"Trimetazidine-Biocom MV": imiyalelo ukusetyenziswa, ukwakheka, analogs kunye nohlolo

Le medicament onesiphumo esizibonakalisa iinkqubo yanda pathways ibakho amalungu neurosensory kunye myocardium. Phambi kokuba uqale unyango, kufuneka uyazi into eyenza iyeza "Trimetazidine-Biocom MV". Imiyalelo zokusetyenziswa, ukwakhiwa ichiza - ulwazi luncedo, nto leyo ixabisa ukufunda.

Form release iziyobisi, kumacandelwana yayo

Ichiza ulilungu ukukhululwa lungiswa kuthetha alahlwa ngokohlobo amacwecwe camera, ekuveliseni ngokusekelwe trimetazidine dihydrochloride. Blister iqulethe amacwecwe 10 pack ingaba ukusuka ku-1 ukuya ku-6 Enye cwecwe 35 mg yecandelo engundoqo. Ukwakhiwa ezikhatshwa wemagniziyam stearate, povidone, aerosil, hypromellose kunye calcium hydrogen phosphate dihydrate.

Titanium dioxide, Macrogol ezingundoqo icwecwe iqokobhe "Trimetazidine Biocom-CF". Imiyalelo yokusebenzisa iingxelo ukuba ukongeza kula izinto Shell ibandakanya hypromellose kunye oxide ngentsimbi ebomvu.

imiphumela kwemithi

isixhobo Antihypoxanth ikuvumela ukuba ukubuyisela nethe okuqhelekileyo iiseli, okuye kwenzeka ngenxa inguqu engentle kuphuhliso imeko lwezidumbu (ischemia, hypoxia). Iipilisi kungalithinteli ukunciphisa ubungakanani ATP iiseli negalelo ekuphuculeni lamajelo inwebu ion, transmembrane intshukumo sodium kunye potassium ion. Uyakwazi ukugcina homeostasis yeselula kwisithuba konyango usebenzisa medicament "Trimetazidine Biocom-CF". Imiyalelo yokusebenzisa ingxelo ukuba ichiza kunciphisa umyinge apho inkqubo igcwala ye asidi ezinamanqatha, ngoko a glucose igcwala enkulu yenzelwa ukhuseleko engabalulekanga nxamnye ischemia. Isenzo ichiza isekelwe wayicima inkqubo igcwala kunye fatty ukuba glucose.

Ichiza, nokugcina eliqhelekileyo lweenkqubo pathways kakuhle iphembelela amalungu neurosensory nentliziyo, kunciphisa ubungqongqo ukuhlukunyezwa transmembrane ion flow kuphuhliso ischemia. Owenza inwebu intliziyo, ichiza kunciphisa izikhombisi enjengokufuduka kwabantu, afunxwe neutrophils polynuclear. Ethetha isiphumo iziyobisi "Trimetazidine-Biocom MV" umyalelo manual iquka data labamele nempembelelo entle myocardium sele yonakele yi ischemia. iziyobisi Hemodynamic engafanelekanga impembelelo.

Pharmacokinetics

Absorption kwenzeka phantse ngokupheleleyo kwaye ngokukhawuleza. Unxibelelwano kunye iiproteni plasma nganto (16%), izinga bioavailability yi-90%. Ngu ukwamkelwa amacwecwe de kube mzuzu xa umgangatho into esebenzayo umzimba eliphezulu, nangabo malunga neeyure ezimbini. Yinto eyaziwayo ukuba ichiza udlula lula nge imiqobo ngegazi-kwithishyu. Half-bomi oluqhutywa malunga ezintlanu iiyure. Ichiza emzimbeni isuswe nezintso, uninzi oko akuthethi ukutshintsha isimo sayo.

ubungqina

"Trimetazidine Biocom-CF" (tablets) yokufundela kusetyenziselwa ukuphumeza unyango isifo elide. Injongo yayo kuboniswe kwezi meko zilandelayo:

• imfuneko ukuphumeza amanyathelo othintelo xa isahlakalo yokuhlaselwa angina;
• isiyezi, ubukho apho lu dityanisiwe izilonda nemithambo;
• cochle-vestibular ukuphazamiseka ukuba indalo kobuchopho (ukonakala wokuva);
• izifo chorioretinal semithambo, ekhatshwa ischemia.

angina prophylaxis zingenziwa ngokusebenzisa ichiza elinye okanye ngokusebenzisa unyango ezintsonkothileyo.

Izimo

Ngokuphathelele Kwiimeko apho kunganqwenelekiyo ukuba ukuthatha amayeza "Trimetazidine-Biocom MV" umyalelo manual, ncomo idata ebonisa nakwenzeka amayeza imithi yile ithi:

• uvakalelo kakhulu ukuya ingxenye main kunye nezinye izithako iindlela;
• lwebele;
• ngexesha nabantwana.

Ekubeni nokhuseleko ukusetyenziswa kweziyobisi ebantwaneni (abaneminyaka engaphantsi kwe-18) kunye ukusebenza konyango kunye nokusetyenziswa yayo iye ayasekwa, ezifana izigulane oku kuthetha akayi elimisiweyo.

Amayeza contraindicated sesibindi yabonisa oluntu kunye ukusilela kwezintso, apho isalathisi ezifana ukucoca creatinine yehliswe kakhulu (yi ml-15 / min okanye ngaphantsi). Nje kuphela ukuba ukujonga izalathiso kunye Izimo zonyango kunye amathuba "Trimetazidine-Biocom MV". Iindleko nayo inamcebiso ukubaluleka xa ukhetha medicament ukuba unyango. On kuya kuxoxwa kamva.

unyango ngamachiza

ubukhulu idosi enye umiselwa ngugqirha (idla hayi ngaphantsi kwama-40 mg kodwa hayi ngaphezulu kwe 60). Kwiiyure 2-3 kufuneka enze indlela eso siwamkelayo umyalezo. Ubude unyango lusekiwe ngokwahlukeneyo izihlandlo ezahlukeneyo.

imiphumela emibi

Phambi unyango, kuyimfuneko ukuba aqhelane ngayo kunokwenzeka ezibi emva nokudla amacwecwe ephilayo "Trimetazidine Biocom-CF" na. Imiyalelo yokusebenzisa le ndlela, ngokusekelwe apho unyango uneziphumo ebezingalindelekanga ziquka nokwaliwa, libonakaliswa njenge amaqhakuvana silume kunye ulusu, nezinye esisabela ayikho eqhelekileyo umzimba. Ngexesha unyango, kwiimeko ezinqabileyo kakhulu, ezinye izigulane kufuneka isicaphucaphu, gastralgia ukugabha kwenzeka, ziphawuleka.

Amatyala libanda kakhulu ekuye esisigxina, kwaye kungenzeka kwazo akunakwenzeka. Ngenxa yoko yokudlula ithamo ekucetyiswa inokubonakalisa ukugungxula yobuso, hypotension.

oyi

Unyango nto ayikuthinteli ukukwazi ukuqhuba kwaye akuyiphazamisi benze imisebenzi ekwenzeni leyo ifuna reactions ngokwasemzimbeni kunye lengqondo ngokukhawuleza.

Iipilisi ayifanelekanga ukuba isetyenziselwe lokuphelisa yokuhlaselwa angina kwaye zingasetyenziswa kuphela iinjongo othintelo zizigulane abaphethwe kuhlaselo.

Unyango kwezigulane nesifo sentliziyo linciphileyo imfuneko mihla le nitrate.

Iindleko analogue iziyobisi, ncomo

Kufuneka kufundwa phambi kokuba unyango lithetha "Trimetazidine" umyalelo manual. Ixabiso lona ulwazi olubalulekileyo uze uthathe ingqalelo xa ukhetha ichiza yonyango (prophylaxis), iingxaki intliziyo (kwemithambo). Iindleko eyiyona ichiza 100-165 engange. tablets 30 189-208 engange. tablets 60.

Ixesha kwiwotshi yamanani kanga "Preductal", "Antistius" okanye "Trimethyl". amachiza onyango kunokwenzeka "Medarum", "Rimekor". Ugqirha angafaka endaweni amayeza ngokumisa "Prekard", "Angiozyme", "Trimitard MV". Kukho ithuba kokunyanga "Tridukardom", "Predizinom", "Trimektalom" okanye "Metagardom". Xa kwayo, ixesha kwiwotshi yamanani kakhulu ethandwayo "Preductal" Eli chiza kakuhle, kodwa iyabiza ngaphezu "Trimetazidine". Imiyalelo zokusetyenziswa, ixabiso kubonisa ukuba unyango ngamachiza luluncedo, uhlolo ukuqinisekisa ukusebenza kulo unyango.

Xa uphononongo lokuba medicament Kuvakala ukuba ichiza kakuhle ishenxisa intlungu entliziyweni, lenza umsebenzi walo ngokugqibeleleyo. Ngenxa esithathwa xa izigulane kunye noogqirha, zimakishwe nguqu zintle, umz, umzimba labantu abafumana unyango, ukuqonda ngcono umthambo. Abantu abaninzi bathi ukuba emva kweentsuku ezimbalwa onyango baphulukana dyspnea, tachycardia kuthatha indawo, buyela uxinzelelo lwegazi eziqhelekileyo. Ngokuqhelekileyo bebonisa intuthuko ngomhla wesine unyango, ngokusekelwe sebenzisa kwemali "Trimetazidine-Biocom MV". Imiyalelo zokusetyenziswa, ixabiso ibonisa ukuba iyeza ifumaneka nje kuphela kodwa esebenzayo, ukongeza, na inani ubuncinane abasabela kunokwenzeka ekunzima abadli ukuphuhlisa. Ukuvela iziphumo ebezingalindelekanga waphawula kwiimeko ezinqabileyo.

Ngoko ke, siye sikunike inkcazelo eneenkcukacha malunga ichiza "Trimetazidine-Biocom MV". Analogue, ixabiso, isikhokelo, ukubuyekeza amayeza zaziwa ngoku kuwe. Ichiza kufuneka kuqeshwa ingcali yaye wabasebenzisa ukumisela umthamo. Imfuno nokutshintshwa medicament njengoko kumiselwe yi igqirha ngokusekelwe kwizinto ezininzi. Le miyalelo likuvumela ukuba wenze unyango isebenzayo ngaphandle yokwenzakala.