Zintsholongwane "Elisebenzayo": imiyalelo ukusetyenziswa, nabalingani real

unyango lwangoku lweenkqubo ezasulelayo, akunakwenzeka ngaphandle ukusetyenziswa kweziyobisi antibacterial. Luvukelo elinyusayo ezincinane kwenza khangela kwamachiza amatsha okanye ukusetyenziswa edibeneyo, imithi ezindala waphumelela uvavanyo. Hayi ngokuthanda eyiyo yokusetyenziswa antimicrobials kungqinwa ngokuqeshwa engalawulekiyo antibiotics ebanzi-spectrum, endaweni ngovavanyo sokuqala uvakalelo enezityalo ukuya machiza kweli qela. Drug "Elisebenzayo", enalo pharmacokinetic ezibalulekileyo kunye eziluncedo pharmacodynamic kwiqela fluoroquinolones zisetyenziswa kakhulu ukuba unyango lwezifo ezosulelayo of etiologies ezahlukeneyo.

iimpawu Clinico-imithi

Le medicament "Elisebenzayo" okanye "levofloxacin" (International Nonproprietary Igama), yi-zintsholongwane evela fluoroquinolones manqaku, eyenzelwe iindlela enteral kunye parenteral yolawulo.

Iyafika "Elisebenzayo" (umyalelo manual inika kanye loo ulwazi) yilo monoftorhinolonom - isomer of ofloxacin, kwaye xa kuthelekiswa namanye amachiza, anazo eziluncedo kakhulu pharmacokinetic:

• bioavailability yomlomo yi-100%, izinga ubudlelwane kunye iiproteni plasma kutsho kuma-40%;
• ubuninzi serum igazi ichiza waphawula 1-2 iiyure emva ifana naleyo ulawulo efakwa emva ulawulo ngomlomo;
• "Elisebenzayo" luphawulwa umqulu banda zokusasaza emzimbeni, ngenxa kwii olungamandla esikule;
• It has a elide nesiqingatha-ibubomi kumzimba ebangela nedosi enye kuphela ichiza ngamnye ngosuku.

Njengoko ukuba ezibalulekileyo fluoroquinolones isiphumo enyangayo ebangela santya zokunyuka egazini uyondelelwano lwee- ichiza unyango, i pharmacokinetic iparameters ngentla zibonelela iimeko ezithandwa ukupheliswa ngokupheleleyo ezincinane.

Ngokutsho uhlobo zabo inyathelo ekukhuleni nokukotshwa iintsholongwane, "Elisebenzayo" kunempembelelo bactericidal, ezichaphazela kungekuphela iifomu esebenzayo iintsholongwane yayintsholongwane eyosulela, kodwa kwi kwezityalo kunye baphola.

Yokucolwa ezinye iziyobisi kwenzeka xa hepatocytes yi deacetylation okanye igcwala. Noko ke, malunga ne-5% beziyobisi salawo yi nezintso njengoko metabolites, yaye intsalela usebenze nge ukuhluza glomerular kunye secretion tubular. Kufuneka kuqatshelwe ukuba emva ulawulo yomlomo inxalenye ebalulekileyo ichiza (malunga nama-70%) salawo ivela emzimbeni kwisithuba seeyure ezingama-24 ukusuka umchamo, yaye malunga ne-80% ye iidosi iyapheliswa emva kweeyure ezingama-48. Isabelo kukhuthaza ichiza ngokusebenzisa iphecana zesisu iphantsi yaye malunga ne-4% kuphela.

Xa usebenzisa ichiza ngeedosi kwama-1000 mg ngosuku (tablets kabini-ngemihla ka-500 mg) kukho amathuba encinane zokuphuhlisa ubukela.

indlela isenzo

Indlela of action isiyobisi ngokusekelwe inhibition enzyme ethile ebizwa DNA gyrase, nto leyo ebandakanyekileyo xa ukuthunga ohlobo ezintle DNA kweleli ezigxekayo kwiinkqubo phindana genetic material. Ngenxa inhibition le enzyme yephule iinkqubo ze DNA phindana, icandelo iseli, iseli ukufa kwenzeka.

"Elisebenzayo": imiyalelo ukusetyenziswa nokubonakaliswa

Ukuza kuthi ga ngoku, le kubonakala ezingundoqo emisela iinkqubo umyalezo ezosulelayo yintsholongwane, okubangelwa Ngeentlobo sengozini ezincinane olwa kubaguli abangaphezu kwe-18.

Ukulungiselela "Elisebenzayo" ndlela incamisileyo ndizilingile unyango izifo zemiphunga esihlobene izifo iphecana yokuphefumla ephezulu nesezantsi ezifana bronchitis etsolo, sinusitis, izifo yokukrala ijwabu semiphunga. Oku kubangelwa, ngaphezu kwabo bonke, i umthondo kweziyobisi elihle kungena epithelium le bronchi kunye nemiphunga apho nasemva kokuba ulawulo ichiza lokuqala idala ingqalelo ngempumelelo.

Ukuqulunqwa efanayo esetyenziswa ngempumelelo ukunyanga wokuchama usulelo iphecana (pyelonephritis, Ngokuzimela, urethritis, njalo-njalo), usulelo iphecana Biliary, prostatitis, usulelo ulusu, usulelo intraabdominal kunye nokudumba.

Ukuze ukunyanga izifo ezosulelayo ye yomoya "Elisebenzayo" unikwe (kuxhomekeke kubuzaza sifo) izihlandlo 1-2 ngosuku 500 mg ipilisi nganye, okanye ukulungiselela injectable.

Kuba unyango lwezifo womchamo na idosi ezaneleyo ukulungiselela 1, 250 mg kanye ngemini, yaye kwiimeko kakhulu, idosi yemihla ngemihla kunokuba 500 mg ( "Elisebenzayo 500"). Imiyalelo yokusebenzisa wathi ithamo kabini-yemihla ngemihla ka-250 mg nga kutshintshwa kuze kufakwe omnye single 500 mg ngokuxhomekeke ubukhali sifo.

Kuba unyango lwezifo ezosulelayo yesikhumba kwakunye nomkhwinya "Elisebenzayo" wabelwa ukuba umthamo 250 mg kabini ngemini.

Izimo

contraindication Absolute kokufumana isiyobisi hypersensitivity kunye ziyabagulisa phambi imbali lwamayeza fluoroquinolones.

data esichazayo emalunga nokujongana ichiza ngexesha lokukhulelwa, hayi, njengoko izifundo ezilawulwa legalelo eteratogenic okanye embryotoxic ayenziwanga kuqhutywa.

Ngenxa yale ukuqeshwa "Elisebenzayo 'ukuba abasetyhini abakhulelweyo kufuneka luthintelwe, ngaphandle kwakwiimeko apho ingozi wolawulo ukwimo lingaphantsi kwe iinzuzo kulo.

Kwimeko beziyobisi izigulana porphyria, kunokubangela ukuqhubela phambili kwesifo.

Ngononophelo ukumnika isisombululo ezizodwa kufuneka usetyenziswe ukuba izigulane amanxeba phambi kwenkqubo luvo (stroke, isifo sentliziyo, ukwenzakala ebuchotsheni zonxinzelelo), ngenxa amathuba aphezulu States convulsive.

Kuba izigulane abasebenza iindlela ezintsonkothileyo emsebenzini okanye ukuqhuba isithuthi, akukho miyalelo ezikhethekileyo, kodwa cinga amathuba neziphumo ebezingalindelekanga kwi-luvo central ngohlobo nobuthongo, ukudideka, kunye nabanye. Ngenxa yesi sizathu kufuneka ayiyeke lo msebenzi.

imiphumela emibi

Enye iziphumo ebezingalindelekanga kakhulu ephuhlisa kwizigulane abafumana fluoroquinolones, kukho ukuphazamiseka yomonakalo intlala chondrocytes ngenxa epiphyseal kunye esikule ngokwayo. Ngenxa yale ichiza contraindicated ngabantu abangaphantsi kweminyaka eli-18 ubudala kunye nabasetyhini abakhulelweyo. Kufuneka kuqatshelwe ukuba izigulane kwama-18 eminyaka ubudala sizoku lwisana ukusetyenziswa ixesha elide iziyobisi waphawula isahlakalo arthralgia okanye nokuphazamiseka of amalungu. Phakathi kwezinye iziphumo ebezingalindelekanga oku kulandelayo.

Ngomhla inxalenye iphecana zesisu - isicaphucaphu, ukugabha, ukungabi namdla, ukuvela njengokungathi ntofontofo kummandla epigastric, usenokuba ukopha zesisu kunye nophuhliso gastroenteritis; ukwanda transaminases kwi plasma yegazi.

Ngomhla inxalenye yenkqubo luvo - uphuhliso iimpawu Encephalopathy, intloko ebuhlungu, isiyezi, ilahleko osezingqondweni, zokulala, kwaye utshintsho rhoqo kwi mood, ukubonakala paresthesias, nemibono kunye iimfeketho zokufeketha.

Ngomhla inxalenye amajoni omzimba - uphuhliso negazi ezifana irhashalala eluswini, ukurhawuzelela, kwaye ukuphuhlisa photodermatitis olunikiweyo elihlala livelile eliphezulu.

Kwinkqubo wokuchama - nophuhliso crystalluria.

Inkqubo yokuphefumla kusenokwenzeka isenzeko bronchospasm kunye kwegazi - kukuhla elibukhali kwi uxinzelelo lwegazi, hypoglycemia yophuhliso basabela kwiseli hemostasis (ngokohlobo thrombocytopenia, njl njl).

Intsebenziswano kunye namanye amachiza

iziyobisi fluoroquinolone nje zilawulwa kunye asidi, njengoko oku kunciphisa ngokubonakalayo ukufunxeka kunye bioavailability imithi. Akunconywa ngaxeshanye yesicelo "Elisebenzayo" ngamalungiselelo yentsimbi, kwakunye namachiza ezichaphazela umsebenzi ukusebenza kwenkqubo luvo. Ukongezelela koko, kukho ubungqina malunga ifuthe probenecid kunye cimetidine phezu kukhuthaza ichiza (ezi izinto banako ukunciphisa ukupheliswa of olwa).

ebonisa zicacileyo imithi kunye levofloxacin hayi. Ngenxa nethe ophantsi beziyobisi inyama hepatic kunye nokungabikho yentsebenziswano enzyme zelo qela cytochrome P450 «Elisebenzayo" akaguquguquki umsebenzi yokugqibela, kodwa nangona oku, njengamanye amalungu fluoroquinolone, ichiza kufuneka zidityaniswe kunye neziyobisi teofilinovogo series ngqo anticoagulants, kungenxa yokwanda kunokwenzeka ingqalelo egazini.

Ukusetyenziswa kweziyobisi ngexesha lokuncancisa

Ukuza kuthi ga ngoku akukho lwazi malunga ukukwazi ichiza ndzulu ubisi lwebele lukamama. Ukuba kukho imfuneko unyango zintsholongwane ngexesha lwebele-zokuxheshisela, indawo yokugcina ixesha olucetyiswayo (ixesha kuxhomekeke ubungqongqo usuleleko kunye nexesha ekulindeleke ukuba unyango isibulala-zintsholongwane). Ukuba kuyimfuneko ukuze kugcinwe lokwaphusa ukuvelisa zokumpompa ngamaxesha athile okanye ukuyeka lokwaphusa ngokupheleleyo ngeendlela zonyango.

Kwiimeko kakhulu, isifuba-zezondlo antibiotics inokuba kuvavanyo lomngcipheko umntwana nonina.

ifomu Ukukhululwa balawule

"Elisebenzayo" lukhutshwe ngeendlela ezimbini: ngokuba zolawulo enteral kunye parenteral. Kuba ulawulo ngomlomo apho azipilisi equlethe 250 okanye 500 mg beziyobisi (ngokulandelelana phantsi amagama zabasebenzi "Elisebenzayo 250" yaye "500 Elisebenzayo"). Kuba ulawulo parenteral isisombululo ekhoyo ukumnika.

"Elisebenzayo" Amacwecwe zithathwa amaxesha 1-2 ngemini phambi izidlo okanye phakathi iindlela yawo elulwelo, ndazikhamela ngamanzi ngokwaneleyo. Kwimeko apho imfuneko ukwahlula ithamo kwisiqingatha beziyobisi, cwecwe nawaphula kwileyibhile ibe ziinxalenye ezimbini.

Ukuze ulawulo parenteral, isisombululo inaliti wokufumaneka esebenzayo lamanani eziletha 500 mg / 100 ml isisombululo ( "Elisebenzayo 500"). Kwimeko isitofu efakwa, ukuqaliswa ichiza wayengekho ngokukhawuleza kunokuba ngeyure 1.

olunye lenguqu ukuya azipilisi i kucetyiswa emva ulawulo ukumnika. ixesha elilindelekileyo ixhomekeke ebukhulwini yosulelo kwaye ubuntununtunu ezincinane yayintsholongwane eyosulela ukuya olwa nawo. Therapy (kungakhathaliseki uhlobo lolawulo) bakhuthazwa ukuba baqhubeke iintsuku 3-4 emva kuqheleke lobushushu bomzimba. unyango ezahlukileyo kunye nokupheliswa yokuqala ichiza akucetyiswa ngenxa umngcipheko ophezulu reactions icala kunye nophuhliso eli uxhathiso microflora iziyobisi.

oyi

Ngaphambi therapy usebenzisa 'Elisebenzayo "yemiyalezo unyanzelisa ubambe iisampuli ngeentsholongwane ubunzima uvakalelo ichiza. Noko ke, ekubeni kuluhlu olubanzi amanyathelo, unyango ukuze kuqaliswe ngaphandle ukuqhuba isampula, kulandelwe ukumiselwa siyobisi ngempumelelo.

Ukunika unyango "Elisebenzayo", ingqalelo ekhethekileyo kufuneka ihlawulwe kuhlalutyo ejoliswe ukuhlola ukuhamba kwegazi kwezintso, ekubeni uninzi ichiza salawo ngokusebenzisa izintso kuyo. Xa ukunyhashwa ichiza umsebenzi idosi yokugqibela kufuneka lulungiswe ngokungqinelana zesigunyaziso creatinine iqala.

ifom ukulungiselela ukumnika kuyathintelwa axutywe izisombululo lwezitofu, ibe basabela ialakalin (ibhiKharbonati yesoda), kunye ne lweeHedfowuni. Ukulungiselela injongo ukumnika dilutions rasvor "Elisebenzayo" elihambelana ne solution sodium chloride isotonic, isotonic glucose isisombululo "Ringers".

Ngexesha reception, "Elisebenzayo" kufuneka uphephe ukusela utywala, ukuba konyusa isiphumo zinetyhefu kakhulu levofloxacin kwinkqubo luvo nokubonakalaliswa iqapheleka kakhulu yeziphumo ebezingalindelekanga.

Ukuba, ke, wagqiba ngokwabo ukuba ukusebenzisa i "Elisebenzayo", imiyalelo ukusetyenziswa, analogue, kufuneka kuvavanywa ngononophelo, kuba inzaliseko kolwazi kunye nokuthembela kwi ulwazi olwaneleyo yokulungiselela siphephe iimpazamo.

Ukugcinwa kunye nonikezelo ezikhemesti

iimeko yokugcina Special ichiza ingafuneki. ngokukhuseleka nokusebenza kwalo kufuneka kuqinisekiswa kwiqondo lobushushu okukufutshane ukuya 25 Degrees Celsius. Ukususela "Elisebenzayo" kwiikhemesti (zintsholongwane) kagqirha.

Xa uthenga imveliso nakanjani kuyimfuneko ukunikela ingqalelo ingqibelelo kunye nokhuseleko zizinto ebekupakishwe, umhla imveliso kunye ezikhabhathini. Kufuneka nakanjani abekho kwibhokisi amayeza "Elisebenzayo" umyalelo manual. Iipilisi kufuneka babe ukuphakheja ezikumgangatho ophezulu. Unga khangela i va oyivileyo kuyo (oko kunokubonakala kunzima engaqhelekanga). Oku kungenxa yokuba ngakumbi yaye ngokufuthi ngakumbi kwimarike zamayeza kukho mbumbulu kunye fakes, abo bangcwele kuhle nako ukunika isiphumo ngokwaneleyo antibacterial xa ndithatyathwa ngomlomo, yaye okubi - zinokubanga iziphumo ebezingalindelekanga kakhulu. Ngoko ke, ukufumana ichiza, musa kuba uyonqena ukubuza ayinikiwe malunga ubukho kwesiqinisekiso esemgangathweni, engqina imvelaphi ichiza, "Elisebenzayo" (tablets). Imiyalelo yokusebenzisa (iziyobisi amayeza ethengiweyo) kufuneka siqulathe ulwazi malunga nemvelaphi mali.

libanda

Kwimeko akukho libanda, iyeza ethile. Symptomatology ezingaphezu iidosi kubangelwa ikakhulu yempembelelo yokugqibela kwi umsebenzi ukusebenza kwenkqubo luvo. Kule meko kukho ukudideka kwengqondo, ukozela, isiyezi, kunye neempawu ze-excitation e-nervous system ngohlobo ukugula ngengqondo, ukuxhuzula, kunye nabanye.

Unyango ejoliswe zinomgutyulo ngokukhawuleza ichiza. Ngenxa bioavailability ophezulu kunye nokusasazwa ichiza wonke umzimba, iindlela ihaemodialysis ezigulela olungasebenziyo. Kuyimfuneko ukuba ayeke ukuhamba beziyobisi emzimbeni kunye ukwenza lo unyango nomqondiso.

Ngenxa nokuphelisa enkulu "Elisebenzayo" yi ukuhluza kwi kidney glomeruli indlela ephumelelayo detoxifying ngayo ukusebenzisa izisombululo netyuwa zolwelo kunye nokufakwa kwamachiza umchamo uhlobo loop amanyathelo.

Izimvo kulungiselelwa

Ngokomthetho waphawula iimpendulo emihle ichiza ngenxa ngempumelelo yalo phezulu ukuba unyango lwezifo ezosulelayo of umyalezo ezahlukeneyo. Njengoko kuchaziwe kwi "Elisebenzayo" imiyalelo yokusebenzisa le ncomo iziyobisi aseleyo izigulane kuphela, kodwa oogqirha, owathi ukusebenza kwayo phezulu, phezulu ukuya unyango lwezifo nosocomial kunye nosocomial.

iirivyu ezimbi nokuxakaniseka kweziyobisi ababesele izigulane eziphambili. Oku kungenxa kuphuhliso nemiphumela okanye kakubi "Elisebenzayo". Umyalelo, Noko ke, inika inkcazelo ebanzi kakhulu le mveliso. izimvo ezingalunganga ngenxa yokusetyenziswa kweziyobisi kwiimeko apho nokungaphumeleli ngenxa-non kokuthotyelwa lwaseNtshona Koloni ziba amanyathelo antibacterial ye ukusulelwa ngeentsholongwane. Kufuneka kuqatshelwe ukuba izimvo ezibalulekileyo kusoloko kubashiya izigulane lokuzimela medicate uthabathe self-amisiweyo, okanye ngengcebiso abahlobo okanye "Elisebenzayo" abahlobo (umyalelo ngexesha elinye kaninzi ayihoywa, ezo musa kakhulu kucetyiswa). ingxelo embi abasebenzi bezempilo Oku anayenza. Oku kungenxa usetyenziso oluchanekileyo ubengo amayeza (ulwazi malunga "Elisebenzayo 500" manual iqulethe iinkcukacha ezaneleyo ukuze efanelekileyo yokusebenzisa iziyobisi).

Drug analogue "Elisebenzayo"

Lokulungiselela "Elisebenzayo" analogs myalelo ochazwe ngolu hlobo lulandelayo: ukusukela ichiza a levofloxacin fluoroquinolone isibulala-zintsholongwane, nucleoside aphezulu-grade kunokuthathwa phantse zonke iziyobisi zesakhiwo efanayo. kufanele kuphawulwe kuqala zonke "Levofloxacin", "USol", "dada", "Levoksimed" Phakathi kwezi, kunye nabanye abaninzi. Kuba "Elisebenzayo" (tablets) Isicelo Umsebenzisi inikeza analogs zamachiza ezifana "Leflok", "Floksium" kunye nabanye.

isiphelo

I esebenzayo Icandelo "Elisebenzayo" chiza - an levofloxacin isibulala-zintsholongwane. Nguye-arhente elihle antibacterial kunye ebanzi-spectrum effect bactericidal. Ngenxa obunamanani aphantsi yeziphumo ebezingalindelekanga kunye nokungabikho ukuba kubekho iintlobo zintsholongwane iintsholongwane ezahlukeneyo, iye isetyenziswe ngempumelelo practice clinical "Elisebenzayo". Imiyalelo yokusebenzisa unika inkcazelo ebanzi kakhulu ngokuphathelele umsebenzi ichiza.