi zinto zingabonwa ngokukhuselekileyo kubasetyhini abaceba ukukhulelwa okwesibini, okanye abo baneengxaki kwi-trimeter yesibini neyesithathu, umzekelo, ukungafani phakathi kobukhulu bomntwana kunye nomhla okhoyo. Kwiqela elijongene nobungozi, kuyinto yesiko ukubandakanya abafazi abakhulelwe abanezinto ezifuywayo okanye i-pathologies ezikhethekileyo, kuba unyango lwabo lunokubangela ukwanda kwimixholo ye-homocysteine egazini. Kwaye kubandakanya bonke abasetyhini abanomngcipheko wegazi, i-thrombophilia okuthiwa, ngokukodwa, abafazi abakhulelweyo kunye nokupheliswa kwentuthuko yobusane sele beqala ukuqala okanye ukungakwazi.

I-Homocysteine: iqhelekileyo ngexesha lokukhulelwa

Kubasetyhini kwindawo, ixabiso eliqhelekileyo lalo lathisi lisuka kwi-4.6 ukuya ku-12: 4 μmol / l. Ukuphambuka kwamancinci kuvunyelwe kwaye akuyi kuba yingozi kuyo impilo yomama ozayo kunye nosana. Kodwa nangona utshintsho oluncinci, olunjengokuhla okanye ukwanda kwinqanaba le nkunkuma ngaphezu kwe-0.5, kakade alwamkelekanga.