Phosphatase acid egazini: ukuzimisela, ukucazulula kunye nezinga

Acid phosphatase - enzayimi ibalekisa yokubola iimolekyuli emzimbeni. Ukuzimisela kwinqanaba layo igazi kubalulekile ukuba zokufumanis imeko yezempilo. Kukho iintlobo ezininzi phosphatases acid, leyo babelane a abenemfundo ncam, kodwa zahluke kakhulu enye kwenye ngokunxulumene kwizihlunu lomzimba, imvelaphi chromosomal, ukwakheka.

iitotali

enzyme Inqwelo e kwiindawo emuncu, kungoko igama. phosphatase acid ifumaneka kwizihlunu ezahlukeneyo kunye neeseli inokufunyanwa kwi lysosomes nangaphaya. Inani elikhulu omiselwe esinobubovu yesinye, kwakunye kwiiseli amalungu alandelayo:

• isibindi;
• spleen;
• wamathambo;
• Iiseli (erythrocytes, iiplatelets, macrophage).

Xa eziphilayo okunempilo umsebenzi phosphatase asidi kunokuba ephantsi. Abameli inkunzi isiqingatha inqanaba yayo ibandakanya phosphatase prostatic, yaye oko wamginya esibindini negazi iiseli. I-enzyme komzimba nemazi akhiwe kutshatyalaliswa ngokupheleleyo sisibindi kunye erythrocytes, neeplatelets.

Lysosomal phosphatase asidi

It akhiwe iiseli ezininzi. ukushiyeka lixabiso autosomal sisifo sofuzo, nto leyo kuthathwa ukuba ngenxa yeenkqubo zophendlo lwezifo metabolic. Symptomatology kwesifo kubonakala ngolu hlobo lulandelayo:

• isicaphucaphu uveza kunye nokugabha;
• ubuthathaka, ukulahlekelwa ukusebenza;
• hliswa wegazi;
• ebuntwaneni - opisthotonus (uhlaselwe ukuba zenzeka zongameleyo le arc umva, izigulane baxhomekeke phezu kwebhedi entanyeni kuphela kunye iinyawo);
• ukopha.

Ukuba inqanaba enzyme ayoneli kuphela iiseli ezimhlophe zegazi, izigulane badla ubunzima exacerbations ze zizifo ezingapheliyo.

Prostatic acid phosphatase

Kucingwa isiphawuli kweenkqubo somdlavuza wendlala. Olu hlobo enzyme kumiselwa kwaye ulwelo imbewu isiphawuli ebunzimeni (ukudlwengula). Acid phosphatase ophakamayo, kunye neentsuku ezimbalwa emva kotyando kwi esinobubovu prostate okanye imvelaphi biopsy.

Isalathisi kangangoko pH ukwenzela ukusebenza kakuhle kwe-enzyme - 4.6. Umsebenzi ubonakala kuphela emva kokuba umntu efikelela ukufikisa.

Okwangoku, ukuqinisekisa umgangatho phosphatase prostatic marker umhlaza besishiya kungena imvelaphi inzala banda yesinye-ngqo iantigens, onako ukuqinisekisa ubukho besi sifo kwizigaba zangaphambili zophuhliso. Kunjalo, izalathi si zokunikwa prostatic acid phosphatase ibalulekile yokuqikelela ukuphinda inkqubo somhlaza emva kotyando ukususa wendlala olukhulu.

Uhlalutyo ukujonga ukusebenza konyango lwe hyperplasia elihle prostatic kunye nezinye izinto ezimbi prostatic.

eritrotsitarnaja phosphatase

Le transcriptase polymorphic ukuba ayikho kuphela iiseli ezibomvu kodwa ezinye iiseli zomzimba. I-pH ezimpilweni ukusebenza bayo ukusuka 5.2 ukuya 6.2.

igazi phosphatase asidi nga sizimisele ukucacisa lukatata. iintlobo ezithile enzyme zinxulunyaniswa miqathango ilandelayo:

• yofuzo ngokwanele hemolytic;
• ngezifo, nto leyo luphawulwa kuphuhliso igazi hemolytic ngasemva esidla legumes;
• anaemia ukusebenzisa iziyobisi ezithile okanye nokuphuhlisa sokosuleleka ngemvelaphi wentsholongwane egazini kunye amagciwane.

Kukho iindlela erythrocyte acid phosphatase ezinxulumene ngqo ukwaphulwa ezenzeka ebuntwaneni.

uhlobo Macrophage of phosphatase acid

I-enzyme kubalulekile lokufunyaniswa sifo Gaucher. Esi sisifo ilifa esizibonakalisa sokuzuza esibindini, udakada, zezintso, ingqondo, glucocerebroside lung (izinto eziphilayo ezivela kwiqela amafutha). Isifo sikhatshwa ukwanda okubonakalayo ubungakanani imizimba akhankanywe apha ngasentla, ukuhla elibukhali kwi inani zonke iiseli igazi, ukuxhuzula, ukuxhuzula yiSpasticity, ukukhubazeka engqondweni.

Macrophage acid phosphatase kwakhona ingqalelo isiphawuli esithile ixhonti cell wegazi. Esi sifo ihamba ukuvelisa ubeka imali ebonakalayo enzyme, efunyaniswa egazini.

osteoclasts phosphatase

Wabiza iiseli osteoclasts ithambo onoxanduva intshabalalo yayo. Eli nyathelo yingqwalasela ebalulekileyo ekukhuleni bone kunye neyunithi zilungiswe. kwamathambo ngesantya High ihamba ezi zifo zilandelayo:

• izifo (ezwi zophendlo lwezifo ukusekwa yesiqhelo ithambo kunye nezinto zalo) Paget kaThixo;
• hypercalcemia of yobubi;
• ukungahlaliseki le ndlala kunye parathyroid namadlala ;
• postmenopause ile kwamathambo.

Isiphumo - Ukophuka rhoqo kunye ukuxozwa okuqhubekayo izakhiwo ithambo. Ukumiselwa osteoclasts phosphatase acid ibonisa amanqanaba ephakamileyo enzyme imvelaphi ezimbi ngasentla.

Ukulungiselela nokuqhuba uxilongo

Iimpawu ubuninzi amiselwa iimeko elebhu. Uhlalutyo kufuneka lwenziwe kuphela emva kweentsuku-2 ukususela kwixesha nezinye iinkqubo zonyango. Ukuba ufuna ukuvavanya umgangatho prostatic acid phosphatase, oku kufuneka kwenziwe hayi ngaphambi ngaphezu kweeyure ezingama-48 emva kokuba biopsy, Ngokucofa endlaleni, isinye catheterization. Kwimeko esahlukileyo, iziphumo kusenokuba positives bobuxoki.

Kucingo olubiyele izinto zophando olwenziwa ungatyanga. Uyakwazi sasela manzi, okusela iti, ikofu, incindi kunye nezinye iziselo akuvumelekanga. Ebudeni bemini, kufuneka ukunikezela iziselo ezinxilisayo, okunamafutha, izikotile yaba ngumsi yonke iphela, iyure-1 ngaphambi kokuba Uhlalutyo - ngokutshaya. Le yokugqibela isiqingatha seyure phambi kokuba ukuthathwa umbandela kufuneka iqhutywe noxolo ngokupheleleyo ngokweemvakalelo.

Kuba lokufunyaniswa igazi lwemithambo iyasetyenziswa, oko kukuthi serum yayo ekuphepheni hemolysis. Iziphumo zophando baziwa ngengomso emva kwesifundo.

Indlela esetyenzisiweyo

Ukucacisa inqanaba iyonke phosphatase acid kusetyenziswa iindlela immunochemical kunye ubhaqo chemiluminescent. Sebenzisa substrates ezizodwa ezisebenzisana enzyme ezithile. iinkqubo Okwangoku zisebenzisa yezabelo luminol peroxidase nodibaniso isisombululo hydrogen peroxide. Le isiphumo idityaniswa umqalisi (umz, n-yodofenol) ekwaziyo ukunyusa chweba kwezisombululo ukuya izihlandlo ezingamawaka amaninzi.

Kukho nezinye iinkqubo ezisebenzisa ialakalin phosphatase kunye AMPPD zeendawana, ukwenza indlela diagnostic nokuba sensitive ngakumbi. Izinto eziluncedo ze-ndlela zezi ukufunda uzinzo wezenzi ezisetyenziswe, akukho ngozi radiology. Iintsilelo ezisekelwe mbaxa axilongwe.

yinto yamihla le

Iyonke zePCR acid phosphatase lubonise U / L. sivumelekile iparameters yayo iyahluka ngokuxhomekeke kubudala kunye nesini.

Iimpawu acid phosphatase Eqhelekileyo prostatic - ngaphantsi kwe 2.1 ng / ml. Zonke manani angasentla ebonisa isiphumo ezakhayo uxilongo.

Xa inqanaba enzyme ukwanda?

Iimeko ezininzi kakhulu apho amanyathelo ubuninzi ngaphezu eqhelekileyo:

• thrombocytopenia - ukuncipha inani leeseli igazi onoxanduva ekunqandeni yayo;
• thromboembolism - ukuvaleka mithambo kwemithambo thrombus ephambili, nabanye udonga inqanawa, okanye embolus, aba bakulo egazini;
• isifo Hemolytic - isifo ephelekwa omkhulu ukutshatyalaliswa iiseli ezibomvu ukukhulula imali ebonakalayo yibilirubin kwi egazini;
• esiqhubekayo Paget kaThixo izifo - ngezifo bone isixhobo apho kukho ukungalingani phakathi ukusekwa bone kunye nokonakaliswa udweliso ngokuthanda evuthisayo;
• ezigula - ebulalayo inkqubo ithumba endalo, nto leyo kuyo B-lymphocyte linoxanduva Yindibanisela iiseli zokhuselo;
• Niemann-Pick izifo - ngezifo amafa luphawulwa ukutya okunamafutha nkene ukuqokelelana lipids kwi amalungu ezinkulu (kwesibindi, udakada, umphunga, intliziyo, izintso);
• Kwiintsuku ezimbalwa emva kotyando kwi esinobubovu wesinye biopsy yayo kwithishyu.

Asidi, phosphatase obrak - iqela enqanda unoxanduva kwiinkqubo ezibalulekileyo emzimbeni. Oku ngoncedo lwabo zavela ngayo kubalulekile elandelelanayo. Ukumisela inqanaba enqanda kuvumela ixesha ukukhangela ubukho leengxaki aze aliqhube ukuxhasa uqeqesho ubulunga ophezulu ebomini.