"VFS": imiyalelo ukusetyenziswa. Analogs, uhlolo kunye Izimo "VFS"

"VFS" Amacwecwe lelona qela kwiklasi yokuqala arhente antiarrhythmic. A iziyobisi ekwaziyo ethintela imijelo sodium xa imifinya of cardiomyocytes. It Uxhokonxwa kuyehla intraventricular kunye Uhanjiso atrioventricular shortens ixesha ezisebenzayo ngempumelelo eliyinjubaqa kwi imithambo, bundle block yesebe, AV-esiludumbo neerhali Purkinje. Kuthethwa akukho ukusebenza ixesha eliqhubekekayo le QT-lokuphumla, ugcinwe kwesibeleko. Xa kungekho ukwenza izinto zokuqala umsebenzi yokungeneli kwentliziyo, iziyobisi "VFS" (umyalelo manual iqulathe ulwazi) alunasiphumo kwi contractility engabalulekanga. Oku akuchaphazeli conductivity le atrioventricular ulwalathiso node anterograde. Menzi akanayo isiphumo esibi iqinile. Kuqeqesho ayinakuba yi zingaphawulwa impembelelo inotropic. Xa ufumana iyeza ayikho elinganeno kwi ukuzenzekela sinus node. Kuye antispasmodic, ntlungu kufutshane nendawo, kwaye inyathelo eliphakathi anticholinergic ukuba akukho isidanga ukubaluleka clinical. Kuye koronarorasshiryayuschee encinane, iipropati umthomalalisi. Umphumo yamanqaku e-orali mane okanye imizuzu zaba ngamashumi omathandathu. Lufikelela umsebenzi likhulu emva kwemizuzu engama-80. Ubude amanyathelo unyango - ngeeyure ezili-8.

Pharmacokinetics kwiimeko ngokubanzi

Le bioavailability nama-40%. Ichiza umzimba esibindini kwaye liyakwazi ukuba zingene BBB. Kukhuthaza beziyobisi lwenzeka kwi yokuchama. Xa ephule kwexesha umsebenzi sezintso of zinomgutyulo linyuke amaxesha 2-3.

Yintoni lithetha "VFS" ezibonisa ukuba ukusetyenziswa?

Ichiza eboniswe ventricular kunye extrasystoles supraventricular, paroxysmal tachycardia kunye nohlobo (akukho izitshanguba entliziyweni zohlobo organic kunye syndrome WPW), enomoya atrial kunye paroxysms atrial.

umthamo abakwisigaba

Ukulungiselela "VFS" yemiyalezo lithethelela ukuba ithamo - 25 mg 1 ixesha nganye iiyure ezisi-8. Xa kungekho okucacileyo japan unyango medicament uthabathe qho kwiiyure ezi-6. Kwezinye iimeko ukuba ukuvuka nedosi kabini enye (50 mg). Ixesha lokuphumla kule meko iiyure 6-8.

Ngosuku lo eliphezulu ukuba akukho ngaphezu mg 300. Ubude unyango kunye bona ulungiso yesekethe ofumana specialist elimisiweyo. Basela amayeza emva kwesidlo. Kucola okanye yokuchitha sixhobo akuvumelekile.

Medicament "VFS": ziziphumo ebezingalindelekanga

Phantsi imimiselo ichiza kagqirha zivunwe izigulane bayo yonke iminyaka yobudala okulungileyo ngokwaneleyo. Noko ke, kukho amathuba neziphumo ezibi ngokusekelwe unyango iziyobisi "VFS". ziphumo bezingalindelekanga Ngoko kumanqanaba angafaniyo ubungnqongqo. Iarhente kungabangela yokuphazamiseka kwiintshukumo zeenkqubo neuropathy central luvo. Ngokukodwa, kukho nesiyezi, diplopia, Ataxia. Phakathi Iziphumo ezingentle iimpembelelo ichiza kwi iingcali yegazi qaphela ephule ebonakala Uhanjiso intraventricular kunye atrioventricular, uphuhliso sinus tachycardia (kunyango ixesha elide). obubonakala Ezingalunganga ziquka ukusebenza arrhythmogenic, yokwandisa QP-uluhlu, ukwandiswa QRS-complex kunye nezinye utshintsho kwi pattern ECG. Ngenxa unyango iziyobisi "VFS" (umyalelo manual ulumkisa ngayo) livela anozizi eluswini, iintlungu entloko okanye ukuziva ubunzima. Ezinye izigulane zifumana i uxabane (irhashalala okanye kwesikhumba). Iqulethe ulwazi malunga neziphumo ezibi amayeza "VFS" umyalelo manual. Ukuphonononga iingcali ngokuphathelele iindlela nokuthwaleka, ngokubanzi, eyakhayo. Noko ke, ngenxa ubunzulu ezinye zeziphumo ezibi ichiza lwenziwa phantsi kweliso n'wina gqirha.
Kwimeko apho iingxaki kunye ukwehla kufuneka ngoko nangoko ndwendwela yincutshe. Kulo mzekelo, ugqirha ukuze ukhethe endaweni lithetha "VFS" iziyobisi efanayo.

Xa wabelwa ukuba amayeza?

Izimo ziquka mothuko cardiogenic, ibloko atrioventricular kwinqanaba lesithathu kwaye yesibini (xa kungekho lomqhubi ngumntu intliziyo rhythm). Akuyi kuvunyelwa ukuba ukusela iyeza lwegazi kwixesha elinzima (uxinzelelo iSystolic ngaphantsi kwe-90 mm / HG.), Hypertrophy kwi myocardium le ventricle ekhohlo libizwe. amachiza Yavalwa kwi cardiosclerosis post-iposi. Ichiza ke kucetyiswa ukuba kuvalwe iindlela ekunene umlenze block bundle yesebe (xa idibene ukuphazamiseka kweli sebe kwicala lasekhohlo), ezingapheliyo ukusilela umsebenzi intliziyo eliphakathi kwaye kakhulu. Contraindicated iyeza kwiminyaka eli-18 (ngenxa yokuba oko lusekiwe ngokhuseleko kunye nokusebenza kwe-arhente), fructose ukunganyamezelani. Akuyi kuvunyelwa ukuba bathathe amayeza abantu kunye syndrome of bakhubazekile resorption galactose / iswekile, ukukhulelwa, intsilelo isomaltase / sucrose. Akukhuthazwa kweziyobisi ngenxa hypersensitivity ukuya amacandelo. Ukuba ufuna ukuchitha kwanonyango oncancisayo kwisigulana, ufuna ukuyeka zisanyisa.

Xa ufuna ukulungiswa ithamo?

Maxa wambi kukho imfuneko yokuba kutshintshwe izixhobo "VFS" ukufumana wesekethe. Imiyalelo, izimvo kwiingcaphephe eziqulathe ulwazi ukunciphisa isixa ichiza okanye ukunyusa lekhefu phakathi amathamo nga ukunconyelwa kunye ibloko atrioventricular kwi isidanga sokuqala, enokuphazamisa Uhanjiso intraventricular, bradycardia. Isilumkiso ukuthobela engile-ukuvalwa neglaucoma, ukuphazamiseka yegazi (peripheral) uhlobo enzima hypertrophy zomzimba yesinye. iisekethe akhuze ngokusekelwe electrolyte lokugaya utshintsha conductivity e kwimicu Purkinje, kuvalwe iindlela omnye imilenze kwibhloko bundle yesebe. Isilumkiso efunekayo xa efumana eminye imithi antiritmicheskih ngaxeshanye amayeza "VFS". Izimvo ziingcali ezininzi akafuni nokuva kakhulu kumba yeenguqu idosi kungekho isiphumo.

Ukuze ufumane inkcazelo engakumbi,

Ngaphambi kokuqalisa uthomalaliso akubikho ukuphazamiseka kwamanzi ukulingana electrolyte kwinkqubo yokufumana iyeza kuyimfuneko ukuze kuqinisekiswe ulawulo rhoqo nangenyameko phezu kwayo. wentliziyo nqgo embundwini ukuze nande kwizigulane abaye baba ndamelwa yintliziyo (yondele), ukusilela intliziyo, okanye abe pacemaker ngumntu. Kwimeko nesiyezi, umbono kabini, yintloko ziyakhuthazwa ukunciphisa izinga. Xa tachycardia sinus ngokusekelwe elide beta-blocker reception kweziyobisi zabelwe kuyimfuneko. Ezi amalungiselelo ziyacetyiswa ngeedosi ezisezantsi. Ngenxa yokuba unyango kufuneka silumke xa imisebenzi izinto ezinokuba yingozi ukuba zifuna ukwandisa ingqalelo kunye ingqalelo ekhawulezileyo okanye indlela.

libanda

Ngenxa yokuba eli chiza nobubanzi ephantsi yentshukumo unyango, ukunxila okanye kakhulu nga kwenzeka lula ngokwaneleyo. ubungozi Ingakumbi ophezulu yityhefu emva kokufumana kwamanye amachiza antiarrhythmic. Xa libanda, ephawulwe zobude PR- kunye QT-ngamathuba, ngezantya kwandisa T-wave ukwanda QRS-complex. Ngokuchasene imvelaphi kunxilwe kuvela asystole, bradycardia, sehla contractility kwi myocardium. Le isigulane zabona sinotrialnaya yaye kuvalwe, ukunciphisa uxinzelelo zomlomo wakhe, iingxaki kwinkqubo yokwetyisa. Ukunxila ihamba paroxysmal polymorphic tachycardia ventricular, ukungaboni, isiyezi, iintlungu apha entloko. Kwimeko wonyango kwangumqondiso libanda, iyaboniswa. Unyango ventricular tachycardia lwenziwa kunye nokusetyenziswa kweziyobisi antiarrhythmic udidi I A and mna C Ukwandiswa QRS-entsonkothileyo, hypotension kunye bradycardia mayisuswe sodium hydrogen carbonate.

Ukusebenzisana nabanye imithi

Xa ethatyathwe kunye inducers of microsomal hepatic enzyme ukusebenza iziyobisi "VFS" ucutho. Oku kwandisa amathuba neziphumo ezinetyhefu. Xa ukufumana amachiza antiarrhythmic ezinye iiklasi landa nokwenzeka zokuphuhlisa impembelelo arrhythmogenic. Isixhobo kwakhona iphucula umsebenzi of non-depolarizing relaxants kwezihlunu.

Yeyiphi kukho ichiza eyiyo kwindlela efanayo yesenzo?

Lithetha "Allaritmin" iqulethe into esebenzayo efanayo iyeza "VFS" - hydrobromide lappaconitine. Le medicament ibhekisela iklasi I iziyobisi antiarrhythmic. "Allaritmin" Eli yeza iyafumaneka azipilisi kwaye njengesisombululo ukuba isitofu ibe isihlunu okanye umthambo. Xa kuthathwa ngomlomo, ifuthe medicament livela malunga neyure. Emva kweeyure 4-5, ufikelela ngempumelelo enkulu. Ubude ukusebenza - Iiyure ezi-8 okanye ngaphezulu. Ukuqaliswa non ifuthe ichiza kwenzeka ngokukhawuleza - kwisithuba imizuzu eli-15-20. Ngokungafaniyo medicament "VFS" lithetha "Allaritmin" ekucetyiswa ethululwayo amaxesha 3 imihla-25 mg. Thatha iyeza kufuneka phambi kokuba atye. Amacwecwe eyo enqwenelekayo. Kwimeko yokunqongophala ukusebenza ukuze kwandiswe idosi esasidla yolwamkelo. Ulawulo efakwa ikhutshwa phandle kancinane, ngaphezu kwemizuzu emi-5. Ngaloo ndlela nesilinganiso zisetwe ubunzima umguli. Isincomo yi 0.3-0.4 mg / kg. Kwezinye iimeko (ingakumbi kakhulu) iziyobisi elawulwa ngokuphindaphindiweyo iiyure ezi-6. Xa kwemisipha elawulwa 0.4 mg / kg emva kwesithuba iiyure ezi-6. Oku kuqatshelwe ukuba ulawulo efakwa ayikhuthazwa ukuphumeza ekhaya. Drug "Allaritmin" liye izithintelo efanayo ukusetyenziswa nje amayeza "VFS". Unyango oluqhutywa esibhedlele phantsi kweliso lomgadi gqirha esweni ECG. Oku kubaluleke ngokukhethekileyo kwi unyango izigulane yokuqala isidanga ibloko atrioventricular, ukusilela intliziyo, decompensated ezingapheliyo uhlobo khosi.

isiphelo

Lithetha "VFS", ukusetyenziswa ekufuneka kulawulwe, njengezinye antiarrhythmics, woba kudidi kwamachiza esinamandla. Xa engekho isiphumo unyango kufuneka sandise neyethu yawo xa uthatha idosi elimiselweyo yincutshe. Oku kungenxa yokuba kukho umngcipheko ukunxila kunye nezigulo ezilandelayo. Phambi kokuba kokunika ichiza, ugqirha kufuneka abeke isigulane ulumkele iziphumo ebezingalindelekanga kunokwenzeka kunye Izimo. Ngenxa yoko, isigulana ubalisa phambi sokucalulana, kuquka kwimbali, kuyo nayiphi na eendaba, kwakunye amachiza ukuba kuthatha ezongezelelweyo. Ngaphambi kokuba le amayeza kufuneka kuvelelwe nezinye iinkalo ezizakuxhasa ukuvula.