Iintlobo kunye nesenzo insulin. itheyibhile

Pharmacology Modern inikeza seswekile uluhlu elikhulu kumalungiselelo insulin. Kwaye namhlanje siza uthethe iintlobo insulin na.

Insulin: Iindidi

Onke amalungiselelo ezikhoyo insulin zahlulwe ngokweendidi ezintathu (ngokuxhomekeke intshukumo kunye nesiphumo konwaywa ixesha):

• "Short";
• "Phakathi";
• "Long".

"Short" insulins

It is a short-ngokwenza amalungiselelo insulin bavame emiselweyo ukuba izigulane kunye neengxaki eswekile yegazi.

Emva kokuba arhente engena umzimba, uqala ukusebenza kwimizuzu engamashumi amathathu. Oku kucacisa ukuba ibe obhobhozayo kakhulu kakuhle amachiza asetyenziswa ukunyanga isifo seswekile. Lidla olu hlobo insulin ezilawulwa kunye insulin inyathelo ixesha elide.

Ukuze ubone ukhetho, kufuneka uthathe ingqalelo ezi zinto zilandelayo:

• imeko ngokubanzi isigulana;
• indawo yokufaka umfanekiso indawo kuthetha;
• oyidlayo.

Amalungiselelo kakhulu ethandwa insulin uqalisa ukwenza ngethuba Imizuzu yokuqala eli-15 emva kokuba yolawulo. Kuthetha "Apidra", "Humagol" yaye "Novorapid".

iimpawu

Phakathi-high speed amalungiselelo insulin lwabasebenzi kukubonelela "Homorap" yaye "Rapid Insumad". Umahluko phakathi kwabo cishe akukho. Umehluko - kwimali ezintsalela ngoku kumafa kwalo acid.

Xa insulins "olukhawulezayo" imvelaphi yezilwanyana nazo iziyobisi "Insulrap SPP", "Iletin rhoqo II" kunye nabanye. Bona ezimiselweyo kakhulu ngokuqhelekileyo ngohlobo II seswekile. Iimali kule udidi ziquka kumafa zayo iiproteni kunye nesakhiwo ezahlukeneyo, kwaye ke ngoko ayifanelekanga ukuba isetyenziselwe zonke izigulane. Umzekelo, "fast" insulins zezilwanyana kufuneka ingamiselwa ukuba abantu imizimba abanako kuqhutyekekwe lipids zezilwanyana.

Reception, umthamo, ukugcinwa 'ezimfutshane "kwencindi

Ukuthatha ichiza ngokukhawuleza phambi kokuba isidlo. Kulo mzekelo, oko ibalekisa ukwetyisa legalelo insulin ukutya kwenzeka kwangoko.

"Fast" insulin na kwenziwa ngomlomo, pre-ukutyala ukuba urhulumente engamanzi.

Uma kwenziwa nolawulo ongama beziyobisi, inaliti kufuneka yenziwe malunga nemizuzu engama-30 phambi kokuba kwisidlo ezicwangcisiweyo.

Le umthamo Umntu ngamnye kunye seswekile, okhethiweyo ngamnye. ithamo omdala uya kuba iiyunithi 8-24 ngosuku, kunye nabantwana - akukho ngaphezu kweeyunithi-8.

amalungiselelo egcinwe + 2- + 8 degrees. Ngokuba lo shelf kufanelekile esemnyango kwisiqandisi le.

insulins "avareji"

Abanesifo seswekile kufuneka uthathe iziyobisi exhasa amaqondo eswekile yegazi eqhelekileyo. Kodwa uhlobo ngalunye seswekile kufuna uhlobo oluthile insulin. Ekubeni ichiza ukuba i-avareji ubude, lisetyenziswa kwimeko apho iswekile kufuneka cleavage ngcembe. Kodwa ukuze usetyenziswe, ukuba okwangoku akukwazeki ukusebenzisa i insulin "mfutshane".

Iimpawu ze "phakathi" kwencindi

Iziyobisi ezineefitsha ezininzi:

• ukuba ukuthatha isiphumo ngokukhawuleza nje imizuzu eli-10 emva kokuba nolawulo;
• kuthetha kuthatha ixesha elide ukugqiba ekungafuneki.

Insulins yale hlobo kunokuba isiseko ezahlukeneyo esebenzayo, ingakumbi, isophane insulin okanye zinc. Ingakumbi Tobacco kakuhle amachiza zilandelayo:

• phakathi insulin yabantu - lithetha "Protafan", "Humulin", "Monotard" yaye "Homolong";
• phakathi kwezibonelelo animal - amayeza "Berlinsulin", "Monotard HM" yaye "Iletin II".

insulins "Long"

Ukuba ukuqaliswa kwangethuba ichiza ivumela seswekile ukuba baphile ngaphandle nobunzima okubangelwa eliphezulu umxholo iswekile egazini. Yintoni eyenza le hlobo amalungiselelo insulin kwezinye iintlobo yaye insulin elide-esebenza kusekhona - le ntetho.

Insulin umahluko ophambili kulo mzekelo kukuba ifuthe ichiza ngamanye amaxesha ithatha ixesha elide ngaphezu kweeyure ezingama-24.

Ukongeza, zonke iintlobo insulin elide-esebenza kumafa yaso ehlanganisa yemichiza ukuqinisekisa ukusebenza ixesha elide beziyobisi. Kwakhona ekulibaziseni ukufunxeka iswekile. Isiphumo therapeutic imalunga 4-6 iiyure kunye nobude senzo kuba iiyure ukuya ku-36.

Long-omele insulin: ngawaphi iindidi

Amayeza ezininzi eziqhele amiselweyo 'deterministic "yaye" glargine ". Owona mahluko - nokuba sezantsi iswekile yegazi.

Insulins ne ixesha elide amanyathelo nazo amalungiselelo "Ultratard," "Ultralente iletin-1", "Huminsulin" "Ultralong" njl

ngeemveliso zamachiza ezibekwa yi igqirha khona, nto leyo inceda ngakumbi ukuphepha iingxaki ezahlukeneyo ngendlela yeziphumo ebezingalindelekanga.

Ukusetyenziswa kunye nokugcinwa ichiza

Insulin olu hlobo kungenziwa kuphela ngenaliti. Kuphela kanye umzimba ukuze iqala ukusebenza. Ziluma wayifaka zengalo, nomlenze okanye ezinqeni.

Phambi ukusetyenziswa, igutyana kufuneka yazanyazanyiswa ukuxuba kulo ufumene uzinzo efanayo. Emva ukuba ilungele ukusetyenziswa.

Le yokuqamba igcinwe phantsi kweemeko ezifanayo njengoko insulin-esebenza elifutshane. ulawulo lobushushu enjalo kuthintela ukuyilwa kukubola kunye pelletising umxube, kwakunye iziyobisi oxidized.

Bafake insulin yedwa, maxa wambi kabini ngexesha lasemini.

Ngemvelaphi insulin

Iiyantlukwano insulin - hayi kuphela ebudeni bexesha amanyathelo, kodwa unemvelaphi. Yaba iziyobisi yezilwanyana insulin twatse naleyo yabantu.

Kuba kudidi lokuqala iimveliso isebenzisa zepancreas eehagu kunye nemfuyo. Isakhiwo begazi kwencindi eziveliswa emazikweni kweehagu, abafanelekileyo ukuba abantu abaninzi. Umahluko kule meko kakhulu engabalulekanga - omnye kuphela acid acid.

Kodwa kwakunzima kakhulu Kakade ke, insulins yabantu, ezithi zisetyenziswe kakhulu qho. Iindlela lwemveliso kungenzeka ngeendlela ezimbini:

1. Indlela yokuqala kukutshintsha acid enye engafanelekanga. Kulo mzekelo, a insulin semisynthetic.
2. Xa indlela yesibini bavelise inxaxheba iziyobisi E. coli, ubuchule nokulungelelanisa protein. Oku kuya kuba yindlela biosynthetic.

Ngokufanayo amalungiselelo insulin yabantu aliqela eziluncedo:

• ukuba aveze indlela enyangayo ezinqwenelekayo kufuna alawula ngeedosi ezincinane;
• Uphuhliso lipodystrophy kwenzeka ngokwentelekiso kungafane;
• aleji iziyobisi phantse anayenza.

degree of zokuhlanjululwa

Kuxhomekeka iqondo iimveliso zokucoca zihlukaniswe:

• zemveli;
• monopikovye;
• monocomponent.

insulins yesintu phakathi amalungiselelo yokuqala insulin. Baya equlethwe nokubunjwa kwayo kukho iintlobo ezininzi zezinto ezingcolisa protein, nto leyo eyaba unobangela ngayo rhoqo komzimba. Okwangoku, imveliso malungiselelo yehla kakhulu.

Kuthethwa Monopikovye insulin unayo imali encinane kakhulu ubumdaka (ngaphakathi kwemida eyamkelekileyo). Kodwa monocomponent insulins phantse ecocekileyo ngokugqibeleleyo, kuba isixa ubumdaka ezingafunekiyo, ngaphantsi komda omncinci kude.

umahluko omkhulu of 'ezimfutshane' yaye 'ubude' insulin

Njengoko ubona, iintlobo insulin (Itheyibhile ibonisa ngokucacileyo oku) bahluka kwizibonakalisi ezingundoqo. Kwaye ezi mpawu kufuneka ithathelwe ingqalelo.

Siye sahlolisisa zonke iintlobo ezikhoyo kwencindi kunye nefuthe lazo emzimbeni womntu. Siyathemba ukuba ingcaciso iye yaba luncedo. Hlala uphilile!