Inhibitors neuraminidase: uluhlu lwamachiza for imiyalelo yosetyenziso

Le nkqubo yamazwe ngamazwe yokuhlelwa isiyobisi okuphosela zonke imvelaphi yemveliso kwi qela amayeza le. Isiseko oku isenzo amayeza ngayo izinto. inqaku thaca uza kunibalisela ngemeko elinye iqela onjalo. Le ibandakanya neuraminidase inhibitors. Uza kufumanisa ukuba yintoni na izithako ezisebenzayo zezi nesiseko sayo, kwakunye simazi amagama abo norhwebo.

neuraminidase inhibitors

Ngaphambi kokuba sithethe ngayo iziyobisi, kuyimfuneko ukuba kwesi qela imithi. Neuraminidase - uhlobo enzyme. Yinto ekhoyo phezu inwebu kumphezulu zonke iintsholongwane influenza. Phezu contact iseli umzimba womntu uyakhululwa izinto eziyityhefu. Ukuze bakufikise ukuvela kweempawu: nangecesina, ukutyhafa, intloko ebuhlungu, njalo njalo.

Neuraminidase inhibitors ingangena kule ntsholongwane. Bona gqiba umsebenzi ezincinane yayintsholongwane eyosulela, ukuthintela uphinda-phindo kunye zoqhagamshelwano kuqhubana ngayo iiseli esempilweni. Uphuhliso lwamachiza ezinjalo kwaqala ngo-1960. Eyokuqala wenza kube lula ukufunda ngokweenkcukacha indlela nempumelelo yazo amagciwane.

inhibitors neuraminidase: iziyobisi kunye nezithako zabo ezisebenzayo

Pharmacology Modern ufuna ukuthenga imithi emibini ukuze kubalulwa izenzo ezinjalo. Abo amagama zorhwebo "Tamiflu" yaye "Relenza". Omabini iimveliso asetyenziswa nokuthintela kunye nokunyanga influenza, kunye neentlobo ezahlukeneyo. Neuraminidase inhibitors zithengiselwa kuphela kagqirha. Kwakhona ukuba ukusetyenziswa amayeza esibhedlele xa kuboniswe. Musa ukuthatha la amayeza abasetyhini abakhulelweyo kunye noomama zokonga. Izimo kusetyenziso ukuba abantwana abangaphantsi kweminyaka emi-5. ukusilela kwezintso kwaye hepatic kudala thethwano ukwahlula ngaphambi kokuba uyisebenzise.

Imichiza esebenzayo kula machiza igama eziBekekileyo kunye indlela yolawulo. "Tamiflu" amayeza iqulethe kwi isakhiwo oseltamivir. Le medicament alahlwa ngokohlobo njengezingxobo enesiqulatho kwamaqondo eparticulate ukuze isetyenziswe ngaphakathi. Drug "Relenza" - oku kuthetha inhalation. Icandelo esebenzayo i zanamivir.

umthamo amalungiselelo

Ngayiphi indlela zisetyenziswa neuraminidase inhibitors (umkhuhlane)? Sele uyazi ukuba zombini amayeza emiselwe ngugqirha wakho. Ukuthenga amachiza kufuneka iphepha likagqirha. Ngoko ke, idosi ixesha ulawulo ngokuqhelekileyo ikhetha yincutshe. Kodwa le ncwadana iqulethe ingcaciso ngalo mba:

• Ichiza "Tamiflu" abadala kunye nabantwana emva kweminyaka 12 isetyenziswa kabini ngemini tablet enye. Ubude zifundo iintsuku ezi-5. Ngokuba abantwana abangaphantsi kweminyaka eli-12 ubudala sele ngokukhethekayo isetyenziswa isixa lokunqunyanyiswa 30-75 mg oseltamivir (ngokuxhomekeke ubunzima bomzimba) kabini ngemini.
• "Relenza" amayeza eyanikelwa inhalation. Guide uncoma ukusebenzisa 10 mg le compound (2 inhalation) kabini yonke imihla. Ukuqhubeka unyango iintsuku ezi-5. Kuthintelo ukusetyenziswa kwe-10 mg beziyobisi kanye ngemini kangangeentsuku ezili-10.

Ukusebenza kunye ezingalunganga abasabela

Iingcali zithi ukuba inhibitors neuraminidase iintsholongwane influenza zinempumelelo ethe kratya unyango ngokukhawuleza iqalisiwe. Ngoko kuyimfuneko kwi iimpawu kuqala ukuba udibane nogqirha. Ugqirha uyakukumisela uphando eziyimfuneko eziya kunceda isigqibo amaqhinga elizayo. Zombini ezi ARVs zisebenza ukulwa iintsholongwane komkhuhlane (kuquka njengesi). Ngokungafaniyo nezinye iziyobisi antiviral, neuraminidase inhibitors kubonisa ukusebenza eliphezulu. iiyure Sele ezimbalwa emva kokuba isicelo lokuqala kuba lula isigulane.

Kubalulekile ukuba "Relenza" yaye "Tamiflu" zinokudityaniswa kunye namanye amachiza okunyanga umkhuhlane, iimpawu zayo iingxaki. Hi ndlela leyi, kunye namayeza zineziphumo ebezingalindelekanga. Umzekelo, i-inhaler, "Relenza" kunokubangela ukuphelelwa umoya bronchospasm. Ayifane umzimba kwenzeka ngohlobo nokudumba. "Tamiflu" kuthetha tapeworm. Ngoko ke, oko lineziphumo ezibi kakhulu: iintlungu esiswini, nokwaliwa, exacerbation kwezifo kwezintso kunye hepatic, ukuphazamiseka neuropsychiatric.

Ngamafuphi

Neuraminidase inhibitor sisixhobo kakhulu ekulweni iintsholongwane influenza. Ngexesha zande, ukuze kuxhakamfulwa ngeenjongo zokuthintela. Kodwa iingcali azilukhuthazi ukusetyenziswa kwala machiza ngokungeyomfuneko. Ukongeza, awukwazi ukuthenga amayeza ngokunokwabo. Ukuba unale inikeza ukuthenga ichiza "Tamiflu" yaye "Relenza" ngaphandle kagqirha, ufanele wazi ukuba zahlukane. Ukusetyenziswa kwezi amayeza akufuneki kuphela ukunciphisa sifo, kodwa kunokuba ezisongela ubomi. Hlala uphilile!