"Theophylline": imiyalelo, analogs

Ndingayisebenzisa njani ichiza "Theophylline"? Imiyalelo ukusetyenziswa, analogs kunye neempawu ze-mali iya kuxoxwa kamva.

Yenziwe ngoobani kunye nemilo

Equlathe amayeza, "Aminophylline"? Imiyalelo Sebenzisa ithi element esebenzayo kwesi sixhobo ligama elifanayo impahla - aminophylline.

Ichiza nawokwazisa ngawo isisombululo ukuba ulawulo efakwa, kwakunye ngohlobo iipilisi, lotions okanye namafutha aqholiweyo.

features kwemithi

Yintoni na iyeza njengoko 'Theophylline'? Imiyalelo yokusebenzisa (ampoules eli chiza zingathengwa kuyo nayiphi na ivenkile) ingxelo ukuba vasodilating, antispasmodic, umchamo kunye bronchodilatory neziyobisi.

Into elikhutheleyo medicament kukho ityiwa theophylline ethylenediamine. It has a isiphumo bronchodilatory kunye bronchodilator, ngenxa isiphumo relaxant yayo ngqo kwi kwimicu kwezihlunu egudileyo nemithambo kwemiphunga kunye yomoya. Le isiphumo ibangelwa inhibition akhetha ngayo umsebenzi phosphodiesterase, kukhokelela ekwandeni Camp intracellular.

iimpawu ichiza

Isixhobo ephawulekayo "Theophylline"? Imiyalelo yokusebenzisa ithi ukuba uyakwazi ukwehlisa hyperreactivity Kwiphecana sokuphefumla. Indlela yesi senzo akwaziwa, kodwa iingcali zithi ukuba ukusetyenziswa kweziyobisi ingqalelo ebangela ukwanda kwenani kunye umsebenzi T-suppressors egazini.

Ukunyusa ukucoca mucociliary, ukwandisa yindibanisela uvalo, ngokunjalo ngokuvuselela umsebenzi kwizihlunu intercostal zemiphunga, isixhobo iyazingenela iziko yokuphefumla, ukunceda ukuphucula uvakalelo wayo, kwaye yandisa umoya alveolar, nto leyo ekugqibeleni kukhokelela ekuthotyweni ubuninzi kunye nobukhulu izigigaba umoya.

Njengoko omnye isiphumo ichiza, "Aminophylline"? Imiyalelo yokusebenzisa (ngamafutha kunye nesisombululo neziphumo ezifanayo kwi eziphilayo) ithi phantsi ingqalelo ithetha ulawulo umsebenzi yokuphefumla, ngokwenjenjalo kuphuculwe igazi inkqubo Ukwanda O2 sehlise uyazikhomba carbon dioxide. Ngaphezu koko, isiyobisi esebenzayo uyakwazi ukukhuthaza umoya hypokalemia.

Kufuneka kuqatshelwe kwakhona ukuba "Theophylline" imiyalelo ukusetyenziswa ichazwa ngezantsi, iyazingenela intliziyo, kwandisa rhoqo kunye ngamandla nokubetha kwentliziyo, yandisa isidingo kwemisipha ngentliziyo kwelo O ₂ kuphula igazi flow kwegazi.

Ukusebenzisa le ekuqulunqeni inceda ukunciphisa Cerebral nemithambo ithoni, zezintso nolusu. Iingcali zithi le arhente koqwalaselo umchamo neuropathy inyathelo venorasshiryayuschim liyancipha ukuxhathisa yemiphunga semithambo, zehlisa uxinzelelo igazi kuye kwasasazwa pulmonary kudaleke igazi kuqukuqela nezintso. Kwakhona, le ekuqulunqeni kuphucula iphecana biliary kwaye ithintela adhesion zegazi kunye nokukhululwa njengabalamli reactions hypersensitivity, uzinzise eludongeni iiseli lwemasti, ulawula microcirculation, ukunciphisa ubungozi thrombus ukubunjwa kuphucula nozinzo erythrocytes.

Ngeedosi ezinkulu iziyobisi ingqalelo ibonisa iipropati epileptogenic.

kinetics

Ziziphi parameters uphawu i "Theophylline 'kuthetha kinetic? Imiyalelo yokusebenzisa (elwe le ukulungiselela isetyenziswa kaninzi) imisela ukuba emva kokungena akhule ekumgangatho wabantu esebenzayo beziyobisi umzimba kunye ukukhululwa koko theophylline engadityaniswanga kwenye, apho kamva enebana iiproteni plasma kwi-40%.

Njengento kuthetha nako ukungena nge njengomqobo placental, kwakunye neziphumo kunye nobisi sikanina.

Inguqu theophylline oluya esibindini yi P450 enzyme cytochrome.

Ifomu yokuqala ichiza imveliso kwi-mali ka-10% kule yokuchama. Ixesha isiqingatha ubomi esi sixhobo kwi non-abatshayayo, kunye izigulana asthma inyumoniya, ziyure ezili-12, abantwana - Iiyure 1-5 sosana - ukuya kwiintsuku ezi-2, kunye abatshayayo - Iiyure ezi-4.

Xa beqeqeshwe?

Iimpawu zibonisa ukuba ukusetyenziswa kweziyobisi kuxhomekeke ukuma ukukhululwa yayo.

Ulawulo Parenteral kuyanconywa:

• izifo kobuchopho ejikeleza yobuchopho;
• isimo asthmaticus ;
• washiya ukusilela ventricular, nto leyo nzima lokubandezeleka yokuphefumla, kwaye bronchospasm;
• umoya ezisanda kuzalwa;
• ukusilela intliziyo ezingapheliyo kunye oyingozi;
• nokudumba imvelaphi kwezintso.

Kwezinye iimeko, esebenzisa ngomlomo "Theophylline" (tablets)? Imiyalelo iingxelo zokusetyenziswa ukuba isixhobo engaqhubi kakuhle entliziyweni yemiphunga, syndrome broncho-obstructive of umyalezo ezahlukeneyo (umz, emphysema, isifuba, COPD, iphika obstructive), belele, ukwandisa uxinzelelo kwi kwegazi pulmonary, ukusilela intliziyo ngokohlobo esinganyangekiyo okanye oyingozi .

Izimo

Xa kufuneka usebenzise iziyobisi "Theophylline"? Imiyalelo yokusebenzisa iingxelo ukuba contraindicated ku:

• hyper- kakhulu emithanjeni okanye hypotension, tachyarrhythmia, izilonda ze iphecana wokudla, kuquka exacerbation;
• gastritis giperatsidnom, kakhulu umsebenzi kwezintso okanye hepatic, ukopha stroke, sokuwa, legazi kwiretina;
• ukusetyenziswa ngaxeshanye ephedrine kwabantwana abangaphantsi kweminyaka engama-3, ukwanda uvakalelo aminophylline okanye theophylline.

Drug "Theophylline": imiyalelo yokusebenzisa

Cellulite (feedback nomonde kuya kuxoxwa ngezantsi) yindlela yokunceda kuhle kakhulu, kodwa oku injongo ephambili ichiza ingqalelo.

Ndingayisebenzisa njani na? Oyidlayo lwemithi ngamnye medicament. Unyango ibhalwe ugqirha onamava ngokuxhomekeke umfanekiso lwezonyango, ubudala yesigulane, kwaye kukho ubungqina ukuxhomekeka ugwayi.

A ukulungiselela ngokwemo isisombululo nga maliqhutywe intramuscularly okanye butofelwe, kwakunye amafutha - ukuya nerazdrazhennuyu isikhumba.

Njengoko kusetyenziswa ukunciphisa umzimba?

Ngaba kunokwenzeka ukuba ukusebenzisa ichiza ilahleko ubunzima "Theophylline"? Imiyalelo yokusebenzisa (of cellulite sisixhobo isoloko isetyenziswa ngohlobo amafutha) iqulethe ngokuphathelele oku kungekho lwazi. Noko ke, iingcali bathi ubuncwane esebenzayo kweli chiza kunceda kakhulu ukunciphisa ubunzima bomzimba, kodwa ngokuyinxenye, ukuba ayibulale "orange udiliza". Yenzeka njani le nto? Isibakala sokuba aminophylline ngoyo igazi emzimbeni, ngokunjalo nokuphucula umsebenzi yabo yamanzi. Loo into efumaneka ezininzi izithambiso ngenxa cellulite (umzekelo, "Turboslim», Draine Minceur, Reflexe Minceur, Phyto-Complexe, Imilo-up , njalo njalo).

Schematics isicelo Amafutha kunye aminophylline zixhomekeke nokuqulunqwa ngokupheleleyo nomakhi.

imiphumela emibi

Basabela ngemvelo zisenokuvela ukusetyenziswa kweemali? Ngokutsho imiyalelo, oku kungabangela:

• zokulala, ixhala, isiyezi, unditsho kunye Barr;
• reflux gastroesophageal, ukugabha, urhudo, isicaphucaphu, heartburn, ukudla, kunye exacerbation kwezifo isilonda Peptic;
• arrhythmias kwentliziyo, iintlungu intliziyo, ukuqhubela phambili sifuba angina, zokucutha, angina zobuxoki tachycardia;
• hematuria, albuminuria;
• ukurhawuzelelwa, ifiva, krwada;
• hypoglycemia;
• siwasebenzise, iintlungu induration kuyo inaliti;
• tachypnea, albuminuria, iintlungu esifubeni, hematuria, komzimba, hypoglycemia, ukubila nokwanda Umchamo ngemihla.

Interaction and libanda

De kube ngoku, amatyala ziye esebenzisa imiyalezo yedatha libanda sele ingxelo. Ukuba le meko kwenzeka, kufuneka uyeke ezithatha ichiza kwaye uqale unyango nomqondiso.

Xa ukufana ezithatha ichiza kunye sympathomimetics a ukusebenza efanayo yesenzo sabo imithi. Njengoko for beta-blocker, kunye nezibonelelo lithium, izenzo ezifanelekileyo ngokufanayo buthathaka.

Isiphumo therapeutic "Aminophylline" ngonyuka kwanciphisa xa isetyenziselwe ngaxeshanye, "rifamycins" "pentobarbital", "i-isoniazid", "Carbamazepine", "sulfinpyrazone," "Phenytoin" (kuquka abatshayayo).

Isenzo ingqalelo ichiza ukuze kwandiswe xa co-elawulwa kunye quinolones, "lincomycin" macrolides "cimetidine", "Allopurinol" isoprenaline, beta-blocker, fluvoxamine, izivimbela, "Disulfiram", "Viloksazinom", kwakunye nangexesha influenza nokugonywa .

Chelators kunye antidiarrheals nokunciphisa adsorption "Aminophylline."

Analogs nokubuyekeza yabathengi

Nokuba kukho analogs le "Theophylline 'iziyobisi? Iingcali impendulo yalo mbuzo kule affirmative. amayeza kujongwa buyisela "Aminophylline-esque", "Eufillin-Darnitsa", amacwecwe kunye iinaliti "aminophylline".

Yintoni abantu bayathetha ngayo uthe kuthetha abathengi? Izimvo yale yokulungiselela kukho into eninzi. izigulane ezininzi ingxelo ukuba isitofu "Aminophylline" sisixhobo esiqinisekisiweyo. ukusebenza ngendlela echanekileyo nenempumelelo musa esingenakubangela naliphi na amathandabuzo, kuquka ukuhlaselwa sisifo sombefu.

Ke ukuba izimvo malunga "Theophylline" cream, ukuba zinokuphikiswa. Abanye abathengi bathi lo kuncedwa nguye angabi. Nangona kunjalo, kukho ezinye izigulane ababelana nemiphumela encomekayo emva kokufaka amafutha cellulite.