Diabetes phosphate: oonobangela, iimpawu, isifo, unyango

Kweli hlabathi lanamhlanje phantse bonke abazali banolwazi esi sifo, njengoko yamathambo. Kwi imfuneko yokuba uthintelo kwesi sifo livimbela ngasinye womntwana nogqirha zokuqala neenyanga lomntwana ebomini. Yamathambo ubhekisela isifo ezifunyenwe, ukuphuhlisa ngenxa ukusilela cholecalciferol - into eyaziwa ngokuba novithamini D.

Noko ke, kwezinye iimeko kubantwana abaselula kakhulu uneempawu izifo, nangona ukunamathela amanyathelo othintelo. Kwimeko enjalo kufuneka kuyakrokreleka izifo ezifana neswekile phosphate. Ngokungafaniyo yamathambo, esi sifo inxulumene ezimbi yemfuza. Ngoko ke, oko sisifo kakhulu ngakumbi kwaye ifuna unyango oluntsonkothileyo elide.

Yintoni phosphate isifo seswekile?

Ngoko liqela yemfuza kwezifo kwaye udibanise kakuhle bezimbiwa ukutya. Kwenye ngezifo ekuthiwa vitamin yamathambo D ezingatshiyo. uhlobo lwiimi seswekile phosphate lwenzeka malunga 1 umntwana ngaphandle 20,000 iintsana ezisanda kuzalwa. Ngokuba lixesha lokuqala esisifo echazwe-1937. Kamva afika ukuba zikhona ezinye iintlobo ukungaqheleki yemfuza. Amaninzi, seswekile phosphate ibanjiwe kwabantwana abancinane. Itsala imfutshane bonke abazali iqinelwa nasiphazamiso uhlaba ithambo.

Ezinye iintlobo zezifo zikhatshwa zezinye izifo metabolic. Ngamanye amaxesha sifo kukuthi nazimpawu ekwaziyo nje ekuchazeni kuyo laboratory iimvavanyo. Esi sifo ihlelwa kunye yamathambo ezifunyenwe, hypoparathyroidism kunye nezinye ukungaqheleki yonyango. Unyango kufuneka ihlanganiswe kudala ubudala.

Izinto ezibangela izifo

Unobangela ephambili seswekile phosphate kwaphula isakhiwo yemfuza. Kwezakhi azuze. Abathwali sofuzo engaqhelekanga kunokuba bobabini abasetyhini kunye namadoda. I-guquko lwenzeka kwi X chromosome-edityaniswe, esoyisayo. Kwiimeko ezinqabe kakhulu, isifo seswekile phosphate nga ifunwe. Ikhulela kwi yamathumba ka mesenchymal zomzimba, kwasekwa Esibelekweni. Kule ngezifo ubizwa ngokuba "yamathambo oncogenic."

Izifo libhekisela tubulopathy iqela - ukuphazamiseka ze nezintso. Ngenxa minerals kunciphise reabsorption kwi tubule proximal, nokuphuhlisa ukuswela phosphorus emzimbeni. Ukongeza, waphazamiseka wamathumbu sokufunxa ukukwazi. Ngenxa yoko, kukho utshintsho bezimbiwa ukwakhiwa ijwabu ithambo. Kukho amaninzi kukwaphula umsebenzi osteoblast. Amadoda lokuphumelela pathologically etshintshiweyo gene eneentombi, yaye abafazi - abantwana amadoda namabhinqa. Njengoko umthetho, amakhwenkwe esi sifo kakhulu ngakumbi kunokuba amantombazana.

Ukuhlelwa diabetes phosphate ebantwaneni

Kukho iintlobo ezininzi sifo, ezahlukeneyo zokubhalisa yemfuza lwezonyango. Ezininzi eziqhele bene yamathambo ezinxulumene X-hypophosphatemic, onomlinganiselo lubalaseleyo zelifa. Nangona kunjalo, kukho ezinye iintlobo ngezifo. Ulwahlulo ibandakanya le fomu zilandelayo sifo:

1. iswekile phosphate hlobo lubalaseleyo ezinxulumene X-. Lubonakala yi utshintsho gene PHEX, nto leyo buqonda i endopeptidase. Le enzyme inoxanduva zothutho kwezimbiwa ezahlukeneyo ngamajelo ion kwizintso kunye emathunjini amancinci. Ngenxa gene ukuguquka, le nkqubo lingancipha, ukusuka apho kukho ion phosphate waneleyo emzimbeni.
2. X-ezinxulumene sofuzo. Lubonakala CLCN5 guquko lwe isakhi ukuba buqonda iproteni linoxanduva lokusebenza lamajelo chlorine ion. Ngenxa unesiphako waphazamisa ukuthuthwa izinto ngalo inwebu le tubules sezintso. Babethwele olu hlobo leengxaki kunokuba bobabini abasetyhini kunye namadoda. Nangona kunjalo, esi sifo kwenzeka kuphela amakhwenkwe.
3. indlela Autosomal evelele seswekile phosphate. Oku kunxulumene neqela kwezakhi chromosome 12. Ngenxa osteoblasts isiphako zophendlo lwezifo yi ziiprotein ekwanti leyo ekhuthaza ngakumbi ukususwa phosphate emzimbeni. Le ngezifo luphawulwa wobulali kakhulu, njengoko kuchasene kwifomu enxulumene X-.
4. Autosomal sofuzo. Rare. Lubonakala DMP1 yayingaphelele gene ise chromosome 4. It buqonda iproteni elinoxanduva lokuphuhlisa ithambo kunye dentin.
5. Autosomal sofuzo, sikhatshwe kokukhutshwa icalcium yokuchama. Ubangelwa kukuba sofuzo isiphene okwindawo kwi chromosome 9 kunye nesigxina sodium-oxhomekeke uxabane channels.

Ukongeza kwezi ntlobo seswekile phosphate, kukho ezinye iintlobo ngezifo. Ezinye iintlobo ze sifo azikhange kufundwe kude kube ngoku.

Umahluko phakathi yamathambo kunye seswekile phosphate

Yamathambo kunye seswekile phosphate kubantwana - le ncam into enye, nangona umfanekiso kwezonyango sifo phantse twatse. Umahluko phakathi kwezi ezimbi kwi umyalezo kunye indlela yophuhliso. yamathambo eziQhelekileyo - ukuba ufumene izifo ezinxulumene ne ukungabi cholecalciferol. Le into iveliswa lolusu phantsi kwempembelelo kwelanga. Sokuxilonga umthamo ivithamin D senziwe phantsi ngokuthabatha entweni yonke imihla bonke abantwana ukususela 1 kwinyanga 3 iminyaka, ngaphandle ehlotyeni. Ngenxa ukusilela cholecalciferol kuphazanyiswa inkqubo Ukunciphisa calcium. Ngenxa yokuba zokuphuhlisa deformation ithambo.

Ngokungafaniyo seswekile phosphate ngayo ukuba libhekisela yesifo awazalwa enaso. Xa oku ngezifo kuphazanyiswa nokufunxwa kwezimbiwa kwi kidney, ngokukodwa - i phosphate. Kwezinye iimeko, kukho calcium intswelo. Ngenxa ukunyhashwa bezimbiwa ukwakhiwa ezimbi zeethishu ithambo ezifana iimpawu. Umahluko phakathi kwazo kujongwe kuphela emva kokuba uxilongo elebhu.

yamathambo Hypophosphatemic kwiintsana: iimpawu

Iimpawu zesi sifo zidla ngoxilongo kunyaka wesibini ebomini. Kwiimeko ezinqabe kakhulu, kukho yamathambo hypophosphatemic kwiintsana. Iimpawu ezinokuthi olufunyanwa ebuntwaneni - kwemisipha hypotonia ekufakeni kokunciphisa. Eyona kwezonyango kubonakaliswa yile:

1. Deformation namalungu umlenze.
2. O-ezimile ugobile kweqondo asezantsi.
3. Ukukhula ukukhubazeka kubantwana - iba buqapheleke emva konyaka-1.
4. Ukuqina sosana kunye ubambo intlala - "izacholo rachitic kunye namaso."
5. Ubuhlungu amathambo isinqe kunye lomqolo.
6. Ukonakala yezinyo lwawo.

Amaninzi isikhalazo eziyintloko abazali kukuba imilenze zosana zigobile. Ngenxa ukuqhubeka kwesifo kukho ukuthamba amathambo - osteomalacia.

Uxilongo seswekile phosphate kunye yamathambo

Ukuba ukungaphili, wayeqhuba isifundo ubume zengqo- igazi. Ziphawuleka hypophosphatemia. inqanaba ikhalsiyam kwiimeko ezininzi eziqhelekileyo, ngamanye amaxesha - zehla. Xa ukuphakama yamathambo kukho ulwando lwe phosphatase obrak. Xa X-ray abonisa kwamathambo bone nokukhula zone ukuhlukunyezwa. Xa umchamo kubonisiwe isixa esikhulu phosphate. Ngamanye amaxesha kukho calcium womchamo.

Unyango yamathambo kunye phosphate seswekile

Kuba unyango seswekile phosphate ezisetyenzisiweyo ngeedosi ezinkulu cholecalciferol. Kwezinye iimeko, eboniswe izongezo calcium. Qiniseka ukusebenzisa amayeza eziqulathe phosphorus. Ukuphucula imeko mzimba nezimbiwa emiselweyo. Ezi zibandakanya "Vitrum" iziyobisi "Duovit", "Alphabet" njalo-njalo. D.

Xa curvatures ezixeliweyo amathambo eboniswe ukuyifundisa unyango ngokwasemzimbeni kunye notyando. Kufuneka ukuba bajonge podiatrist.

amanyathelo othintelo kunye noqikelelo

Kuba zothintelo kuquka uhlolo wabantwana kunye ugqirha, uhamba esemsebenzini, ukuqeshwa ivithamin D ukusuka kwinyanga yokuqala yobomi. Ukuba usapho abagulayo nolwalamo seswekile kufuneka bangenele uvavanyo yemfuza Esibelekweni olungekazalwa. Ukuqikelela ikakhulu obuhle kwangethuba unyango.