Hormone 17-OH-yiprogesterone. 17-OH-dlala: izinga igazi

Eyona Injongo yomjikelo hormone kwabasetyhini ngethuba lomjikelo sexesheni - ovulation. Ngethuba lale nkqubo, oko phantsi kolawulo ngxenye. Kulo mzekelo, izinto kulawulwa iimveliso secreted kwi posa sobuKristu: FSH kunye LH.

ekumisweni ovulation

Kwisigaba pre-ovulatory zomjikelo sexesheni follicle ovarian ivavanywa zinguquko eziliqela. Ezi nguqu olwenzekayo phantsi kwempembelelo FSH. Emva kokuba follicle ufikelela ubungakanani ethile, kwakunye umsebenzi ezisebenzayo kwi incopho LH ovulatory yenziwe. Oku kuya kusungula "ekukhuleni" iqanda (Iqela lokuqala meiotic). Emva kwesi sigaba discontinuity kwenzeka ukusekwa follicle, uphume kuyo eqandeni. Isithuba phakathi incopho kunye ovulation sigaba ngokomyalelo iiyure 36-48. Ngexesha postovulatory lesigaba ukubana kwenzeka kuphathelela iqanda isibeleko tube Imibhobho. Kwimeko ekukhulelweni kuye ngomhla wesithathu anesine umbungu ingena kuloo ndawo ibinomthwebeba zesibeleko. Kukho umzila wayo. Ukuba ekukhulelweni lwenzeke, ngoko ke iqanda emini ofela tube Imibhobho.

Substances inxaxheba empilo umsebenzi nemazi lokuzala

In kwamadlala ezidalwe akhiwa ngayo iikhompawundi eziphilayo esebenzayo. Ewe kuthiwa iihomoni. Kuyinto ngenxa kubo ngokusebenzisa inkqubo hypothalamic-yebhinqa-ovarian kunye nokuqinisekisa kukho umsebenzi ngamandla ngamalungu okuzala. compound nganye wenza imisebenzi ethile. Esinye izinto inxaxheba kwiinkqubo kule nkqubo okuzala, ngu 17-OH-yiprogesterone. Isigaba Follicular elibaleka ukwanda okubonakalayo ingqalelo yayo. Le ephindeneyo kuhlelwe hi mpimo lowutsongo kwi isizalo. Ukwandisa umxholo iziyobisi linqanam kwincopho PH. Emva koko, phakathi komjikelo, uyazikhomba kuncitshiswa ixesha elifutshane. Hormone kwisigaba follicular ukucola ukwanda endometrial zichatshazelwa estrogen. Umchiza ngenxa ufakwa iinguqu. Unobangela ongundoqo sexesheni yi zokuyeka ngesiquphe imveliso yi-corpus luteum umjikelo yiprogesterone ukugqitywa. Ezifihlakeleyo yokufakelwa kwesigaba luteal stroma endometrial wambumba basabela decidual. Iyafana iinguqu ezenzeka ekuqaleni yokukhulelwa. Hormone inika ummiselo unamadlala kwi wesibeleko, wehlise contractility kwisisu. Umchiza kwakhona abangaphangeliyo sexesheni.

Hormone 17-OH-yiprogesterone. incazelo

Yeyona steroids siphu-. Yayo cortisol adrenal wabumba phantsi kwempembelelo enqanda ezifana 11-b 21-hydroxylase okanye hydroxylase. 17-OH-dlala ngo abafazi nokulungelelanisa androstenedione. Le ebonakalayo siphu- testosterone kunye estradiol. It senziwa amaqanda kunye adrenal. Igazi hormone-17-OH abakhoyo free wabopha kunye neeproteni othwala njengoko transcortin kunye ezinjengealbumin. Xa engekho liyancipha yoxinaniso neqanda kweziyobisi. Kwimeko umzila beqanda kwi zamaqanda, lo luteum corpus iyaqhubeka ukuvelisa kuyo.

yoxinaniso

17-OH-dlala anda kusasa. Ubuncinane imixholo yawo sikali ngethuba ebusuku. Emini, inqanaba bayo. Nezixandileyo xi ziyohluka ngethuba lomjikelo sexesheni. Ukwanda kakhulu kwinqanaba waphawula imini phambi kokuba kwincopho LH. Oku kulandelwa kwisigaba ukuzikisa ingqondo iphezulu (yee-cycle). Ngexa lokukhulelwa, isiqulatho kweziyobisi uyandiswa kakhulu. 17-OH-dlala, umlinganiselo yayo kumiselwa ngokungqinelana yobudala yabantwana uqulathwe imali encinane. Ukwakhiwa ndaweni inye zifumaneka kuphela kwixesha echumileyo yaye ngoko nangoko emva kokuzalwa. Kulo mzekelo, kwiintsana ngaphambi umxholo na ngobukhulu. Kulaa veki yokuqala ewela kwinqanaba udibaniso. It yaphawula a Ukunyuka okuqhubekayo xa ufikisa. Ngeli xesha, dlala-17-OH abafikisayo ngcembe afikelela xi efanayo abadala.

Kutheni ufuna uvavanyo igazi?

17-OH-dlala yinto yimveliso eliphakathi. Noko ke, isifundo sakhe kulinyathelo elibalulekileyo lokufunyaniswa ezimbi ezahlukeneyo. Ngu ubungqina isifundo ziquka nenzalo, hirsutism, ukuphazamiseka umjikelo. Xa hyperplasia adrenal njengonyango kwizigulana ezilawulwa unyango replacement steroid. Ukuhlola olwalo uhlalutyo ukusebenza nalo ababelwa. 17-OH-dlala wafunda kwiintsana. isifundo yayo ingqondo okusolwayo 21-hydroxylase intswelo. Ukuswela le enzyme awayezibona iziphene uhlobo hyperplasia adrenal.

Ukulungiselela nokuvavanywa kweelebhu

Ukuba ugqirha ayinalo naliphi na ixesha, igazi unika phezu wesithathu kumjikelo Ngosuku lwesihlanu. Uphononongo lwaqhutywa kwi ungatyanga kusasa. Oku akuvumelekanga ukusetyenziswa yekofu okanye iti. Ukuvunyelwa ukuba usele amanzi ethafeni. Ekubeni isidlo yokugqibela phambi kokuba ukunikela igazi kufuneka iiyure ubuncinane ezisibhozo. Iingcali bekubona ukufunda ihomoni engafanelekanga kwesigaba sesibini ngomhla 20-23. Ukuba ixesha umjikelo iintsuku 42, isampuli yegazi lwenziwa ngomhla 35 th. Ngosuku 23 isigaba sokuqala usaqhubeka. Inqanaba dlala lifinyele, kodwa oko akuthethi kubonisa ukungasebenzi kwisigaba luteal okanye anovulation. Kwenza akukho mqondo ukuqhuba isifundo yoxinaniso ngethuba lokukhulelwa ukuthatha naziphi na iziyobisi. Kulo mzekelo, ephezulu 17-OH-dlala - eqhelekileyo. Isiqulatho esinjalo yokhathalelo kwangaphambi ingafuneki.

nokutolikwa iziphumo

Njengoko kukhankanyiwe ngasentla, inqanaba yesiqhelo dlala hormone, 17-OH ixhomekeke yobudala. Ukubaluleka kunye sex kwesi sifundo. Ukufumaneka iyamiselwa ng / ml. Umxholo Optimal abantwana ukuya inyanga - 0-16,63; iinyanga 1-2-. - 1,8-9,7; iinyanga ezi-3. - 0,07-1,7. Kwizigulane phantsi konyaka omnye - 0-1,65; ukuya kwiminyaka-3 - 0-0,99; ukususela-3 ukuya ku-10 - 0,07-1,69. kwinqanaba kuvumelekile abantu - 0.5-2.1. Kuba namankazana kwisigaba follicular - 0,41-2,72; ovulatory - 0,33-2,8; luteal - 0,33-2,8. Xa ezintathu yokuqala siswini dlala-17-OH kufuneka abe khona xa iqela 1,17-5,62; Okwesibini - 1,17-6,7; kwi wesithathu - 1,24-11. Xa umxholo postmenopausal ngokupheleleyo 0,13-0,51.

hyperplasia adrenal

It is a ngezifo naso sokuhlasela. Ngokwesiqhelo ikhula ngenxa ukuswela enqanda ababandakanyeka Yindibanisela steroid. Ukungabikho iikhompawundi banokuba kumanqanaba ahlukeneyo sandla. Ukubakho ngo-hyperplasia naso uvela virilization (ukuyilwa imikhwa ubudoda kwabasetyhini). Kwiingozi ezimasikizi, umntu deficiency enzyme Uxhokonxwa yanyhashwa kakhulu kudibaniso steroid, ilahleko ityuwa, nto leyo inokuba ezisongela ubomi. intswelo kwenxenye enzyme kwafunyanwa abadala, isenokuba yiyo iziphene endalweni. Kulo mzekelo, ekuqaleni iintshukumo zokwaphulwa kwemithetho zenzeka ngendlela afihlakeleyo, kwaye azisoloko labonwa ebuntwaneni. kuyondelelaniswe kakuhle enqanda anokuba uphawu okuqhubekayo. Phantsi yempembelelo yezinto ezimbi zophendlo lwezifo kwanda amathuba utshintsho ezisebenzayo morphological kwi adrenal, ibonwa efanayo naso syndrome. Ngenxa yoko zophuhliso miseka ngokwesini elivisayo. Xa eninzi dlala, 17-OH igxininisa umsebenzi yayo phezu Yindibanisela androgens. Ezi zihlanganisi ajikeleza ebuntwaneni ningandiqumbisi amantombazana amazwi iimpawu ngokwesondo uhlobo eyindoda. Ngoko ke, ukufunda eyavela kubalulekile ekuqinisekiseni impumelelo unyango ezifunyenweyo.

Ukuswela eyingozi ngakumbi i-enzayim ye-21-hydroxylase

imiboniso ezimbaxa Unqongophalo lifinyele aldosterone Ukwakheka. Le hormone adrenal libonelela ngolawulo amanzi kunye netyuwa ukulingana, ukulibaziseka kumzimba yetyuwa. Kwiintsana, kukho "ilahleko ingxaki." Kuba imeko enjalo luphawulwa zemali ulwelo kukuninzi. Ngelo xesha linye umzimba ukuba arhoxe ngokubonakalayo ityuwa kuyimfuneko. Ngenxa yoko, isiqulatho potassium iqala kukuthi ande, sodium - ukuhla. Partial enzyme insufficiency sachaza zingacimeka picture clinical. Ukusola intswelo kuvela ngasemva kwephulwa lokufikisa kunye nokukhula ekufikiseni, kwi ubudala nangaphezulu - kunye ubudlolo kwakunye kakuhle ngethuba lomjikelo sexesheni, amantombazana - kunye hirsutism.

isiphelo

Umsebenzi hormone ngesondo yenye zinto zijongwayo nje kuphela ukusebenza kwenkqubo sokuzala kwabasetyhini. Indlela iikhompawundi, ukuzinza kwabo umsebenzi eqhelekileyo, ukuthatha inxaxheba kwiinkqubo ezahlukeneyo, ngokunjalo kukho xi kangangoko unefuthe kuphuhliso lomzimba nempilo ngokubanzi. Iingcali zithi naziphi na ukutenxa ekhoyo imigangatho amayeza azisoloko uphawu ngezifo. Kule meko, kwimeko nganye akudingi unyango. Noko ke, oogqirha bacebisa ukuba ukunikela rhoqo igazi beyaleza, ukuba bapase iimviwo. Ezinye izifo ube ifomu afihlakeleyo kunye diagnosis ngesiquphe kukhokelela kwintlekele. Okubaluleke kakhulu imo yamabhinqa hormone. Not ezichongiweyo enokuphazamisa lwabantwana kunye nobudala iqhubeka, ebangela ukuphazamiseka ekusebenzeni sokuzala kunye nezinye iinkqubo emzimbeni. Kwezinye iimeko, ukungachumi - enye yezona ngxaki zingxamisekileyo namhlanje - sisiphumo loxilongo emva kwexesha. Kuba izigulane zifumana unyango replacement, kufuneka lokukhangela-ups kunye nokuhlolwa kwegazi rhoqo. Iziphumo ukuvumela ukuba ukuhlola nje kuphela ukusebenza kwezonyango iziyobisi, kodwa ukulungisa scheme isicelo sabo.