"Sodium dichloroacetate": ukwakhiwa, izimvo kunye nemiyalelo yokusebenzisa

Ngenxa izazinzulu ukusuka University of iziko Alberta lwasungulwa eKhanada, koyiswe umhlaza. It zingaphunyezwa kuphela ukusebenza sisifo ayo baye bacinezelwa. iziyobisi ceba "sodium dichloroacetate," ngokutsho izazinzulu, ukuba ukuhlangabezana nale ngxaki kunye nzima kunye neentlobo ezininzi zomhlaza.

uphawu iziyobisi ingakumbi sisebenzayo ekulweni umhlaza wemiphunga, ingqondo kunye nesifuba. Buyela kwi-30 zenkulungwane yamashumi amabini, izazinzulu ziye zagqiba ukuba ukungaqheleki esebenzayo weeseli mitochondria kunokubangela zomhlaza. Mitochondria ezi organelles ebalulekileyo iseli ephilileyo, kude kube ngoku, izazinzulu babekholelwa ukuba intshabalalo yabo - asiyiyo unobangela somhlaza, kwaye isiphumo. Ngoko ke, ukususela ngo-2005 Michelakis ngubani yathandabuza lo mbono, uvavanyo waqalisa umsebenzi phezu molecule sodium dichloroacetate.

izifundo Laboratory ichiza

iimvavanyo zaselebhu neemvavanyo kwizilwanyana zibonise ukuba ichiza "dichloroacetate sodium" yi isilumeki enqanda ayo ukuba zicinezelwa ngenxa yokuba ezinye izifo kungakhathaliseki uhlobo lomhlaza. Ukuncitshiswa ziiseli zomhlaza kuzuzwa normalizing imisebenzi organelles. Ichiza yahluke kakhulu ukusuka ichemotherapy ukuba awunatyhefu yaye akenzi bamcudisela kwiiseli esempilweni malunga nesigulane eso.

UNjingalwazi Michelakis uphawula ukuba nsimbi iziyobisi equlethwe imveliso, kwenza kube lula ukujongana ntlobo zomhlaza, ngaphandle sarcomas. Imithi nefuthe kwimfundo ngumhlaza, zibe abachatshazelwa ngamanye amayeza. Osisiqu esinye isiyobisi asisiso nayiphi na iinkampani zamayeza, ngoko ichiza ayikho lomenzi. Oku kwamchaphazela kabuhlungu nakho kwakhe.

imifuniselo Laboratory wabonisa ukuba ichiza, ephindezela iziphumo ukulawula kwiiseli umhlaza ngaphandle kokuchaphazela usempilweni ngexesha elinye kumalungu omzimba.

ukuba uqale nini ezithatha ichiza?

Kubaluleke kakhulu ukuba unyango lomhlaza lithetha "Sodium dichloroacetate" ukuthatha xa imeko umzimba nangoku eyanelisayo. Musa ukulinda ukuba indlela ezagxila nechemotherapy, nto leyo eye obonakalisayo ebalulekileyo. Ukongeza, iiseli umhlaza badla ukumelana nezifo kwimichiza. elide sele kudlule amagqirha waphawula. kuqala izifundo ezimbalwa ichemotherapy waba nempembelelo entle ekuhambeni esi sifo, elandelayo, phezu koko, olungasebenziyo. Ngoko ke, ichiza kufuneka aqale ukuthatha ngokukhawuleza kangangoko kunokwenzeka, nkqu kunye nezifundo of chemistry. Nangona kunjalo, umthamo mayingagqithi 15 mg 1 kg ubunzima nganye.

Ukulungiselela "sodium dichloroacetate": isakhiwo

Ukubunjwa ichiza - i-sodium ityiwa dichloroacetic acid. Sol into ethile kwi ekwimo monohydrate, oko kukuthi i-12% - .. Water acacisa.

Izazinzulu kungoku ekukhangeleni iindlela zokunciphisa ubungozi beziyobisi ingqalelo nokusebenza kwayo ekulweni nomhlaza.

ichiza

Kuyimfuneko ukwazi, xa uthe wagqiba ukuthenga ichiza "sodium dichloroacetate." Indlela ukuthatha ichiza ukunceda ephilayo abagulayo, izazinzulu sele zichongiwe. Ngokusekelwe 1 kg ubunzima - 25-50 mg imini yonke. Ukusetyenziswa kweziyobisi iminyaka emibini-50 mg kunokubangela peripheral neuropathy, ngoko idosi idosi lancitshiswa ku-25 mg, nto leyo ekhuthaza ukumisa izenzakalo ezingemnandi.

Ukuba amachiza umthamo 25 mg nganye 1 kg ubunzima ebangela ukungacoleki kokutya, isicaphucaphu, antsi eminweni, ukuphefumla iingxaki (inokubangela ukuba ukudakumba, lafa, isiyezi, ukozela, Ukuchama rhoqo, ixhala), ithamo kufuneka incitshiswe ku-10 mg nganye 1 kg ubunzima bomzimba . Ngamanye amaxesha iingcebiso ngokubanzi ukuba ziyeke ukuthatha iintsuku ezimbalwa. Babuya ngoko ke kuyimfuneko ukuba babuyele idosi enye - 25 mg nganye 1 kg ubunzima bomzimba ngosuku. amatyala waphawula of citric acid, eyanika izenzakalo ukunciphisa peripheral neuropathy emva kokufumana ukulungiselela "sodium dichloroacetate". Imiyalelo ukusebenzisa imfuneko yaze yangxenga ifuthe lomanyano le medicament ingqalelo ngamanzi (100-150 ml). Oku kulula ukuyenza, ekubeni beziyobisi ingohlobo umgubo. Kufuneka uzame ukuthintela isikhumba ukuqhagamshelana imveliso - oko kubangele ubuhlungu.

Sebenzisa i ichiza lysis yamathumba

Ichiza kungabangela lysis yamathumba amabi, xa wegazi etsolo emithanjeni, lymphoma non-Hodgkin kaThixo, etsolo mielotsiticheskoy wegazi, umhlaza webele, cell carcinoma, leukemia ezondeleyo emithanjeni, umhlaza wamatyhalarha, cell carcinoma, medulloblastoma.

Lysis of ithumba ekuthiwa apoptosis ngokukhawuleza kakhulu iiseli zomhlaza (ukufa kweeseli), sikhatshwe kukwehla kabukhali nobume bempilo (kwiimeko ezizodwa, kunokubangela ukufa). Kwiimeko ezinjalo, kufuneka ngoko nangoko gxotha ichiza aze adibane nogqirha. Emva kweentsuku nje ezimbalwa, mhlawumbi, bavunyelwe ukuba aqalise ukusebenzisa iziyobisi, ngoxa kuncitshiswa umthamo.

Ulwazi malunga ukungavumelani iziyobisi lithetha "dichloroacetate Isiqalelo setyuwa" kunye nezinye iziyobisi ayikho ngenxa ezintsha layo (ngaphandle - amayeza "Lasix").

Sebenzisa ngaxeshanye iti kofeinizirovannymi, ngeedosi eziphezulu uvitamin B1, ukuhlanganiswa citric acid, coenzyme Q, kunye alpha-lipoic acid wongezelela ngempumelelo.

Ukusebenza ichiza

Ukusebenza medicament "sodium dichloroacetate" kuxhomekeke kwizinto ezininzi. Ngokuphawulekayo kunciphisa iimpawu zalo zonyango lwe imeko abaziintsizana isigulane. Ngokomzekelo, xa ngenxa yokugula abachaphazelekayo amalungu abalulekileyo, okanye intshabalalo yenzeka phantsi kwempembelelo kusetyenziswe amachiza. Kwakhona, musa bacebisa ukusetyenziswa kwemali, ukuba isigulane lingaphumi, rhoqo ziintlungu, yena uthatha iziyobisi.

Oku kunciphisa ukusebenza yokulungiselela kunye nesifo olomeleleyo boyise esibindini. Xa ungakwazi ukumelana iiseli ithumba abafileyo kunye neemveliso nokucazululwa eziwela kulo igazi, le meko kuba nzima ngakumbi.

Xa umthamo ukusebenza phantsi ichiza liphantsi, xa japan idosi enkulu iba buqapheleke. Kodwa kukho ezinye izinto eziyingozi. Maxa ngeedosi eziphezulu, kusenokunyanzeleka ukuba iimveliso kuwohloka ithumba kwesibindi sekunzima. Oku kuya kubangela ukunxila, isicaphucaphu nokugabha. Ngoko ke, lo idosi kufuneka zikhethwe ngokuchanekileyo.

ukuthenga phi?

Kuthekani ukuba umntu athenge ichiza "sodium dichloroacetate"? ukuthenga phi? Ekhoyo ingqalelo ichiza e Canada, ukuze ingayalela usebenzisa i Internet amacebo ukususela abalimi. Kukho kwakhona ithuba ukuthenga nabathengisi beziyobisi eRashiya, ukuyithenga eKhanada. Ixabiso iyeza ayikho phezulu, ngoko uyithenge ungamelana izigulane ngoweqela iyaxela ezahlukeneyo kwezentlalo.

Izimvo kulungiselelwa

Imiphumo emihle ichiza "sodium dichloroacetate" leyo ngokutsha ukuqinisekisa oko, ingalandwa kwizigulana ezininzi umhlaza. Ichiza lisetyenziswa ngexesha elinye kunye ikhondo chemotherapy, kunye namanye amayeza akazange ukunciphisa ukusebenza kwayo. Abanye oogqirha akakholelwa kwakhona izigulane zabo. Amangala xa izigulane ezibe phezu namaKaledi. Abaninzi zalatha yokunqongophala ziziphumo ebezingalindelekanga ngelixa ezithatha ichiza.

izimvo ezingalunganga bambalwa kakhulu. Bonke nangona sebekhomba loo kwawo beziyobisi "sodium dichloroacetate." Yintoni na? Yinto eyaziwayo ukuba ezinye izigulane ichiza zange kunceda kukuphelisa esi sifo. Abanye abantu baye baphawula ukuvela ukuphinda sifo.

Indlela ukuqinisekisa ubunyani ichiza

Sobunyani "Sodium dichloroacetate" iziyobisi zibonisa izinto ezininzi: liphethe ziikristale ezimhlophe, incasa ekrakra. Ukuba umbala ziikristale tyheli, lo medicament uba libya, kwaye ayikhuthazwa. Xa ukunyibilikisa ichiza emanzini, kufuneka singalahlekani incasa yawo krakra. Xa ihlanjululwa ukuba oluludaka umgubo ukuba ngamaxesha isicelo eluswini zengalo okanye umphezulu engaphakathi emagxeni emva kwesithuba ngomzuzu 1 ngexesha kwimizuzu eli-10, ngoko ke emveni kwexesha kunye nodonga olufutshane usenziwa indawo avulekile. Kwaye emva kweeyure 5-10 kule ndawo iza kuba bomvu, kucace gca. Emva kweentsuku nje ezimbalwa kule ndawo nesikhumba aqale amaxolo. Le ndlela yokuqinisekisa Kucetyiswa ukuba basebenzise kwimeko kakhulu: ukudibanisa ngumgubo kwe-sulphuric acid esetyenziselwa izithuthi ibhetri, basabela kwenzeka kunye yokuzivelela ubushushu kunye ivumba dichloroacetic acid. iyeza Self inamalunga akukho ivumba. I iphezulu umgangatho ichiza, ivumba ngaphantsi. Ukuba incasa umgubo, oko kuya kubangela imilenze, Unjengokuphola nesiphumo astringent.