T-cell lymphomas: iintlobo, iimpawu, uxilongo, unyango kunye abane

lymphomas T-seli sivame ukuxilongwa kwizigulane ebudaleni ikwandim, kodwa ulutsha kunye nabantwana ithambekele sifo. Ke amadoda ubunzima kuso kaninzi ngaphezu abafazi.

Yintoni i-lymphomas T-cell

Lymphoma - abulalayo sisilonda esidumbileyoesingaphakathi lymphoid inyama kunye namanye amaziko. Kwimeko ka-T-cell lymphoma, esi sifo sichaphazela ulusu kunye nkovu ezalathelwe (okt ekuthethwa epidermotropny). Iziqalelo ezingundoqo abandakanyeka kukuvela neoplasms ezi T-lymphocyte (iiseli ngokuqhelekileyo ukunika impendulo eyaneleyo omzimba). T-cell lymphoma (umfanekiso eboniswe ngezantsi) ukuze kwakheke ngenxa ukuqokelelana yethishyu zophendlo lwezifo izinto cellular.

Oonobangela kunye nezinto ezinegalelo

• ufuzo
• Immunodeficiencies.
• exposure engapheliyo imiba ezibi: imitha yelanga, arhente silwe imichiza.
• Age umba (izigulane abadala).
• Ubukho iintsholongwane kwi ephilayo (HIV, Epstein-Barr, hepatitis C, B, T-lymphocyte virus), isifo emathunjini.
• Ukubakho izakhi kwi inkqubo yomzimba yokuzikhusela, organ kunye izihlunu abohlukeneyo, immunosuppressive therapy ukuqeshwa.

Zonke ezi zinto zibe mandundu (ngokulandelelana, musani ukubacaphukisa uphuhliso sifo), uxinzelelo, ukungondleki, nomthwalo luvo, ukungaphumeleli ukuthobela urhulumente yokuphumla kunye nomsebenzi.

ngezigaba

• T-cell lymphoma ulusu. lymphomas ezifanayo ngokuqhelekileyo ukuphuhlisa ngenxa izakhi ezahlukeneyo lymphocyte T, ekhokelela phindo kwamalweyile ngendlela yokugqibela kwaye, ngenxa yoko, sisebenza nabo ngomaleko sangaphandle. Luphawulwa uhlobo asebenzayo polymorph yabangxamayo lymphomas ukwenzeka (nebhodi, nangezilonda, amabala, kumadyunguza). Kwaye ke kwizigulane zokuqala ezikhala isenzeko eso okanye sirhawuzele amabala, ekugqibeleni zibe umonakalo, yaye kamva kwi nakujoliso olutsha ithumba.
• Neuropathy T-cell lymphoma. Le ibandakanya zonke lymphomas ukuba T-iseli okanye NK-cell imvelaphi (ngaphandle neoplasm of ubuntwana T-iiseli kunye leukemia T-lymphoblastic). Lidla ezi lymphomas zenzeka kunye nezilonda igazi, ulusu, lomongo wethambo kunye enyama yangaphakathi, yaye kwiindawo nkovu, kuyenye utshintsho infiltrative waphawula.
• Angioimmunoblastic T-cell lymphoma. Ebonakalisa njengoko ngokulitywina lymphoid zomzimba (ngethuba loviwo histological of nodes nkovu) immunoblast plasma iiseli, kunye inguqu ezilandelayo olupheleleyo ubume bawo kwaye ukuyilwa imithambo yegazi engaqhelekanga.
• T-cell lymphoma lymphoblastic. Novobrazovanie, olusekelwe ezingaqhelekanga iiseli T. iiseli T yona ayivuthwa, abayingxenye yabo uba rhoqo imilo, baza ngokukhawuleza angalawuleki bawe. Wadibana olu hlobo lymphoma kunqabile. Ukuba ngaba wehlelwa efanayo umahluko uphethwe wegazi oyingozi.
• Non-Hodgkin i-T-cell lymphoma. It limela iqela elikhulu yamathumba ukuba iqanjwa aqolileyo T-lymphocyte yaye akayi zinxulumene sisifo Hodgkin kaThixo (ngamanye amazwi, isifo Hodgkin i-). Yelo qela zigqitywa iimviwo histological (kunye chlamydia e Ukulungiselela ibhaqhe izinto ezithile cellular Berezovsky-Sternberg kwi-lymphomas non-Hodgkin kaThixo none).

isigaba yophuhliso

1. Ekubulaleni omnye nkovu node.
2. Ukusasazeka ithumba ukuya kwiindawo ezimbini nkovu ukuba ibekwe kwelinye icala uvalo.
3. izakhiwo nkovu Multiple kumacala omabini uvalo.
4. iindawo nkovu kunye enyama yangaphakathi, ubukho metastases kwi izintso, lomongo wethambo, isibindi okanye amaqumrhu iphecana zesisu.

iimpawu ngokubanzi

Ubukho okanye ukungabikho izinto ezithile zonyango kuxhomekeke kuhlobo thumba kunye nendawo yayo. Noko ke, zikho iimpawu ezithi ezendeleyo phantse yonke T-cell lymphoma:

• Ukubila ebusuku.
• Rapid ilahleko lokulinganisa nasihlahla.
• fungoides Mycosis.
• ukusebenza elisezantsi grade-in lobushushu emzimbeni.
• fatigue rhoqo nokunganaki.

fungoides mycosis

fungoides Mycosis - enye mpawu osetyenziswe okuluphawu T-cell lymphoma. Efunyanwa kulo asixhenxe ekhulwini lezigulane nesi sifo, kwaye iintlobo ezintathu: weklasiki, ikhanda kunye erythrodermic.

fungoides mycosis Classical udlula ngezigaba ezithathu zophuhliso:

• Erythematous - elingephi zonyango ezifanayo ukuba ukhwekhwe, nangokhwekhwe njalo njalo. Izigulane ingxelo ubukho amabala seqanda okanye setyhula, elintlangothi ezibukhali, ezinobukhulu obahlukileyo, kunye epinki-nemisonto umbala kunye enamaxolo komhlaba. izinto ezinjalo badla khona phezu kobuso kunye umntla, ngokwenyusa kancinane kangangoko watyhutyha ezinye izabelo. izilonda ezinjalo musa ukuphendula kunyango kwaye ayikwazi kuqhutywa ixesha elide, okanye ngesiquphe zinyamalale. Ngaphezu koko, amabala zinokudityaniswa kunye ukurhawuzelela, nto leyo wayeka ngendlela eqhelekileyo.
• infiltrative zineengxaki - kwenzeka emva kweminyaka embalwa abaqala kuyo. Xa indawo umonakalo amabala ngasentla kunye nemida ashinyeneyo, esondezwe okanye nepravilnymi kodwa ecacileyo, purple kunye bechuba phezu komhlaba. Xa isayithi ye-umonakalo ezingekhoyo iindawo brown okanye yome solusu. ukhula ukurhawuzelelwa, oko nodandatheko. Kukho ilahleko ubunzima ngokukhawuleza, nangecesina, lymphadenopathy ukuze sibekho.
• Ithumba - on-site okanye umonakalo kwi eluswini kukho lingatshitshi imbonakalo ashinyeneyo ebomvu natyheli yalula uhlobo ithumba ukulenza okanye atshabalalisa kancinane imilo, ngokungathi umnqwazi mushroom. Netoti kwiziseko ezinjengezo isusela ukusuka milimitha omnye ukuya kumashumi amabini, kwaye inani zinokuba nomahluko. Xa Ithumba ibhuqiwe, izilonda ezibuhlungu abunjwe endaweni yayo, ubunzulu apho ukufikelela ifascia okanye ithambo. Amaninzi luchaphazela udakada, iindawo nkovu, imiphunga kunye zesibindi. ukunxila Narostaet wakhe ube buthathaka. Izigulane kufa ukwehluleka kwentliziyo, amyloidosis, inyumoniya.

ifomu Eritrodermicheskoy luphawulwa ukuvela narostaet ukurhawuzelela kabuhlungu, ububomvu kunye ukudumba, imbonakalo confluent erythematous-carcinomas amabala, hyperkeratosis yomphantsi kunye neentende, kwakunye ukulahleka iinwele. Banzi zonke iindawo nkovu kwi axillary, inguinal, femoral kunye neendawo cubital. Xa afumaneka plotnoelastichnye Ngokucofa yalula iipakethi nkovu hayi soldered ukuba ancedisana ezingqongileyo (kwesikhumba). Lihodradka waphawula (ukuya degrees 39), ukwehla kobunzima, ukubila ebusuku nokudinwa. isiphumo ebulalayo kunokwenzeka xa ukudibanisa kwandisa ukunxila kunye nokungaphumeleli intliziyo.

Phambi ifomu ikhanda kwisikhumba okunempilo kukho umonakalo ezininzi, ekugqibeleni ekufumaneni harater amabi. Ukufa kwenzeka izigulane kungekapheli nonyaka.

obubonakala kwezonyango lymphomas cutaneous

T-cell lymphoma ulusu kaninzi kwenzeka sizoku lwisana unyango elide-ezikhoyo engafanelekanga kwezifo dermatological. Ukubangela ukwenzeka zikwazi herpes virus, imitha, tikaka njalo njalo. lymphomas efanayo kwenzeka ngamanqanaba amabini: lokuqala (inkqubo yenzelwe kwi dermis), aphakamileyo (xa kolusu le zibangelwa lymphocyte afunxwe izibilini).

Iimpawu eziphambili zezi:

• irhashalala isikhumba Polymorphic.
• Ukunyuka ukurhawuzelela.
• Ukubakho, izinto tyaba encinane ifomu nodular.
• Inkangeleko umonakalo tyheli, kamva zibe iindima hyperpigmentation kunye yoma (ifom xa nebhodi).
• Lo mfanekiso kwezonyango efana ukhwekhwe (at uhlobo melkouzelkovoy).
• Womile, ukudumba, ububomvu kunye iyaxobuka ulusu (kunye uhlobo erythrodermic sifo).

Symptomatology of lymphomas peripheral

isifo Clinic ixhomekeke eqongeni kunye nohlobo inkqubo yezifo.

Ebalasele ukwanda yethishyu lymphoid kwimimandla entanyeni, nasemiphakathweni kunye axillary.

Izigulane ezikhala ukubila ngokugqithisileyo, kakhulu ukwehla kobunzima, ukungabi namdla wokutya, ubuthathaka jikelele, ifiva, kwaye kukho udakada zikhulisiwe kwesibindi (leyo yinto exhaphakileyo) - xa ukuphelelwa umoya, ukhohlokhohlo nezolo kunye nokuboniswa ubunzima esiswini.

ekuxilongweni

• Ukuhlolwa, ukuqokelelwa kwezikhalazo kunye anamnesis somdlavuza.
• igazi jikelele kunye nocazululo nomchamo.
• Blood eziphilayo, kwakunye uvavanyo antibodies iintsholongwane hepatitis.
• A biopsy le nkovu node umonakalo (ekuvumela ukuba uqinisekise lokufunyaniswa T-iseli lymphoma).
• US.
• MR.
• CT.
• umzimba Onkoskrining.
• isifundo Immunofenotipirovannoe.
• wasiqwalasela Ezinto yemfuza.
• Uhlalutyo Cytogenetic.

therapy

Unyango T-cell lymphoma ixhomekeka kwifomu ze nqanaba lenkqubo.

Umzekelo, ukuba fungoides Inqanaba mycosis erythematous therapy anticancer olulodwa andiyimisanga, kwaye corticosteroids engaphandle kunye interferon iyasetyenziswa.

Olona nyango anti-Ithumba ukwenza ichemotherapy kunye radiotherapy.

Ngokuhambelana luhlobo sifo (odangeleyo, ndlongondlongo, kwaye silwe kakhulu) umiselwa ubude kunye nokwakhiwa unyango, kunye nokubuyiselwa kwimo yesiqhelo.

lymphoma odangeleyo ke sithi singanyangwa, kodwa kuphela waphawula rhoqo xa le nkqubo iqhubeka, amaqhinga kutshintsha.

Xa unyango iifom ngxwaba ukusetyenziswa indibanisela iziyobisi chemotherapeutic kunye Rituximab (omzimba monoclonal).

Xa kuziwa kwi-lymphomas ndlongondlongo kakhulu, amisele amachiza asetyenziswa unyango leukemias ahlekise.

Lidla ichemotherapy kudityaniswe cell stem abohlukeneyo.

Noko ke, unyango ngokukuko lymphoma kukuba ukuqhuba kwanonyango radiation ezingamashumi amathathu (njengoko kuchaziwe kwi Elekta Synergy), yaye emva kokufumana arhente chemotherapeutic.

Iingxaki abafumana agents chemotherapeutic kungabandakanya: umphunga, isifuba, njalo-njalo. therapy Imitha kube nzima kuphuhliso yamafutha coronary.

Emva unyango ngempumelelo yinto yesiqhelo enyanzelekileyo.

T-cell lymphoma: sase-

• Xa ubhaqo ngexesha esi sifo (isigaba sokuqala) kunye nokunikezelwa zonyango elingama seminyaka emihlanu-eyaneleyo asibhozo anesihlanu ekhulwini, kwaye izigulane yabantwana - ukuya kumashumi alithoba ekhulwini.
• Ngokuphathelele lymphoma angioimmunoblastic kuqikelelo yedanisayo. I-avareji bempilo nezigulane unesifo esinjalo amabini kuphela kwaye enesiqingatha - iminyaka emithathu. Umlinganiselo wokuqhothoza kuphela isinye kwisithathu izigulane kufuneka kwisithuba seminyaka emihlanu.
• Phambi ifomu T-lymphoblastic ALS kuxhomekeke kubukho / engekho sisilonda esidumbileyoesingaphakathi le umongo wethambo. Ukuba wamathambo kakubi, isiphumo idla intle. Kungenjalo, ukuphuculwa ekhulwini amabini kuphela izigulane kungalindeleka.
• Abantu abane kunye basinde mushroom avium ixhomekeka kwifomu ze nqanaba lenkqubo. Ngoko, xa ibha ukusinda ifomu - ukuya kutsho kwiminyaka elishumi, kunye ALS esibi kwimeko ukulawula yinyumoniya, njalo-njalo; ifomu eritrodermicheskoy sorovozhdaetsya wokujoyina iingxaki ezahlukeneyo ezibangela ukufa kwenzeka kwisithuba emibini - kwiminyaka emihlanu; ngelixa uhlobo ndiyakuthanda of a ALS ihlwempu, ukufa kwenzeka kwisithuba esingangonyaka.