"Valsartan": imiyalelo ukusetyenziswa. Medicine "Valsartan" - analogue kunye nohlaziyo

Ichiza ubizwa ngokuba "Valsartan" umyalelo ncwadi yemigaqo ichaza njengendlela zidityanisiwe, kuquka kumaqela amayeza yoluvo uhlobo vasodilators. Ukusetyenziswa kweli chiza kunempembelelo ngokukhawuleza unesifo kwisigulana. Kwakhona, eli chiza nefuthe uyakhetha zingavisisani kwi receptors AT ₁ ukuba banoxanduva lokuphunyezwa kwenkqubo ye angiotensin II. Ukongeza, imiphumo uphawu umchamo abanokuzifumana umzimba womntu sisixhobo edityanisiwe, njengoko "Valsartan". Analogs yale ukulungiselela - Isingxobo "Diovan" "Exforge" "Tantordio" yaye "Valsakor" - kufuneka iipropati efanayo.

Iimpawu yezenzo imithi

Njengoko kuba iimpawu isenzo amayeza-arhente umfutho, oko kukuthi, yavlyas ochasene ngqo-kuthiwa angiotensin II receptor, ngempumelelo evalela i AT ₁ receptors kwaye kwandisa plasma uyazikhomba angiotensin II. Xa amayeza efanayo "Valsartan" (imiyalelo zokusetyenziswa ucacisa nokubunjwa kwayo) oko zinqanda enzyme angiotensin-ukuguqulela. Kwakhona, akukho nto unayo nayiphi na umsebenzi agonist malunga AT ₁ -receptors. Phakathi kwezinye izinto, le "Valsartan" original akuthethi ukuvala imiphantsi ion kunye receptors nezinye iincindi zamadlala zibalulekile ummiselo eqhelekileyo inkqubo sentliziyo. Ukongeza, ichiza alunasiphumo kwi tireoglobulinpa kwinqanaba, uric acid, cholesterol iyonke kunye plasma iswekile.

Pharmacokinetics

Ukuba sithethe malunga pharmacokinetics le arhente anti-unesifo, njengeyeza for "Valsartan", ngoko ke, njengokuba umthetho, oko ako ngokukhawuleza kakhulu ukusuka iphecana zesisu emva ulawulo ngomlomo, nangona iqondo ukufunxeka kuxhomekeke umehluko ngabanye.

Kule umfutho luqala ukuba kwenzeka emva kokuba elinamanci - imizuzu elikhulu elinamanci mabini emva nomthamo elinye ichiza, nesiphumo iphezulu nezinyangayo ifunyanwa kwi-avareji ngenxa yezine - iiyure ezintandathu. Kukuzibophelela bioavailability yale ichiza phezu nje-22%. Naye, nangokuzikhanyeza iiprotheni igazi (ikakhulu albumin) yi 94-98%. Ukususwa plasma beziyobisi "Valsartan", apho isakhiwo inefuthe ngqo kuwo, imalunga 2 L / h. It ibonakala arhente umfutho isikakhulu ituwa (malunga nama-70%), kunye, ubukhulu ongaphantsi kakhulu kunye nomchamo. Umenzi iyagxininisa ukuba kwimeko kwimiqobo ye bile duct okanye ukuqina biliary, eli chiza ukunyuka AUC kwi-avareji kwisiqingatha. Kutshintshiselwano ukusetyenziswa kweziyobisi naluphi na utshintsho kwi iipropati pharmacokinetic kunye iparameters waphawula.

Inkcazelo beziyobisi

Wavelisa iziyobisi umfutho "Valsartan" (imiyalelo ngokusebenzisa ekufuneka lubandakanyiwe pack nganye) ngokohlobo amacwecwe, umboniso-camera, kwaye ekwimo ngumgubo emhlophe. Le into cishe ezingenakunyibilika emanzini eziqhelekileyo kwaye lula enyibilikayo methanol kunye ethanol. Ubunzima molekyuli yale kuqulunqo imalunga 430-435. Ke ukwakhiwa kwale eliphakathi vasodilating, ngoko iimpawu yokusebenza iqulathe i angiotensin II uhlobo receptor kunye umchamo thiazide.

INKUNDLA ukusebenzisa amayeza

Athathe ipilisi "Valsartan" imiyalelo zokusetyenziswa ikakhulu akunconywa njengenxalenye ekuthiwa unyango indibaniselwano abantu abaphethwe ezinganyangekiyo sisifo sentliziyo okanye lwegazi.

Ngapha koko, le arhente inemifanekiso umfutho kusetyenziswa ukuncedisa wokusindisa abantu iposi engabalulekanga etsolo (kubandakanywa nzima kwekhono ventricular iSystolic okanye ukusilela ventricular ngasekhohlo). Izigulane kunye nesifo sentliziyo abenza iziyobisi bemveli, womchamo nazo kaninzi ilawulwa amayeza "Valsartan". Analogue esi sixhobo nazo zingasetyenziswa zonke iimeko ngasentla.

balawule

Thatha ichiza umfutho, oogqirha ngokuqhelekileyo isincomo amaxesha enye okanye ezimbini ngosuku asibhozo okanye amane milligrams, ngokulandelelana. Xa kungekho isiphumo unyango ezinqwenelekayo, idosi yemihla ngemihla lungandiswa. Nangona kunjalo, oku kufuneka kwenziwe ngcembe emiselweyo kuphela ngugqirha. Ithamo liphezulu ichiza inye milligrams ezimakhulu mathathu anamanci mabini.

Uluhlu Izimo nokusetyenziswa

Sebenzisa iingcali isixhobo-vasodilator sicebisa ngamandla ukuba kukho umntu hypersensitivity nakweliphi na amabakala alo. Xa ifakiwe ziyabagulisa analogously kufuneka ayeke ukuthatha iipilisi "Valsartan". Ichiza lokuqala kufuneka ukuba athathwe yi kwizigulane ayifikanga kweminyaka elishumi elinesibhozo. Le yokugqibela kungenxa yokuba ukhuseleko ukusetyenziswa kweziyobisi umfutho kwiimeko ezinjalo ayiqondwa ngokupheleleyo.

Sebenzisa ngexesha lokukhulelwa

Emiselweyo ichiza "Valsartan" abafazi wozeleyo inkwenkwe, contraindicated ngokupheleleyo. Ezi zifundo zonyango eziququzelelwe kubonisa emngciphekweni lezikolo zikhona iziphumo ezibi-arhente umfutho ekukhuleni kosana olungekazalwa. Nangona kunjalo, kwimeko kwezifo ezinzima ezisongela ubomi apho akunakwenzeka ukusebenzisa abanye, amayeza ezikhuselekileyo, okanye ke ucango, isicelo beziyobisi-vasodilator. Ngokwahlukeneyo kufuneka athi malunga inadmissibility ukusetyenziswa kwe isixhobo ngeli ekondleni usana olusanda kuzalwa kunye ubisi lwebele.

reactions engemihle

Ukuqeshwa ichiza umfutho ezifana, njengoko "Valsartan" kunokubangela yimbonakalo kunokuba kakhulu ebuhlungu, isiyezi, ukhohlokhohlo kunye buthathaka. Ukongeza, kukho ngokufuthi isicaphucaphu, urhudo, hyperkalemia, syncope, kunye ugwayi. iintlungu esiswini, vertigo, neutropenia, thrombocytopenia, arthralgia, iqolo, myalgia, ukudinwa, yaye ukudumba kunokwenzeka ngenxa yolawulo iziyobisi efanayo "Valsartan". Izimvo ezigulane ngaphambili uyisebenzise, nomakathi kwakhona abonise lomngcipheko pharyngitis, nokuthimliswa, sinusitis, iintlobo zosulelo wentsholongwane egazini kunye nezifo ezichaphazela amasebe eliphezulu zemiphunga. Ukongezelela, abantu abaninzi baye baligcina hyperbilirubinemia, sinciphise hematocrit, hypercreatininemia, ukunyuka isiqulatho nitrogen urea igazi ukuhla haemoglobin kunye. Ukongeza, kufuneka ukhumbule ukuba ukwamkelwa ngaxeshanye abangathathi-vasodilator "Valsartan" kunye namayeza evela kwiqela womchamo potassium-zingawucongi kunokubangela uphuhliso hyperkalemia. Kwimeko libanda, iziyobisi zingenzeka iimeko ezifana bradycardia, hypotension okanye tachycardia.

izinyathelo basic

Xa ndiqukumbela, kufuneka kuthiwe ukuba kuyimfuneko ngononophelo ezigqithisileyo kuphela phantsi kweliso zonyango olungqongqo onyule yokwamkela yomenzeli umfutho xa izigulane sodium izivuka, waphula umthetho kakhulu le kidney, stenosis amabini kwemithambo sezintso ekuthiwa-okanye unciphiso okuphawulekayo elijikeleza umthamo wegazi. Oku kubangelwa ikakhulu ukuba izigulane ophezulu umngcipheko kunye umfutho hypotension. Ukongeza, kufuneka sinikele ingqalelo ekhethekileyo kubantu abanengxaki kwesibindi biliary okanye ukuphazamiseka okunzima esibindini. Izigulane ne kwemithambo stenosis sezintso kufuna esweni lomgadi lamanani urea nitrogen kunye serum creatinine. Kwakhona, ingqalelo ekhethekileyo ngokwayo ifuna izigulane kunye nezithintelo phecana biliary, sisamkela womchamo potassium-ungayekwa, izongezo potassium kalisodergaszczye ekhethekileyo okanye iziyobisi. Ekugqibeleni, balumke ngeyona kufuneka zisetyenziswe "Valsartan" abantu iziyobisi umfutho umsebenzi wakhe linxulumene kunjengokuqhuba naziphi izithuthi, yaye abo umsebenzi lowo interfaced ngqo nge xi eliphezulu ingqalelo.