Ichiza "sofosbuvir": imiyalelo ukusetyenziswa, indlela yokusebenza, analogs

Ukuza kuthi ga ngoku, abantu behlabathi ezintathu namakhulu ezigidi abantu abanentsholongwane hepatitis C. Noko ke, nangoku iphuhlise lugonyo kulo sifo yingozi.

Iimpawu zesi sifo

intsholongwane eyoyikekayo yosulela iiseli ebalulekileyo umzimba ubomi babantu - esibindini. Emva koko hepatitis C kudala ikopi engaphaya iiseli abachaphazelekayo ekusasazeni izifo.

Namhlanje wachaza iindlela eziliqela igciwane lohlobo kwesibindi:

• yi igazi;
• tattooing, imithi, kunye nezinye iinkqubo zisetyenziswa xa neenaliti non-abawaziyo;
• ukusebenzisa inaliti enye ebese abantu;
• inkanuko;
• ukusuka kumama ukuya emntwaneni ngexesha lokukhulelwa.

Iimpawu zonyango

Oogqirha abaninzi thelekisa hepatitis C ne-HIV. Kuphila na kwesi sifo esibulalayo okwangoku kunokwenzeka. Noko ke, kukho amayeza ezithile ezilungiselelwe ukuthintela ukunwenwa kwentsholongwane.

Xa impatho enjalo ngokuqhelekileyo isicelo amachiza amabini: "alpha interferon" yaye "Ribavirin". Eyokuqala kuthintela ukusasazeka kwentsholongwane iiseli ezinempilo, kwaye eyesibini ijolise ekuthinteleni ukwanda yayo. Noko ke, irejimeni onjalo unyango inani elikhulu yeziphumo ebezingalindelekanga kunye nokusebenza ephantsi.

Ngoko ke, abaphandi kuqhubeka ukuphuhlisa amachiza amatsha ukuba ukunceda ekulweni hepatitis C. Enye impumelelo ezintsha imithi ichiza ezintsha "sofosbuvir". Imiyalelo yokusebenzisa ezinayo yonke ingcaciso eyimfuneko malunga naloo nto.

Inkcazelo yokulungiselela

Ichiza ifumaneka azipilisi imilo setyhula, ogama umphezulu isale kuphela enyibilikayo juice esiswini. Olu lwazi liqulathe iqhotyoshelwe ichiza "sofosbuvir" umyalelo. Ukubunjwa iqulathe into iziyobisi unique Ngokuba negama elifanayo njengoko eziyobisi excipients.

Umthamo ofunekayo ichiza 400 mg yaye cwecwe efanayo. Le mpahla iqulathe iipilisi-28, nto leyo ngokwaneleyo kwikhondo unyango inyanga.

Effects on emzimbeni

Lichaza ukusebenza umzimba ziyafumaneka kwi ichiza "sofosbuvir" umyalelo manual. Indlela yokusebenza, ngendlela elula, kukuba izinto ezisisiseko yinto medicament inhibitor lwe enzyme C. hepatitis mihla Kuye nefuthe ezimbaxa kwi ephilayo abachaphazelekayo yintsholongwane. Ulingo lwezonyango lubonise ukuba nkqu kwindawo ephilayo isifo kakhulu buthathaka phantsi kwempembelelo iziyobisi kuye iziphumo ezincumisayo ngokuthe ngcembe. Oku kuyinyaniso genotypes abanesifo 1-4.

Nangona kunjalo, ngeli usulelo hepatitis C nosuleleko yi-HIV, oogqirha abaninzi bathi kufanelekile ukusebenzisa eli chiza. Inyaniso kukuba kulo mzekelo, iye yaba impumelelo yayo. Kubalulekile ukuqonda ukuba nangona umhlahlandlela equlethe ichiza imiyalelo "sofosbuvir" ukusetyenziswa, umenzi ilumkisa zokwenza self. therapy ngokunzulu nxamnye uhlobo ezingapheliyo sohlobo C linokukwenziwa kuphela ukuba ugqirha onamava. Ikhosi konyango lwenziwa phantsi kweliso yeengcali.

Ukusetyenziswa kweziyobisi

Oogqirha abaninzi bakholelwa ukuba "sofosbuvir" ichiza kufuneka zithathwe kuphela xa zidityaniswe kunye namanye amayeza. Kuba oku ngokwemveli wasebenzisa schemes zilandelayo, leyo ixhomekeke kweejini esi sifo:

• Xa genotypes 3-6 uhlobo amayeza "sofosbuvir" emiselweyo iziyobisi, "Ribavirin" yaye "interferon alpha". unyango kulo mzekelo kufuneka ngaphezu kweenyanga ezi-3.
• Kwimeko sohlobo 1 kwakunye nakwenzeka zokusetyenziswa medicament ezifana "Interferon Alpha" (phambi sokucalulana ngamnye okanye contraindication). Kulo mzekelo, ikhondo uye wandiswa yi izihlandlo ezibini.
• Xa usebenzisa indibaniso zamalungiselelo 2 genotypes dweliso 'sofosbuvir "ichiza" ribavirin "iinyanga ezi-3.
• Kwimeko umguli elindele ukuba esinye isibindi Kucetyiswa ukuba basebenzise zombini amayeza, "Ribavirin" yaye "sofosbuvir". Imiyalelo yokusebenzisa icebisa ukwandiswa unyango de abohlukeneyo.

Kwimeko xa kukho iziphumo ebezingalindelekanga ezinxulunyaniswa ne ukuthatha omnye nothomalaliso iziyobisi indibanisela kufuneka kupheliswa unyango. Idatha kwi ukusebenza konyango kubaguli abaye bengekafiki yobudala emntaneni, kulo ihlabathi.

Ichiza "sofosbuvir" thatha 1 ixesha ngosuku idosi amiselwe ngugqirha. Kukho imithetho ekufuneka ilandelwe kulo mzekelo:

• Kufuneka ayetyisi okanye yahlula amacwecwe, njengoko bazenze zambi incasa kukrakra kakhulu. Le isezwa iyeza esidlweni.
• Kwimeko emesis zingadlulanga iiyure ezimbini emva kokuba medicament kufuneka asele idosi engaphezulu.
• Ekususeni iyeza, ukuba lolibaziseko ngaphantsi kweeyure ezingama-18, ukuthatha tablet ephosiweyo. Ukuba ixesha sele idlule ngaphezulu - ukulithatha ithamo elilandelayo ngexesha elicwangcisiweyo.

oyi

Zonke iintlobo ulwazi olongezelelweyo ukuba kubalulekile ukwazi xa uthatha ichiza, liqulathe iqhotyoshelwe ichiza "sofosbuvir" umyalelo. Iimpawu zibonisa ukuba ukusetyenziswa kweziyobisi kwi kunyango entsonkothileyo kakhulu ukujonga iziphumo ebezingalindelekanga.

Kunyango ngamachiza, kufuneka wazi oku kulandelayo:

• kunciphise ingqondo nesantya reaction, ngoko ufanele uyeke uqhuba kwaye eminye imisebenzi;
• ukukhulelwa akufuneki, ngoko umele ukuqinisekisa ukuba iindlela ethembekileyo zokucwangcisa.

imiphumela emibi

Namhlanje watyhila ukuba zonke iziphumo ebezingalindelekanga ukulungiselela "sofosbuvir". Imiyalelo yokusebenzisa iqulethe data ukuba ixhomekeke indibanisela ichiza kunye namanye amayeza.

Kwimeko yokudibanisa ichiza kunye neziyobisi, "Ribavirin" yathi:

• ngaphezulu kwama-10% amatyala - ukuhla komgangatho haemoglobin kunye nokwanda yibilirubin egazini, isicaphucaphu, ukudinwa, ukuphazamiseka kokulala, intloko ebuhlungu, uvalo;
• 1% amatyala - ukudumba ingaphakathi kwi empumlweni nasemqaleni, ukunciphisa izinga yesinyithi egazini, ukudakumba, ukukhohlela, wacaphuka lagxila, iingxaki kunye nokusebenza phecana wokudla, ilahleko iinwele, ukurhawuzelela, cramping, nomkhuhlane.

Nolawulo eyongezelweleyo ichiza inkqubo "Interferon Alpha" kukho umngcipheko ukuba iya kuba:

• anaemia, ugwayi, isiyezi, zasinciphisa inani neutrophils, neeplatelets lymphocyte naqhama yibilirubin egazini, irhashalala, ukurhawuzelela, ifiva, urhudo, ukugabha, ifiva;
• ukwehla kobunzima, ukudandatheka kunye one-, migraine, ukuqhina, ukuphelelwa umoya, iintlungu kunye nezinye.

iinkcukacha ngaphezu zonke iziphumo ebezingalindelekanga okuchazwe apha ichiza "sofosbuvir" umyalelo manual.

analogs

Kukho inani analogue le "sofosbuvir" iziyobisi. Baya lungahlulwa-hlulwa zibe ngamaqela-2. Analogs osisiqu esebenzayo zezi: "Viropak", "Grateziano", "Hepsinat", "Hopetavir". Uluhlu amayeza ukuba babe "sofosbuvir" efanayo isiphumo enyangayo ibanzi kakhulu. Ukuze igama nje ezinye zazo: "Algeron", "Ledipasvir", "Neovir", "TSikloferon" kunye nabanye abaninzi.

Noko ke, wena iyakwazi ukuphawula inani yeenzuzo "sofosbuvir" phambi koontanga bakhe;

• Kweentsholongwane genotypes ezahlukeneyo sohlobo C;
• ukusebenza eliphezulu;
• izifundo ezifutshane unyango xa kuthelekiswa namanye amachiza amaninzi;
• azisebenzisele kakuhle;
• Ayichaphazeli umgangatho yesigulane yobomi.

iindleko

amayeza Modern ongakwaziyo amachiza amaninzi kangaka esebenzayo ngempumelelo ukunceda ekulweni hepatitis C, ziye ocande nqanaba ezigulo ezondeleyo. amayeza isiJamani "sofosbuvir" ifanele kwizigulane abadala. Imiyalelo yokusebenzisa ikuvumela ukuba usithelekise namanye amayeza afanayo.

Ngenxa yokuba eli chiza ubonisa ukusebenza eliphezulu, zinezibonelelo ecacileyo xa kuthelekiswa ne-analogue, ixabiso layo liphezulu kakhulu. Ikhosi enye iya kuxabisa isiguli amawaka ambalwa eerandi. Kungenxa yoko le nto ukufumana amayeza "sofosbuvir" ezikhemisti nzima.

Namhlanje, siyobisi ogqibeleleyo kwaye akhuselekile ukuba isetyenziswe unyango sohlobo C, kuyiyo indlela. Olu lwazi siqinisekisa iqhotyoshelwe medicament "sofosbuvir" umyalelo. Analogs, ngokutsho oogqirha, musa ukuvumela ukuba bazuze iziphumo ezibalulekileyo enjalo.

Ngenxa yokuba eli chiza isaziwa njenge inani elikhulu kumagqirha ehlabathini lonke. Bakholelwa ukuba namhlanje imithi olusebenzayo okungakumbi lula kakhulu ubomi izigulane ugula, nje ayikho.