Collagen - ntoni na? Iimpawu, isifo kwaye afumane unyango lwezifo

une "collagen" ufumaneka njengonyango namhlanje. Yintoni na? Eneneni lo gama uzisa ndawonye inqwaba zizifo ezahlukahlukeneyo ukuba unayo enye into efanayo - utshintsho kwizicwili, ezifana izilonda collagen fibrinoid.

Kakade ke, izigulane kwafunyaniswa ukuba "kwizicwili systemic" uqhuba ibe yokothuka. Ngoko ke kuqala kufuneka ufunde ngakumbi ngezi zifo kunye neempawu zazo. Zeziphi izifo zibandakanywa iqela kwizicwili? Yintoni unobangela zabo? Ziziphi iimpawu kufuneka sinikele ingqalelo kuyo? Ngaba Ndilufumana izifo collagen ngonaphakade? Yintoni na uqikelelo banike oogqirha? Iimpendulo zale mibuzo ukhangela abantu abaninzi.

Collagen: ntoni na?

kwizicwili iyaziwa ukuba uhlobo izinto ukwakha umzimba. Umzekelo, sisiqinisekiso skeleton kunye nesikhumba somntu, emithanjeni, lo stroma amalungu angaphakathi, kananjalo Wawuzalisa ngokulungileyo interstices phakathi izakhiwo ezahlukeneyo. Yiyo le ngelaphu, kwaye ngaphezu kwesiqingatha ubunzima bomzimba womntu. izinto nokuqina ukwenza imisebenzi emininzi kwaye ebalulekileyo, kuquka trophic, zokuzikhusela, noshowo, inkxaso kunye zeplastiki. Yeyona izifo zomzimba nokuqina idibene, ibinzana elithi "collagen".

Yintoni na? Eli qela ezimbi aneempawu kunye indlela yophuhliso eqhelekileyo. Isifo ukuvela imvelaphi kwephulwa homeostasis omzimba kwaye zihamba ziinguqu collagen fibrinoid.

Types of izifo collagen

amayeza Modern eyaziwa ezahlukahlukeneyo collagen. yokuhlelwa kwazo sisekelwe imvelaphi sifo. Umzekelo, isifo ehlasela kwizicwili inokuba bekhubazekile. Eli qela libandakanya ngeyo syndrome kunye yiMarfan kunye mucopolysaccharidoses kunye enesi-. Iimpawu kwabo bakholisa ukuvela nkqu Esibelekweni.

Kukho kwakhona izifo ezifunyenwe ukuba abonise emva kokuzalwa - ngamanye amaxesha ebuntwaneni okanye lokufikisa, kwaye maxa wambi nkqu mdala. Oku ezimbi qela ziquka vasculitis systemic, skerodermiyu, isifo samathambo, rheumatism, eozinovilny fasciitis, periarteritis nodular, kunye nabanye abaninzi.

Eyona eziphambili ezibangela izifo

amatyala yesifo azalwa anxulunyaniswa neengxaki yemfuza nethe kobume collagen. Njengoko lweefomu ezifunyenwe esi sifo, kukho isizathu kunokuba obungafaniyo kakhulu, kwaye ukufunda indlela leengxaki isephantsi.

Izazinzulu uthambekele ukukholelwa ukuba ilifa ethile yemfuza anayo phantse onke amatyala. Kodwa sifo zivuse eziliqela. Umzekelo, kuvame ukuqala lalwano emzimbeni lwezifo ezosulelayo yintsholongwane, kubandakanywa amagciwane uqilikwane, i-herpes, rubella, yimasisi, njalo-njalo. D.

Oonobangela inokuba hormone ezenzeka ngexesha lokufikisa, ukukhulelwa kwabadala, isisu njalo njalo. D. Kukwakho nezinye izizathu ezibangela isifo kuphuhliswa. Collagen ukuze sivete yi ni ntshikilelo nkqi, kwentlungu, ulawulo iziyobisi, undercooling eyomeleleyo, elihlala livelile. Ngamanye amaxesha sifo emva kogonyo.

Le Pathogenesis kwesifo

Nangona ukwahluka eli qela izifo, phantse zonke mzekelo, a ngezifo senzeka kule nkqubo efanayo. Xa imiphumo into, uvakalelo kwamajoni omzimba, nto leyo kusekwe izakhiwo protein ezithile, ezithi ke ngoko mazifakwe kwi inwebu serous kwaye lwamalunga, ingaphandle impahla. Ukubakho izakhiwo omzimba evusa kukukrala ezikumila kunje ye emzimbeni. Ngenxa yoko, inkqubo yomzimba yokuzikhusela uqala ukuba inyama yayo nokuqina.

Ngokuchasene imvelaphi iinkqubo ezichazwe apha ngasentla ukuba utshintsho bebona zophendlo lwezifo izicwili. Kakade ke, uhlobo ngalunye sisifo kwizicwili inemisebenzi ethile. Ngokomzekelo, xa scleroderma inkqubo samathambo ukudumba kuchaphazela ijwabu ulusu kunye izihlunu ongama, lubonakala a iimpahla nodosa utshintsho periarthritis.

Collagen: ifoto kunye picture clinical jikelele

Yintoni na umfanekiso onyango? Ziziphi iimpawu zihambisana collagen? Iimpawu, Kakade ke, iya kwahluka ezahlukeneyo isifo kunye nendawo inkqubo arhabaxa. Noko ke, ezinye iimpawu eziqhelekileyo zinako ukuqatshelwa.

Ogulayo eqhubekayo fever ukuya degrees 38. Izigulane ezikhala Ukugodola kunye ukubila ngokugqithiseleyo. Kukho ubuthathaka kunye nokwehla yokusebenza. Phantse naluphi na uhlobo collagenosis kuphuhlisa ngokudibeneyo kwaye izihlunu syndrome, nto leyo luphawulwa ubuhlungu bamalunga, myalgia kunye arthralgia. reactions Maxa wambi negazi, ukubonakala yabangxamayo eluswini, iintlungu esiswini, ukuqunjelwa.

Periarteritis nodosa kunye neempawu zayo

Collagen ezahlukeneyo kwindalo, ngoko ke kubalulekile ukuqwalasela iintlobo ezininzi ekuso kwaye inzima. Periarteritis nodosa luphawulwa izitshanguba zonke zontathu inoomaleko zodonga inqanawa. Inkqubo yokukrala inxaxheba phantse zonke iimpahla umzimba.

Iimpawu ixhomekeka kuhlobo kwemithambo ngemithambo bamangaliswa. Xa kufikwa izitya izintso, izigulane iintlungu isaziso yokuqala, ukuphazamiseka nencindi ngumchamo. lwegazi eziqwalaselweyo ukusilela progressive kwezintso. Xa ukudumba iindonga imithambo yegazi yobuchopho xa isigulane ukuphuhlisa nokuphazamiseka engqondweni ezahlukeneyo. Ikota kwizigulane kunye periarthritis nodular waqaphela sombefu.

Systemic lupus zomzimba

Systemic lupus zomzimba - enkulu zenkqubo kwizicwili. Yintoni na? Esi sifo, nto leyo sikhatshwa izitshanguba kuzo phantse zonke iinkqubo omzimba. Kuvela kwi eluswini obomvu ukudumba nakujoliso olutsha (ebusweni, banalo kwindawo luphawu kakhulu nemihlathi kunye nempumlo into efana amaphiko ebhabhathane).

Kukho ilahleko iinwele kunye nezikhonkwane, inwebu yangaphakathi kuvela isilonda kunye ukhukhuliseko. Le nkqubo yokukrala iquka namalungu amancinane. Isifo ihamba ukuphazamiseka zeenkqubo sentliziyo zokuphefumla. pathology sezintso saphawula kunye ukubonakala iimpawu luvo.

scleroderma systemic

Scleroderma - esinye isifo samathambo apho inkqubo yokukrala luchaphazela eluswini, izihlunu ongama, imithambo yegazi peripheral, amalungu kunye nezihlunu. Kulo mzekelo, ezi mpawu ecaca utshintsho nje isikhumba. Okokuqala, lo kudumba apho kwesikhumba. Le dermis uba libunile okanye, kungenjalo, ebomvu. Xa inyathelo lesibini iindumbisa esi sifo uba ashinyeneyo kakhulu, isikhumba kakuhle isigulane kunye azikhuli owomileyo akhekha emzimbeni izisekelo.

Inyathelo lesithathu ihamba kunye yoma yesikhumba nezihlunu ongama. eziphilayo abantu isigulane amandla, iminwe ngcembe gqitha, ubuso kuthatha uhlobo imaski ngenxa yokuduka amabinzana yobuso.

Le axilongwe

Indlela ukuxilonga isifo inyama? Le ngokoyiswa kwimibutho eyahlukeneyo kukhatshwa ukuvela iimpawu ezithile kakhulu, kwaye eveza ingqalelo oyingcali nakunxibelelwano kumguli anamnesis. Okulandelayo, zinginginya iintlobo zovavanyo elebhu. Ngokukodwa, igazi isigulane yabantu zihlolelwe ubukho kwabamakishi non-elithile nangokurhala, ezizezi lwefibrinogen, iiproteins C-lovukelo, alpha-2-globulin. Uphando olwenziwe phambi eziphilayo abamakishi ngumzimba ukuba ezithile izifo ngamnye ngamnye.

Amaxesha amaninzi, ukuze ahlaziye ngokupheleleyo imeko yomguli, kukho biopsy olwenziweyo. Ukuthatha iisampuli uhlalutyo izicwili izihlunu, ulusu, zezintso, synovium ngokudibeneyo.

Kukho izixhobo zophando ukuba ukunceda ekuboneni izifo ezifana collagen. Uxilongo lubandakanya uvavanyo X-ray namalungu kunye namathambo. Emifanekisweni ugqirha uyakwazi ukubona iimpawu ezithile ukuphazamiseka kwizicwili, kuquka kwamathambo, utshintsho imiphezulu articular kunye necrosis aseptic, nokunciphisa lwamathanda edibeneyo njalo njalo. D.

Ekubeni collagen Idla yi izitshanguba ngamalungu angaphakathi kubalulekile njengoko ultrasound esiswini, nezintso, kwisisu pleural kwentliziyo (echocardiography). Ngaphezu abelwa ikhompyutha okanye livakale magnetic Itomography, nto leyo evumela ukuba ukuhlola imeko ephilayo, kwakunye umonakalo owenziwe izibilini elimele.

Unyango ngamachiza lwezifo collagen

Yeyiphi unyango zifuna collagen? Unyango lwezifo eli qela kufuneka nakanjani babe ezintsonkothileyo. scheme therapy senziwa ngamnye, oko njengoko kuxhomekeke kwi kwifomu nebakala esi sifo, ukubakhona kwezifo ezihamba, ubudala yesigulane.

Ekubeni kollagenozah waphawula ukudumba izakhiwo kwizicwili, kwizigulane zokuqala ezimiselweyo amachiza-ukudumba. Kumanqanaba okuqala zophuhliso iziyobisi olusebenzayo non-steroidal, ingakumbi ezo ezinamaphepha ibuprofen.

Kwezo meko, ukuba isifo siqhubela phambili ngokukhawuleza kakhulu, kwisikimu unyango ezilawulwa glucocorticosteroids, uye iipropati ucaca ngakumbi anti-ukudumba. Ngokubanzi wasebenzisa "prednisolone" (idosi iphezulu imihla akukho ngaphezulu kwe-15 mg).

iziphumo ezintle ezifunyenwe unyango ngamachiza cytotoxic ( "Azathioprine", "Tsiklofofamid"). unyango olunjalo ilawulwa ukuba steroid akazange sinike isiphumo ofunekayo okanye yabangela iintshukumo eziqatha ezingalunganga.

Unyango lwe esi sifo yondele eyenziwa esibhedlele. Izigulane agxothwa esibhedlele kuya kuphela emva kukwazi ukumelana iimpawu eziphambili. Kubalulekile ukulandela ngqo indlela echanekileyo zomsebenzi ukuphumla, kwakunye balandele yokudla, hayi kuphela kakhulu kodwa kwakhona ubomi.

Ezinye iindlela zonyango

Zeziphi ezinye iindlela zokunyanga ifuna collagen? Unyango kuyimfuneko nje kuphela kakhulu kodwa kwakhona ngexesha isalamane kakuhle umzimba. Ukuze ukwehlisa ukuqhubela phambili kwesifo, hemocorrection kusetyenziswa iindlela, xa hemosorbtion ethile plasmapheresis. Ezinye izigulane kwakhona impilo yomzimba. Lidla iziphumo ezihle ngokuthi kubekho iikhosi rhoqo magnetotherapy, iontophoresis, phonophoresis.

Xa isifo samathambo kunye nezinye izifo kuba umthambo luncedo kwezonyango, nto leyo eya kusinceda sihlale ukushukumiseka eqhelekileyo. Izigulane bayacetyiswa ukuba rhoqo unyango Spa kumaziko iprofayl. Kwezinye zezifo collagen nempembelelo elungileyo unikwa radon, hydrogen emanzini neebhafu carbon dioxide. Kakade ke, irejimeni kufuneka imiselwe igqirha ngokuxhomekeke iintlobo sifo, ubudala kunye nemeko umntu ogulayo.

amanyathelo othintelo kunye noqikelelo izigulane

isifo collagen (naluphi na uhlobo wayo) luphawulwa zenkqubela phambili, ikhondo esinganyangekiyo. Unyango ngamachiza yenza kube lula ukuba kunciphisa imbonakalo sifo yaye ukuphumeza ngaphezulu okanye uxolelo ixesha elide kangako. Noko ke, ukuze uyeke ngokupheleleyo sifo phantse akunakwenzeka. Ingakumbi esiyingozi collagen systemic, nto leyo aphela rhoqo kunye nophuhliso yokuphefumla ahlekise okanye ukusilela intliziyo.

Ukuthatha iihomoni kunye immumodulyatorov ngokuqinisekileyo kubalulekile. Kodwa izigulane kufuneka esweni imo yempilo kunye noxolelo, njengoko oku kuya kunceda ndizeka okubi entsha. Izigulana kufuneka mabacetyiswe ukuba ukunqanda ukungakhuseleki kwizinto ukunisa, nokuba yinto ni ntshikilelo eyomeleleyo kunye nophazamiseko hormone okanye emzimbeni kakhulu kwaye elangeni ngokugqithiseleyo. Phambi nasiphi na isifo esosulelayo, ngoko nangoko funa uqwalaselo lwamayeza. Nakujoliso olutsha of ukudumba esingapheliyo kufuneka singaweli kuthomalaliso olwaneleyo.