"Umhlathi": imiyalelo yokusetyenziswa. "I-Passage": izibonakaliso zokusetyenziswa, ukuphononongwa, iimpawu ezifanayo

Ukutshatyalaliswa kubhekiselele ekuqhumeni komsindo ngomlomo (ngamanye amaxesha ngeempumlo) zeziqulatho zesisu okanye i-duodenum. Le nto ibangelwa ukubethelwa kwemisundu yeendaba.

Kwinkqubo yokuhlanza, inxalenye yesisu isavaliwe, kwaye umzimba wakhe ukhululekile ngokupheleleyo. Ngelo xesha, ukungena kwayo kuvula, kunye ne-oopopus kunye nomlomo womlomo.

Isenzo sonke esichaziweyo se-reflex silawulwa yiziko lokuhlanza, elise-medulla oblongata. Isimo somntu onjalo singabonwa ngezifo ezithathelwanayo, ukutyhefuza, ukuqokelela kweengxube egazini, ukucaphukisa i-peritoneum, isilonda sezilonda, isisu sokugulisa, abafazi abakhulelweyo, njl njl.

Ukuhlanza i-episodic akuhambisani nokuphuma kwegazi, kwaye akuyikubeka engozini impilo yomguli. Kodwa ukuba loo nkqubo iphindaphindiwe kaninzi, ingakhokelela kwimiphumo emibi. Ezi zibandakanya ukungcola kunye nokungalingani kwe-electrolyte, oku kungaholela ekufeni. Yingakho xa uhlamba ngokukhawuleza, kufuneka uhlale uqhagamshelana nogqirha. Kufuneka kwakhona ukuthatha izidakamizwa ezikhethekileyo ezikunceda ukukhusela i-reflex.

I- antiemetics ethandwa kakhulu ibandakanya eso sidakamizwa njenge "Passage". Izibonakaliso zokusetyenziswa kunye nemiyalelo yalo mayeza iya kunikwa ngezantsi.

Ifomu yokukhululwa, ukupakishwa kunye nokubunjwa

Ngowuphi uhlobo onyango "I-Passagex" eyenziwa? Iingxelo zengxelo zabathengi ukuba loo mveliso ithengiswa ngefomethe eziphathekayo. Zifakwe kwiipakethe zemizila kunye nekhadibhodi yekhadibhodi, ngokulandelanayo.

Isithako esisebenzayo samachiza ekubhekiselwe kuyo yi-domperidone. Njengezinto ezincedisayo, i-aspartame, i-xylitol, i-lactitol, i-magnesium stearate kunye ne-menthol isetyenziswa.

Iimpawu ze-Pharmacological

Imiyalelo yokusetyenziswa ("iPassazyks" kufuneka isetyenziswe kuphela kwimiqondiso) iyazisa ukuba i-ejenti ephantsi kokuqwalaselwa yiyobisi ye-antiemetic. Nguyena ophikisanayo we-dopamine receptors.

Eli nyanga liyakwazi ukwandisa ubude beengxabano zepistaltic kwingxenye yesantya yesisu kunye ne-duodenum. Iphinde ijonge ukukhutshwa kweziqulatho zendlela yokugaya (ngokunciphisa le nkqubo), isusa iisusulu kunye nokuhlanza, yandisa ithoni ye-sphincter esophageal (kwicandelo eliphantsi).

Kufuneka kwakhona kuqaphele ukuba i-domperidone inqongophala ingena emngceleni wegazi. Yingakho ukusetyenziswa kwesi sirha kubunqabile kuhamba kunye ne-extrapyramidal.

Kufuneka kwakhona kuqatshelwe ukuba i-domperidone inako ukukhuthaza ukukhululwa kweprolactin kwi-gland.

Isenzo (i-antiemetic) yesilwanyana esibuzwayo ngenxa yokuhlanganiswa kweempembelelo zesisu kunye nokuchasana kwidopamine kwindawo ye-chemoreceptor. Kwakhona kufuneka kuthiwe ukuba le nto ayinayo ingozi ekukhuseleni isisu.

Izakhiwo zeCinetic

Ziziphi iimpawu zokwazisa zesilwanyana "Passagex"? Imiyalelo yokusetyenziswa ibonisa ukuba emva kokuthatha ithebhulethi ehlaziywayo, isithako sayo esisebenzayo siphuthuma kwigazi.

I-Domperidone ine-bioava availability (malunga ne-15%). Ubuncwane bayo buninzi bubonakala emva kwemizuzu engama-65.

Ukunciphisa i-acidity yejusi yesisu kunokunciphisa ukutyunjwa kwesilwanyana.

Ngokutsho kweengcali, i-domperidone ihanjiswe kakuhle kwiintlobo ezahlukeneyo. Ngokubhekisele kwingqondo, ukugxininiswa kwesilwanyana kulo mncinci. Ukuqhagamshelana neeplasini zeplasma malunga ne-92-93%.

Kufuneka kwakhona kuqaphele ukuba isilwanyana "Passagex" (amacwecwe) sisetyenziswe kwiindonga zesibindi kunye namathumbu. Ikhutshwe ngamathumbu (malunga nama-66%) kunye neentso (malunga ne-33%).

Isiqingatha sobomi beziyobisi ngamahora angama-8 ukuya ku-8. Ngenxa yokungaphumeleli kwintsiba, eli xesha lide.

Iinkcazo

La mayeza anqunyelwe ukuhlanza kunye neentlanzi ezivela kwimvelaphi eyahlukeneyo, kubandakanywa nezifo eziphilayo kunye nezisebenzayo, unyango lwe-radiation kunye nezifo. Kwakhona, le ngcebiso inokumiselwa i-toxemia, i-morphine intake, ukuphazamiseka kokutya, ukusetyenziswa kwe "Levodopa", "Apomorphine" kunye ne "Bromocriptine."

Ziziphi ezinye iimeko apho ingasetyenziswa khona imithi "Passagex"? Imiyalelo yokusetyenziswa ibonisa ukuba le mayeza aqhelekelelwe ukuba atonywe kwipatheni yesisu (kuqukwa ne-post-operative), i-hiccups, i-radiopaque kunye ne-endoscopic i-tractes tract. Kwakhona, isicatshulwa kumbuzo siyadingeka ukukhawuleza i-peristalsis kwiinkqubo zokuxilonga, ukuphazamiseka kwe-dyspeptic okubangelwa ukulibaziseka kwe-gastric emptying, i-esophagitis kunye ne-reflux ye-gastroesophageal.

Iipilisi ze "Passagex", izibonakaliso zokusetyenziswa kwazo ezixoxwa ngasentla, zibonakaliswe kakuhle kwintlungu yokugqithisa esiswini, ukuguquka, ukuvala, ukugubha, nokugubha.

Ukungqinelana

Ufanele ungathathi nini amaphilisi e-Passex? Izikhokelo zokusetyenziswa, ukuhlaziywa kwengxelo zichazela oku kulandelwa kwezi zilandelayo:

• Hypersensitivity;
• Abantwana abangaphantsi kweminyaka engama-5, kunye neentsana ezineesisindo somzimba ezingama-20 kg;
• IPlactinoma;
• Phenylketonuria.

Kufuneka kwakhona kuqaphele ukuba le mpendulo ayinqunywanga ukuba ukuvuselelwa kwe-gastric motility kungabungozi (ngokuphuma kwegazi, ukuphazamiseka okanye ukukhutshwa kombane).

Ngoqaphele, le nkunkuma ingasetyenziselwa ukuxhamla okanye ukungafihli, ngokukhulelwa kunye ngexesha lokukhulelwa.

Iipilisi ze "Passagex": imiyalelo yokusetyenziswa

Iipilisi ezithengwayo "iPassaziks" zicetyiswa ukuba zithathwe iiyure ezingama-¼ ngaphambi kokutya.

Ukufumana i-dyspepsia engapheliyo, abantu abadala baxelwe i-10 mg yesilwanyana (1 tablet) kathathu ngosuku. Ukuba kuyimfuneko, amayeza angathathwa ngaphambi kokulala.

Abantwana abaneminyaka engama-5 kule nkunkuma banike i-2.5 mg nganye yeekgreyiti ezili-10 zesisindo kathathu ngosuku kwaye, ukuba kuyimfuneko, ngaphambi kokulala.

Kwiimeko ezinzima kunye neemeko ezinzima (ngeentlanzi kunye nokuhlanza), izigulane zabantu abadala zimiselwe i-20 mg yesilwanyana kane ngosuku nangesikhathi sokulala. Kuncinci abantwana abaneminyaka engama-5 batyunjwa ukuba bathathe ama-5 mg amayeza nganye kwi-10 kg yesisindo kane ngosuku nangesikhathi sokulala.

Xa kunokwenzeka ukungabi nako, ukulungiswa kwe dose ngefesenti yokufumana ngaphandle kwamaxesha ama-1-2 kuyadingeka yonke imini.

Umlinganiselo ophezulu wamachiza ngosuku ngabantu abadala abangama-80 mg (oko kukuthi iipilisi eziyi-8). Ngokuphathelele abantwana, akufanele kube ngaphezu kwe-10 mg nganye kwi-10 kg yesisindo somntwana.

Iziganeko ezimbi

Ingaba iziphumo zempembelelo zamacwecwe e-chewing "Passagex"? Iingcali zithi esi sixhobo singabangela imiphumo engafunekiyo kwifom ye:

• Iintlobo zexesha elifutshane lomathumbu;
• Iimpawu ze-Extrapyramidal;
• Ukwandisa i-prolactin kwiplasma;
• I-Galactorrhea, i-dysmenorrhea kunye ne-gynecomastia;
• Rash kunye nemihlathi.

Iimpawu zokugqithisa

Ziziphi iimpawu zokugqithisa ngaphezulu kunokubangela izidakamizwa "I-Passage"? Umyalelo uthi izinto ezinjalo ziquka ukulala, ukuphazamiseka nokuphendulwa kwe-extrapyramidal.

Ukunyanga kweemeko ezinjalo kucetyiswa ukuba uthathe umbane kwaye uxoxe nodokotela.

Ukusebenzisana namanye amachiza

Ukwamkela okwamanye amayeza "Passagex" kunye ne-anticholinergics kunokunciphisa impembelelo yangaphambili.

Ukudibanisa ne- antacids kunciphisa ukufumaneka kwayo.

Xa udibaniso lwe-domperidone kunye neziyobisi zivimbela i-isoenzyme CYP3A4 (umzekelo, i-antibiotics yeqela le-macrolide, i-antifungal agents ye-azole, i-Nefazodone, i-HIV protease inhibitors), isigulane sinokunyuka kwinkxalabo yezinto ezisebenzayo kwigazi.

Iyeza kumbuzo alichaphazeli ukuxinwa kwe-digoxin kunye neparacetamol kwiplasma. Ayikwazi ukukhankanywa ukuba iyakuchukumisa ukuxilwa kweziyobisi (ngokufanayo kunye nokulawulwa ngomlomo) ngokukhululeka okuqhubekayo kwesithako esisebenzayo okanye eboshwe nge membrane ene-enteric.

Ukubeleka nokukhulelwa

Isiza "Passazyks" asivunyelwe ukuthathwa ngexesha lokukhulelwa.

Kula mabhinqa, ukuxinwa kwe-domperidone ebisi kunesihlandlo ezine ngaphantsi kwiplasma. Ayaziwa ukuba ngaba unempembelelo embi kwiintsana. Ngoko ke, ukuba kufuneka usebenzise le mayeza ngexesha lokuncelisa, utywala kufuneka luyeke.

Iipilisi ze "Passagex": ezifana neendleko

Iindleko zeemali ezikulo mbuzo zi malunga nama-ruble angama-220-360. Ukuba kuyimfuneko, isicatshulwa esichasayo sinokutshintshwa ngenye yezilwanyana ezifana ne-Motilium, i-Domstal, iKinidril, i-Avioplant, iDoprokin-C, iDiskkineton, i-Emeset, i-Motinol, E.

Kufuneka kukhunjulwe ukuba zonke izakhiwo eziluhlu zingabinempawu zabo. Ngoko ke, ukuyisebenzisa esikhundleni se "Passazaksa" kulandela emva kokubonisana nodokotela.

Uphononongo malunga neziyobisi

Uninzi lwezigulane ezisetyenziselwa izilwanyana ezibhekiselwe kumbuzo, zithetha ngobuchule obuphezulu. Ngokutsho kwabathengi, eli phephelo liphelisa ngokukhawuleza ukuvakalelwa kwesohlwayo kunye nokuthintela ukuhlanza.

Kufuneka kwakhona kuqatshelwe ukuba eli liyeza lingafakwa kunye nezinye iimpawu. Ngokomzekelo, ngokuqhelekileyo kusetyenziswa ubunzima esiswini okanye ukubetha. Kule meko, iipilisi zokuhlafuna zicetyiswa ukuba zithathe esinye isiqhelo kathathu ngosuku iintsuku ezintlanu.

Iingxaki ezingundoqo zezidakamizwa "I-Passagex" ziquka imiphumo emibi eyenzekayo ngaphandle kwemvelaphi yolawulo lwayo, kunye nokuba khona kweenkcazo ezahlukeneyo.