Ichiza "Akineton": imiyalelo ukusetyenziswa, inkcazelo, izimvo

Le into esebenzayo "Akinetona" na hydrochloride biperiden. Tablet yokuhlala 2 mg into esebenzayo. Ngaphezu koko, ubukho amacandelo ezongezelelweyo (umbona starch, iitapile starch, monohydrate lactose, nemagnesium stearate, microcrystalline kwincindi, copovidone, calcium hydrogen phosphate dihydrate, talc, amanzi acocekileyo) ithatha ichiza "Akineton".

Imiyalelo zokusetyenziswa, ifoto lubonisa ukuba uhlobo elucwecweni eli chiza umbala ngokoqobo omhlophe, uhlobo Valium. Kwelinye icala cwecwe kukho umngcipheko imilo cross beveled.

1 ml sisombululo iqulethe zincancise biperiden xa isixa milligrams-5. Awongeziweyo amaqela zezi: injecting amanzi kunye sodium zincancise.

imiphumela kwemithi

Main nto biperiden - holinoblokator central inyathelo.

Igalelo ibandakanya xi ubuchule umsebenzi cholinergic neuronal kwi striatum, nto leyo iyunithi noshowo kwenkqubo extrapyramidal.

Ichiza ebangela ukusebenza ganglioblokiruyuschimi, abawayo iziphumo m-anticholinergic antispasmodic kwaye mayimodareyithe kwimida (antispasmodic).

Ukusetyenziswa ichiza inceda ukuphelisa yalityatya lafa, leyo kuphakama ukusetyenziswa kweziyobisi cholinergic (umz, pilocarpine) kunye catalepsy nokoma kwezihlunu izigulane abafumana neuroleptics. Liyakwazi eyenza ukuphazamiseka.

Pharmacokinetics

"Akineton" lonyanzeliso kwiiproteni plasma kwi 91-94%. ukucoca Plasma iya kuba 11.6 ± 0.8 ml / min / ubunzima bomzimba kg. A idosi enye ye-kuqulunqo ngomlomo a bioavailability malunga 33 ± 5%.

Ludlulele ubisi lwebele.

Biperiden umzimba ngokupheleleyo emzimbeni womntu. Xa umchamo, iyeza ayimiselwanga ngendlela kutshintsha. Ezi metabolites emikhulu bicycloheptane kunye piperidine, ezo Imveliso esuka endleni kunye nomchamo.

Elliminatsiya kwenziwa ngezigaba ezibini, kunye ubomi kwisiqingatha (T 1/2) wemizuzu 90 ngexesha lesigaba sokuqala kunye neeyure 24 - isigaba sesibini. Kubantu abalupheleyo, nakwisiqingatha ubomi nga kwandisa kakhulu.

Ubungqina obubonakalayo buxela

"Akineton" ezisetyenziswa ukuphazamiseka extrapyramidal kubefundisi ulawulo amayeza athile (neuroleptics, antipsychotics).

Kwakhona, ichiza eboniswe uxilongo lwesifo syndrome Parkinson kaThixo, parkinsonism (arhente alawulwa ngayo kunyango Kudibaniso kwisiseko)

Izimo

Injongo yale chiza aluboniswa xa hypersensitive ukuba isithako esebenzayo beziyobisi "Akineton".

Imiyalelo yokusebenzisa yazisa ukuba ichiza kufuneka kuphetshwe kwi lokufunyaniswa sifo isigulana ezifana yesinye, engile-ukuvalwa neglaucoma, utshintsho obstructive ethunjini (stenosis pylorus, konedumbe ileus genesis).

Arrhythmia, sokuwa, ukuncancisa, abadala, ukukhulelwa zezona zinto apho "Akineton" zilawulwa ngokuqaphela okukhulu.

imiphumela emibi

CNS iziphumo ebezingalindelekanga sibonakalalisiwe asthenia, ukudinwa, silale, ubuthathaka, antsi, isiyezi, imvakalelo inkxalabo, ixhala, memory ongaboniyo, ukudideka, nemibono, catalepsy, ukuxhomekeka iziyobisi iziyobisi "Akineton".

Imiyalelo yokusebenzisa ukuthetha malunga icala elingenzi nto-yaye ube yinxalenye yale mbono - mydriasis, ukuphazamiseka yokuhlala.

inkqubo Cardio-nemithambo ubonakala bandile lo izinga lentliziyo (tachycardia); ngamanye amaxesha - deceleration (bradycardia); xa ufaka ifomu inaliti yokulungiselela - izinciphiso uxinzelelo lwegazi (hypotension).

Ngomhla inxalenye yenkqubo yokwetyisa - umlomo owomileyo, iimpawu dyspeptic, ukuqhina kwesisu.

Ngakwicala ukutya - ukunciphisa ukubila.

Ngomhla inxalenye yenkqubo wokuchama - kwizigulane kunye ukukhula (hypertrophy) of esinobubovu prostate - nzima kunokwenzeka uchama.

ziyabagulisa: ukungxama kakhulu eluswini, ukulunywa.

Indlela Yokusebenzisa

Kuba intramuscular, efakwa, kunye azipilisi somlomo ukulungiselela kufanelekile "Akineton".

Imiyalelo yokusebenzisa icebisa ukuba uthomalaliso "Akinetonom" jikelele kuqala iingedosi ezincinane, ithamo ngakumbi ukwanda stepwise ngokuxhomekeke isiphumo enyangayo ezinqwenelekayo kunye neziphumo ebezingalindelekanga.

Abantu abadala ukusetyenziswa ibe yeviwayo yamalungiselelo ukuqala unyango xa umthamo we-1 mg 1-2 yokwamkela emini okanye ezi-2 mg yahlulwe amathamo amabini ngosuku. Ngaphezu koko, umthamo angandiswa 8 mg ezimbini ukuya kwezine ngeedosi ahlukene. Nangona kunjalo, umthamo kufuneka andise ngaphezu kwe-2 mg ngosuku. Musa ukudlula idosi iphezulu kuthetha 6 ukuya Th-16 mg iintsuku ezintlanu. ithamo Single ifomu iziyobisi injectable mayingagqithi 2.5-5 mg. Le ithamo ukuze kuphindwa emva kangangesiqingatha seyure, kodwa ke inani zolawulo ngosuku mayingagqithi amaxesha 4. Ithamo ubuninzi medicament kwifomu injectable-20 mg iintsuku ezintlanu. Xa amachiza sifikelelwayo, ngoko lenguqu ukuya ulwamkelo "Akinetona kunamandla."

Kodwa musa ukulibala malunga nendlela umntu ukuba isigulane ngasinye nothomalaliso ukuqeshwa biperidenom.

ngezifo Extrapyramidal ezivele ngenxa yokufakwa amayeza athile (antipsychotics okanye neuroleptics) ifuna isabelo into zinikwe idosi enye ye-2 mg ngomlomo okanye parenterally. Phinda ulawulo amathamo bathi ukuze ube zonke seyure. Noko ke, njengoko kubonisiwe ngasentla, inani zolawulo mayingagqithi amaxesha 4. Ithamo ngomlomo kufuneka yahlulwe amathamo enye ukuya kwezintathu.

isifo Parkinson kaThixo ibandakanya ngokuwenza ichiza ngomlomo kwi 6-8 mg ngeedosi 2-4 umahlule imini, ithamo ukuba kancinci Linyuke ku 6-16 mg.

Abantwana phantsi kwenjongo nyaka lubonisa ithuba ichiza ngendlela injectable ngokucotha, nedosi enye ye-1 mg okanye 0.2 ml. Xa iminyaka ukusuka komnye unyaka ukuya kwiminyaka emithandathu zilawulwa 2 mg okanye 0.4 ml. Ukususela kwiminyaka 6 ukuya kwi-10 - 3 mg okanye 0.6 ml. Le ithamo ukuze kuphindwa emva kangangesiqingatha seyure nonxunguphalo. Phambi neziphumo ezibi kulawulo ichiza kufuneka inaliti ephelisiweyo.
Ngexesha yeviwayo lwe nothomalaliso kweziyobisi yobudala ukususela kwiminyaka emi-3 ukuya kweli-15 ukuthatha umthamo 1-2 mg kwiiyure 1-3 ebudeni bemini.

Amacwecwe awukwazi ukusela ungatyanga, uze usele ngomlinganiselo amanzi. Xa isenzeko ziziphumo ebezingalindelekanga kokungafunekiyo kwinkqubo yokwetyisa kufuneka athathe eli chiza kwangoko emva kwesidlo, ukunciphisa ubungqongqo impembelelo embi lithetha "Akineton".

Imiyalelo zokusetyenziswa ibonisa ukuba kwimeko kwenicotine eziyityhefu abadala kunyango entsonkothileyo oluqhelekileyo nayo ilawulwa eli chiza, kwaye umthamo walo 5-Th-TB-10 mg lweefomu injectable, kodwa kuphela kwiimeko ezisongela ubomi yesigulane.

Xa etheni imixube phosphorus organic nomthamo biperiden ikhutshwa phandle ngabanye ngokuxhomekeke ebukhulwini izilonda. Qala evela ithamo of mg 5 kwimeko kulawulo efakwa, ulawulo ngokuphindaphindiweyo kuqhubeka de iimpawu zinyamalale yityhefu.

libanda

Libanda, kubonakala imiphumela iqapheleka anticholinergic ezibangelwa iyeza "Akineton".

Imiyalelo yokusebenzisa, oogqirha wokwenene sinikele ingqalelo into yokuba unyango kule posimptomnaya imeko (nokulondolozwa sentliziyo kunye neenkqubo zokuphefumla, unyango ioksijini, ukulungiswa komzimba, a wokuchama catheter iseti, xa kuyimfuneko). Ifuna ukuqaliswa inhibitor cholinesterase (physostigmine kakhulu) .

intsebenziswano

"Akineton" ngoxa ukusetyenziswa m-holinoblokatorami, iziyobisi nokuba antihistamine kunye namanyathelo antiepileptic uphucula ukuchazwa yokugqibela. Nakuba kunjalo, isicelo ngaxeshanye metoclopramide kunciphisa isiphumo yayo nezinyangayo. Kukho ukungavumelani isiyobisi esichazayo baligalele. Ukuqeshwa quinidine ukunyuka kumaxesha ingozi yokuba iimpawu zeDyskinesia. ukusebenza M-cholinergic ngakumbi xa isicelo levodopa.

Ukugcinwa kunye nokuthengiswa

Ukuthenga eli chiza kufuna amayeza ukunika ayinikiwe. Ukuze sigcine "Akinetona" kufuneka ukuthobela lobushushu, t. Lobushushu E. Ambient mayingagqithi degrees 25 (scale Celsius). Sifuna ukufikelela kwabantwana kwiziko "Akineton".

Manual unika ithuba lokugcinwa kwezinto ichiza - kweminyaka emihlanu.

oyi

Ukuqeshwa biperiden ngexa lokukhulelwa kunye nokuncancisa (lokwaphusa) ifuna lisibonisa engqongqo.

Biperiden bangangena ukuya usana ngobisi lwebele, ebangela kukuphanza lokuncancisa yethutyana ukuba ukupheliswa ichiza "Akineton".

lencazelo ubonisa ukuba ungenisa isigqibo sokuqeshwa biperiden ngexa lokukhulelwa kunye lokwaphusa ingqalelo yingozi usana, umbungu.

Abadala uba factor umngcipheko ukuba unyango kunye eli chiza. Ngoko ke mabaqeshe "Akineton" eli qela labantu ngononophelo olukhulu.

Kickaha kungekho nabuphi na ubungqina bokusetyenziswa ukhuseleko ebuntwaneni, nto le yo ebangela ukuba awusebenzi abantwana iziyobisi "Akineton".

Inkcazelo yokulungiselela (yesikhokelo) lixela ukuba into yokuba kufuneka silumke xa usebenzisa eli chiza xa izigulane sokuwa okanye fibrillation.

Nokusebenzisa ixesha elide basenokuba ukuxhomekeka iziyobisi.

Umngcipheko zokurhoxa syndrome kubandakanya ukuyekwa ngokuthe ngcembe unyango "Akinetonom".

ukusetyenziswa beziselo zotywala aqulethe kufuneka kuphetshwe ngexesha therapy.

Unyango nalo eli chiza ifuna ndizila ukuqhuba izithuthi kunye nemidlalo izinto ezifuna yoxinaniso ophezulu kunye reactions lengqondo okukhawulezayo, ekubeni ihambisana ingozi enokubakho ngenxa ingozi yokuba nesiyezi.

"Akineton". Imiyalelo yokusebenzisa. analogs

Ntonye bokulungiselela ezi izinto zilandelayo: "Biperiden" "Mendileks" "hydrochloride biperiden".

"Akineton". reviews

Ichiza lusebenza kakhulu unyango Parkinsonism iingcangcazela kwi kwesebe buphelisiwe emva kwexesha elifutshane lekhefu. Uthi kakuhle kunyanyezelwa iziyobisi "Akineton".

Impendulo ku kwiiforam uthetha malunga amathuba okubonakalisa ezinye iziphumo ebezingalindelekanga ngexesha uthatha ichiza.

Lwentengo "Akinetona". indawo abanokuthenga

Ixabiso le-isisombululo ibe malunga 800 engange.

Ixabiso ekwakhiweni ngomlomo "Akinetona" - 560-580 engange.