Ichiza "Amiodarone": analogue, imiyalelo, ncomo

Heart, njengokuba usazi, umzimba wethu iphambili, kodwa kaninzi lutshitshe. Ukuze ukubuyisela nokusebenza yayo yesiqhelo basebenzisa iintlobo iziyobisi. Enye yazo "Amiodarone". Analogs zibiza kakhulu ngakumbi, njengoko ziveliswa phesheya kwaye ayisoloko olusebenzayo.

Ukubunjwa ichiza nokumila

Le medicament "Amiodarone", nto leyo buyekezwa ngeentlobo yenziwa kwenye elucwecweni 200 mg esisebenza - hydrochloride amiodarone. Amalungiselelo yenziwe njengesisombululo, apho 3 ml yi-5% of esisebenza.

Icandelo Auxiliary yakhiwa tablet omnye: neetapile starch, crystalline microcellulose, lactose, maltodextrin, primelloza, polyvinylpyrrolidone, wemagniziyam stearate.

Amacwecwe zagutyungelwa njengeceba of umbala omhlophe kunye kancinane, ngokungangqalanga cream umthunzi. Babe uhlobo Valium kunye kuyinkalo kunye Valium. Ngoko ke, ukuba kuyimfuneko, kulula ukuba kwahlulwa kubini ngokulinganayo.

Drug ethengiswa iibhokisi zekhadibhodi, apho namadyungudyungu enye okanye ezimbini iipilisi ezilishumi. Ichiza nawo iglasi, polymeric kunye zeplastiki neebhotile, okuye amacwecwe-30 okanye 100.

Indlela amayeza amanyathelo iziyobisi

iipropati Antiarrhythmic kwaye antianginal luphawulwa "Amiodarone" analogue kwezinye iimeko buyisela kuye. wesenzo anti-arrhythmic isekelwe phezu ukuncitshiswa yangoku ion potassium xa phantsi iiseli inwebu - cardiomyocytes. Oku kubanga ukuncipha esiludumbo sinus eyenza bradycardia.

Ukusetyenziswa ichiza "Amiodarone" (iipilisi) kungandisa ubude womatshini eliyinjubaqa Uhanjiso intliziyo. Abangaphangeliyo ukuba conductivity of iindlela zamabanga izigulane syndrome kakhulu ka Wolff-Parkinson-White syndrome. Ngenxa yoko, isiphumo ichiza antianginal bakhelwe ekunciphiseni mpilo engabalulekanga kunye nokunciphisa ifuthe layo imisipha lwemithambo. Ubunjwe ayodini, leyo ukusetyenziswa ubungakanani utshintsha isiqulatho ihomoni, oko kukhokelele kwiqondo yempembelelo yabo myocardium lifinyele.

"Amiodarone" indlela osebenza, kunye nempembelelo ngokukhawuleza kwi isicelo yayo kwenzeka kuphela emva kweveki enye yokusetyenziswa rhoqo beziyobisi, kwaye ubuninzi kuphunyelelwa emva kweeveki ezimbini-ezintathu.

Ngaphakathi ezabalazela 40% lokusela idosi, Cmax plasma ivela emva kweeyure 3-7. Le isiphumo uyakwazi ukuqhubeka iiveki eziliqela. iinkqubo pathways kwenzeka ubukhulu becala esibindini, apho kukho into esebenzayo abunjwe dezetilamiodaron, nto leyo metabolite ezinkulu. Buyela enyongweni secreted kunye nomchamo, T1 / 2 - emva nedosi enye ye ichiza 3,2-20,7 h, kunye nonyango elide - emva 53 ± 24 iiyure.

Medicine "Amiodarone": zikhombisa ukuba ukusetyenziswa

Amisele ichiza lokhuseleko kunye nonyango arrhythmias, leyo egulela engozini ubomi babantu, ngokunjalo arrhythmias ventricular, enomoya ventricular kwi nokutshintsha ezingazinzanga wasebenzisa iziyobisi "Amiodarone."

Ubungqina obubonakalayo buxela ukuba ukusebenzisa ichiza ne:

• enomoya atrial;
• arrhythmias supraventricular;
• syndrome Wolff-Parkinson-White;
• ivela tachycardia;
• fibrillyatsionnogo ventricles ukwazi;
• arrhythmia ezivele ngenxa insufficiency ezesifuba semithambo;
• iintlobo ezingapheliyo yokuba nesifo sentliziyo;
• iposi engabalulekanga.

"Amiodarone": imiyalelo yokusebenzisa

Tablets zenzelwe ulawulo yomlomo emva kwemizuzu eli-15 emva kwesidlo.

Ngexesha ventricular oyidlayo isifo fibrillation olucetyiswa gqirha, yi 800-1200 mg ngosuku. Kufuneka yahlulwe 3-4 imisitho. Unyango kulo mzekelo ithatha malunga 5-10 iintsuku ukuqinisekisa imeko ezinzileyo ze isigulane kufuneka sandisiwe, kwaye rate kuthi xhaxhe ku 600-800 mg ngosuku. Olu nyango kakhulu, nto leyo kamva uyaqhubeka zothintelo, idosi esezantsi umxholo iziyobisi.

ixesha yesondlo therapeutic ziintsuku 7-14, kweli xesha iziyobisi ukuthatha 200-400 mg. volume iziyobisi ezifana eyabelwe ukuzinzisa imeko yomguli ngexesha poslereabilitatsionny.

Ngokufuthi unyango "Amiodarone" emiselweyo xa isigulana esibhedlele, kwaye ubuchule bakhe ukulawula ugqirha. Oku kwenza kube lula ukuba ukunciphisa iziphumo ebezingalindelekanga kwaye ngamnye ukunyenyisa ithamo ichiza.

Xa angina isifo medicament usebenzise kabini ngosuku mg 200. Emva kweeveki ezimbini, idosi wanciphiswa kanye ngemini. I single yedosi idosi iphezulu kufuneka ingadluli 400 mg kunye ngemihla - 1200 mg.

Xa kutyunjwa la machiza ebantwaneni kufuneka kukhunjulwe ukuba ipilisi kuchaphazela umntwana ngokukhawuleza kakhulu omdala. Ngoko ke, ithamo ebalwa ngokususela ubunzima umntwana. Ngenxa yoko, ikilogram ubunzima kufuneka kuwa-10 mg medicament. Le ithamo kufuneka igcinwe lonke ixesha kwezonyango seentsuku ezilishumi okanye de imeko yesigulane ngcono. Apha, le iinkcukacha ukunciphisa umlinganiselo mg 5 kilogram ubunzima umzimba umntwana ngamnye. ithamo lulondolozo lokuthintela amkelwe, kusekelwe obunzima buyikhilogram enye 2.4 mg ka iziyobisi "Amiodarone."

Izinto ezibonisa ukuba ichiza emiselweyo ukusebenzisa isisombululo ngokusekelwe isithako inxaxheba amiodarone hydrochloride kwi arrhythmias zosulele inhliziyo. Kulo mzekelo, ichiza ilawulwa yegazi, ngokucotha lesitofu emzimbeni nge dropper. Ukuze wenze oku, 250 ml ka-5% isisombululo iswekile 1 okanye 2 kancinci lesitofu ithamo lwemithi 5 mg ubunzima bomzimba ikilogram. Ngeli xesha, isigulana eso esweni esebenzisa ECG kunye noxinzelelo lwegazi Ufundo yomlinganiselo.

imiphumela emibi

iziyobisi ezininzi kagqirha "Amidaron" kweli lizwe lethu. Analogs ayisoloko nako endaweni kuye. Kodwa nangona neziphumo ezihle beziyobisi emzimbeni womntu, ziye zachongwa kunye neziphumo ebezingalindelekanga.

Iimpawu ezingalunganga ikakhulu ngenxa libanda, iziyobisi. Le ukuhlukunyezwa nemithambo yegazi, ezifana bradycardia, ukusilela umsebenzi sinus node, ibhloko intliziyo, ilahleko kokuxhumana intshukumo. Kwakhona phezu inxalenye yenkqubo nokuphefumla wabonwa kwentamo abanesigulo Embi pulmonary, inyumoniya Embi, Hamm syndrome - Rich, iintlungu esifubeni, abanesigulo yemiphunga, tachypnea, aqaqambayo bronchopulmonary. ukusilela Hepatic kwaqondakala xa ekufumaneni ukulungiselela "Amidaron". Amacwecwe kwiimeko ezinqabileyo kunokubangela senyongo, hepatitis, ukuqina ngamanye amaxesha.

Ukungaphumeleli ukuthobela idosi kunokubangela i kungalingani elibalulekileyo hormone, distireoza kunye hypothyroidism, kunye iseti wayedla ezingaphezulu. Libanda kunokukhokelela ukuphazamiseka izixhobo ezibonwayo, ebangela ukuqokelelana lipids kwi inwebu ukuya umfundi. Kwakhona, kukho nombala ngokukhawuleza kakhulu eluswini, photosensitivity, urticaria okanye erythema. irhashalala Minor Ndibubonile nje ubuso, alopecia, dermatitis. iziphumo ebezingalindelekanga kwakhona sichaphazele umsebenzi ekuzaleni ebantwini. Kule meko kukho orchitis, namandla, kunye epididymitis. thrombocytopenia kakhulu ezinqabileyo, ukusilela kwezintso, okanye angioedema vasculitis.

Izimo nokusetyenziswa

"Amiodarone" (feedback wayengekho akusoloko HIV) esikhethwe ngqongqo ngabanye. Kukho abantu ukuba eli chiza zange ukunceda okanye ukuba kuphunza ngokupheleleyo akukho utshintsho kubume bentlalo, abanye baqalisa ziliminxe emva ulusebenzisa, waziva iyangongoza intliziyo. Xa amazwi abo, Propafenone iyakwazi ukuphazamisa inkqubo yonyango iihomoni kwanda. Ngoko ke, ngaphambi kokuba lo mveliso amayeza kufuneka nje ukufunda ngenyameko imiyalelo, kodwa ukunikela ingqalelo ukwalatha, iziphumo ebezingalindelekanga kunye Izimo.

Ngenxa yoko, ichiza kufuneka ingasetyenziswa xa kukho atrioventricular block grade 2-3, yokothuka cardiogenic, hyperthyroidism. Ukulungiselela "Amiodarone" alisetyenziswa uvakalelo yalo phezulu ukuya arhente esebenzayo kunye iodo. Ban Kukwaphula kakhulu Uhanjiso ezesifuba iziqephu bradycardia kunye syncope. Musa ukusebenzisa iziyobisi ngexesha lokukhulelwa kunye zisanyisa. Zisanyisa, ngexesha yonyango ngamachiza kufuneka uyeke ukuluncancisa.

izincomo ezithile

Kumele kwenziwe phantsi kweliso ngononophelo gqirha unyango enyangayo iziyobisi "Amiodarone". Imiyalelo yokusebenzisa lithethelela ukuba usebenzise iipilisi emva kwesifundo X-ray ophezu kwesibindi, imiphunga kunye electrocardiogram. esweni enjalo kufuneka yenziwe kwixesha elizayo, ukuba isigulane iyaqhubeka ukuthatha amayeza.

Ubuzaza iziganeko ezibi kusoloko kuxhomekeke idosi, esebenzisa isigulane. Ukuba zama ukusebenzisa neziyobisi manqaphanqapha kangangoko kunokwenzeka kunye nenani ezincinci. Kubangela mgaqweni ukubetha ukurhoxiswa "Amiodarone" iziyobisi.

Imiyalelo yokusebenzisa - ncomo bathi, nangona iziphumo ebezingalindelekanga, eli chiza liye usindiswe ngaphezu kwesinye ubomi - uthi ukuba isenzo amayeza ye ichiza egcinelwe omnye iiveki ezimbini emva kokuba ukurhoxiswa kwayo.

Iipilisi ziqulathe iodine, into leyo eyenza igalelo kumgangatho nokwanda kwe radioiodine kwi le ndlala lengqula. Ngoko ke, ekuqaleni konyango unyango, ngexesha ekupheleni kufuneka avavanyelwe isixa hormone rhoqo ukuba.

Ngexesha ukungenelela therapeutic kuyimfuneko ukuphepha ukungakhuseleki ilanga ixesha elide, akukho mfuneko yokuba athathe ilanga evulekileyo. Ichiza kufuneka ilawulwe ngobunono kubantu abadala kunye zomzimba jikelele okanye ngethuba lokuqhubeka zonyango ioksijini. Ngononophelo kufuneka asebenzise abaqhubi bezithuthi kunye nabantu abo umsebenzi lu dityanisiwe enamandla ethile.

Kwiimeko of libanda, sinokufumana zisiba yeziphumo ebezingalindelekanga, kwakunye hypotension, arrhythmia. Ngamana kwenzeka bradycardia okanye ukusilela AV Uhanjiso. An ngokugqithiseleyo kunokubangela isibindi kwekhono.

Kulo mzekelo, sicebisa lavage esiswini nangoko, iirejista amalahle luvuliwe, laxatives saline kucetyiswa izisombululo. Ukuba bradycardia isitofu atropine, agonists ezisetyenziswayo receptors beta-adrenergic, wenza isantya.

Ubudlelwane kunye neminye imithi

Amanyathelo kufuneka zisetyenziswe ngaxeshanye iziyobisi kunye nezinye iziyobisi, ingakumbi xa kwiqela elifanayo antiarrhythmic. Akukho mfuneko ukudibanisa kunye lolwamkelo esikolweni "erythromycin", "pentamidine" yaye "vincamine." Kukho ingozi polymorphic ventricular tachycardia nodibaniso 'sultopride ". Ayikhuthazwa ukudibanisa inani lokuNgena beta-blocker with "amphotericin B" neziyobisi ezibangela nefuthe isisu, umchamo. Ngokukhathalela ukusebenzisa amayeza kunye corticosteroids, lakhula, "Astemizole", "terfenadine." Nmb ukwandisa kakhulu iziphumo amachiza afana "Warfarin", "Phenytoin" "Tacrolimus" okanye "digoxin". Xa ukusetyenziswa kudibaniso nge "cimetidine" imenza inkqubo yokucolwa emzimbeni.

Ubomi nokugcinwa nemigangatho

Le medicament "Amiodarone", isenzo sakhe ngqo kwi ekupheliseni tachycardia, fibrillation ventricular, tachyarrhythmia kunye nokunciphisa enomoya atrial, ibhekisela amalungiselelo kudidi "B" iqela. Ubude bethuba lokusetyenziswa kwe ichiza ngaphantsi kweminyaka emithathu. Iipilisi kufuneka igcinwe epholile, emnyama kunye ingafumaneki abantwana.

ukusetyenziswa kwe "Amiodarone" ichiza kufuneka kulawulwe ngokungqongqo. Iresiphi ukusebenzisa oko abhale ugqirha. Kulo mzekelo, umntu kufuneka ngokupheleleyo ngaphandle.

Analogs medicament

Ukuba ngesiquphe zange ezingangeniyo ichiza "Amiodarone" analogs zingafunyanwa kulo naliphi ekhemesti. Phakathi kwazo kukho iziyobisi ezifana: "Amiodarone Belupo" yaye "Amiodarone Aldaron", "Angoron" yaye "Atlans" kwaye afake ngamayeza ayikwazanga "Kordaron" okanye "Kordinil". Ifana 'Amiodarone "emibi emzimbeni womntu" Medakoron "yaye" Palpitin ". Kwezinye iimeko, ichiza indawo yi "Sedakoronom" yaye "Sandoz".

La machiza mhlawumbi ziqulathe ukwimo enye osebenzayo okanye efanayo isiphumo yabo antiarrhythmic zonyango "Amiodarone". Analogue basoloko wavelisa aphesheya kwaye izihlandlo eziliqela ibiza kakhulu.

baqinisekiswa

Izigulane ezininzi zithi nokuzinziswa imeko yabo emva ngokuthatha amayeza, "Amiodarone". Imiyalelo yokusebenzisa - ngokufuthi analogs iziyobisi ezikhethiweyo zisekelwe iimpawu ngabanye eziphilayo - uthembisa ukubuyisela izinga kwentliziyo, uxinzelelo. Xa ukwamkelwa uveza ngeedosi ezincinane, ngokubanzi akukho ngxaki, kwaye izenzo kweziyobisi ngendlela eyiyo.

Emva ukusetyenziswa elide beziyobisi kwezinye izigulane wabonakala, uphelelwa ngumphefumlo, iyangongoza intliziyo, uvalo nokudandatheka, utshintsho kwimo nokwanda ihomoni, kukho ukuphazamiseka phecana emathunjini, kwaye kwezinye iimeko, isicaphucaphu nokugabha.

Abantu abaninzi kakhulu ukulisebenzisa unyango lwe angina, kwaye qaphela ukuba kubi akukho ngaphezu kunoogxa amazwe. Amanye amadoda uyoyika, khawuthathe ichiza, ngokuba oko kwenziwe kuzo, unako ukwenza iqela zomhlaza. Kukholelwa ukuba ichiza kufuneka kwenziwe kuphela phantsi komqathango olunokubatshayela ubomi babantu, kuzo zonke ezinye iimeko, ufanele khangela enye. Ukongeza, eli cwecwe kungaba nefuthe elibi function oyindoda yenzalo, kwakhona ukuba kuqwalaselwa kwi yolwamkelo zabo.

Noko iziyobisi ezininzi "Amiodarone" kube ilikhubalo, Bulelani apho sifo ewuthile, kodwa waqhubeka ephila. Hayi yokuba analogue wayeza kuba yimpumelelo nje. Ngoko ke, xa ukunyanga isifo sentliziyo, musa zingalujongi ichiza off, ingakumbi xa ugqirha ikhuthaza oko.