Tablets "fenigidin": imiyalelo, real

Yintoni na amayeza kwakuthetha "fenigidin"? Imiyalelo zokusetyenziswa nesixhobo sonyango, Izimo yayo, iziphumo ebezingalindelekanga kunye analogs zichaziwe ngokucacileyo kweli nqaku. Ukongeza, uya kufunda xa kunikwa ichiza (kubonakala), ziziphi idosi kufuneka athathwe, oko bathi ngayo, izigulane kunye noogqirha.

Ukubunjwa kunye nefomu yokhululo iziyobisi

Drug "fenigidin" enokufunyanwa Pharmacy ifomu ipilisi. Ba camera kwaye ziqulathe isithako esebenzayo ezifana nifedipine. Xa intengiso arhente lonyango unikelwa kwibhokisi ibhokisi, apho kunokuba noba zithutha-40, okanye 50.

Kwakhona bahlola medicament ezinokuthengiswa njengesisombululo yolawulo efakwa okanye intracoronary. Eli chiza iqulathe esisebenza efanayo cwecwe.

iimpawu kwemithi zamachiza

Yintoni na ichiza 'fenigidin'? Imiyalelo zokusetyenziswa ichiza ithi ukuba a uyakhetha calcium channel blocker iklasi 2, kunye dihydropyridine nezakhi.

Indlela yokusebenza kweli chiza kukuba ukucola calcium ukungena kwiiseli ze ezinemigca agudileyo izihlunu kunye cardiomyocytes. Amayeza uyakwazi ekuphembeleleni i iqinile kunye neziphumo antianginal. Kwakhona uyakhula neuropathy kunye nemithambo yenhliziyo, lihlisa nethoni ezityeni, kunciphisa uxinzelelo lwegazi, ukumelana systemic semithambo, contractility engabalulekanga, imfuno entliziyweni izihlunu oksijini kwaye yehlise afterload entliziyweni. Ukongeza, ichiza iphucula kakhulu ukuhamba kwegazi sentliziyo.

Tablets "fenigidin 'abe umsebenzi encinane okanye akukho anti-arrhythmic. Ngaphezu koko, akukho musa zisidimaze Uhanjiso engabalulekanga.

Pharmacokinetics beziyobisi

ako Apho iziyobisi "fenigidin"? Imiyalelo isicelo ithi emva kokuba senziwe iipilisi zibe ngeempahla zabo esebenzayo ako ngokukhawuleza ukusuka lokugaya. Ichiza umzimba esibindini. Oku kwenzeka xa "yokupasa yokuqala", nto leyo uluhlu lwe metabolites engasebenziyo.

protein medicament ndibopha nama-92-98%. Kwisiqingatha ubomi ithatha malunga 2 h.

Ihamba into neziyobisi metabolites ekwimo unmodified (ngezixa umkhondo) ikakhulu nezintso. Kwakhona, ichiza imveliso ngokusebenzisa emathunjini (malunga nama-20%).

Ubungqina obubonakalayo buxela ukuba ukusebenzisa amayeza

Ukuba kukho oogqirha ezinxaxhileyo amisele izigulane zabo neziyobisi "fenigidin '? Ukusetyenziswa kweli chiza eboniswe kule miqathango ilandelayo zophendlo lwezifo:

• ukuze kuthintelwe nemivumbo, kuquka angina vasospastic;
• ngokuba ukukhululeka angina;
• e wesimo unesifo;
• umfutho wegazi;
• isifo Raynaud kaThixo.

Izimo ukusetyenziswa iyeza

Kwezinye iimeko, xa kungekho tyala kufuneka kwenziwa kwisigulana ichiza 'fenigidin'? Imiyalelo yokusebenzisa le amacwecwe phantsi ingqalelo ithi ukuba contraindicated kwi zokwahluka zilandelayo:

• uthuke cardiogenic;
• emithanjeni hypotension (iSystolic uxinzelelo lwegazi xa sele ezixabisa ngaphantsi kwe-90 mm HG ..);
• e stenosis kakhulu aortic;
• ngexesha nciphisa;
• ukuhluleka ezinzima;
• ukuba isigulane sine-uvakalelo bhetele ukuya element esebenzayo ezifana nifedipine.

Iindlela isicelo kwaye umthamo ichiza

Ichiza "fenigidin" xi emiselweyo kuphela kwizigulane ngabanye. Kuba ulawulo ngomlomo idosi yokuqala ka-10 mg kane ngemini.

Ukuba oyifunayo, umthamo amayeza ebegqwese ukwanda. Kulo mzekelo, idosi bekuya kuba 20 mg kane ngemini.

Kwiimeko ezithile lwezonyango (umz, lobeko angina, okanye kakhulu hypertension) ixesha elifutshane ixesha uvumelekile ukunyusa ithamo ngamachiza kwi-30 mg kane ngemini.

Ukuze sibophe ntlekele unesifo, kwakunye angina, ichiza ingasetyenziswa non-ngomlomo kunye sublingually. Kule meko ibhalwa isixa 10-20 mg (ngamaxesha ambalwa 30 mg).

Kuba ukukhululeka lentlekele unesifo kunye angina medicament esebenzayo maxa wambi ilawulwa yegazi (mg-5 iiyure ezingaphezu 4-8).

bolus Intracoronary of sisombululo iziyobisi ezilawulwa 100-200 mg. unyango olunjalo ngokuqhelekileyo luqhutywa ukuze ukususwa ahlekise inkantsi kwemithambo. stenoses nemithambo oyidlayo yokuqala kufuneka ube malunga 50-100 micrograms.

Le idosi iphezulu yemihla ngemihla ingqalelo sithi medicament phezu nokudla 120 mg. Ukuze ulawulo efakwa, umthamo wayo mayingagqithi 30 mg.

imiphumela emibi ichiza

Isisombululo efakwa and tablets "fenigidin" kungabangela iqela elikhulu yeziphumo ebezingalindelekanga. Loluphi uhlobo cinga ngoku:

• nemithambo yegazi: asystole, ukuthoba eluswini, tachycardia, ventricular, imvakalelo ubushushu, ukwanda ukuhlaselwa angina, tachycardia, nokudumba peripheral, hypotension, bradycardia.
• Neuropathy central system luvo: intlungu kwezihlunu, intloko ebuhlungu, ukuphazamiseka ezibonwayo ukukhanya, paresthesia, ukuphazamiseka kokulala kunye lafa.
• Ukwetyisa: utyatyazo, isicaphucaphu, isibindi zisiba, hyperplasia of seentsini. Ukuba usebenzisa ichiza ixesha elide kakhulu, kwaye ngokwemithamo eziphakamileyo, kusenokubakho ukuqunjelwa, cholestasis intrahepatic kunye transaminases zesibindi eziphakamileyo.
• inkqubo hemopoiesis: thrombocytopenia kakhulu kunqabile saphawula kunye leukopenia.
• Ezingokuqandusela System: gynecomastia akufane waphawula.
• inkqubo wokuchama: ukwandisa imveliso umchamo ngemihla. Ukuba uthathe ichiza ixesha elide kwaye ngokwemithamo eziphakamileyo, kusenokubakho kukwaphula nezintso.
• Umzimba: irhashalala.
• reactions Local: ukuba bafake ichiza butofelwe, kunokwenzeka ukuba uvutha kuyo inaliti.

Umntu akufuneki silibale ukuba umzuzu omnye emva ulawulo intracoronary, isigulane babonakale iimpembelelo ezingalunganga inotropic of nifedipine kwaye ukwandisa izinga lentliziyo kunye noxinzelelo lwegazi. Ezi mpawu uphela ngokuphela emva malunga 8-15 imizuzu.

Ukusebenzisana kweziyobisi kunye namanye amayeza

Ngaba thina, kunye namanye amachiza ukuba uthathe amayeza "fenigidin Impilo"? Imiyalelo livalelwe kumqulu elumkisa ukuba impilo yabantu ukuze kube kubi kakhulu xa sicinga ukuba basebenzise amayeza kakuhle. Kulo mba, phambi kokuba ulwamkelo sicebisa ukuba udibane nogqirha wakho.

Xa isicelo ngexesha elinye-of womchamo, iiarhente umfutho nezakhi phenothiazine kwengeniso umfutho of nifedipine.

Ukusetyenziswa ngaxeshanye kweziyobisi anticholinergic kunokulungiswa ingqalelo kunye memory kubaguli pre-retirement kunye yobudala yomhlala-phantsi.

Ukuba ngexesha elifanayo ezithatha ichiza kunye beta-blocker, ngoko loo mntu aphuhlise kakhulu esimbaxa hypotension, kwaye kwezinye iimeko - kunye nokungaphumeleli intliziyo.

Ukusetyenziswa ngaxeshanye ngezithako kwandisa iziphumo antianginal of nifedipine.

Ezilahlwayo reception calcium unciphisa ukusebenza kakuhle element esebenzayo. Oku esidityaniswe yokusebenzisana zingavisisani ngenxa yokwanda lwee- ion icalcium kulwelo ekuthiwa-extracellular.

Aziwayo amatyala ubuthathaka dystrophy, nokudinwa jikelele ngexesha uthatha ichiza kunye neetyuwa wemagniziyam.

Ukuba usebenzisa "fenigidin" kunye digoxin, oko kungacothisa ukushenxiswa yokugqibela ukususela emzimbeni, nezithi ke ngoko zibe ngenxa ukwanda eyavela egazini.

A ngexesha elinye-ithamo amayeza kunye diltiazem kuphucula umfutho.

Ukusetyenziswa ngaxeshanye theophylline kusenokwenzeka ukuba kutshintsha uyondelelwano lwee- kubemi plasma yegazi.

into rifampicin ekwaziyo ngokuphembelela umsebenzi enzyme zesibindi nokukhawulezisa yokucolwa of nifedipine, nto leyo ekugqibeleni kukhokelela ukuhla kakhulu ngempumelelo yayo.

Ukuba ukusetyenziswa kweziyobisi ngaxeshanye kunye phenytoin, phenobarbital kunye carbamazepine, amathuba sibenza uyondelelwano lwee- iziyobisi esebenzayo kwi plasma yegazi.

Kukho iingxelo ezininzi yokwanda nifedipine boxinzelelo plasma kunye nokwanda AUC yayo isicelo esisodwa kunye itraconazole ne-fluconazole.

Ukuba uthathe ichiza kunye fluoxetine, kusenokwenzeka ukomeleza iziphumo ebezingalindelekanga nifedipine emzimbeni womntu.

Kwiimeko ezinqabe kakhulu, ukusetyenziswa ehamba iyeza kunye quinidine kunciphisa uyondelelwano lwee- yokugqibela egazini kwaye susa ichiza - ukuyandisa ngokubonakalayo, leyo, Kakade ke, igalelo isongezo QT lokuphumla phezu electrocardiogram.

izinto ezifana esebenzayo njengoko ranitidine kunye cimetidine, maxa wambi kwandisa lwee- nifedipine egazini, ukwandisa impembelelo yayo umfutho.

Amayeza eziqulathe utywala kunokwandisa iimpembelelo nifedipine, ebangela isiyezi kunye nezinye ngayo elibi.

Medicine "fenigidin" ngethuba lokukhulelwa zisanyisa

ezilawulwa ngokungqongqo kunye nezifundo ukhuseleko olwaneleyo element esebenzayo ezifana nifedipine ngethuba lokukhulelwa alubanga. Ngoko ke, sebenzisa ayikhuthazwa eli chiza ngexesha yokumitha.

Ngenxa yokuba nifedipine iyekelela kunye nobisi sikanina, umele akuphephe ukusetyenziswa kwayo ngexesha lwebele-ekondleni usana okanye uyenze ukuze ayeke zisanyisa.

Izifundo zovavanyo lubonisa iziphumo embryotoxic, foetotoxic kunye naMahlathi of nifedipine emzimbeni eli bhinqa.

Analogs medicament

Ichiza singavalwa "fenigidin"? Analogue esi sixhobo ziyafumaneka kuzo zonke kwiikhemesti. Phakathi kwazo kukho ezi amayeza zilandelayo: "Adalat", Sponif "," Vero Nifedipine, "" Sanfidipin "," Zanifed "," Osmo-Adalat "," Kaltsigard kunamandla "," Nifecard "," Kordafen "," Nifelat " "Kordafleks", "Nifedipine", "cordipin", "Nifedikor", "Corinfar", "Nifedikap", "Nikardiya", "Nifedeks", "Nifadyev", "Nifegeksal", "Nifebene" kunye nabanye.

Yabela ezi mali kumele ugqirha kuphela.

Medicine "fenigidin": Ukubuyekezwa koogqirha kunye nezigulane

Iingcali qaphela ukusebenza "fenigidin" iziyobisi. Ngokukhawuleza kuwukhulula angina, kwakunye inceda iingxaki unesifo, isifo Raynaud kaThixo, kunye noxinzelelo lwegazi. Noko ke, phezu inxalenye izigulane, zininzi izinto ezingakhiyo ngale ukulungiselela. Ngokutsho kwabo, nto ibanga iziphumo ebezingalindelekanga ezininzi. Eyona kubonakaliswa sivame nobuhlungu bomzimba kunye nesiyezi. Noko ke, oogqirha bathi ngayo ezinjalo kunokwenzeka kuphela xa isicelo olungachanekanga ichiza. Kule nkalo, kufuneka isetyenziswe kuphela phantsi kweliso oyingcali, ingakumbi xa ogulayo iqhosha etsolo engabalulekanga, okunzima ejikeleza yobuchopho, isifo seswekile, ukuphazamiseka wesibindi, nezintso, kwakunye lwegazi okubulalayo hypovolemia.