"Asparkam": analogue, imiyalelo zokusetyenziswa

Imithi elawula iinkqubo pathways le ephilayo, liqela olwahlukileyo lwamachiza ezisetyenziswa ukunyanga zonke iintlobo zezifo. Kwaye ke ayibonakali eli binzana engacacanga nantsingiselo, yinyaniso. Nasiphi na isifo, nayiphi na inkqubo zophendlo lwezifo okwenzeka emzimbeni wethu, sikhatshwe kophulwa iinkqubo pathways kwinqanaba zeselula. Nokuba nokulungiswa ukuphazamiseka pathways asisininzi ikhokelela recovery. Enye amachiza asetyenziswa ulungiso ukuphazamiseka wathi umzimba "Asparkam". Oku kumiselwe ezimbi ezininzi. Makhe sijonge "Asparkam" analogue beziyobisi asetyenziswa namhlanje.

abalinganiswa amayeza of "Asparkama"

Njengoko sele kukhankanyiwe, ukulungiswa "Asparkam" libhekisela kwiqela amayeza ezichaphazela iinkqubo pathways umzimba. Indlela yokusebenza ye ichiza isekelwe phezu kwezi ngongoma zilandelayo.

Luphawu kuyaziwa kuyimfuneko ukuze kugcinwe rhoqo ukwakhiwa intracellular ionic medium. ingqalelo ekhethekileyo ihlawulwe iinkqubo weseli yokucolwa potassium nezinki ion. Ngenxa nokukwazi ekuthiwa-asparginatov (a yinxalenye ichiza) ukuba bathathe inxaxheba intracellular administering yothutho ion "Asparkama" kunegalelo ekwandeni yoxinaniso kunye nokuphuculwa weseli ukutya kwabo.

Ngenxa yokuba umzimba iphambili ibhityile ephendulayo ukuba ukungalingani ion (ingakumbi ion potassium), intliziyo, "Asparkam" ebonisa isiphumo cardioprotective ngokususa i ion ukungalingani cardiomyocytes. Oku sibonise ukwehla kwiinkqubo excitability kunye Uhanjiso, ethe yabonakalisa isiphumo antiarrhythmic kweli chiza.

Esebenzisa azinampembelelo okuqulethwe "Asparkam" ion wemagniziyam ichaphazela Impompo sodium-potassium cellular, ukunciphisa uyazikhomba sodium vnutriklutochnuyu neenkqubo igalelo repolarization yeseli ndizayo. Ukwanda kwi inwebu olunokubakho kukhokelela ekubeni isixa amancinane ion calcium kwi icytoplasm inxaxheba kwiinkqubo ze-electromechanical kufuphi nokuhlangana actin kunye myosin cardiomyocytes.

Asparginat koko, inxalenye ichiza, ikhuthaza ukusebenza kweenkqubo pathways akunyusi kuphela njini acid acid, kodwa ke Yindibanisela iiswekile acid kunye lipids, inxaxheba ekumiseleni nethe intracellular. Oku kuphucula amandla yokucolwa kwi ancedisana kobuchopho engabalulekanga kunye sites. "Panangin" - analogu "Asparkama" - ngenxa yeziqulatho ezifanayo potassium nezinki asparginata eveza iziphumo ezifanayo pharmacodynamic. Le nyaniso negalelo kakhulu ukwanda "Pananginum 'efanayo kulo mkhuba cardiological.

Ezona mpawu pharmacokinetic of

Sam "Asparkam" analogue ye ichiza ngokukhawuleza kwaye phantse ngokupheleleyo ngenisa kwegazi. Kukhuthaza ichiza lwenzeka ubukhulu becala esebenzisa nezintso. Emva idosi enye yechiza ubuninzi yoxinaniso umsinga igazi ekufikelelwe kuso phakathi iiyure 1-2. "Asparkam" ukusuka kwemithambo yegazi iwela njengoko ion potassium, magnesium asparginatov iiseli kwaye iqala inxaxheba kwiinkqubo zabo metabolic.

Ubungqina obubonakalayo buxela

azipilisi "Asparkam" eyoqulunqo ekujongwe (kwaye zisetyenziswa ngempumelelo) ukulungiselela unyango izifo ezinxulumene insufficiency intliziyo. Ngaloo ndlela, ebonisa ukuba khona ingaba imeko karhulumente postinfarction emva cardioversions okanye ekhatshwa arrhythmia kunye Uhanjiso engabalulekanga. "Asparkam" iyasebenza ukunyanga ukusilela kwentliziyo nokusetyenziswa kwe glycosides kwentliziyo, kwakunye Kwiimeko libanda, okanye ityhefu saluretikami (amachiza umchamo ukuba ngaphandle ukwandisa diuresis ukuthuthukisa ukukhuthaza ukususwa ion emzimbeni).

Ifom injectable "Asparkama" iye isetyenziswe ngempumelelo kwi nothomalaliso entsonkothileyo sisifo sentliziyo esinganyangekiyo, kuquka iqhosha post-engabalulekanga, ukuphazamiseka isingqi Uhanjiso kwi kunyango ehlangene.

Izimo ukuba ichiza

Ngenxa yokuba "Asparkam" iqulethe izixa ezikhulu magnesium kunye ion potassium, oko contraindicated ngexesha ukusilela etsolo kwaye esingapheliyo kwezintso, kwakunye nokwanda uvakalelo amacandelo omnye okanye ngaphezulu beziyobisi.

Uthuke cardiogenic (xa uxinzelelo lwegazi iSystolic sisehla sibe ngaphantsi kwama-90 mm HG. V.) Ngaba akukho Kucetyiswa ukuba basebenzise "Asparkam" analogs. Imiyalelo yokusebenzisa ibonisa ukuba ichiza nayo contraindicated izifo Addison kunye insufficiency ezisebenzayo adrenal, kwiimeko block vysokostepennoy atrioventricular isigulana kunye nomxholo eliphezulu potassium nezinki ion kwi plasma yegazi.

Umthamo kunye noLawulo

Xa usebenzisa azipilisi "Asparkam" iziyobisi ukuthatha ipilisi enye okanye ezimbini emva izidlo kathathu ngemini. Ubude unyango umiselwa ugqirha ngokuya ngokusekelwe ikhondo lwezonyango izifo data elebhu kunye neendlela zomculo.

Le fom injectable yabelwa kuphela lolawulo efakwa. Okubhalwe igutyana omnye kufuneka ichithwe ngo-50 okanye 100 ml engenazintsholongwane isisombululo iswekile isotonic, elawulwa yegazi ngokucothayo. ulawulo-phindo kungaba waphinda akukho ngokukhawuleza ngaphezu kweeyure 4-6 esemva kwaleyo yokulungiselela odlulileyo indawo "Asparkam". Analogs beziyobisi (umz: "Panangin") ababelwe twatse. "Panangin" like "Asparkam", inefuthe ngokukhawuleza kwi nethe of myocardiocytes. Ngoko ke, lo Togu "Asparkama" in Russian lisetyenziswa kwizibhedlele zentliziyo.

imiphumela emibi

Kwimeko lokufumana azipilisi kwangathi isahlakalo ukuphazamiseka ye phecana zesisu, apho kubonakaliswa ziintlungu kunye epigastric elivuthayo, isicaphucaphu, ukugabha. ulawulo ezondeleyo izilonda le isifo.

Ekubeni ichiza inefuthe kugqibelelo nemithambo yegazi, xa inxalenye yayo kunokubangela arrhythmias, ukuphazamiseka Uhanjiso, ibhloko atrioventricular, lisibekele uxinzelelo lwegazi.

luvo uthi lubandakanywe nezenzo paresthesia, esibuhlungu, twitching.

Ngenxa isiqulatho eliphezulu ion magnesium umthondo yabo kwinkqubo luvo ukuze yokuphefumla umsebenzi kukudakumba. kaninzi yayigcwele ukusungulwa kuyabuya ubushushu "Asparkam" iziyobisi. Analogs beziyobisi uneempawu efanayo reactions egwenxa kunye nezihlandlo kwazo. Ngenxa yoku, qiniseka ukuba ukucela ulwamkelo ngaphambi yomguli beziyobisi.

imiyalelo Special ukusetyenziswa "Asparkam" iziyobisi

Analogs abantwana ezisetyenziswa kakhulu izigulane ezingabantwana, nangona kukho okwangoku data zaneleyo ngokusetyenziswa "Asparkama" ebantwaneni. Ngaphandle koku, ichiza iye isetyenziswe ngempumelelo ukuze ukunyanga izifo sentliziyo ngo wezifo.

Ukuba unyango ixesha elide "Asparkama" ekucetyiswa esweni ngenyameko electrolytes e plasma yegazi, iliso electrocardiographic iparameters. Kwakhona ngononophelo obukhulu beziyobisi lisetyenziswa izigulane kunye namaqondo potassium esiphakamileyo plasma yegazi.

"Asparkam": nabalingani

Phakathi market zoxubo yangoku generic "Asparkam" ichiza kukunika "Panangin". Ngempumelelo eliphezulu, analog esebenzayo "Asparkama" lisetyenziswa eRashiya njengoko na isakhiwo efana kunye ngokulandelelanayo zikhombisa efanayo. Kwaye umzekelo practice zentliziyo. Ngaloo ndlela, "Panangin" - nelo ukuba 'Asparkama "kunye nokwakheka efanayo.

Phakathi kwezinye iziyobisi ukuba ngendlela efanayo, kufanele kuphawulwe "Inosine" "Riboxinum" "Meksaritm" "Propanorm" "Ritmokard".