Anticoagulants - iziyobisi ezichaphazela igazi ekunqandeni

Phantsi kweemeko eziqhelekileyo, igazi ulwelo ebonelela intshukumo kwinkqubo yakhe kwegazi. Xa izifo ezosulelayo kunye olwaye lwamfimfitha, kwakunye intoxications Ukutshintsha iimpahla zayo physico-acid, kuchaphazela iinkqubo pathways kunye nokusebenza kwamalungu zangaphakathi. Ngoko ke kubaluleke eziphilayo iye rate ekunqandeni. Kokuba okukhawulezileyo zilibaziseke. Xa iyeza, sebenzisa ezininzi arhente amayeza ngoncedo apho uyakwazi ukunyenyisa isantya igazi ekunqandeni. Anticoagulants - iziyobisi ukubambezela i inkqubo coagulation igazi, njengendlela ukukhawulezisa le mpendulo yokhuselo, ebizwa coagulants.

Indlela of coagulation kunye thrombus Ukwakheka - yinkqubo entsonkothileyo zengqo- ekhusela umzimba ukusuka ukopha phakathi ephula ingqibelelo nemithambo. Le nkqubo yenziwa ngeendleko prothrombin, nto leyo kuhlelwe esibindini, neeplatelets, nto leyo ngqo Imicu collagen ye kungqameko isitya yonakele. Kwinkqubo haydrolisis eyabelwe iikhompawundi zegazi-rich (adenozintrifosfatnaya kunye adenozindifosfatnaya acid), thromboplastin kunye vasoconstrictors - norepinephrine, epinephrine, serotonin. Bona ezinciphisa sayo isitya. Thromboplastin phantsi kwempembelelo calcium plasma iiproteni enxulumene prothrombin kunye thrombin iifomu, nto leyo iproteni (lwefibrinogen) is kuguquka fibrin ezingenakunyibilika, ngokulitywina i mithambo yegazi.

Blood ekunqandeni kubamba izifo ezinxulumene calcium kunciphise egazini, ukuhla zegazi ukubala, prothrombin kuyondelelaniswe ukuphazamiseka lwefibrinogen, thrombokinase umsebenzi elanele vitamin K. The coagulants asetyenziswe amayeza, thrombin, lwefibrinogen, calcium chloride, menadione, aminocaproic acid, imifuno amalungiselelo (amagqabi umba, pepper amanzi).

Anticoagulants - iziyobisi zinqanda umsebenzi ngokobugcisa inkqubo, enika coagulation igazi kwaye uthintele ukuyilwa egazi kwimikhumbi yegazi. Bathi anqanda zonke okanye ezinye izigaba igazi ekunqandeni. Yinto eyaziwayo ukuba karhulumente ulwelo igazi egcinwa yi-enzayim ezithile antitrobminom. Ukuze kuthintelwe ukuyilwa amahlwili egazi, anticoagulants kusetyenziswa amanyathelo ngqo. Bona kuchaphazela izinqumisi igazi ibambezele inkqubo emzimbeni okanye ityhubhu. Sodium citrate (sodium citrate) kunye EDTA (ethylenediaminetetraacetate acid) ukubopha calcium insimbi igazi ukuyijika ibe calcium citrate nokuba complexed kunye EDTA. Ngokunxulumene nokususwa ion calcium ukusuka kwinkqubo igazi ekunqandeni ezikhandelwa thrombin kunye fibrin. LweeHedfowuni inactivates imiba thrombogenic kwaye abangaphangeliyo ukuguqulwa prothrombin ukuya thrombin. Anticoagulants - isenzo ngqo zamachiza ezimiselweyo gazi and laboratory Haematology izifundo kuthintelo igazi ekunqandeni kunye nonyango zizifo zihamba i ekunqandeni olukhawulezisiweyo igazi. La machiza asetyenziswa uthintelo kunye nonyango iingxaki thromboembolic.

Anticoagulants of ngqo inyathelo - bishydroxycoumarin, coumarin, sinkumar - ukuvala Yindibanisela enzayim abandakanyeka igazi ekunqandeni. Bona anqanda thrombin uluhlu esibindini. Le nkqubo senzeka eziphilayo kwisithuba seeyure 12-72 kwaye siboniswa kwisithuba seentsuku ezimbini ukuya kwishumi. Esi amayeza elide-esebenza. Anticoagulants - amachiza ngqo ezimiselweyo nokuthintela kunye nokunyanga thrombosis, Embolism, thrombophlebitis.