Antibiotics fluoroquinolones - mlilo esebenzayo impilo yakho

Ngowe-1962, xa amachiza yokuqala olomeleleyo kule klasi, akukho namnye kwangaphambili ukuba ibe yimpumelelo. Baye basungula njengendlela ukunyanga izifo womchamo, kodwa kamva baba antibiotics athandwa kakhulu. Ukuziqhelisa lwezonyango, eli qela idosi baba ngenkuthalo isicelo kwi-imi- 80 lwekhulu XX kuphela. Namhlanje, imithi, fluoroquinolones nje zilahleka kwi unyango lwezifo zemiphunga. Ngomhla kummandla eRussia yokuhlela ethandwayo ehlabathini ezi antibiotics izizukulwana ezizayo. Kodwa ke, ngelishwa, eli candelo akavumeli bengabameli ukuchonga ukwakhiwa kwawo iikhemikhali kunye spectrum yomsebenzi. Ngoko ke, amaninzi malunga fluoroquinolones (antibiotics), yithini, ukwabiwa amaqela-2 - ubudala yaye ezintsha.

ngezigaba amachiza

LomThetho wamaYeza iqela kwakude "Ofloxacin" iziyobisi "enoxacin" "ciprofloxacin" kunye nabanye. antibiotics New - ichiza "sparfloxacin", "Klinafloksatsin", "moxifloxacin". Noko ke, ezinye amachiza kuphuhliswa azisafumaneki, njengoko abaphengululi neziphumo ebezingalindelekanga ezimandundu ezinxulunyaniswa ne ukusebenzisa kwabo zifunyenwe.

Ukusetyenziswa antibiotics

Eli qela iziyobisi ngokwemveli asetyenziswe izifo womchamo, usulelo amathumbu kunye nezifo, ezosulela ngesondo. Kuba unyango lwezifo zemiphunga asetyenziswa antibiotics fluoroquinolone, ngelishwa, bambalwa kakhulu, nangona bekwazi ukuba isebenze kwiintlobo ezithile kwamagciwane.

le mithi

Antibiotics Fluoroquinolones baphilela kakuhle iphecana emathunjini, kwaye kwandiswe mxube engamanzi kwizihlunu emva kweeyure ezi-3 emva kokuba isicelo sabo. Ukuba ngaxeshanye ukutya ukutya, kukufakwa bit esebenzayo kade, kodwa intshukumo iya kuba esebenzayo. Indlela yesenzo kweziyobisi yeyona inhibition ye DNA gyrase kunye eziphilayo topoisomerase IV, ngoko akukho cross-ukuxhathisa kwezinye izinto elwa. Ezi antibiotics esisetyenziswa ngokubanzi zuza (ababhinqileyo izifo uhlelo zokuzala), xa inflammations ingakumbi amalungu zangasese, nto leyo zivele ngenxa umsebenzi ngamandla ze micro-eziphilayo engena kwisiqwenga eliphezulu lenzala. Thatha quinolones bancome ungatyanga, nangona kuvumelekile kwaye usebenzise emva kokutya.

imiphumela emibi

Nemithi, fluoroquinolones ukuba ukunyamezeleka kakuhle phezu yokufakwa kunye iinaliti efakwa. reactions Ezingalunganga zinqabile, kodwa ukuba benza ke, ngokokuqhelekileyo kuchaphazela umsebenzi wokugaya nomsebenzi luvo. Kungahle isicaphucaphu, urhudo, intloko ebuhlungu, isiyezi, amahlaba, uvalo. Ngokubanzi, eli qela-ntsholongwane luphawulwa pharmacokinetic iparameters awongamileyo.

amanyathelo Basic step fluoroquinolones

1. Ukungena ngokusebenzisa inwebu kungena kwiseli.
2. Inhibition le gyrase DNA enzyme.
3. DNA biosynthesis.
4. Intshabalalo algorithm division cell.
5. Utshintsho kubume cell.
6. ukufa kweeseli.

Eli qela imithi ezisetyenziswa kakhulu amayeza, kwaye xa kusetyenziswa iyakwazi yokubonelela ngenkxaso esebenzayo impilo yabantu.