Antivirals

iziyobisi Antiviral - amachiza ukuba zenze iintsholongwane ngokonakalisa izakhiwo zabo okanye ukuphazamiseka ebalulekileyo imisebenzi.

Kungoku kuphuhliswa inani elaneleyo nemithi. Bonke bephela zihlelwa yi iimpawu iintshukumo amayeza kwaye izinto ezibonisa ezithile zonyango. Nika iqela zilandelayo -arhente antiviral: ukusasazeka spectrum antiherpethetical, protivotsitomegalovirusnye, umkhuhlane, anti-retroviral. Abameli esaziwa kakhulu uhlobo yokuqala neziyobisi "ribavirin" yaye "Lamivudine". La machiza kufuneka iindlela ezintsonkothileyo amanyathelo, ezinxulumene nokunciphisa nucleic ngokuzibophelela kwi-enzayim ye-ntsholongwane. Njengoko igama intsimi lwesicelo kwala machiza kakhulu ibanzi kwaye iquka abaninzi DNA - kunye iintsholongwane RNA aqulethe ezingabangela ukuba PC engqondweni, ifiva Bangre, hepatitis C, kunye ne-AIDS.

Amachiza Antiherpethetical zimelwe mali abane, apho zabo isakhiwo morphological analog analogue acyclovir, penciclovir, famciclovir, valacyclovir. Iifom yokugqibela idosi ezimbini engasebenziyo. Xa abantu, baya eziguqulelwe kwi-acyclovir kunye penciclovir. Oku kubangela iipropati zabo morphological kunye histological.

Indlela yokusebenza ye-acyclovir na intsebenziswano kunye enzyme wentsholongwane egazini, ebezikuyo ephazamisa umjikelo yabo yophuhliso. Isiphumo ukutshatyalaliswa gciwane. Le intsebenziswano inikwa yi isakhiwo acyclovir, nto leyo dezoksiguanedina analog (purine analogue). Uninzi novelwano ichiza le ntsholongwane herpes simplex. Kukho iintlobo ezincinane ezo abanganyangekiyo kweli chiza. Le nemiphumo kuchazwa ngokuthi kusetyenziswe unyango immunosuppressive. Indlela ukumelana na ukuguquka kweenkqubo intsholongwane enzyme, ukutshintsha ingakumbi ichiza. Kwimeko apho iimeko ezinjalo iziyobisi amanye amaqela amayeza ( "Foscarnet"). Abantwana antivirals ziquka "Valacyclovir." bioavailability High, nto leyo ngaphezu kwamashumi amahlanu ekhulwini unobangela neziphumo ezifanayo. Oku kuthetha ukuba kufuneka ngeedosi ezincinane kakhulu ichiza (xa kuthelekiswa ne "acyclovir") ukuze kufikelelwe isiphumo.

Indlela yokusebenza ye penciclovir cishe akukho kwahluka izicwangciso qela. Kwakhona kukwaphulwa DNKmikroorganizma yokuqaphela. Noko ke, oko uyahluka ngokuthi kakhulu echaphazela varicella-Zoster virus (VZV).

Ngu protivomegalovirusnym iziyobisi ziquka "Ganciclovir", "Valganciclovir", "Foscarnet", "Cidofovir", "Fomiversen". Bona zinendlela kunokuba nzima samanyathelo, nto leyo ibandakanya inhibition lokhuphiswano DNA polymerase le silwanyana. Isiphumo sale intsebenziswano yi nokwaphulwa zobude chain DNA ekhokelela ekufeni kwalo. Inkoliso amachiza antiviral ukuba kupheliswe iimpawu zosulelo cytomegalovirus - oko kuthetha eli qela imithi. Noko ke, ukusetyenziswa emva elide yokunganyangeki ngamachiza inokuphuhlisa, leyo into kunciphisa uluhlu lokusetyenziswa kwazo.

Amachiza Antiviral kungaba nefuthe ngqo kwi-human immunodeficiency virus. Ngoko ke, ezinye namayeza afanelekileyo, nto leyo iba inyathelo efanayo, kudityaniswe iqela antiretroviral. Bonke zinendlela entsonkothileyo yemisebenzi enxulumene ne ukuvaleka iinkqubo enzyme yento ephilayo, waphula umthetho wayo ukuphindaphindeka.