"Ademethionine": imiyalelo ukusetyenziswa, analogs, ncomo

Yintoni na ademetionine iziyobisi? Imiyalelo yokusebenzisa yokulungiselela, equlethe kwicandelo ziza kuchazwa apha. Siya kunixelela ukuba malunga indlela ibiza isixhobo efanayo ukuba abasebenzisi bathi ngayo, njalo-njalo.

Isiyobisi, incazelo yayo

Ziziphi fom iziyobisi ezikhoyo "Geptral" (inn "Ademethionine")? Imiyalelo Sebenzisa ithi esi sixhobo iyafumaneka iintlobo ezimbini ezahlukeneyo:

• Le lyophilizate, yenzelwe ukulungiselela isisombululo efakwa okanye intramuscular. Le fomu ubunzima lyophilized amhlophe, kungekho inclusions amazwe. Kwakhona, xa kukho ikhadibhodi bundle iqulathe kuphela eyodwa na uhlobo ulwelo ezingenambala nengafihliyo.
• "Ademethionine" - iipilisi ezigqityiweyo kwimvulophu emhlophe, biconvex kunye elimbhoxo. Ngaphezu koko homonymous into esebenzayo, oku kuthetha luqulathe nezinto abangabancedani ezifana MSC, Na-carboxymethyl dust kunye stearate mg.

iimpawu pharmacodynamic

Yintoni iimpawu ademetionine iziyobisi? imiyalelo Isicelo inikeza ukuba uthe imiboniso yezinto choleretic, holekineticheskoe, detoxifying, yoluvo kwaye hepatoprotective kwaye anti-nokudakumba kunye neziphumo antioxidant.

Ngenxa yoko, kukhuselekile uqaphele ukuba element ichiza ingqalelo esikwaziyo ukuphakamisa secretion ngayo ibile ducts, ningandiqumbisi ngokwahlukana kwayo emathunjini.

Kwakhona qaphela ukuba ichiza "Ademethionine" analogs leyo ziboniswa ngezantsi, Wawuzalisa ukunqongophala SAM, kodwa ke kukhuthaza ukuyilwa esibindini. Ngapha koko, oku kuthetha kakuhle kwandisa plasma yoxinaniso of cysteine, taurine, isiqulatho glutamine esibindini, ngaloo ndlela normalizing iinkqubo pathways esibindini kunye nokunciphisa umgangatho methionine in serum.

Phantsi kweemeko oko kuthetha "Ademethionine" kakhulu ngempumelelo? Imiyalelo yokusebenzisa zibonisa ukuba eli chiza engaqhubi kakuhle wobisi kunye cholestasis tubular hepatic. Iqhuba conjugation LCD kunye sulfation iiseli isibindi, yaye emva koko zehlisa letyhefu zabo.

Ngokutsho iingxelo ziingcali, iziphumo choleretic kunye hepatoprotective emva liyekiswe unyango "Geptralom" egcinwe ukuya kwiinyanga ezi-3.

Xa kunikwa uxanduva oku kuthetha abantu ngamakhoboka opioid, kulandele isifo sesibindi, iphucula lo msebenzi omzimba monooxygenase iinkqubo igcwala, kodwa inegalelo Isemantiki kweempawu zonyango kukuyeka iziyobisi.

ukusebenza bucala emva kokuba isicelo kwalo leziyobisi kancinci. Noko ke, uya uzinzo kwiiveki ezimbini ezidlulileyo.

kuthetha nokubanako kinetic

unyango "Ademethionine" ugxile? Imiyalelo yokusebenzisa leengxelo ngomlomo bioavailability yayo yi-5%, kwaye xa usebenzisa-ziphene - 100%.

I kwincopho yoxinaniso beziyobisi egazini ngexesha idosi enye ye-tablet elinye elifana neli iiyure 2-6.

I-plasma protein-ebotshiwe imeko yale arhente kuphela hi mpimo lowutsongo. Kufuneka kuqatshelwe ukuba ichiza ungena kakuhle endlwini BBB, nokuba kungomlinganiselo aphezulu kube lula ukubonakala nkqu ulwelo lwe-cerebrospinal.

Biotransformation ye ichiza kudandalaza esibindini. Ukupheliswa bawo-ixesha iiyure 1.5. Lithathwe kweziyobisi nezintso.

Ubungqina obubonakalayo buxela ukuba nesikhundla indlela

Kutheni sifuna unyango "Ademethionine" (ixabiso ichiza elikhankanywe ngezantsi)? Eli yeza lidla olumiselweyo:

• iimpawu zokudakumba;
• cholestasis intrahepatic kwaye ithi cirrhotic pretsirroticheskih, kuquka steatosis hepatic;
• cholecystitis ezingapheliyo ngaphandle ngamatye;
• kohlobo;
• cholangitis;
• izilonda eziyityhefu hepatic imvelaphi ezahlukeneyo, kuquka wentsholongwane egazini, utywala neziyobisi (lakhula tricyclic, nemithi, antivirals, antitumor kunye anti-TB iziyobisi, zokucwangcisa ngomlomo);
• ukuqina;
• cholestasis intrahepatic amabhinqa akhulelweyo;
• Encephalopathy, kubandakanywa ezinxulumene insufficiency hepatic (utywala).

Siphelisa ukusetyenziswa

Kuphantsi kwaziphi iimeko kufuneka ingamiselwa ichiza "Ademethionine" okanye "Geptral"? Oku kuthetha ukuba kusetyenziswa enokuphazamisa yemfuza echaphazela umjikelo methionine, kwakunye ibangela hyperhomocysteinemia okanye homocystinuria. Kwakhona ke contraindicated ukufumana kwi esakhula nobuzaza kakhulu ademetionina.

Umthamo "Ademethionine" Amacwecwe

Iingcali Guest zithi lijongene indlela aya kuthatyathwa kwindlela phakathi nokutya ekuseni, hayi kukutyumza okanye ukuhlafuna. Kulo mzekelo, cwecwe kufuneka zisuswe Ibukisheni ngqo kokuba kudliwe.

Idosi yemihla ngemihla yale imithi amacwecwe 2-4, kunye nexesha unyango kuxhomekeke ubungqina.

Imiyalelo yokusebenzisa yezisombululo

Ndingayisebenzisa njani isisombululo injectable "Ademethionine" analogue leyo inokufunyanwa na ekhemisti? Le ukulungiselela ethengiswa ampoules, intramuscularly okanye yegazi. Ngaloo Inaliti efakwa ikhutshwa phandle kancinane kakhulu.

Isisombululo ichiza elungiselelwe kanye phambi ngenaliti usebenzisa ngumgubo lyophilized ukuba sijike ukuxutywa obakhoyo iphakheji kwikhadibhodi.

Emva Inaliti beziyobisi eseleyo kufuneka itshatyalaliswe.

Kufuneka kuqatshelwe ukuba uhlobo injectable "ademethionine" asihambisani izisombululo obrak kunye nemixube equlethe ion Ca.

Idosi yemihla ngemihla ye-arhente TOLC 1-2 ampoules. Unyango ngale medicament ithatha iiveki ezimbini.

Xa ndidandathekile ichiza kuqwalaselwa lisetyenziswa idosi efanayo. Xa le mali ikhutshwa phandle iintsuku 15-18.

Ukuba isigulana sidinga unyango inkxaso, koko wathunyelwa azipilisi "Heptral".

imiphumela emibi

Yintoni embi abasabela kunokubangela amayeza "Ademethionine" (400 mg) Njalo xa unyango kunye eli chiza xa izigulane ukuba urhudo, iintlungu esiswini kunye isicaphucaphu.

Kwiimeko ezinqabe kakhulu ukusetyenziswa isisombululo "Geptral", kwakunye nefom walo wecwecwe kunokubangela uphuhliso:

• Imp (ngamanye usulelo womchamo);
• nokudumba laryngeal, reactions hypersensitivity;
• paresthesia, ixhala, intloko ebuhlungu, sokulibala, isiyezi, ukudideka;
• ukurhawuzelelwa, obubonakala isikhumba komzimba, irhashalala, angioedema, ukubila;
• ukudumba iindonga imithambo zangaphandle, ukuphazamiseka iimpahla ngentliziyo negazi, komzimba;
• nokuqunjelwa, umlomo owomileyo, ukugabha, esophagitis, isicaphucaphu, iintlungu esiswini, urhudo, ukuqunjelwa, ukuphazamiseka komsebenzi we phecana wokudla, ukuqumba, yokulunywa biliary, isibindi ukuqina, wopha ezahlukeneyo GI phecana;
• ubuhlungu bamalunga, spasm imisipha;
• oluthile, umkhuhlane-ezifana syndrome, ifiva, kuthibaza, nokudumba yoluvo, asthenia.

Iindleko iziyobisi, analogs kunye nohlolo

Yimalini olu nyango "Ademethionine"? Ixabiso le mveliso imalunga 1500 engange azipilisi nganye kwaye malunga 1900 engange inaliti nganye.

medicament ingxelo kungenziwa indawo uma oyifunayo ngokusebenzisa ezifana "Glutamic acid" "Karnith" "Histidine" "carnitine", "Epilapton", "Elkar".

Yintoni abantu bathi abasebenzisi iziyobisi ngayo? Ngokutsho iingxelo kwizigulane abaye neziyobisi isifo sesibindi "Ademethionine" yeyona gepatoprotektor kokwenyani kuphela. Izigulane unesifo "kwesibindi" bathi iziphumo ezingcono unyango kungenziwa kuphela xa ichiza esebenzayo ezithathwe amaxesha 2 ngonyaka ngezifundo nyanga-3.

Ke ukuba oogqirha, ukuba ingxelo ukuba ichiza "Ademethionine" ngaba ukunika isiphumo ngokukhawuleza yaye ngokukhawuleza izifo ukudumba kwesibindi, kulandele ekuma of inyongo kwi kwizihlunu zomzimba.