"Domidon": imiyalelo ukusetyenziswa, kwaye yintoni na ukuba

Nokuphazamiseka olusebenzayo lokugaya nayo wonke. Amaninzi, ubuhlungu kummandla epigastric kuvela ngenxa ukutya kakuhle kunye engafanelekanga. Ukuphucula yokwetyiswa ukukhawulezisa yokulahla esiswini, gastroenterologists Sicebisa uthatha lithetha okhethekileyo. Omnye wabo wabhekisela amayeza "Domidon". Imiyalelo ukusetyenziswa, impendulo kunye ezibonisa eli chiza zithiwe thaca apha ngasezantsi.

Form, ukwakheka, ukupakishwa kweziyobisi

Medicament "Domidon" umyalelo lugcinwe ekupakishweni eyenziwe yekhadibhodi, ekuveliseni azipilisi. Benza lo domperidone, kwaye ezifana monohydrate lactose, povidone, umbona starch, izithako microcrystalline kwincindi, titanium dioxide, starch pregelatinized, nemagnesium stearate, isodiyam lauryl sulfate, polyethylene ethers 4000, methylcellulose hydroxypropyl okanye sepifilm 752 Blanc.

Ekuthengisweni kwale ndawo iya iiseli nentaba.

Pharmacology

Yintoni na le amayeza njengoko "Domidon" (tablets)? Imiyalelo Sebenzisa ithi le motility ivuselela GI. Umgaqo kwalo msebenzi uchazwe yi ukukwazi ukuvala receptors D2-dopamine. Ngenxa yale isiphumo kwandisa ixesha iintshukumo peristaltic ngo-12 tiperstnoj emathunjini kunye kwindawo esiswini antral. Kwakhona ibalekisa yokulahla amalungu athi kwaye yandisa umoya okanye ubunzulu kuvuleke iminxunya (i sphincter asezantsi).

Olu nyango alunasiphumo kwi secretion esiswini. Its ukusebenza anti-emetic ngenxa kwindibaniselwano isiphumo gastrokinetic, kunye kwingcinezelo receptors dopamine kwindawo trigger chemoreceptor, ezithi zibekwe ngaphandle njengomqobo segazi lobuchopho. Ukongeza, eli chiza akubikho hiccups kunye isicaphucaphu.

iimpawu kinetic

Yintoni Lubalasele kinetics beziyobisi "Domidon"? Imiyalelo yokusebenzisa ingxelo ukuba esi sixhobo wendele ngokukhawuleza ngokupheleleyo emathunjini. It umzimba esibindini neendonga iphecana zesisu, apho kukho bioavailability ephantsi (15%).

Ukuncipha juice iasidi esiswini nokutya kakhulu isantya kwaye sehlise ukufunxeka domperidone. Its xi peak plasma kuko iyure enye emva kokungenisa.

Unxibelelwano beziyobisi kwiiproteni plasma nama-91-94%. It ayiqondakali ingene nge BBB, kodwa wenza kakuhle ngobisi sikanina (i nqanaba malunga 1/4 ye xiyimiso iyonke egazini).

Inguqu eziphilayo yokulungiselela ikhutshwa phandle N-dealkylation kunye hydroxylation.

Ixesha isiqingatha ubomi ichiza iiyure 7-10. Xa ukusilela kwezintso (esibi), eli nani buyanda.

Lithathwe neziyobisi emzimbeni kunye endleni kunye nomchamo.

Ezibonisa yokwamkelwa

Kwezinye iimeko, abadala ityumbe "Domidon" tablet? Ukusetyenziswa kweli chiza eboniswe ukugabha kunye isicaphucaphu kwakunye neentlungu esiswini eliphezulu, imvakalelo nenzaliseko kunye heartburn.

Njengoko abantwana, bacebisa ukuba eli ziko kuphela isicaphucaphu nokugabha.

Izimo

Xa ukusebenzisa iziyobisi "Domidon" (imiyalelo ukusetyenziswa nokuba yintoni na - konke oko kuxelelwa kweli nqaku)? Izimo esi sixhobo zezi:

• ukopha zesisu;
• hypersensitivity;
• perforation yethumbu / isisu ;
• emathunjini mechanical;
• hypophysis Ithumba (prolactin-secreting);
• kunye neefom ngomlomo "Erythromycin", "ketoconazole" okanye ezinye inhibitors ka CYP 3A4, kwakunye arhente leyo yandisa interval Q-T.

Drug "Domidon": imiyalelo yokusebenzisa

iipilisi Izincomo kufuneka athathwe ngaphakathi kuphela ngaphambi kokudla. Xa ufumana amayeza emva itye nokufunxwa yabo noko kancinci.

Abantwana abaminyaka-12 kunye nabantu abadala, le iyeza emiselweyo 10-20 mg kathathu ngemini. Ithamo iphezulu yemihla ngemihla iziyobisi wayeneminyaka engama-80 mg.

Ubude unyango samabanga - iiveki-4. Ukuba kuyimfuneko, sebenzisa ngakumbi ichiza kufuneka udibane nogqirha wakho.

Ngophuhliso ukusilela kwezintso kufuneka ukunciphisa ubuninzi ichiza. Ngokubhekiselele ukusilela wesibindi, kulo mzekelo, noko emiselweyo.

imiphumela emibi

Ngaba ukuvela reactions amayeza ezibi "Domidon"? Imiyalelo yokusebenzisa ingxelo ukuba iziphumo ezibi hlobo azenzeki:

• ukwanda kumanqanaba prolactin;
• anaphylaxis ;
• uvalo, ukuphazamiseka;
• nokudumba, kululwa interval Q-T, iyangongoza, dysrhythmia kunye nentliziyo rate;
• umlomo owomileyo, ukuphazamiseka extrapyramidal, intloko ebuhlungu, unxano, sokulibala, ukuba nochuku, isiyezi, ukozela, silale, yombono;
• izifo zesisu;
• gynecomastia, galactorrhea, amenorrhea;
• ukurhawuzelelwa, dysuria;
• Ukuchama rhoqo, irhashalala;
• stomatitis, conjunctivitis;
• asthenia, intlungu imilenze;
• ukwanda AST, ALT cholesterol.

izincomo ezithile

Yintoni kufuneka azise umguli, phambi kokunika iziyobisi "Domidon"? Imiyalelo Sebenzisa ithi esi sixhobo ayikwazi ukudityaniswa antisecretory kunye namayeza esesiwini.

Kuba unyango abantwana abangaphantsi kweminyaka eli-12 ubudala ezinobunzima nomzimba ngaphantsi kwama-35 kg sebenzisa akufuneki ibe le amayeza.

Ngexesha unyango nalo eli chiza kufuneka ayiyeke ukusuka kulawulo lwendlela nokusebenza ngoomatshini yingozi.

ukubuyekeza yabathengi

Ke kaloku, ukuba uyakwazi oko kumnqongo uphawu ichiza "Domidon". Imiyalelo zokusetyenziswa kwaye yintoni, sasinixelele ngasentla.

abathengi abaninzi usebenzisa le sibonelelo ingxelo ukuba ngempumelelo ephelisa heartburn, hiccups kunye isicaphucaphu. Kwakhona, ichiza igalelo yokulahla ngokukhawuleza esiswini, ukunciphisa imvakalelo noncwino ukungakhululeki ubuncinane.

Ingqalelo igalelo elibi kuphela kweli chiza linani elikhulu yeziphumo ebezingalindelekanga.