Product "Onbrez Brizhaler": imiyalelo ukusetyenziswa, ukwakheka, analogue, umthamo

Kuba unyango obstructive uphawu isifo yemiphunga esingapheliyo waphuhliswa kwaye kuvavanywa ngayo nendlela ichiza ezintsha "photos Onbrez Brizhaler 'evezwa ngezantsi.

iimpawu ngokubanzi

Iyeza yenziwa yinkampani Swiss AG "Novartis". Kukho iidosi ezimbini (kwi 0,300 mg kunye 0,150 mg) medicament "Onbrez Brizhaler". Inkcazelo yokulungiselela luphawu njengokuba ngumgubo emhlophe ngenxa inhalation, nto leyo lupakishwa njengezingxobo.

It arhente inhalation sympathomimetic ukuba ukunyanga izifo obstructive ye isixokelelwano sokuphefumla. Lingcwaba lomfo beta2-agonists uyakhetha.

Xa njengezingxobo gelatin nzima ubungakanani idosi wesithathu eliphakamileyo ngaphaya ngaphandle umbala ikepusi kunye nomzimba. On top of the ipeyinti emnyama isicelo logo inkampani, nto leyo ifumaneka ngezantsi nangobetho amnyama ezantsi philisi iqulethe isiqu «IDL 150", eliphezu nangobetho abamnyama.

Xa njengezingxobo gelatin nzima ubungakanani idosi ezincinane lesithathu ngaphaya ngaphandle umbala ikepusi kunye nomzimba. Kwi kwisiqingatha eliphezulu camera logo inkampani ipeyinti blue, nto leyo ifumaneka ngezantsi band oluhlaza, yaye inxalenye esezantsi philisi uqulathe blue ileyibheli «IDL 300", eliphezu umgca oluhlaza.

isakhiwo

Enye philisi iqulethe indacaterol maleate xa isixa-mali ka-0,194 mg idosi nganye kwaye 0,389 mg kuninzi balawule. Icandelo abancedisayo asetyenziswe ngendlela ubisi sugar excipient, ukuba uyakwazi ukunyenyisa ubunzima kwiziqulatho.

Complex has a iqokobhe philisi "Onbrez Brizhaler" composition, yaye uqeqesho iquka uluhlu lwazo zonke izithako. Ukutyabeka senziwa umthamo we shellac, gelatin, oxide zentsimbi kunye black ferric, amanzi acocekileyo, propylene ethers.

eliphezulu oyidlayo philisi iqokobhe iqulethe izithako ezahlukileyo kancinane. Ukutyabeka lakhiwa ngokusebenzisa shellac, gelatin, oxide zentsimbi kunye ferric emnyama ecocekileyo zolwelo medium, propylene ethers, isakhi Brilliant oluhlaza, titanium dioxide.

indlela Action

Iziyobisi "Onbrez brizhaler" Umsebenzisi Isicelo ichaza isiphumo isithako indacaterol esebenzayo leyo xa ukunyuka ligand yamachiza aphendula adrenozavisimyh beta2-receptor. Le isiphumo amayeza kungenxa ipoti ye-enzyme adenylcyclase phakathi kwiiseli, apho ibalekisa adenosine utshintsho ngohlobo molekyuli elibujikele 3 ', monophosphate 5'-adenosine.

Ukunyuka icandelo lokugqibela ukuba buthathaka izihlunu kwi egudileyo inyumoniya. Indacaterol liveza umsebenzi ophezulu ngokunxulumene beta2-receptor. selectivity lwayo iyafana yesenzo formoterol.

Njengezingxobo "Onbrez Brizhaler" xa ukurhogele umboniso bronchodilatory isiphumo basekuhlaleni isixokelelwano sokuphefumla.

indima kwayo amaqhina oqhagamshelwano kunye nokuphungulwa iindonga zemiphunga distension nokulolonga okanye kakhulu karhulumente isifo obstructive kwindawo ethile static kunye neguquguqukayo.

Kanye ulawulo imini kukhokelela ekuphuculweni yokusebenza ebonakalayo lomgadi amalungu zifo. Le into esebenzayo liqala ukwenza ngokukhawuleza in 10 minutes ukuthi kuziveza umsebenzi. Oku kakhulu ngempumelelo ngakumbi ifuthe salbutamol xa umthamo we 0,200 mg okanye salmeterol / fluticasone xa kukho umthamo 0.050 / 0.500 mg. Umsebenzi ubuninzi indacaterol kunokwenzeka emva kweeyure 3-4 kuphela ukusuka kulawulo yi inhalation. Morning okanye ngokuhlwa ukusetyenziswa kweziyobisi ayitshintshi ifuthe layo bronchodilator.

loo ngxabano

Medicine "Onbrez Brizhaler" yemiyalezo ucebisa ukusebenzisa ukulapha kulondolozo utshintsho obstructive bronchodilation iphecana nokuphefumla kwizigulane kunye pulmonary uhlobo obstructive ezingapheliyo kwesi sifo. Ngenxa yoko sifo eso umda flow umoya unciphisa isixa womoya arhogelwe, ukuphuhlisa nokubamba-bamba umphefumlo. Isigaba sokuqala sifo bungabonakala ukukhohlela, isikhohlela, dyspnea, kunye hoarseness ngexesha imithwalo ngamandla.

Indlela yokusebenzisa

On amayeza "Onbrez Brizhaler" Izikali kunye nolawulo ukuze abadala beqabe imiyalelo. Ngokuqhelekileyo, oogqirha bacebisa mihla kokuchitha imixholo inhalation elinye philisi umthamo 0,150 mg. Le nkqubo lwaqhutywa usebenzisa inhaler okanye brizhalera, kuba njengesongezelelo ichiza. Umthamo angandiswa kuphela idinga kagqirha.

Obunzima inhalation kwemiphunga luyenziwa philisi enye ngosuku kunye ne nedosi ye-0,300 mg. Le nkqubo lwaqhutywa usebenzisa brizhalera. ubungakanani obukhulu yemihla ngemihla medicament ulinganiswa 0,300 mg.

Imithi "Onbrez Brizhaler" umyalelo manual ayibandakanyi kuhlaziywe iimfuno esithathwa kwizigulane abalupheleyo. Inhalation ezingafanelekanga abantwana, abelwe kuphela emva kweminyaka eli-18.

Ukuba isifo kudityaniswe kukusilela umsebenzi wesibindi nezintso ngohlobo qatha okanye ngcathu, uhlengahlengiso idosi akwenziwanga. Kunye ukunyhashwa enamandla amagunya akhankanywe apha ngasentla musa ukuqhuba amayeza therapy.

Kuba iziyobisi "Onbrez Brizhaler" yokusebenzisa indlela kuphela inhalation brizhalerom ngokuqinileyo efanayo lifinyele. Philisi isiyobisi asifanele ukuginya. Kufuneka zisetyenziswe ngexesha elithile yonke imihla. Ukuba kukho ikhefu kunyango, ulawulo olulandelayo oluqhutywa kwiiyure zilandelayo elimisiweyo imihla.

Ekwakhiweni pack nganye "Onbrez Brizhaler" iklip isixhobo ngenxa inhalation of package womphandle kunye eziquka njengezingxobo okubhalwe olungumgubo. Iyeza inikwa a ngenyoka, screen, nesivalo, isiseko kunye iqhosha ukhame isixhobo.

Phambi uhanahaniso cover inhaler i lisusiwe. Ukuvula ifowuni ugcina inxalenye yayo esezantsi, kwaye emva koko baphambuke kwicala ingundaba.

Ukususela iphakheji bathathe philisi enye ngezandla ezomileyo. Emva koko eyafakwa inhaler, ehleli ukuya kwindawo echongiweyo. Musa ukubeka iyeza kwi ingundaba. isixhobo wokuvala ngonqakrazo liviwa.

Inyathelo elilandelayo liya kuba imngene philisi. Ukuza kuthi ga ngoku, kwindawo nkqo bachitha isixa semali kanye pridavlivaniya amaqhosha ezimbini ihlaba. Ngesiqhelo, oluvakalayo schelchkoobrazny isandi ebonisa okuhlatywa capsule ngeso lenyama. Emva koko cofa amaqhosha amabini kwisixhobo inhaler.

Le fowuni igqalwa ilungele ukuze zisetyenziswe kwaye ingasetyenziswa kuyo. Ekuqaleni isicelo phambi kokuba ingundaba emlonyeni wakho, isigulane ephefumlayo ngokunzulu. Ke ubeka ityhubhu emlonyeni, ephethe kuyo umlomo kwimicu ebambe. Brizhaler ubambe lomzimba enye eliphezulu kwaye baqhube ngokukhawuleza, iyunifom kunye inhalation omninzi. Musa ukuyichukumisa iqhosha iintsimbi ukuze lihlaba.

Ekwenzeni ukuphululwa iimpawu weva kakubi, efunyanwa kokutshintsha iqokobhe uze sokutshiza imixholo. Ogulayo incasa bebunencasa emlonyeni. Ukungabikho uphawu evakalayo ezinqwenelekayo kufuna inhaler yoshicilelo ukuvavanya capsule. Kuyinto hooter kunokwenzeka kwindawo kwintshayelelo. Ukuba akuphumelelanga, leli philisi lwancothulwa ngoncedo iimpompo ukukhanya iyunithi kwisiseko. Ukuba ukuphinda-cofa amaqhosha ecaleni. Xa ezininzi imngene philisi ukuba baphuke phantsi.

Ngexesha inhalation kungabangela isandi iimpawu, kule meko isigulane ubamba umoya wakhe kuba ixesha ezifunekayo okuwisa ingundaba le kwisisu ngomlomo. Kuphela koko iyaphuma emoyeni. Oku kuya kuthintela kuyabuya ezingemnandi. Akuvunyelwe wavuthela ithumbu isixhobo.

Ukukhangela ukufumaneka umgubo ngaphakathi philisi, omnye kufuneka kuphakamisa isiciko kwaye sijonge kulo inhaler. Xa ibonwa ukuba imixholo philisi kakhulu, ngoko uvale ifowuni kwaye ukuba awaphinde onke amanyathelo ngentla ukuzilungisa ukuze zisetyenziswe. Le philisi kususwa ngokupheleleyo, kuyadumaza iinaliti omnye okanye emibini amayeza.

Inhalation kungabangela a ukukhohlela elibukhali. Isizathu sale meko kukufumana idosi ezele medicament. Ngamanye amaxesha ibetheke encinci ngumgubo ukusuka philisi em- ngomlomo. Zombini ukunyhashwa akufuneki kubangela inkxalabo.

Emva inhalation isigulane kufuneka enze isixhobo yokuvula, le nqaba ingundaba engenanto philisi iqokobhe isusiwe kulahlwe kuyo. Pipe koko ithotywe ukuvala umlomo kunye isiciko. Musa ukundilahla leli philisi engenanto ngaphakathi isixhobo, qala kwaye spin ngayo.

Kunye entsha epakishwe kufuneka asebenzise inhaler endala. Ukugcina isixhobo sopakisho kwaye kuphela namadyungudyungu efanelekileyo kwindawo eyomileyo.

On amayeza "Onbrez Brizhaler" manual icebisa ukuba agcine iirekhodi zazo usebenzisa ikhalenda amanqaku, olusetyenziswa kumphezulu engaphakathi pack. Xa abantu epheleleyo iza khumbula ukuba kuyimfuneko ukubamba inhalation elandelayo.

Kuba isixhobo ngeveki lokucoca kufuneka ukosula komhlaba zibhubha nomphandle wocango ngelaphu elicocekileyo, eyomileyo. Musa ukusebenzisa ulwelo nokucoca. Zonke iindawo inhaler kufuneka owomileyo.

Iimpawu zonyango

Imithi "Onbrez Brizhaler" umyalelo manual ayiqulathanga izindululo ukusetyenziswa kwizigulane kunye nesifuba. Oku kuchazwe yi kukungabikho ulwazi abahlele ukusebenza kakuhle kunye nokhuseleko nolawulo lwabantu abanjalo.

Ukuphunyezwa usenokuphelekwa inhalation ubukhali linyukile. Ukuba ngaba wehlelwa iinkqubo komzimba ezinxulumene ukuphefumla nzima okanye igwinya, iindumbisa ulwimi, imilebe kunye nobuso entloko, imvula ngohlobo urticaria, unyango kufuneka zilahlwe kunye nezenzo ephikisayo.

iyeza Inhalation ukuze bandiqumbise bronchospasm uhlobo ngamazwi, ephethe umngcipheko ubomi umguli. Naluphi na Imiqondiso yokuba unobangela ukucinywa ingxamisekileyo amayeza kunye nokusetyenziswa amayeza ukuphelisa uhlaselo.

Drug "Onbrez Brizhaler" umthwalo ekwaziyo esi sifo, nto ke leyo ebangele ukuba lisetyenziswa amanyathelo esingxamisekileyo nisaqala bronchospasm ahlekise. Ukuba imeko yomguli yayisiba kunye nezithintelo imiphunga ngenxa inhalation amayeza, ngoko sihlolisise imeko yomguli lezempilo kunye nendlela yonyango. Egqithayo idosi iphezulu yemihla ngemihla nje ayamkelekanga.

Ukuba iphuhlise yokuhlaselwa kakhulu (, kunye abanesifuba), isigulane kufuneka esibhedlele ngokungxamisekileyo yokurhaxwa. unyango ngokunzulu kufuneka ziqale ngokukhawuleza kangangoko kunokwenzeka. Kuba unyango ngamachiza indlela epinephrine, corticosteroids, aminophylline.

Ichiza wayisezela kunye nomthamo elicetyiswayo yi ayisoloko elungele inyathelo ebalulekileyo kwinkqubo yegazi, isiphumo ngathi izinto zalo ezibangela impendulo adrenozavisimyh beta2-receptor. Kakhulu izakhi ngenyameko kufuneka lwenziwe kubantu abanezifo iinqanawa myocardium negazi, kuquka uhlobo insufficiency coronary, igazi isingqi utshintsho, kunye noxinzelelo oluphezulu lwegazi, convulsive ukuxhuzula uhlobo thyrotoxicosis. Isilumkiso kuyafuneka, kwaye xa impendulo non-elifana kweempembelelo izinto ezibangela impendulo iziqalelo beta2-adrenoceptor.

Ichiza ekwaziyo yokunciphisa kakhulu umgangatho ion potassium egazini, ngaloo ndlela ebangela ukuphuhliswa kweenkqubo eziyingozi entliziyweni kunye nempahla. Lo ukuncipha K ⁺ kwi plasma kuthathwa ukuba okwexeshana, oko akuthethi ukuba wemvula. Xa iintlobo kakhulu kwimiqobo inyumoniya kunye hypokalemia kuphuhlisa yokunqongophala kwe-oksijini. hypoxia Unyango okungathetha arrhythmia intliziyo.

ulawulo Inhalation amachiza zedosi ophezulu-kwesinye kwandisa kumanqanaba iswekile egazini. Kulo mba, sicebisa esweni ngenyameko abantu plasma yoxinaniso seswekile yeswekile. Ukuze uzikhusele hyperglycemia kufuneka basebenzise amayeza rhoqo kwaye ngokwemithamo eziphakamileyo.

Malunga medicament "Onbrez Brizhaler" uluvo ngcali ubonisa iziyobisi ngezisebenzelwanoezibuya amahlwempu agonists sites beta2-adrenoceptor kunye exposure elide.

Kuthethwa data ngayo utshintsho kwinkqubo iphecana yokuphefumla obstructive kwifomu ezigulo ezondeleyo kuphela. Xa kakubi medicament, ezifana uhlobo isifuba inyumoniya, kukho ingozi yokuba zisenzeka yokusabela ezimbaxa apho isigulane esibhedlele bathimba inubatsiyu.

Akukho data ezivela eklinikhi, nto leyo awayeza kubonisa inyathelo indacaterol kwinkqubo ethwele umntwana phambi pulmonary ezingapheliyo obstructive. Yintoni na impembelelo enokubakho ngayo emzimbeni womntu bengaziwa. Abafazi sikwimo lokuphathwa eli chiza xa kufuneka ufumane uncedo kulindeleke ukuba emzimbeni kamama, amakhulu ubungozi ukuba usana olungekazalwa. Njengabanye agonists beta2-adrenergic, iyeza buyasikhulula izihlunu kwamagingxi isibeleko, ethi ichaphazele amandla yabasebenzi.

Kwakhona akukho lwazi malunga indacaterol hit okanye metabolites yayo ngobisi yabantu. Kukho ubungqina zoqhagamshelwano kunye into esebenzayo, kwakunye agents beta2-adrenergic bephefumla kwi amadlala mammary, nto leyo ekhokelela imfuneko ukupheliswa ichiza "Onbrez Brizhaler" nokuncancisa.

Phantsi kwempembelelo yeziyobisi akukho inguqu ukuchuma amadoda kunye nabafazi, njengoko kuboniswa izifundo kwinkqubo zokuzala.

Ichiza kunokuba nefuthe kulawulo lothutho okanye umsebenzi kunye iindlela ezintsonkothileyo, njengoko ebangela maxa nesiyezi kunye ingqalelo kakuhle.

Ngubani kufuneka asebenzise

Le medicament "Onbrez Brizhaler" umyalelo awusebenzi xa bacetyiswe uvakalelo kakhulu ukuya isithako esebenzayo, lactose okanye ezinye amacandelo ezongezelelweyo.

Inhalation contraindicated abantwana abangaphantsi kweminyaka eli-18. Bona musa ukwenza izigulana ukuswela Lapp-yelactose, galactosemia, ukunyamezelana ilifa lactose kunye galactose iimolekyuli.

Lithetha "Onbrez Brizhaler": Ukubuyekezwa oogqirha

He kubhekwa enye amayeza ezintsha ukusetyenziswa esisiseko izifo obstructive yemiphunga kwemiphunga. Kukho intabalala ubungqina ukusebenza kunye nokhuseleko indacaterol. Esi sixhobo kufakwa kwiprogram GOLD eliquka izindululo yamazwe unyango kwefom sifo yemiphunga nezengekho obstructive esingapheliyo.

Ulingo lwezonyango ziye zaqhutywa kunye inxaxheba indacaterol malunga-10 000 izigulana na kwesi sifo. Kufumaniseka ukuba ubuncwane esebenzayo uba noludumileyo ebalulekileyo asebenzayo phezu pacifiers kunye nezinye bronchodilators mihla unyango olusisiseko Khobzey.

On amayeza "ncomo Onbrez Brizhaler 'loogqirha iyiphakamisa inyathelo ultradlitelnom kunye lwamkelo elinye yonke imihla. Le mveliso inikeza ngokukhawuleza bronchodilator ukusebenza emva kwemizuzu emihlanu ekupheleni yokuntlokothiswa.

Kwakhona kuba imali "Onbrez Brizhaler" iimpendulo kubonisa ukuhla kwireyithi ngokonakala nobume bempilo kwizigulane kunye nezithintelo emiphungeni. Ngexesha exacerbation yokuhlaselwa karhulumente iqhubela phambili ngokukhawuleza, isigulana ibekwe esibhedlele, ukuze kubekho isiphumo ebulalayo. Esibhedlela kuyabiza.

It is a unyango ngamachiza Khobzey mihla, umenzeli wayo esebenzayo emiphungeni ngenxa inhalation of inhalation, oluqhutywa isixhobo ngesandla. Ichiza ebangela ukuthanjiswa izihlunu kwamagingxi kwimibhobho inyumoniya, into leyo eyenza igalelo ukwanda ngokukhawuleza. Le ukusebenza eliphezulu kunciphisa iimpawu zesi sifo. Ngoko ukuphelisa Ukuphelelwa emva kweentsuku ezingama-30 ukususela ekuqaleni yokuntlokothiswa. Ngako oko ke ufanelwe philisi "Onbrez Brizhaler" ingxelo entle. Ukusetyenziswa ichiza ivumela umntu ogulayo ukuba isebenze yaye usenokuphila ubomi obuqhelekileyo nokufezekisa.

umbono kwizigulane

Eyona ndlela for "Onbrez Brizhaler" angqina zabantu abanengxaki umonakalo kwemiphunga ngendlela ezingapheliyo, ezingqina impumelelo inhalation. Emva kweentsuku ezi-5 unyango, izigulane ezininzi wabona ukwehliswa ukuphelelwa umoya, yaye emva kwikhondo unyango abantu baqala ukuza kukuchasa, phantse kanzima.

Njengezingxobo unokuviwa "Onbrez Brizhaler" ncomo ezimbi. Bona onxulumene ukubonakala ezinye izigulane kunye neziphumo ngokwezonyango ephawulekayo sentliziyo. Ezi ziquka izinga intliziyo ukwanda kunye noxinzelelo oluphezulu lwegazi. Ngaloo ndlela kufuna unyango nokususwa le arhente.

analogs

Intloko medicament "Onbrez Brizhaler" mgangatho bronchodilator amayeza amanyathelo ezisisiseko. Uphethe ngcono xa kuthelekiswa amayeza ngenxa yokuba salmeterol, formoterol kunye tiotropium.

Medicament "Flomax" kucingelwa ukuba i-analogu beziyobisi Swiss. Le ibandakanya bromide tiotropium esetyenziswa ingxenye antiasthmatic. Oveliswa ngokohlobo njengezingxobo, imixholo olungumgubo inhalation kwi ne nedosi ye-0,018 mg. Umqulu iqulethe amaqhosha 30 kubo, apho kuyinto inhaler apha.

Enye indlela enjalo ingqalelo iziyobisi "Salmeterol" njengoko zetoti enemitha ukuba inhalation. Idosi enye eziqulathwe 0,025 mg okanye 0,050 salmeterol mg. It libhekisela bronchodilator, uyakhetha inyathelo beta2-Adrenomimeticalkie.

Uyakhetha agonist isenzo kwi ichiza β2-adrenoretseptery yi "formoterol" ngokohlobo ngumgubo ngenxa inhalation, nto leyo lupakishwa njengezingxobo. Drug waphatha kokuphazamiseka inyumoniya izifo kwemiphunga, bronchospasm somoya, aleji umoya obandayo okanye ukuzilolonga.