"Artrozan": imiyalelo yokusebenzisa

"Artrozan" imiyalelo zokusetyenziswa ibhekisa kudidi lwezonyango kunye amayeza of oxicams. Eyona nto ephambili esebenzayo yokulungiselela - meloxicam into iyasebenza uyakhetha Cox-2 inhibitor. Osihloko sithi "Meloxicam" eli chiza ibhaliswe kwirejista yabahambi.

Ifom elucwecweni ichiza kwenziwa amacwecwe ezinobunzima 15 mg okanye 7.5 ezipakishwe namadyungudyungu Ulinganiso nentaba.

Ngeempawu amayeza amayeza "meloxicam", oya kuthi uzuzwe enolievoy ubuncwane acid, njengendlela amanyathelo anti-ukudumba kunye iintlungu. Le ndlela isekelwe phezu ukukwazi ichiza ukuze kuthintelwe inkqubo synthesizing prostaglandins. Phantsi yempembelelo indlela iziyobisi kwenzeka, ngexesha apho emane zinqanda umsebenzi enqanda Cox-2, nto leyo uthathe inxaxheba biosynthesis engundoqo.

Ngoxa ezithatha ichiza, "Artrozan" kuchaza isenzo yalo ngale ndlela. Ukuba iyeza ilawulwa ngeedosi eziphezulu, ngoko ngexesha ixesha elide ukusebenzisa kwabo ukuhla kwi selectivity for Cox-2. Iyeza ngaphantsi ichaphazela Cox-1, olukhusela iphecana zesisu. Loo nto ngenxa yesi senzo bakhethe yaye wakhusela iphecana zesisu ukusuka ilunga kunye izilonda okwenziwa sisilonda sikabhobhosi.

Isiphumo nechiza elichasene-ukudumba "Artrozan" yemiyalezo idibanisa kunye kwezithandani umsebenzi enzyme of Cox-2, nto leyo wenza ngethuba lenkqubo arhabaxa.

Pharmacokinetics "Meloxicam" luphawulwa ngolu hlobo lulandelayo. Distribution "Artrozan" bakwazi ukoyisa imiqobo umzimba-tissue, ngenxa kule ezimbaxa kunye iiproteni plasma kutsho kuma-99%. Ukubunjwa Ixabiso lwamalunga xi fluid kulo mzekelo yi-50%.

Nethe: Ichiza umzimba phantse ngokupheleleyo iiseli zesibindi, ngaloo ndlela kukho ukuyilwa avela eziliqela pharmacologically cala.

Kukhuthaza: Le mveliso "meloxicam" ubonisa malunga nezabelo ngokulinganayo ngakumbi umchamo kunye endleni ngohlobo imveliso metabolic. Kuphela-5% of amacandelo na imveliso evela emathunjini.

Iimpawu pharmacokinetic beziyobisi "Artrozan" yemiyalezo kwakhona imisela ukuba iimeko ezizodwa. Kwizigulana ezithile, abadala xa efumana kugqitywe yehlise beziyobisi, kwaye kwimeko iimpawu ukusilela hepatic kunye kwezintso, ichiza ukusebenza engabonakaliyo phezu pharmacokinetics.

Ukulungiselela "meloxicam" ako kakuhle ukusuka iphecana zesisu, i bioavailability zenqanaba yayo efikelela 89% kwaye azichaphazeli ekudleni. Reception kwi amathamo zedosi eveliswa inika ingqalelo inxenye beziyobisi emzimbeni.

Distribution: Ngesiqhelo, lusebenze CSS kuthi ngomhla wesithathu ukuya ngomhla wesihlanu unyango, lo gama ukusetyenziswa kwayo ixesha elide zibonelelwa esitalini boxinzelelo ezinokuthelekiswa kunye iparameters zokuqala pharmacokinetic.

Le umthamo ichiza "imiyalelo Artrozan 'ukuba ukusetyenziswa kubalwa ngolu hlobo lulandelayo.

Sebenzisa beziyobisi kwifomu oludityanisiweyo kucetyiswa. Lwemithi wacebisa:

- kule lokuqala lonyango, iintsuku 2-3, isicelo "Artrozan" -ukoly;

- emva kweentsuku ezintathu okanye ezine kulawulo intramuscular kufuneka uye ukufumana amayeza ngomlomo - ngokohlobo amacwecwe.

Esithathwa zolawulo intramuscular, kunye nolawulo yomlomo ezifanayo kwaye elingana umgangatho (7.5 okanye 15 mg) kanye yonke imihla iintsuku. Ithamo kunye nexesha isicelo emiselwe ngobunzulu intlungu kunye neqondo ubuzaza komtshiso oko. Ekumiseleni ithamo kufuneka zithathelwe ngononophelo ingqalelo ingozi yeengxaki ukusuka phecana zesisu.

Xa kukho ukusilela kwezintso, idosi yemihla ngemihla ubuninzi elingekho ngaphezulu kwe-7.5 mg.

Ukusebenzelana nabanye iziyobisi ukuze nzima kukuvela neziphumo ilunga-ezilinyaziweyo kwisiqwenga zesisu. Musa ukuthatha amachiza ngexesha lokukhulelwa nokuncancisa.

Product "Meloxicam" kufuneka alondolozwe kwindawo emnyama ukuba akukho ngaphezu kweminyaka emibini.

Drug wathengisa ngokumiselwa kuphela.