Fibrate - yintoni na? Ukubunjwa, ukusebenzisa, ukuchasene

Njengoko uyazi, izifo ze-vascular ziyodwa yezinto eziqhelekileyo kwiimeko zehlabathi. Phantse wonke umntu osekhulile unesifo sengxinzelelo kunye ne-angina. Abaninzi banembali yezifo ezinzima, ezifana ne-myocardial infarction kunye nokusasazwa kwe-cerebral. Okwangoku, kuqinisekiswa ngokwesayensi ukuba i-pathologies ye-vascular system ihambelana ngqo ne-dyslipidemia. Le meko ibonisa ukutshintsha kwimixholo ye-cholesterol kunye nama-acid acids egazini. Ukuqhelanisa i-lipid balance, izigulane zisebenzisa i-fibrates kunye nemimiselo. La maqela amachiza ayimfuneko kuzo zonke izigulane ezandise i-cholesterol egazini, kungakhathaliseki ukuba isondo kunye nobudala.

Fibrate - yintoni na kwaye zisetyenziselwa ntoni?

Kuyaziwa ukuba unyango lwe-atherosclerosis alunakwenzeka ngaphandle kokusetyenziswa kweemimiselo. Ziyalelwe zonke izigulane ezithandana nokunyanya, ischemic disease disease, thrombosis. Ukongeza kwiimimiselo, kukho elinye iqela leziyobisi - i-fibrates. Indlela yabo yesenzo ihlukile. Ngoko ke, la mayeza ayimiselwe ngumntu wonke. Ziyimvelaphi ye-fibroic acid. Inkqubo ephezulu yezenzo zabo kukulungiswa kwe- lipid metabolism emzimbeni. Fibrate - yintoni na kwaye yintoni? Ndiyabulela ekusebenziseni la mayeza, kukho ukwehla okukhulu kwi-triglycerides egazini. Iindlela eziphambili zezenzo ze-fibrates kukuba zivuselela i-enzyme-lipoprotein lipase, ngokukhawuleza ukutshintshisiswa kwamanani. Oko kukuthi, zichaphazela iinkqubo ze-biochemical ezenzeka emzimbeni. Ukongezelela ukulungisa i-dyslipidemia, i-fibrates nayo inezinye iziphumo. Phakathi kwabo - ukulwa nama-radicals amahhala, okuchasene nokuvuvukala kunye nefutyoni. Ziyi-anticoagulants.

Izibonakaliso zokusetyenziswa kwe-fibrates

Ngenxa yokuba ezi zineziphumo zinemiphumo emihle, zineentlobo ezininzi zezicelo. Isibonakaliso esiphezulu sokuqeshwa kwabo sisifo se- metabolic syndrome. Le meko ayiyiyo isifo esizimeleyo, kodwa ibhekwa njengento ebalulekileyo ekukhuleni kweentsholongwane zentliziyo. Iingqinisiso zesifo se-metabolic syndrome:

1. Ukukhuluphala kwamathumbu (ukunyuka kobunzima bomlenze ukusuka kwi-90 cm nangaphezulu).
2. I-cholesterol ephakamileyo ekuhlolweni kwegazi.
3. Ukunciphisa inani leepoprostini eziphezulu.
4. Amanqanaba okwandisa ama-triglycerides kunye neLDL.

Kwiimeko ezininzi, i- syndrome ye-metabolic idibene ne-2 ye-diabetes mellitus, ebonwa ngabantu abadala. Ezi zinto zibeka phambili ekuphuhlisweni kwe-atherosclerosis, oko kukuthi, ukuqoqwa kweep lipids kwiindonga zebhedi ye-vascular. Fibrats - yintoni le nto kwaye yintoni injongo abayimiselweyo? Ukongeza kwi-syndrome ye-metabolic syndrome, izibonakaliso zokusetyenziswa zi: iifayili ze-dyslipidemia kunye ne-hypertriglyceridemia. Ziyaboniswa nakwizigulane ezineembali zesifo sikashukela kunye ne-gout.

Ziziphi iimeko apho i-fibrates iphikisana nayo?

Nangona i-fibrates ineenzuzo ezininzi xa kuthelekiswa namanye amachiza ukunciphisa i-cholesterol (statins), ayinakusetyenziswa ngabo bonke abagulane. Kufuneka kukhunjulwe ukuba la mayeza ayichaphazela imetabolism, ngoko ke, phantsi kweemeko ezithile, akuvumelekanga ukuba ayisebenzise. Ukuqhotyoshelana kokuncitshiswa kokusetyenziswa kuku:

1. Ukukhulelwa kunye nexesha lokuncelisa.
2. Izifo zesibindi. Oku kungqinelana ngenxa yokuba leli qela leziyobisi lichaphazela i-metabolism of fatty acids. Ngesibindi se-cirrhosis kunye ne-alcoholic hepatosis, umsebenzi walo mzimba unzima kakhulu. Ngesi sizathu, i-fibrates ingabangela iziphumo ezinzima kwizigulane ezinjalo, ukungafihli.
3. Calculous cholecystitis. Enye yemiphumo ye-fibrates yenyuka kwi-lithogenicity, oko kukuthi, ukubunjwa kwama-gallstones.
4. Ukungaphumeleli kwimihlathi engapheliyo. Iifibrate zandisa izinga lokudalila egazini. Ngako oko, zinokunyusa ukuhluleka kwimizimba engapheliyo.
5. Ilumkiso kufuneka linikezelwe kwii-fritesi kwizigulane ezisebekhulile kunye nezigulane. Kwakhona, ukusetyenziswa kwabo akuthandeki kubantu abajongene nokudakwa kotywala.

Imiphumo emibi ye-fibrates

Fibrate - yintoni na kunye nemiphumo emibi engaba nayo? Kufuneka kuqatshelwe ukuba, ngokungafani namanye amayeza, eli qela leziyobisi lisoloko lingabangela ukuphendula. Ngako oko, zinokumiselwa kwizigulane ezineembali, i-hay fever, njl. Nano kunjalo, i-fibrates inezinye iziphumo ezibi. Into eqhelekileyo kwezi zilandelayo: iisuluko kunye nokuhlanza, ukunyanzelisa, ukubetha. Ziyakuchukumisa inkqubo yesantya. Kwezinye iimeko, kubangelwa intloko, ukungazinzi kunye nesimo esixinezelekileyo. Imiphumo emibi ikwaqwalaselwa nokutshintsha kwi-biochemical test test: amazinga okwanda kwe-creatinine, ALT, AST. Ukungabikho kwezifo ezingapheliyo nezifo zesibindi, oku akuyingozi kwimpilo yesigulane.

Ziziphi iziyobisi eziseqeleni le-fibrates?

Kuza kubekho, kukho amagama angama-10 ale qela leziyobisi. Iifibrate ziquka amayeza: I-Clofibrate, Bezafibrate, iGemfibrozil, kunye neFenofibrate. Ngamanye alezi ziyobisi ahluke kwinani lemiphumo kunye nemilinganiselo. Iiblulethi "I-Clofibrate" sele yaziwa iminyaka emininzi kwaye ayifumaneki ngokukhawuleza ngeli xesha. Nangona baqhuba kakuhle, bahlala bebangela iziphumo zecala ngendlela yokuphazamiseka kwendlela yokugaya, ubuhlungu besisu (myositis), kunye ne-lithogenicity ephezulu. Isicikisi esincinci sisilwanyana "Bezafibrate". Akayonto engaphantsi ekusebenzeni kwaye ngokukhawuleza ekhutshwe emzimbeni. Iipilisi "i-Gemfibrozil" ayikhuthazwa ukuba isetyenziswe ngenxa yemiphumo emininzi (kodwa ngaphantsi kokusebenzisa isicatshulwa "Vala"). Kwakhona ngenxa yesidingo sokusetyenziswa ixesha elide kunye neepayidi ezinkulu. Ummeli wamanqaku anje weli qela yiyilisi "Fenofibrate". Isebenza kakuhle kwaye akukho miphumo echaphazelekayo. Ukongezelela, umiselwe kwizigulane ezine-gout, njengoko enciphisa izinga le-uric acid.

Fibrates: imiyalelo yokusetyenziswa kwezi zi yobisi

Zingaphi kaninzi kwaye zingakanani amayeza okusebenzisa la mayeza, kuxhomekeke kuluhlobo luni lwamachiza olumiselwe ngumgqirha oya kuzo. Ngokuqhelekileyo kufuneka badliwe malunga neenyanga (okanye ngaphezulu) kwiipilisi eziyi-2-3 ngosuku. Isalathiso esiyinhloko sisifo se-metabolic syndrome. Le yile fayili echazwe ngokuqhelekileyo. Ukulungelelaniswa kufuneka kudibaniswe nesondlo esifanelekileyo kwaye ilawulwe phantsi kolawulo lwentambo ye lipid. Iipilisi "iGemfibrozil" zifaka i-1-2 ngamaxesha ngemini engama-30 ngaphambi kokutya kweenyanga eziliqela. Iimpawu zabo ziyimithi "Gevilon" kunye ne "Normolit". Isilwanyana "Bezafibrate" sitholakala kwiipilisi ze-200 mg kwaye sithathwa amaxesha ama-2 ngosuku ngenyanga enye. Kwakhona kukho isalathiso sayo-isilwanyana "Retard", esine-400 mg yezinto ezisetyenziswayo. Isilwanyana "Fenofibrate" sineendlela ezimbini zokukhululwa: iipilisi kunye ne-nanoparticles. Banikezela ngokunyusa ngokuthe ngempumelelo kunye nokufumaneka kwemvelo, kusetyenziswa kanye ngosuku (200 mg) ngeenyanga eziliqela. Ukufana kwakhe ngamayeza "Traikor" kunye ne "Lipantil".

I-Fibrates: ukusebenzisana kweziyobisi

Ngaphambi kokuba uqale ukusebenzisa leli qela leziyobisi, kufuneka uqhagamshelane nodokotela kwaye ukhumbuze ukuba yintoni na amanye amayeza asetyenziswayo. Iifibrate ayikwazi ukudibaniswa nama-nephro- ne-hepatotoxic agents. Ngokukodwa, kunye neziyobisi "Cyclosporin." Ukusetyenziswa kwe-fibrates akuthandeki kwizigulane ezithatha i-anticoagulant Warfarin. Kwakhona, iziyobisi zeli qela akufanele zidibaniswe nezinye i-agentlipidemic agents (statins). Njengoko lokhu kwandisa amathuba okuphuhliswa kwe-myositis.

Ukuphononongwa koogqirha kunye nezigulane malunga ne-fibrates

Uninzi lwezigulane lunelisekile ngokusebenzisa i-fibrates, kuba libona ukuhla kwezinga le-LDL, i-triglycerides kunye ne-cholesterol. Oogqirha bancomela ngamachiza kubo bonke abagulane abane-syndrome ye-metabolic ngenxa yobuchule babo obuphezulu kunye nobubanzi bezenzo. Impendulo kuphela yokuchasene nokusetyenziswa kwee-fibrates, ezifumaneka rhoqo kwizigulane ezigugile.