"Ursofalk": analogue, imiyalelo ukusetyenziswa ndimkhulule ifomu

Medicament "Ursofalk" yemiyalezo uchaza ichiza kunye kuluhlu olubanzi umsebenzi, nto leyo eye, phakathi kwezinye izinto, hepatoprotective, cholelitolitic, iipropati immunomodulatory. Kwakhona, ichiza kunciphisa kakhulu amanqanaba yegazi.

izinto esebenzayo

Eyona nto elikhutheleyo medicament enze ursodeoxycholic acid. Kuyinto isipho mali ethile inyongo kwabantu, kodwa ngenxa yokuba ukuphazamiseka ezithile ukusebenza kwesibindi amagama kunye ngokufanelekileyo, umxholo iyeza duct lincitshiswe.

Ursodeoxycholic acid ibe yinto ephambili ekhoyo nje kuphela ukulungiselela "Ursofalk". Analogs ze ubume imithi iipropati - la machiza ngokuba "Ursosan", "Ursol", "Urdoksa". Thetha ngakumbi apha ngezantsi.

imiphumela therapeutic lithetha "Ursofalk"

• ukusebenza Choleretic linciphileyo inani asidi duct hydrophobic nokwandisa kokukhululwa kwabo sayo emathunjini. Ukongeza, ichiza ngenxa ekubeni unxibelelwano kunye ileum kunciphisa receptors nokufunxwa asidi hydrophobic ityhefu.
• isenzo Immunomodulating ibangwa kukuba ursodeoxycholic acid unako zokunciphisa kwebinzana iimolekyuli hepatocytes lolu phando kwiklasi yokuqala, yaye cholangiocytes - lolu phando iimolekyuli bodidi lwesibini. Kwakhona iyeza kunciphisa Yindibanisela cytokines pro-arhabaxa.
• Isiphumo cytoprotective kukuba nako izinto ezisebenzayo ukungena kulo lipid inwebu yeseli inwebu, nto leyo iseli inwebu omeleza iipropati zokukhusela iyaphuculwa.
• ukusebenza Hypercholesterolemic isekelwe ukucuthwa le ileum yokufunxa nokuncipha cholesterol kudibaniso esibindini, ngokunjalo zinomgutyulo yayo enyongweni.

Ngaphandle iziphumo ngasentla, ichiza "Ursofalk" (imiyalelo zokusetyenziswa kungqinwa) yenza a uboniso olunombala wamanzi kunye zinemoletyhule cholesterol ukuba kunciphisa lithogenicity inyongo. Ngenxa ukuguqulwa iikhompawundi cholesterol kuyayinciphisa ukuyilwa Amatye ngamanyala lawo.

Pharmacokinetics

Emva ulawulo ngomlomo beziyobisi emathunjini amancinci ako ursodeoxycholic acid, kukufakwa esilawulwa izithuthi inxaxheba ileum kwi-terminal isabelo, yaye zezothutho isixando - kule jejunum kunye ileum kwi inxalenye ephezulu. Malunga nama-60-80 epesenti iidosi ingena egazini.

Le into esebenzayo ezetyiswa ngayo esibindini yaye ngokuyinxenye disintegrates ethunjini, nto leyo ekhokelela ukuba ukuyilwa zinetyhefu-nee ezisixhenxe lithocholic acid, mvisiswano leyo, kwelinye icala, ifunxwe kungena egazini kwaye ubukhulu ezincinane detoxifies esibindini. Half-ubomi neziyobisi - ezintathu - iintsuku ezintlanu. Oku ikakhulu kwazona kwi ituwa njengoko metabolites.

Ubungqina obubonakalayo buxela ukuba ukusetyenziswa

Ukulungiselela "Ursofalk" ibonisa yesikhokelo ezisetyenziswa izifo esinyini inyongo, isibindi, sikhatshwe ekwandeni yegazi, cholestasis, isibindi imisebenzi ethile ukwehla. Phakathi izifo ezo kuchazwe kwesibindi biliary (zaseprayimari), biliary reflux gastritis, sclerosing cholangitis (zaseprayimari), biliary reflux esophagitis, hepatitis of umyalezo ezahlukeneyo, abanesigulo esinganyangekiyo.

Ichiza ezimiselweyo ubukho enyongweni, kodwa kuphela ukuba rentgennegativnye ububanzi, ubukhulu yabo ayidluli elinesihlanu eemilimitha, kwaye isigulane akuthethi ukuphazamisa ukusebenza senyongo. Le medicament lisetyenziswa kwimeko zesibindi yetyhefu (umz, utywala Ityhefu), ngonobangela wokufa kwayo sikhatshwe cholestasis (abantwana), zeDyskinesia biliary, atresia ngayo ibile ducts intrahepatic. izigulane athatha kwakhe isondlo parenteral, ukuze kupheliswe yokunqaphela of inyongo, kwakunye nabantu abaye baba utyando ukuze esinye isibindi.

Njengoko arhente umbala lusekelwe "Ursofalk" iziyobisi (iziyobisi analogs kwakhona ingasetyenziswa kwezi meko) ngaxeshanye ulwamkelo neziyobisi kubachaphazela ngokungalunganga ukusebenza kwesibindi (zokucwangcisa hormone, iziyobisi ukususela cholestatic).

ifomu Release komsindo

iifom ezimbini ukukhulula chiza "Ursofalk": ukumiswa (akukho analogue, ekuveliseni Switzerland) kunye njengezingxobo (analogs ziveliswa eJamani). Inguqulelo yokuqala ichiza isetyenziswa ikakhulu abantwana okanye abantu ubunzima ligwinya. njengezingxobo Gelatin zimnyama, nzima, isiciko uvuthuluka zaveza emhlophe, ngaphakathi - granules ezimhlophe okanye powder. Ifumaneka iipakethe 10, 25, 50 okanye 100 ziingceba. Ukumiswa kwakhona abe umbala omhlophe, lubonakala yi guquki bomzi, iqulathe amaqamza, it has a vumba yelamuni. Ifumaneka iibhotile ngeemililitha 250, gcwalisa zifakwe yokulinganisa icephe.

250 mg of ursodeoxycholic acid sibhalwe ekulungiseleleni, imali efanayo into esebenzayo langoku ngeemililitha ezintlanu (enye scoop) oluludaka "Ursofalk" capsule. Le isiraphu iquka la macandelo abancedisayo: glycerol, anhydrous citric acid, xylitol, propylene ethers, sodium chloride, microcrystalline kwincindi, benzoic acid, lemon isongo, isodiyam citrate, amanzi okuhlamba, sodium cyclamate. izithako zamabanga njengezingxobo thaca colloidal lesilicon dioxide, titanium dioxide, isodiyam lauryl sulfate, umbona starch, nemagnesium stearate, gelatin, amanzi okuhlamba.

Indlela ukuthatha "Ursofalk"

Le medicament kwimeko kuyo yolwamkelo omnye unqwenela ukwamkela ngokuhlwa. Philisi bususiwe, ngaphandle ukuhlafuna, wabahlamba phantsi ngamanzi inani elifanelekileyo. Njengoko sele kuchaziwe, amayeza "Ursofalk" abantwana Kubhetele ukusebenzisa ngohlobo ukunqunyanyiswa (isiraphu). Idosi kufuneka ibalwe ugqirha, ngokusekelwe uhlobo kwesifo kunye neempawu omzimba yesigulane. Iintsana (nge ubunzima ngeekhilogram ezintlanu) kufuneka zinikwe ngexesha lokulala kwikota yokulinganisa ngecephe oluludaka.

ngokuba umthamo isibindi mihla abantu abadala Ngokuqhelekileyo yi 10-15 mg ubunzima bomzimba kilogram ngalinye, ikhondo unyango ithatha iinyanga ezintandathu ukuya kwiminyaka emibini, akukho acetyiswayo kule meko ngenxeba yokwamkela medicament. Kuba abantu oesophagitis reflux biliary okanye biliary reflux gastritis ngemihla ithamo "Ursofalk" chiza - unyango 250 mg - ezilishumi - zaziintsuku ezilishumi elinesine. Xa sclerosing cholangitis kunye kwesibindi biliary ngosuku, bavame ukuyala abafumana 10-15 mg ubunzima bomzimba kilogram ngalinye, kodwa ukuba kuyimfuneko, ithamo lanyuka ukuya 20 mg nganye 1 kg. Therapy ngokuqhelekileyo ithatha iinyanga ezintandathu ukuya kwiminyaka emibini. Izigulane abanesigulo esinganyangekiyo uthathe amayeza yonke imihla xa umthamo we-20-30 mg kwekilogram ubunzima bomzimba ngaphezu kweenyanga ezintandathu ukuya kwiminyaka emibini. Kwimeko zesibindi zinetyhefu iboniswa ukwenza amachiza idosi yemihla ngemihla 10-15 mg kwekilogram ubunzima bomzimba ngalinye ukulungiselela ezintandathu - iinyanga ezilishumi elinambini.

"Ursofalk" amayeza. analogs

Uphawu oluthelekisayo amayeza kunye namachiza afanayo kumafa kunye neepropati imithi.

• Drug "Ursosan". Le mveliso yenziwa kwi Czech Republic iJamani, iyafumaneka kuphela ngohlobo iipilisi. Indlela yokusebenza kumayeza efanayo. Noko ke, kwiitheraphisti, hepatologists, oogqirha sisifo esosulelayo kwi umbuzo apho isiyobisi ngcono, "Ursosan" okanye "Ursofalk" ngamxhelo baphendule ukuba Kukhethwa ukuba ukhethe yesibini. kwizigqibo ezinjalo zenziwa ziingcali ngokwesiseko nimana zabo zekliniki kunye nengxelo evela kwizigulane. Medicine "Ursofalk" utshintshela lula ngaphezu analog ingqalelo, naye uya normalizes imeko olusebenzayo esibindini. Kodwa musa ukulibala malunga iimpawu zakho ze-ephilayo, kukho abantu lithetha "Ursosan" kunceda ngcono. Ukongeza, ichiza kubalulekile kancinci zitshiphu: pack kunye njengezingxobo-50 liya kuxabisa 650-830 engange, lo gama i-50 njengezingxobo amayeza "Ursofalk" Kuya kufuneka ukuba uhlawule 850-1200 engange.
• "Urdoksa" lithetha. Le amayeza generic iyaveliswa ekhaya. Noko ke, ukuvelisa inkampani yezemithi ukuthenga izinto eziyimfuneko aphesheya, kanti eRussia kukho inkqubo yokuvelisa ichiza kuphela. Kwakhona ifumaneka njengezingxobo, ixabiso ngamaqhosha 50 uyahluka 440-960 engange. Omabini la machiza pharmacologically efanayo, xa isiphumo wavelisa umahluko obonakalayo akukho ulandelwe.
• "Ursol" amayeza. Medicine, njengakwimeko yangaphambili, wenziwe eRashiya. Noko ke, abantu abaninzi bathi ukuba zonke ezi mali ngcono inyibilike amatye lwesinye nenyongo. Kodwa kukho abo ukusebenza unyango phezulu xa ezithatha ichiza "Ursofalk". Le njengezingxobo babe isakhiwo esifanayo, ngoko Shiyiselanani okanye enye khetho kunzima. Xa unikel 'ingqalelo ngexabiso, kungcono ukuba bathenge ichiza "Ursol" kutshiphu - engange 460-905 ngenxa njengezingxobo 50.

imiphumela emibi

medicament "Ursofalk 'Wanyamezela Intle kakuhle zizigulane. Analogs kweziyobisi linophawu tolerability elungileyo. Kwezinye iimeko, ngexesha unyango kukho calcification of enyongweni ukuphuhlisa ilindle mushy, intlungu epigastric. Ukongezelela, ukuze ukuphuhlisa mngundo ngokohlobo pruritus, urticaria. Iingxelo ze libanda, ziye ingxelo ukuza kuthi ga ngoku.

Izimo

uvakalelo oluphezulu zobuqu amacandelo zeziyobisi sisiseko ukwala ukusetyenziswa. Iyeza contraindicated kubantu abane cholangitis, okanye occlusion we bile duct esinganyangekiyo, cholecystitis oyingozi. Musa libeke ichiza ukuba izigulana yaphula umsebenzi lwemoto le senyongo, inyongo yokulunywa.

Ukukhulelwa ne zisanyisa

Ngokutsho izifundo, ursodeoxycholic acid akuthethi ukubonisa mutagenic, yaManzi naMahlathi, umsebenzi embryotoxic, kodwa amandla ayo ukungena umqobo gematoplatsentarny kwaye kuchaphazela ikhondo ukukhulelwa khange kufundwe de kube sekupheleni. Ngoko ke, uthathe amayeza "Ursofalk" ebudeni ukuba nomntwana kuphela xa kukho imfuneko kwaye amiselwe ngugqirha. Amava ukusebenzisa amayeza kwixesha zisanyisa ayifumaneki.

Unxibelelwano namanye amachiza

unyango ngaxeshanye kunye esesiwini ukulungiselela equka aluminiyam hayidroksayidi, kunye namayeza 'Colestipol "yaye" Cholestyramine "kubangela ukuba kuthoba kukufakwa lwenkqubo yemfundo into esebenzayo. Ichiza angayitshintsha xiyimiso xa iziyobisi "Tacrolimus" plasma yegazi. Ukuba kukho imfuneko yokusetyenziswa odibeneyo kumayeza anjalo kufuneka athathwe ngamaxesha athile iiyure ubuncinane ezimbini.