Iyeza 'MabThera'. Imiyalelo yokusetyenziswa

Uluhlu lwezilwanyana ezichasayo ziquka izilwanyana "MabThera". Inkcazo yesichengisi ibonisa ukukwazi kwayo ukubopha ngqo kwi-transmembrane antigen ekhoyo kwi-95% ye-non-Hodgkin's lymphomas yefom yeB-cell. Isithako esisebenzayo sisisigidib.

Iyeza "MabThera". Imiyalelo: izibonakaliso

Amachiza anqunywe kwi-B-cell engeyi-Hodgkin's lymphoma:

- i-chemo-resistant or recurrent, i-CD20-positive ngeqondo eliphantsi lokulahla okanye inkohliso;

- isigaba sesithathu esilandelayo esilandelayo kunye ne-chemotherapy kwizigulane ezingapheliyo;

- isilandela emva kokusabela ekuthatheni inyango njengengcali exhasayo;

- I-CD--positive ye-B enkulu inkulu ngokudibanisa ne-CHOP chemotherapy.

Isixhobo esithi "MabThera" myalelo uncoma ukusebenzisa i- lymphocytic leukemia engapheliyo :

- ngokudibanisa ne-chemotherapy kwizigulane ezingagcinwanga unyango oluqhelekileyo;

- ukubuyela kwakhona okanye ukunyanzeleka kwe-chemo kunye kunye ne-chemotherapy.

Isilwanyana siboniswa kubadala abanefom esebenzayo yesifo se-rheumatoid arthritis ngokudibanisa nesilwanyana "Methotrexate" ngeempendulo ezinganeleyo okanye ukunganyameli kwemirhumo yokusetyenziswa.

Ukungqinelana

Isixhobo esithi "MabThera" asicebisi umyalelo wokunyamezela omnye.

Ilumkiso kufuneka lugcinwe xa kugunyazwa isilwanyana kwizigulane ezine-arrhythmia, i-angina, ukungapheli kwintliziyo engapheliyo, uxinzelelo lwegazi oluphezulu okanye oluphantsi, i-thrombocytopenia, i-neutropenia, i-COPD (ngenxa yobungozi be-bronchospasm).

Iziphumo eziPhakathi

Ngokusetyenziswa kweziyobisi "MabThera", isicupunu, intlungu esiswini, ukuhlanza kunokwenzeka. Imbonakalo engebiyo ibandakanya i -hypotension ye-orthostatic, i- arrhythmia, i-tachycardia, i-bradycardia, i-disal function disorder, i-edema yomda, intlungu kwisifuba kunye ne-lumbosacral umqolo. Isilwanyana "MabThera" sinokubangela i-peripheral neuropathy, neuritis, ukulala okanye ukulala, ukuphazamiseka okanye ukudandatheka, ukuxhalaba, ubuthathaka, ukuxakeka kwesisu, iintloko. Iimpembelelo ezimbi zizimpembelelo. Imiyalelo ibandakanya i-rhinitis, ukuvuvukala kwe-pharynx okanye ulwimi, ukuphefumula okufutshane, i-bronchospasm, ukukhwabanisa isikhumba, ukulahleka kwesisindo, ukuphazamiseka kwengxaki, ukunyibilika, ukuvutha komkhuhlane, intlungu, intlungu kwintsimi yomsi kunye nendawo yesifo sokutya, Izifo.

Isistim

Isilwayo sijojowe ngokukhawuleza singeniswe ngaphakathi. Xa i-monotherapy isetyenziswe kanye ngeveki kwi-375 mg kwiiveki ezine. Izinga lokuqala lolawulo lokuqala li-50 mg / h. Ukunyuka ukuya phezulu (400 mg / h) isantya kufuneka kwenziwe ngokuthe ngcembe.

Imiyalelo ekhethekileyo

Kwimizuzu engamashumi amathathu ukuya kumashumi mathandathu ngaphambi kokusungulwa, ukulungiswa (ukulungiselela) kunye nama-analgesics kunye nama-antihistamines Kunconywa.

Ngexesha lokunyanga kwaye emva kweenyanga ezilishumi elinesibhozo emva kokugqitywa kwayo, abafazi bexesha lokubeletha kufuneka basebenzise izithintelo zokukhulelwa.

Iziyobisi ezixilisayo kufuneka ziphelelwe ngaphantsi kweeyure ezilishumi elinesibini ngaphambi kokungeniswa kwesilwanyana "MabThera."

Ukusebenza kunye nokukhuselwa kweziyobisi kubantwana akuzange kusekwe.

Ngokumalunga neziyobisi "MabThera" iingxelo zeengcali zithembeke. Ngaphezu koko, ngexesha lophando kwafunyanwa ukuba ukulawulwa ngokukhawuleza kweziyobisi njenge-monotherapy, kunye nokusetyenziswa kwayo njengalowo uncedisayo iminyaka emibini, kunciphisa amathuba okudlulela kokuhamba kwe -lymphoma ye- follicular.