Iibhilethi "I-Pyrazinamide" ine-bactericidal okanye i-bacteriostatic effect anti-tuberculosis effect kuye kuxhomekeke kwi-concentration. Umsebenzi wonyango ugcinwa kuphela phantsi kweemeko ezicwangcisiweyo (kwi-pH ye-5.6 nangaphantsi). Ku Ukuphuhliswa koxhatshazo, amathuba okunciphisa kunye nokusetyenziswa kwamachiza kunye namanye ama-agent angenakuxhamla, kunokwenzeka ukulungiselela isilwanyana. Iyeza "Pyrazinamide" (umyalelo wokusetyenziswa uqinisekisa le nto) iyona ndlela iphumelele kwisifo sofuba esifumaneka okokuqala, kwimeko ye-caseous-pneumonic, i-tuberculoma, i-lymphadenitis. Isilwanyana sinciphisa ukuthutha kwe-urate kunye ne-uric acid, kunokususa i-hyperglycemia. Isilwanyana esivela kwiphepha lokugaya sisondele ngokupheleleyo kwaye siphumelele ngokukhawuleza. Iiprotheni zeplasma, isizabisi sibophezela ku-10-20%. Emva kweyure okanye ezimbini, ukugxininiswa okuphezulu kweziyobisi kubonwa. Amachiza afakwa kakuhle phakathi kwamanzi kunye nezicubu, zifakwe kwizitho, kubandakanywa nemiphunga, isibindi, iintso, kwakunye neendawo ezifakwe kwi-lesion. Imveliso idlula iBBB. I-Metabolism ivela kwisibindi.
Iinkcazo
Iyeza "Pyrazinamide" (iingxelo zeengcali ziqinisekisa oko) yinto yokuqala yokwenza unyango lwesifo sofuba.
Uhlobo lokungcola
Kuqinisekiswe ukuba i-monotherapy ayisebenzisi ngokwaneleyo. Ngokumalunga nalokhu, iyeza "Pyrazinamide" licebisa ukuba lisetyenziswe kunye nezinye iziyobisi ezinomsebenzi wokulwa nesifo sofuba. Kubantu abadala, umyinge u-30-35 mg / kg kanye ngosuku. Kwizigulane ubunzima abugqithisi iikhilogram ezingamashumi amahlanu, le dose lilingana namacwecwe amathathu (1.5 g). Kwisisindo esingaphezu kwe-50 kg kufuneka uthathe 4 ithebhu. (2 g). Kubantwana, i-dose ephezulu i-2 grams. Isilwanyana sithathwa ngokutya. Kucetyiswa ukuba uphuze iyeza ngexesha lesidlo sasekuseni.
Ithetha "Pyrazinamide". Imiyalelo yokusetyenziswa. Imiyalelo ekhethekileyo
Iyeza alinakubangela ukudlula xa isigqirha sogqirha siyagcinwa. Xa uthatha isixa esikhulu semithi, kukho imiphumo emibi esuka kwinkqubo yesantya ephakathi - ukungcola, iintloko kunye nabanye. Kukho ingxaki Umsebenzi wesibindi, iziganeko zesifo se-dyspeptic. Utyhefu lubonisa unyango olumqondiso. Ukubeka iliso ngenyanga nge-bilirubin, i-AST, i- uric acid kunye nama-ALT aqhutyelwa phambili naphakathi nexesha lokuphulukiswa kwezilwanyana ezingapheliyo emva kwezigidi ezingama-60 ubudala. Kwiintlupheko zomsebenzi wesibindi, ukukhutshwa kweziyobisi kuyimfuneko. Izigulane zesifo sikasifo sikasifo sikasifo sikasifo sikasifo sikasifo sikasifo sikasifo sikasifo sikasifo sikasifo se-diabetism Xa kudibaniswe namayeza "Rifampicin" kunokuthiwa i-hepatotoxicity. Isicelo esinzima kunye nesilwanyana seprobenecid, ukuhla kwe-excretion kunokwenzeka kwaye, ngenxa yoko, ukwanda kwingozi. Ku nokuba novelwano oluphambene nemithi "I-Isoniazid", "i-Ethionamide", i-acid ye-nicotine kunye nezinye iindlela ezinesimo esifanayo semichiza. Iyeza "Pyrazinamide" (umyalelo wokusetyenziswa uqinisekisa le nto) ifanelekile iminyaka emihlanu. Gcina le nkunkuma kwizikhumba ezivaliweyo, kwiindawo ezikhuselweyo ekukhanyeni.