"Paroxetine": imiyalelo ukusetyenziswa, ncomo. analogue iziyobisi

Yintoni ukuthini iziyobisi "Paroxetine"? Imiyalelo zokusetyenziswa ichiza kuya kwenziwa kweli nqaku. Kwakhona uthatyathwe kuwo uye wakuqonda contra-iziboniso kwaye ziyafumaneka kulo iyeza, ukuba uthe waba naziphi na iziphumo ebezingalindelekanga, yintoni fomu ifumaneka nendlela ichiza lisebenzisana kunye nezinye iziyobisi.

Ubume, zokubopha uhlobo wokukhulula iziyobisi

Drug "Paroxetine" uya ezithengiswayo ngohlobo amacwecwe, umboniso-camera. Ba setyhula kwaye lenticular imilo, umbala omhlophe, kunye nengozi kwindawo rough.

Le into esebenzayo igqalwa sithi kuthetha paroxetine hydrochloride hemihydrate. Kwakhona, ichiza kumafa waso inkxaso izinto ngohlobo colloidal lesilicon dioxide, microcrystalline kwincindi, crospovidone, calcium hydrogen phosphate, copovidone, talc nezinki stearate.

Tablets "Paroxetine 'ukuba kuthengiswa imiqulu blister lamaqhosha 10 ezithi zibekwe kwibhokisi yekhadibhodi.

Isenzo amayeza ye ichiza

Yintoni na ichiza "Paroxetine", apho analogue kuya kancinane igama ngakumbi? Kuyinto yeQela. Lo inhibitor of (uyakhetha) serotonin luvo reuptake ebuchotsheni. Le nto imisela iziphumo zayo anti-edakumbisayo nokuba ayasebenza ngokwenene na ukunyanga one- nokuphazamiseka ukuba likhoboka lento ethile.

Kujongwa qhagamshelana medicament unalo oludla ephantsi kakhulu α2-, α1- kunye β-adrenoreceptors kwakunye m-holinoretseptorami, dopamine, 5HT1-ezifana, 5HT2-efana kunye histamine H1-receptor.

Yenza imisebenzi lengqondo kukwaphulwa ichiza "Paroxetine"? Izimvo oogqirha bathi iyeza alunasiphumo kwi psyche abantu kakubi. Ngaphezu koko, akukho nto potentiate iziphumo nokudakumba-ethanol imisebenzi lengqondo.

Kusolwa abaphandi yaqaphela yeQela ezinjalo iipropati isebenze buthathaka kuphela xa ilawulwa kwi iidosi eziphezulu kwalawo ezifunekayo inhibition serotonin reuptake. Asikwazi ukuba eli chiza obangela ukutshintsha ngokuphawulekayo kwemigangatho uxinzelelo lwegazi, EEG kunye nezinga intliziyo.

Le pharmacokinetics kwisixhobo yezonyango

iziyobisi "Paroxetine" njengoko ugxile? Imiyalelo yokusebenzisa, oogqirha lokwenyani ukuba emva ulawulo yomlomo ukwimo esebenzayo ifunxwe ukusuka wokugaya kwaye umzimba nge esibindini.

Le xi emileyo of medicament egazini kwafezekiswa kwiiveki 1-1.7 emva kokuba unyango ngamachiza. Le esisebenza beziyobisi awulungelelananga kuthunyelwa kwizihlunu. Kulo mzekelo, oko ekhulwini elinye kuphela ufumaneka plasma. Unxibelelwano kunye neeproteni ze ngokomyalelo 95%.

Bucala umzimba esibindini. Ngenxa yoko, metabolites abapholileyo kwakheka. Bakhawuleza bungaveli emzimbeni, kwaye umsebenzi amayeza phantsi kwaye nafuthe iziphumo zonyango kweli chiza.

iziyobisi "Paroxetine" njengoko kuboniswa? Qaphela, oosokhemisti ratings uxele ukuba malunga ne-64% ukwimo esebenzayo iyakhutshwa kunye nomchamo, lo gama i-36% - ethunjini (in inyongo).

Le pharmacokinetics beziyobisi kwiimeko ezizodwa clinical

Uyondelelwano lwee- into esebenzayo igazi plasma ukunyuka waphula umthetho wezintso kwaye isibindi, kwakunye nabantu abadala.

Ubungqina obubonakalayo buxela ukuba kusetyenziswe isixhobo yezonyango

Kwezinye iimeko, izigulane emiselweyo yeQela "Paroxetine"? kwi isicelo yesikhokelo isixhobo iqulathe uluhlu lulandelayo ufundo:

• naluphi na uhlobo ukudakumba, kuquka zemveli kakhulu, lovukelo, kwaye lukhatshwa ixhala;
• ukuphakuzela yokudla, kuquka agoraphobia;
• ukuba likhoboka lento ethile (OCD okanye olufinyeziweyo);
• ngokubanzi ixhala yokudla;
• zentlalo ixhala disorder, okanye ekuthiwa lumo.

Izimo ukusetyenziswa isixhobo yezonyango

Kwezinye iimeko, xa kungekho tyala ayikwazi ingasetyenziswa kwizigulane yeQela "Paroxetine"? kwi isicelo yesikhokelo isixhobo iquka uluhlu zilandelayo Izimo:

• sokuwa eziguquguqukayo;
• usebenzisa of inhibitors monoamine oxidase, kwakunye kwisithuba seeveki ezimbini-emva zokurhoxa zabo;
• yobudala yabantwana;
• kokumitha;
• Hypersensitivity amacandelo zeziyobisi;
• ngexesha lokuncancisa.

Sebenzisa ngononophelo okukhulu

Ziziphi iimeko kufuneka kulawulwe kwe bucala "Paroxetine"? Imiyalelo yokusebenzisa ithi le amalungiselelo ilawulwa nge isilumkiso izigulane isibindi, engile-ukuvalwa neglaucoma, ukusilela kwezintso, mkhuba, hyperplasia ingozi prostatic, ithi convulsive, ukuphazamiseka kwentliziyo, ukuxhuzula. Ukongeza, ukuba usebenzisa amayeza olungasebenziyo kunye cardioversion, kwakunye amayeza kwandisa ingozi ukopha. Simele sinikele ingqalelo kakhulu ubukho ubungozi zezigulo ukopha kwaye elungele ukuya ezinjalo States sifo.

Bucala "Paroxetine": ukuthatha njani amayeza?

Thina ucinga iyeza sithathwa ngomlomo kanye ngosuku (kusasa) ngexesha isidlo sakusasa. Iipilisi kufuneka kuginywa yonke, ahlambe phantsi ngamanzi ethafeni.

Ebudeni kwiiveki ezintathu zokuqala emva kokuqala unyango idosi yoxhaso ngamnye. Oku esikolweni (ukuba kuyimfuneko).

Ngexesha ukudandatheka imali ekucetyiswa elide le medicament yi mg 20 kanye ngemini. Ukuba kuyimfuneko, ithamo ebegqwese ukwanda nge-10 mg. Max wafumana ichiza kufuneka mayingagqithi mg-50.

Kuba kukuthenga disorder idosi ukuba likhoboka kokuqala i yeQela yi-20 mg ngosuku. Emva koko, kwenyusa ku-10 mg. I-avareji umthamo Kucetyiswa ngemihla unxaxho esinjalo 40 mg. Xa kuyimfuneko etsolo oko kwandiswa ukuya kuma-60 mg.

Ukuba isigulana umntu one-, ungenza ekuqaleni uthabathe ukuya ku-10 mg beziyobisi ngosuku. Ukunciphisa ubungozi iimpawu panic kunokwenzeka idosi elandelayo ichiza linyuke nge-10 mg. Kwi-avareji, xa unxaxho onjalo kwamkelekile ukuba usebenzise 40 mg "paroxetine" ngeeyure, inani eliphezulu - 50 mg.

Xa lumo okanye ixhala zentlalo ukuphazamiseka volume medicament lokuqala kufuneka ngaphezu kwama-20 mg ngosuku. Ukuba emva kokuba olo nyango nezo ziphumo zinqwenelekayo sele engekaphunyezwa, ngoko 2 iiveki iidosi kancane kancane ukuba iphezulu, oko kukuthi ukuya ku-50 mg ngosuku.

In ngokubanzi ixhala disorder zonyango kunye nomthamo lokuqala medicament yi mg 20 ngosuku

Ukuba isigulane une sesibindi okanye ukusilela kwezintso, ithamo ekucetyiswa kufuneka-20 mg ngosuku.

abantu abadala ngosuku agqitywe akukho mg ngaphezulu kwama-40 amayeza.

Ukuze kuthintelwe uyeka uyeka ezithatha ichiza kucetyiswa ngokuthe ngcembe.

amacala libanda

Ingaba kukho amatyala libanda, kunye lakhula ezifana "Paroxetine", "Fluoxetine"? Iingcali uqaphele ukuba ukusetyenziswa inani elikhulu iipilisi ngokwenene kuchaphazela kakubi umzimba womntu. La mava nomonde isicaphucaphu, umlomo owomileyo, sinus tachycardia, ukugabha, unditsho, lafa, bradycardia, mydriasis, ukuphazamiseka, ukuba nochuku, ukubila, nystagmus, ukwanda koxinzelelo lwegazi, somnolence, nesingqisho nakwiindawo ezibalulekileyo.

Kwiimeko ezithile ezinqabe lo gama usebenzisa amachiza kunye namanye amachiza psychotropic, kwaye utywala comatose nomonde kunye ukwehluka uphawu kwi ECG. Xa libanda kakhulu, isigulana serotonin syndrome kunye rhabdomyolysis.

Kufuneka wenze ntoni kwiimeko ezinjalo? Kwimeko libanda, iziyobisi "Paroxetine" kufuneka lavage esiswini, uthabathe le carbon iyasebenza. Ukuba kuyimfuneko, unyango nomqondiso.

imiphumela emibi

Zintoni iziphumo ebezingalindelekanga amayeza kungabangela 'Paroxetine "? Izimvo oogqirha bathi esi sixhobo inceda ngokwenene ukuphuhlisa ngayo ezibi. Ezi zibandakanya ezi miqathango ilandelayo nezifo:

• Ngomhla inxalenye yenkqubo luvo kunye nenkqubo neuropathy luvo: mkhuba, ukozela, ukudideka, lafa, serotonin syndrome, ukudinwa, nemibono, sokulibala, uvalo, isiyezi, depersonalization, ukudinwa, ukushaya, ukuxhuzula, ukuphazamiseka, kunesifo, ukuphazamiseka extrapyramidal, myoclonus, ixhala.
• inkqubo Musculoskeletal: buthathaka kwezihlunu, arthralgia, myopathy kunye myalgia.
• Iimvakalelo: Umbono awucaci kwaye luzizi xa lilonke.
• inkqubo wokuchama: ukusoloko ukuchama okanye ukugcinwa womchamo.
• wokugaya: inyuswe okanye ihliswe wokutya, hepatitis, utshintsho ukungcamla, umlomo owomileyo, isicaphucaphu, urhudo, ukugabha, nokuqunjelwa.
• inkqubo Reproductive: anorgasmia, kwekhono ngokwesondo, hyperprolactinemia okanye galactorrhea, namandla kunye nezigulo ukuchama.
• nemithambo yegazi: hypotension intolerance.
• Nokwaliwa: ukurhawuzelela, irhashalala, angioedema, kunye urticaria, ecchymosis.
• Okunye yazo: nokuthimliswa, ukubila, secretion ezingafanelekanga of hormone antidiuretic, hyponatremia.

Intsebenziswano kunye nezinye iindlela zonyango

Ukusetyenziswa ngaxeshanye asidi akuchaphazeli parameters pharmacokinetic kunye kukufakwa ichiza "Paroxetine".

Contraindicated ukusetyenziswa ngexesha elinye-mali phambi kwethu nge Mao inhibitor.

ukwamkelwa ngaxeshanye medicament "paroxetine" ngeziyobisi anqanda enzyme zesibindi, ufuna nokuthotywa idosi yokuqala.

niyolule bucala ukopha kwisiqalo lokusetyenziswa ngexesha elinye-"ye warfarin."

ukusetyenziswa ngaxeshanye le medicament "paroxetine" kunye lakhula tricyclic, aspirin, neuroleptics Nedlac, NSAIDs yaye kuthetha phenothiazine uthotho ikhuthaza inkqubo ekunqandeni igazi.

ulawulo ngaxeshanye kunye arhente serotonergic (ezifana "tramadol" yaye "sumatriptan") ngokulula kukhokelela kwiziphumo eziphuculweyo serotonergic.

Kubalulekile ukukhumbula!

Ukunqanda uphuhliso syndrome neuroleptic (yingozi), ichiza okukhulu isilumkiso "Paroxetine" emiselweyo kwizigulana bathabatha antipsychotics.

abantu abadala kwisiqalo beziyobisi angase hyponatremia.

Xa iimpawu zokuqala uxhuzula kunye nonyango mania yeQela uvinjwa.

Kwiiveki zokuqala zonyango with "paroxetine" ufuna esweni ngenyameko isigulane ngenxa azibulale.

Ngexesha unyango nikhumke kulo iziselo ezinxilisayo ngenxa isiphumo zabo ngcono ityhefu.

ukusebenzisa Paediatric

Drug "Paroxetine" ungamiselwanga abantwana, njengoko ngokhuseleko kunye nokusebenza kwi unyango izigulane kweli qela akukasekwa.

Bucala "Paroxetine": nabalingani

Ichiza na indawo "Paroxetine"? Kufuneka kuqatshelwe ukuba olu nyango, kukho kakhulu noogxa ezimbalwa. Phakathi kwabo, bekuya kuba enqwenelekayo ukuqaqambisa amachiza zilandelayo: "Reksetin", "Adepress", "Pliz", "Apo-Paroxetine", "Aktaparoksetin", "Paxil", "sertraline", paroxetine hydrochloride hemihydrate, "" Sirestill "njalo-njalo.

Ukuba bathenge zonke ezi amayeza e ekhemesti, ungakwazi kuphela ngokumiselwa.

Izimvo medicament

Drug "Paroxetine" has a lot of reviews engumxube, naziva, iingcali kunye nezigulane. Kwelinye icala, ukuba adunyiswe kunene oko kunegalelo ukupheliswa ngokukhawuleza naluphi na uhlobo kukudakumba (kubandakanywa iqala kakhulu, lovukelo, kwaye lukhatshwa ixhala), kwakunye yokothuka, ukuba likhoboka lento ethile, ngokubanzi kunye nentlalo-nexhala disorder. Kwelinye - izigulane ezininzi bathi ngoko nangoko emva ichiza baba kakhulu inani elikhulu ngayo ezibi. Ngenxa yoko, abantu baye bade kwafuneka ukuba ayeke unyango.

Ngokubanzi, iingcali qaphela ukuba "Paroxetine" - oku sisiyobisi kakuhle kakhulu kwaye kakuhle uhlangabezana njani nale umsebenzi owabelwe lona. Noko ke, inokusetyenziswa kuphela specialist yayo eyenzelwe injongo.