Medicine 'Methotrexate'. umyalelo

Medicine "Methotrexate" imiyalelo kusebenza kudidi anti-metabolites, analogs pyrimidine. Izithethantonye: "Zeksat", "Treksan", "Triksilem" kunye nabanye.

Lithetha "Methotrexate" (tablets) uvumelekile ukuba ukusebenza njenge arhente enye okanye njengenxalenye nechemotherapy ezintsonkothileyo.

Izenzo ezibonisa ziquka leukemia myeloblastic kunye lymphoblastic, myelogenous leukemia ezingapheliyo flow kwi lamva, lymphosarcoma. Njengenxalenye amayeza himiolecheniya ehlanganisiweyo "Methotrexate" sikhokelo icebisa umhlaza ovarian, wemiphunga, webele.

Xa amathamo eziphezulu (ngelixa ukufumana filinata calcium) iziyobisi ezimiselwe osteogenic nee-, ithumba Ewing kaThixo, choriocarcinoma zesibeleko nee- yethishyu ethambileyo.

Ukusekwa (Inaliti) isetyenziselwa ukuba akhulule iimpawu ze-kolusu psoriatic.

Lithetha "MTX" lwesakhiwo yemichiza (umsebenzisi iqulethe ulwazi) kufutshane folic acid kwi oku nomkhwezeli. Njengoko i ochasene antimetabolite nokubonelela antifolievym isiphumo, ichiza imenza division iseli, uphuhliso izicwili ziyanda esebenzayo, lomongo wethambo ngokunjalo. Le medicament "MTX" negalelo njengengubo ukukhula neoplasms amabi.

Iyeza emiselweyo ngaphakathi.

Xa unyango entsonkothileyo le "Methotrexate" manual iziyobisi icebisa umntu omdala 0.03 grams kabini ngeveki. Ngokuba abantwana ithamo ngosuku - 0,02 grams sentimitha sikwere indawo umphezulu yomzimba nganye.

Ubude unyango - ukuya kwiiveki ezimbini.

indlela ngokunzulu ibandakanya ukutyunjwa dose abadala 0,02-0,025 grams yonke imihla. Ubude unyango - ukuya kwiintsuku ezintlanu.

Kule khosi ukuthatha amayeza "Methotrexate" manual icebisa ukuba ukuthatha ikhefu kwiiveki enye okanye ezimbini.

Amayeza contraindicated kumazwe immunodeficient, isifo sesibindi, thrombocytopenia, leukopenia, igazi (kubandakanywa aplastic kunye apoplastic) hypersensitivity.

Akukho data ngokwaneleyo ukuba baqhube izifundo zonyango lwe amayeza "Methotrexate" abakhulelweyo kunye phindeke. Malunga nalo amayeza kwixesha kokubeleka kwaye ngexesha zisanyisa akukho wabelwa.

Kukho babe iziyobisi "Methotrexate" iziphumo ebezingalindelekanga. Eli chiza ingenza gagging, isicaphucaphu, urhudo, nangokurhala kwi isifo somlomo (stomatitis). ukusebenzisa ixesha elide iziyobisi "MTX" iphawulwe sisilonda esidumbileyoesingaphakathi ne ukopha isifo ngomlomo ngesimilo okwenziwa sisilonda sikabhobhosi, kunciphise ukubalwa zegazi, ilahleko iinwele, sinciphise isiqulatho ihemoglobin egazini. Kwezinye iimeko, usuleleko zasesekondari inokubonakalisa, enokubangela hepatitis ityhefu (njenge xa kufakwa amathamo ephakamileyo), izilonda sezintso.

Ukwenzela ukuphepha uphuhliso nemiphumo engathandekiyo le khosi unyango kuliwa phantsi kweliso elibukhali likagqirha.

Kwimeko libanda, azifani kubonakaliswa ezithile. Uxilongo imeko ikhutshwa phandle umpakati "Methotrexate" plasma iziyobisi.

oyi

Esi sixhobo alisetyenziswa effusion, ascites, izilonda, sisilonda sikabhobhosi, isifo sezintso pleural okanye sifo.

Musa ukuthatha varicella amayeza (kuquka kutshanje zidluliselwe okanye emva ngokudibana onesifo), zoster herpes kunye nezinye izifo ezihlasela zosulele of imvelaphi esosulelayo.

Ekuqaleni kwaye ngexa unyango kuyimfuneko ukulawula umfanekiso igazi peripheral, isibindi kunye nomsebenzi kwezintso.

Ekusebenziseni iziyobisi ukhwekhwe okanye isifo samathambo, ngokupheleleyo wegazi senziwe ubuncinane kanye ngenyanga.

Ngethuba lokwenza uphando yafunyanwa iziphumo mutagenic kwaye umhlaza amayeza "Methotrexate".